ATE40688T1 - Acridincarboxamid-verbindungen. - Google Patents

Acridincarboxamid-verbindungen.

Info

Publication number
ATE40688T1
ATE40688T1 AT83303610T AT83303610T ATE40688T1 AT E40688 T1 ATE40688 T1 AT E40688T1 AT 83303610 T AT83303610 T AT 83303610T AT 83303610 T AT83303610 T AT 83303610T AT E40688 T1 ATE40688 T1 AT E40688T1
Authority
AT
Austria
Prior art keywords
hydroxyl
optionally substituted
lower alkyl
alkyl optionally
acridincarboxamide
Prior art date
Application number
AT83303610T
Other languages
English (en)
Inventor
Graham John Atwell
Bruce Charles Baguley
William Alexander Denny
Gordon William Rewcastle
Original Assignee
New Zealand Dev Finance
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by New Zealand Dev Finance filed Critical New Zealand Dev Finance
Application granted granted Critical
Publication of ATE40688T1 publication Critical patent/ATE40688T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D219/00—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems
    • C07D219/04—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D219/00—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems
    • C07D219/04—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
    • C07D219/06—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D219/00—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems
    • C07D219/04—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
    • C07D219/08—Nitrogen atoms
    • C07D219/10—Nitrogen atoms attached in position 9

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Materials For Photolithography (AREA)
  • Electroplating And Plating Baths Therefor (AREA)
AT83303610T 1982-06-25 1983-06-22 Acridincarboxamid-verbindungen. ATE40688T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
NZ201084A NZ201084A (en) 1982-06-25 1982-06-25 4-carboxamidoacridine derivatives and pharmaceutical compositions containing such
EP83303610A EP0098098B1 (de) 1982-06-25 1983-06-22 Acridincarboxamid-Verbindungen

Publications (1)

Publication Number Publication Date
ATE40688T1 true ATE40688T1 (de) 1989-02-15

Family

ID=19920017

Family Applications (1)

Application Number Title Priority Date Filing Date
AT83303610T ATE40688T1 (de) 1982-06-25 1983-06-22 Acridincarboxamid-verbindungen.

Country Status (6)

Country Link
US (1) US4590277A (de)
EP (1) EP0098098B1 (de)
JP (1) JPS597171A (de)
AT (1) ATE40688T1 (de)
DE (2) DE3379168D1 (de)
NZ (1) NZ201084A (de)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ212525A (en) * 1985-06-24 1989-02-24 Dfc New Zealand Ltd Formerly D Nitrogen-containing heterocyclic compounds, and pharmaceutical compositions containing such
CZ283038B6 (cs) * 1991-01-11 1997-12-17 Laboratoires Glaxo Sa Akridinové deriváty, způsob výroby a farmaceutické prostředky s jejich obsahem
GB9100637D0 (en) * 1991-01-11 1991-02-27 Glaxo Lab Sa Chemical compounds
US5296602A (en) * 1991-03-18 1994-03-22 Sloan-Kettering Institute For Cancer Research Multisubstituted 1-hydroxy-9-acridones with anticancer activity
WO1993003729A1 (en) * 1991-08-12 1993-03-04 Research Corporation Technologies, Inc. N-substituted phenoxazines for treating multidrug resistant cancer cells
US5696131A (en) * 1993-01-22 1997-12-09 Xenova Limited Treatment of cancers
WO1993024096A2 (en) * 1992-05-28 1993-12-09 Xenova Limited Use of n-(2-(dimethylamino)ethyl)acridine-4-carboxamide and its analogues for cancer treatment
RU2036198C1 (ru) * 1993-04-01 1995-05-27 Товарищество с ограниченной ответственностью "Полисан" N-МЕТИЛ-N-( α,D -ГЛЮКОПИРАНОЗИЛ) АММОНИЯ-2-(АКРИДОН-9-ОН-10-ИЛ)АЦЕТАТ(ЦИКЛОФЕРОН), ОБЛАДАЮЩИЙ ИНТЕРФЕРОНОГЕННОЙ, ПРОТИВОВИРУСНОЙ, В ТОМ ЧИСЛЕ АНТИВИЧ, АНТИПАРАЗИТАРНОЙ, АНТИПРОМОТОРНОЙ И РАДИОПРОТЕКТИВНОЙ АКТИВНОСТЬЮ
GB2288333A (en) * 1994-03-17 1995-10-18 Radopath Ltd Benzoic acid containing chloro and or nitro groups for cancer or viral therapy
US6071908A (en) * 1995-08-18 2000-06-06 Auckland Uniservices Limited Radiation-activated cytotoxin therapy of neoplastic disease
WO1998017649A1 (en) * 1996-10-18 1998-04-30 Xenova Limited Process for the preparation of n-[2-(dimethylamino)ethyl]acridine-4-carboxamide
GB9621795D0 (en) * 1996-10-18 1996-12-11 Xenova Ltd Pharmaceutical compounds
WO2000069390A2 (en) 1999-05-17 2000-11-23 Cancer Research Ventures Limited Compositions for improving bioavailability of orally administered drugs
AUPS234402A0 (en) * 2002-05-15 2002-06-13 Auckland Uniservices Limited Anti-tumour polycyclic carboxamides
GB2424884B (en) * 2003-12-31 2008-06-11 Council Scient Ind Res C-8 linked pyrrolo[2,1-c][1,4]benzodiazepine-acridone/acridine hybrids
US7056913B2 (en) 2004-03-30 2006-06-06 Council Of Scientific And Industrial Research C8—linked pyrrolo[2,1-c][1,4]benzodiazepine-acridone/acridine hybrids
WO2005118580A2 (en) * 2004-05-12 2005-12-15 The Government Of The United States Of America As Represented By The Secretary, Department Of Health Tricyclic compounds as inhibitors of the hypoxic signaling pathway
CN109265396A (zh) * 2018-09-12 2019-01-25 李玮 多环酰胺化合物的合成新方法与抗癌活性

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3686180A (en) * 1970-11-04 1972-08-22 Smith Kline French Lab Substituted 9-lower alkylacridine-4-carboxylic acids
DE3063905D1 (en) * 1979-09-14 1983-07-28 New Zealand Dev Finance Compounds having antitumour properties, process for their preparation, these compounds for use as antitumour agents and pharmaceutical compositions containing them
DE3164407D1 (en) * 1980-04-28 1984-08-02 New Zealand Dev Finance Compound having antitumour properties
NZ198115A (en) * 1981-08-21 1985-05-31 New Zealand Dev Finance 9-anilinoacridines;pharmaceutical compositions

Also Published As

Publication number Publication date
DE3379168D1 (de) 1989-03-16
JPS597171A (ja) 1984-01-14
EP0098098B1 (de) 1989-02-08
US4590277A (en) 1986-05-20
DE98098T1 (de) 1985-02-14
EP0098098A3 (en) 1985-05-02
EP0098098A2 (de) 1984-01-11
NZ201084A (en) 1985-10-11

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