ATE38043T1 - Teilweise retro-invertiertes decapeptid als spezifischer renininhibitor mit hoher bestaendigkeit gegenueber enzymatischer hydrolyse. - Google Patents

Teilweise retro-invertiertes decapeptid als spezifischer renininhibitor mit hoher bestaendigkeit gegenueber enzymatischer hydrolyse.

Info

Publication number
ATE38043T1
ATE38043T1 AT84200715T AT84200715T ATE38043T1 AT E38043 T1 ATE38043 T1 AT E38043T1 AT 84200715 T AT84200715 T AT 84200715T AT 84200715 T AT84200715 T AT 84200715T AT E38043 T1 ATE38043 T1 AT E38043T1
Authority
AT
Austria
Prior art keywords
inverted
high resistance
enzymatic hydrolysis
decapeptide
renin inhibitor
Prior art date
Application number
AT84200715T
Other languages
English (en)
Inventor
Trapani Romano Di
Massimo Pinori
Antonio Silvio Verdini
Original Assignee
Eni Ente Naz Idrocarb
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eni Ente Naz Idrocarb filed Critical Eni Ente Naz Idrocarb
Application granted granted Critical
Publication of ATE38043T1 publication Critical patent/ATE38043T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0212—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -N-C-N-C(=0)-, e.g. retro-inverso peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/02—Linear peptides containing at least one abnormal peptide link
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/86—Renin inhibitors
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S930/00—Peptide or protein sequence
    • Y10S930/01—Peptide or protein sequence
    • Y10S930/32—Modification to prevent enzymatic degradation

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Plant Substances (AREA)
AT84200715T 1983-05-25 1984-05-17 Teilweise retro-invertiertes decapeptid als spezifischer renininhibitor mit hoher bestaendigkeit gegenueber enzymatischer hydrolyse. ATE38043T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT8321282A IT1164240B (it) 1983-05-25 1983-05-25 Decapeptide parzialmente retro-invertito inibitore specifico della renina con elevata resistenza alla idrolisi enzimatica

Publications (1)

Publication Number Publication Date
ATE38043T1 true ATE38043T1 (de) 1988-11-15

Family

ID=11179494

Family Applications (1)

Application Number Title Priority Date Filing Date
AT84200715T ATE38043T1 (de) 1983-05-25 1984-05-17 Teilweise retro-invertiertes decapeptid als spezifischer renininhibitor mit hoher bestaendigkeit gegenueber enzymatischer hydrolyse.

Country Status (8)

Country Link
US (1) US4585586A (de)
EP (1) EP0127235B1 (de)
JP (1) JPH0672154B2 (de)
AT (1) ATE38043T1 (de)
AU (1) AU558573B2 (de)
CA (1) CA1249396A (de)
DE (1) DE3474671D1 (de)
IT (1) IT1164240B (de)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1164225B (it) * 1983-05-13 1987-04-08 Anic Spa Analoghi retro-invertiti del pentapeptide potenziante la bradichina bpp5a e metodi per la loro preparazione
US4727060A (en) * 1984-11-13 1988-02-23 Ciba-Geigy Corporation Novel 5-amino-4-hydroxyvaleryl derivatives
IT1190389B (it) * 1985-09-19 1988-02-16 Eniricerche Spa Esapeptidi ad attivita' ipotensiva
DE3783280T2 (de) * 1986-07-16 1993-05-06 Eniricerche Spa Teilweise retro-invertierte analoge des tuftsin, methode zu ihrer herstellung und pharmazeutische zusammensetzungen, die sie enthalten.
ATE107658T1 (de) * 1988-01-26 1994-07-15 Sankyo Co Renin inhibierende polypeptide, ihre herstellung und anwendung.
DE4004820A1 (de) * 1989-08-05 1991-04-25 Bayer Ag Renininhibitoren, verfahren zur herstellung und ihre verwendung in arzneimitteln
US5242903A (en) * 1989-08-05 1993-09-07 Bayer Aktiengesellschaft Renin inhibitors

