ATE40688T1 - Acridincarboxamid-verbindungen. - Google Patents
Acridincarboxamid-verbindungen.Info
- Publication number
- ATE40688T1 ATE40688T1 AT83303610T AT83303610T ATE40688T1 AT E40688 T1 ATE40688 T1 AT E40688T1 AT 83303610 T AT83303610 T AT 83303610T AT 83303610 T AT83303610 T AT 83303610T AT E40688 T1 ATE40688 T1 AT E40688T1
- Authority
- AT
- Austria
- Prior art keywords
- hydroxyl
- optionally substituted
- lower alkyl
- alkyl optionally
- acridincarboxamide
- Prior art date
Links
- AORNIVFSXFONEC-UHFFFAOYSA-N acridine-1-carboxamide Chemical class C1=CC=C2C=C3C(C(=O)N)=CC=CC3=NC2=C1 AORNIVFSXFONEC-UHFFFAOYSA-N 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 2
- 101100294106 Caenorhabditis elegans nhr-3 gene Proteins 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 230000000844 anti-bacterial effect Effects 0.000 abstract 1
- 230000000259 anti-tumor effect Effects 0.000 abstract 1
- 125000003236 benzoyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C(*)=O 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 abstract 1
- 125000003170 phenylsulfonyl group Chemical group C1(=CC=CC=C1)S(=O)(=O)* 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D219/00—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems
- C07D219/04—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D219/00—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems
- C07D219/04—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
- C07D219/06—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D219/00—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems
- C07D219/04—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
- C07D219/08—Nitrogen atoms
- C07D219/10—Nitrogen atoms attached in position 9
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Materials For Photolithography (AREA)
- Electroplating And Plating Baths Therefor (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| NZ201084A NZ201084A (en) | 1982-06-25 | 1982-06-25 | 4-carboxamidoacridine derivatives and pharmaceutical compositions containing such |
| EP83303610A EP0098098B1 (de) | 1982-06-25 | 1983-06-22 | Acridincarboxamid-Verbindungen |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE40688T1 true ATE40688T1 (de) | 1989-02-15 |
Family
ID=19920017
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT83303610T ATE40688T1 (de) | 1982-06-25 | 1983-06-22 | Acridincarboxamid-verbindungen. |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US4590277A (de) |
| EP (1) | EP0098098B1 (de) |
| JP (1) | JPS597171A (de) |
| AT (1) | ATE40688T1 (de) |
| DE (2) | DE98098T1 (de) |
| NZ (1) | NZ201084A (de) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ212525A (en) * | 1985-06-24 | 1989-02-24 | Dfc New Zealand Ltd Formerly D | Nitrogen-containing heterocyclic compounds, and pharmaceutical compositions containing such |
| GB9100637D0 (en) * | 1991-01-11 | 1991-02-27 | Glaxo Lab Sa | Chemical compounds |
| DK0569380T3 (da) * | 1991-01-11 | 1997-12-22 | Glaxo Lab Sa | Acridinderivater |
| US5296602A (en) * | 1991-03-18 | 1994-03-22 | Sloan-Kettering Institute For Cancer Research | Multisubstituted 1-hydroxy-9-acridones with anticancer activity |
| WO1993003729A1 (en) * | 1991-08-12 | 1993-03-04 | Research Corporation Technologies, Inc. | N-substituted phenoxazines for treating multidrug resistant cancer cells |
| DE69329336D1 (de) * | 1992-05-28 | 2000-10-05 | Xenova Ltd | Acridin carboxamide zur behandlung von krebs |
| US5696131A (en) * | 1993-01-22 | 1997-12-09 | Xenova Limited | Treatment of cancers |
| RU2036198C1 (ru) * | 1993-04-01 | 1995-05-27 | Товарищество с ограниченной ответственностью "Полисан" | N-МЕТИЛ-N-( α,D -ГЛЮКОПИРАНОЗИЛ) АММОНИЯ-2-(АКРИДОН-9-ОН-10-ИЛ)АЦЕТАТ(ЦИКЛОФЕРОН), ОБЛАДАЮЩИЙ ИНТЕРФЕРОНОГЕННОЙ, ПРОТИВОВИРУСНОЙ, В ТОМ ЧИСЛЕ АНТИВИЧ, АНТИПАРАЗИТАРНОЙ, АНТИПРОМОТОРНОЙ И РАДИОПРОТЕКТИВНОЙ АКТИВНОСТЬЮ |
| GB2288333A (en) * | 1994-03-17 | 1995-10-18 | Radopath Ltd | Benzoic acid containing chloro and or nitro groups for cancer or viral therapy |
| EP0850224B1 (de) * | 1995-08-18 | 2003-04-09 | Auckland Uniservices Limited | Durch strahlung aktivierte cytotoxin therapie |
| GB9621795D0 (en) * | 1996-10-18 | 1996-12-11 | Xenova Ltd | Pharmaceutical compounds |
| SK50599A3 (en) * | 1996-10-18 | 2000-05-16 | Xenova Ltd | Process for the preparation of n-[2- -(dimethylamino)ethyl]acridine-4-carboxamide |
| DK1189637T3 (da) | 1999-05-17 | 2006-12-11 | Cancer Res Ventures Ltd | Produkter til forbedring af biotilgængeligheden for oralt indgivne medikamenter |
| AUPS234402A0 (en) * | 2002-05-15 | 2002-06-13 | Auckland Uniservices Limited | Anti-tumour polycyclic carboxamides |
| JP4718328B2 (ja) * | 2003-12-31 | 2011-07-06 | カウンシル オブ サイエンティフィク アンド インダストリアル リサーチ | Ｃ８連結したピロロ［２，１−ｃ］［１，４］ベンゾジアゼピン−アクリドン／アクリジン・ハイブリッド |
| US7056913B2 (en) | 2004-03-30 | 2006-06-06 | Council Of Scientific And Industrial Research | C8—linked pyrrolo[2,1-c][1,4]benzodiazepine-acridone/acridine hybrids |
| WO2005118580A2 (en) * | 2004-05-12 | 2005-12-15 | The Government Of The United States Of America As Represented By The Secretary, Department Of Health | Tricyclic compounds as inhibitors of the hypoxic signaling pathway |
| CN109265396A (zh) * | 2018-09-12 | 2019-01-25 | 李玮 | 多环酰胺化合物的合成新方法与抗癌活性 |
| CN118852160A (zh) * | 2024-09-24 | 2024-10-29 | 世华合创生物技术开发(山东)有限公司 | 一种三环酰胺化合物、制备方法及应用 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3686180A (en) * | 1970-11-04 | 1972-08-22 | Smith Kline French Lab | Substituted 9-lower alkylacridine-4-carboxylic acids |
| EP0025705B1 (de) * | 1979-09-14 | 1983-06-22 | Development Finance Corporation Of New Zealand | Verbindungen mit Antitumor-Eigenschaften, Verfahren zu ihrer Herstellung, diese Verbindungen zur Verwendung als Antitumor-Mittel und sie enthaltende pharmazeutische Zusammensetzungen |
| EP0039224B1 (de) * | 1980-04-28 | 1984-06-27 | Development Finance Corporation Of New Zealand | Verbindung mit Antitumor-Eigenschaften |
| NZ198115A (en) * | 1981-08-21 | 1985-05-31 | New Zealand Dev Finance | 9-anilinoacridines;pharmaceutical compositions |
-
1982
- 1982-06-25 NZ NZ201084A patent/NZ201084A/en unknown
-
1983
- 1983-06-21 US US06/506,335 patent/US4590277A/en not_active Expired - Lifetime
- 1983-06-22 JP JP58112595A patent/JPS597171A/ja active Pending
- 1983-06-22 AT AT83303610T patent/ATE40688T1/de active
- 1983-06-22 EP EP83303610A patent/EP0098098B1/de not_active Expired
- 1983-06-22 DE DE198383303610T patent/DE98098T1/de active Pending
- 1983-06-22 DE DE8383303610T patent/DE3379168D1/de not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| US4590277A (en) | 1986-05-20 |
| NZ201084A (en) | 1985-10-11 |
| JPS597171A (ja) | 1984-01-14 |
| EP0098098A3 (en) | 1985-05-02 |
| EP0098098B1 (de) | 1989-02-08 |
| DE3379168D1 (de) | 1989-03-16 |
| EP0098098A2 (de) | 1984-01-11 |
| DE98098T1 (de) | 1985-02-14 |
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