ATE404531T1 - Tetrahydronaphtalen-derivate als vanilloid- rezeptor-antagonisten - Google Patents

Tetrahydronaphtalen-derivate als vanilloid- rezeptor-antagonisten

Info

Publication number
ATE404531T1
ATE404531T1 AT03780088T AT03780088T ATE404531T1 AT E404531 T1 ATE404531 T1 AT E404531T1 AT 03780088 T AT03780088 T AT 03780088T AT 03780088 T AT03780088 T AT 03780088T AT E404531 T1 ATE404531 T1 AT E404531T1
Authority
AT
Austria
Prior art keywords
derivatives
pain
tetrahydronaphtalen
receptor antagonists
useful
Prior art date
Application number
AT03780088T
Other languages
English (en)
Inventor
Masaomi Tajimi
Toshio Kokubo
Masahiro Shiroo
Yasuhiro Tsukimi
Takeshi Yura
Noriyuki Yamamoto
Muneto Mogi
Hiroshi Fujishima
Tsutomu Masuda
Nagahiro Yoshida
Toshiya Moriwaki
Klaus Urbahns
Original Assignee
Xention Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Xention Ltd filed Critical Xention Ltd
Application granted granted Critical
Publication of ATE404531T1 publication Critical patent/ATE404531T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C275/28—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C275/32—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by singly-bound oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/10—Drugs for disorders of the urinary system of the bladder
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/24—Oxygen or sulfur atoms
    • C07D207/26—2-Pyrrolidones
    • C07D207/263—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms
    • C07D207/27—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms with substituted hydrocarbon radicals directly attached to the ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/20—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms
    • C07D211/22—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/40—Oxygen atoms
    • C07D211/44—Oxygen atoms attached in position 4
    • C07D211/46—Oxygen atoms attached in position 4 having a hydrogen atom as the second substituent in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D211/62—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
    • C07D295/135—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/04—One of the condensed rings being a six-membered aromatic ring
    • C07C2602/10—One of the condensed rings being a six-membered aromatic ring the other ring being six-membered, e.g. tetraline
AT03780088T 2002-12-09 2003-11-28 Tetrahydronaphtalen-derivate als vanilloid- rezeptor-antagonisten ATE404531T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP02027528 2002-12-09

Publications (1)

Publication Number Publication Date
ATE404531T1 true ATE404531T1 (de) 2008-08-15

Family

ID=32479714

Family Applications (1)

Application Number Title Priority Date Filing Date
AT03780088T ATE404531T1 (de) 2002-12-09 2003-11-28 Tetrahydronaphtalen-derivate als vanilloid- rezeptor-antagonisten

Country Status (11)

Country Link
US (2) US7544716B2 (de)
EP (1) EP1572632B1 (de)
JP (1) JP4440113B2 (de)
AT (1) ATE404531T1 (de)
AU (1) AU2003288200A1 (de)
CA (1) CA2508845C (de)
DE (1) DE60322946D1 (de)
DK (1) DK1572632T3 (de)
ES (1) ES2311744T3 (de)
PT (1) PT1572632E (de)
WO (1) WO2004052845A1 (de)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2003230411A1 (en) * 2002-05-16 2003-12-02 Cytovia, Inc. Substituted 4-aryl-4h-pyrrolo(2,3-h)chromenes and analogs as activators of caspases and inducers of apoptosis and the use thereof
DK1569896T3 (da) 2002-12-06 2007-12-10 Xention Ltd Tetrahydronaphthalenderivater
PT1572632E (pt) * 2002-12-09 2008-09-19 Xention Ltd Derivados de tetra-hidro-naftaleno como antagonistas do receptor vanilóide
WO2004092136A1 (ja) * 2003-04-18 2004-10-28 Ono Pharmaceutical Co., Ltd. 含窒素複素環化合物およびその用途
EP1670761B1 (de) * 2003-10-01 2009-01-28 Xention Limited Tetrahydronaphthalin- und harnstoffderivate
WO2005035471A1 (ja) 2003-10-14 2005-04-21 Ajinomoto Co., Inc. エーテル誘導体
CA2542494A1 (en) * 2003-10-15 2005-05-06 Bayer Healthcare Ag Tetrahydro-naphthalene and urea derivatives
JP2007523888A (ja) * 2003-11-08 2007-08-23 バイエル・ヘルスケア・アクチェンゲゼルシャフト テトラヒドロ−キノリニル尿素誘導体
JP2008532956A (ja) * 2005-03-05 2008-08-21 バイエル・ヘルスケア・アクチェンゲゼルシャフト ヒドロキシテトラヒドロ−ナフタレン誘導体の使用
DE102005023944A1 (de) 2005-05-20 2006-11-23 Grünenthal GmbH Substituierte benzokondensierte Cycloheptanon-Derivate und deren Verwendung zur Herstellung von Arzneimitteln
AU2007304588A1 (en) * 2006-10-04 2008-04-10 Neurokey A/S Use of hypothermia inducing drugs to treat ischemia
US8030504B2 (en) 2006-12-20 2011-10-04 Abbott Laboratories Antagonists of the TRPV1 receptor and uses thereof
DE102022104759A1 (de) 2022-02-28 2023-08-31 SCi Kontor GmbH Co-Kristall-Screening Verfahren, insbesondere zur Herstellung von Co-Kristallen

Family Cites Families (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2004763A (en) 1932-06-11 1935-06-11 Du Pont N (p-amino-phenyl) morpholine and method of preparing the same
US3142699A (en) * 1958-04-24 1964-07-28 Bayer Ag Urethane compounds and process therefor
DE1187791B (de) * 1962-02-03 1965-02-25 Bayer Ag Die Verwendung von organischen Salzen als verkappte Beschleuniger fuer Isocyanatreaktionen
US3878206A (en) 1973-06-06 1975-04-15 Morton Norwich Products Inc 9-(Substituted amino)imidazo{8 4,5-f{9 quinolines
US4443473A (en) * 1981-06-30 1984-04-17 The Procter & Gamble Company Carbamate derivatives
US4477389A (en) * 1982-10-25 1984-10-16 The United States Of America As Represented By The Secretary Of Agriculture Polyhalogenated phenyl isocyanate synthesis with excess phosgene and either triethylamine or tetramethylurea
WO1990012797A1 (en) 1989-04-19 1990-11-01 The United States Of America, As Represented By The Secretary, U.S. Department Of Commerce Sulfer-containing xanthine derivatives as adenosin antagonists
US6333337B1 (en) * 1998-01-27 2001-12-25 Icagen, Inc. Potassium channel inhibitors
US6103708A (en) 1998-05-12 2000-08-15 American Home Products Corporation Furans, benzofurans, and thiophenes useful in the treatment of insulin resistance and hyperglycemia
AU763824B2 (en) 1999-02-22 2003-07-31 Medifron Dbt Co., Ltd. Vanilloid analogues containing resiniferatoxin pharmacophores as potent vanilloid receptor agonists and analgesics, compositions and uses thereof
ATE309237T1 (de) * 1999-03-12 2005-11-15 Boehringer Ingelheim Pharma Aromatische heterozyklische verbindungen als antientzündungwirkstoffe
US6294694B1 (en) 1999-06-04 2001-09-25 Wisconsin Alumni Research Foundation Matrix metalloproteinase inhibitors and method of using same
DE60026318T2 (de) 1999-08-10 2006-08-10 Kumiai Chemical Industry Co., Ltd. Isoxazolin derivate und herbizide, die diese als aktiven bestandteil enthalten
JP2001322988A (ja) 2000-03-09 2001-11-20 Nippon Bayer Agrochem Co Ltd 殺センチュウ性トリフルオロブテン類
GB0028702D0 (en) * 2000-11-24 2001-01-10 Novartis Ag Organic compounds
GB0105895D0 (en) 2001-03-09 2001-04-25 Smithkline Beecham Plc Novel compounds
US20040259875A1 (en) * 2001-07-31 2004-12-23 Takeshi Yura Amine derivatives
AU2003245773A1 (en) * 2002-02-15 2003-09-04 Glaxo Group Limited Vanilloid receptor modulators
RU2331635C2 (ru) * 2002-05-08 2008-08-20 Байер ХельсКер АГ Производные гидрокси-тетрагидро-нафталенилмочевины
CL2003001415A1 (es) * 2002-07-12 2005-01-07 Janssen Pharmaceutica Nv Compuestos d derivados de naftil, quinolinil e isoquinolinil urea; composicion farmaceutica; y uso en el tratamiento y prevencion de condiciones de dolor y en el sibndrome del colon irritable y condiciones asociadas.
JP2006508970A (ja) 2002-11-18 2006-03-16 ノバルティス アクチエンゲゼルシャフト イミダゾ［１，５ａ］ピリジン誘導体およびアルデステロンにより仲介される疾患の処置方法
DK1569896T3 (da) * 2002-12-06 2007-12-10 Xention Ltd Tetrahydronaphthalenderivater
PT1572632E (pt) * 2002-12-09 2008-09-19 Xention Ltd Derivados de tetra-hidro-naftaleno como antagonistas do receptor vanilóide
US7375126B2 (en) * 2003-06-12 2008-05-20 Abbott Laboratories Fused compounds that inhibit vanilloid receptor subtype 1 (VR1) receptor
US7015233B2 (en) * 2003-06-12 2006-03-21 Abbott Laboratories Fused compounds that inhibit vanilloid subtype 1 (VR1) receptor
EP1670761B1 (de) * 2003-10-01 2009-01-28 Xention Limited Tetrahydronaphthalin- und harnstoffderivate
EP1725529A1 (de) * 2004-01-23 2006-11-29 Amgen Inc. Bisbicyclische amide als vanilloidrezeptorliganden und deren verwendung bei der behandlung von entzündlichen und neuropatischen schmerzen
US7544803B2 (en) * 2004-01-23 2009-06-09 Amgen Inc. Vanilloid receptor ligands and their use in treatments

Also Published As

Publication number Publication date
DE60322946D1 (de) 2008-09-25
EP1572632B1 (de) 2008-08-13
US20090209514A1 (en) 2009-08-20
AU2003288200A1 (en) 2004-06-30
CA2508845C (en) 2012-02-21
DK1572632T3 (da) 2008-10-27
JP4440113B2 (ja) 2010-03-24
WO2004052845A8 (en) 2005-06-09
CA2508845A1 (en) 2004-06-24
AU2003288200A8 (en) 2004-06-30
PT1572632E (pt) 2008-09-19
US7544716B2 (en) 2009-06-09
JP2006509017A (ja) 2006-03-16
WO2004052845A1 (en) 2004-06-24
ES2311744T3 (es) 2009-02-16
EP1572632A1 (de) 2005-09-14
US20060135505A1 (en) 2006-06-22

Similar Documents

Publication Publication Date Title
HK1082946A1 (en) Hydroxy tetrahydro-naphthalenyurea derivatives
DE60315704D1 (de) Tetrahydronaphtalen-derivate
NO20074567L (no) Glucagonreseptorantagoniser, fremstilling og terapeutisk anvendelse
ATE454372T1 (de) Am histamin-h3-rezeptor wirksame mittel, herstellung und therapeutische anwendungen
EA200700027A1 (ru) Антагонисты рецептора глюкагона, их получение и терапевтическое применение
ATE404531T1 (de) Tetrahydronaphtalen-derivate als vanilloid- rezeptor-antagonisten
DK1957484T3 (da) Glucagon-receptorantagonister, fremstilling og terapeutiske anvendelser
WO2007106181A3 (en) Glucagon receptor antagonists, preparation and therapeutic uses
WO2005082893A3 (en) Histamine h3 receptor antagonists, preparation and therapeutic uses
DK1951659T3 (da) Glucagonreceptorantagonister, fremstilling og terapeutisk anvendelse heraf
WO2005044802A3 (en) Tetrahydro-quinolinylurea derivatives as vrl antagonists
ECSP045413A (es) "derivados de hidroxi-tetrahidro-naftalenilurea"
UY27794A1 (es) Derivados de hidroxi tetrahidro-naftalenilurea
TH78306A (th) อนุพันธ์ไฮดรอกซีเททตราไฮโดร-แนพธาลีนิลยูเรีย
TH78306B (th) "อนุพันธ์ไฮดรอกซีเททตราไฮโดร-แนพธาลีนิลยูเรีย"

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification

Ref document number: 1572632

Country of ref document: EP