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4269827A (en) * 1980-06-23 1981-05-26 The Massachusetts General Hospital Process and composition for reducing blood pressure
JPS5759846A (en) * 1980-08-06 1982-04-10 Ferring Pharma Ltd Polypeptide homologue and manufacture of hydroxy or keto homologue of dipeptide
IT1212508B (it) * 1981-12-22 1989-11-22 Anic Spa Analoghi retro - invertiti dei penta - ed esapeptidi c - terminali della sostanza p. utili come vasodilatatori
IT1190891B (it) * 1982-06-24 1988-02-24 Anic Spa Metodo per la sintesi in fase solida di polipeptidi retroinvertiti

Also Published As

Publication number Publication date
IT1164240B (it) 1987-04-08
JPH0672154B2 (ja) 1994-09-14
US4585586A (en) 1986-04-29
DE3474671D1 (en) 1988-11-24
CA1249396A (en) 1989-01-24
AU558573B2 (en) 1987-02-05
JPS59231056A (ja) 1984-12-25
EP0127235A2 (de) 1984-12-05
EP0127235A3 (en) 1985-09-04
EP0127235B1 (de) 1988-10-19
IT8321282A0 (it) 1983-05-25
AU2855484A (en) 1984-11-29

Similar Documents

Publication Publication Date Title
ATE43848T1 (de) Hydroxysubstituierte peptidverbindungen.
ES8601858A1 (es) Homologos de la aprotinina
DK520284A (da) Enzyminhibering
ATE24516T1 (de) Amino- und substituierte aminophosphinylalkanoyl- verbindungen.
DE3580057D1 (de) Heterocylische mercaptocarbonsaeureamide, -imide und -nitrile als korrosionsinhibitoren.
ATE71111T1 (de) Peptid-derivate, renin- und saeureprotease hemmende mittel.
ATE153670T1 (de) Peptidboronsäurederivate mit protease inhibierenden aktivität
MX9305784A (es) N-(aceilaminometil) glutaril amino acidos.
ATE389023T1 (de) Kontrolle der schotendehiszenz
NO960939D0 (no) Kininogenaseinhibitor
ATE38043T1 (de) Teilweise retro-invertiertes decapeptid als spezifischer renininhibitor mit hoher bestaendigkeit gegenueber enzymatischer hydrolyse.
ES2153113T3 (es) Compuestos de benzotiofeno.
CA1269496C (en) MERCAPTOCYCLOALCOYLCARBONYL- AND MERCAPTOARYLCARBONYLDIPEPTIDES
EP0127234A3 (en) A retro-inverso analogue of the (5-14) decapeptide of equine angiotensinogen, as a specific renin inhibitor with high resistance to enzymatic hydrolysis
DE59812724D1 (de) Serin-proteinase-inhibitoren
AU583499B2 (en) Amino thiol dipeptides
ES2060134T3 (es) Inhibidor de tejido de metaloproteasas (timp-2).
DE69734378D1 (de) An der Regenierung von Luciferin beteiligtes Enzym
DE3774947D1 (de) Alpha-acylamino-aminoalkyl-phosphonat-inhibitor des angiotensin umwandelnden enzyms.
IT1264084B1 (it) Peptide ad attivita' di substrato e/o inibitore dell'enzima transglutaminasi e suo uso in diagnosi e terapia.
PT101847A (pt) Peptido substituido derivado de lisina e prolina
SU1540328A1 (ru) Ингибитор сероводородной коррозии стали
SU1596698A1 (ru) 5-α,α-ДИМЕТИЛБЕНЗИЛ-2-ГИДРОКСИБЕНЗОАТ БЕНЗИЛГЕКСАМЕТИЛЕНТЕТРАММОНИЯ В КАЧЕСТВЕ ИНГИБИТОРА КОРРОЗИИ СТАЛИ В МИНЕРАЛИЗОВАННЫХ СРЕДАХ
DE3881321D1 (de) Octapeptide als hemmer myristoylierender enzyme.
ATE89828T1 (de) Octapeptide als hemmer myristoylierender enzyme.

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee