ATE376004T1 - Arzneistoffzufuhrverfahren unter verwendung von sulfatierten chitinösen polymeren - Google Patents

Arzneistoffzufuhrverfahren unter verwendung von sulfatierten chitinösen polymeren

Info

Publication number
ATE376004T1
ATE376004T1 AT03793024T AT03793024T ATE376004T1 AT E376004 T1 ATE376004 T1 AT E376004T1 AT 03793024 T AT03793024 T AT 03793024T AT 03793024 T AT03793024 T AT 03793024T AT E376004 T1 ATE376004 T1 AT E376004T1
Authority
AT
Austria
Prior art keywords
drug delivery
delivery method
chitinous polymers
therapeutic agent
sulfated chitinous
Prior art date
Application number
AT03793024T
Other languages
English (en)
Inventor
Agis Kydonieus
Clive Elson
Maya Thanou
Original Assignee
Chitogenics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chitogenics Inc filed Critical Chitogenics Inc
Application granted granted Critical
Publication of ATE376004T1 publication Critical patent/ATE376004T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
    • A61K31/727—Heparin; Heparan
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/24—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Inorganic Chemistry (AREA)
  • Dermatology (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
AT03793024T 2002-08-20 2003-08-07 Arzneistoffzufuhrverfahren unter verwendung von sulfatierten chitinösen polymeren ATE376004T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US10/224,173 US7265097B2 (en) 2002-08-20 2002-08-20 Methods of drug delivery using sulphated chitinous polymers

Publications (1)

Publication Number Publication Date
ATE376004T1 true ATE376004T1 (de) 2007-11-15

Family

ID=31886764

Family Applications (1)

Application Number Title Priority Date Filing Date
AT03793024T ATE376004T1 (de) 2002-08-20 2003-08-07 Arzneistoffzufuhrverfahren unter verwendung von sulfatierten chitinösen polymeren

Country Status (7)

Country Link
US (2) US7265097B2 (de)
EP (1) EP1546216B1 (de)
AT (1) ATE376004T1 (de)
AU (1) AU2003256882A1 (de)
CA (1) CA2496376C (de)
DE (1) DE60316970T2 (de)
WO (1) WO2004018010A2 (de)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7265097B2 (en) * 2002-08-20 2007-09-04 Chitogenics, Inc. Methods of drug delivery using sulphated chitinous polymers
US7691830B2 (en) * 2005-02-17 2010-04-06 Clive Elson Method and composition for treatment of a mucosal tissue disorder
US20060257355A1 (en) * 2005-05-10 2006-11-16 Abiomed, Inc. Impregnated polymer compositions and devices using them
US20080085331A1 (en) * 2006-10-06 2008-04-10 Gluskin Anna E Composition and method for raising blood glucose level
PL2205623T3 (pl) * 2007-10-29 2016-09-30 Ochronne tetrapeptydy do pielęgnacji skóry
BRPI0801422B8 (pt) * 2008-03-26 2021-05-25 Fund Sao Francisco Xavier composição e método para inibição da severidade das aderências pós-cirúrgicas
DK2321640T3 (en) 2008-08-21 2017-02-27 Immunogenics Llc FORMULATION FOR ORAL ADMINISTRATION OF PROTEINS
CN102711463B (zh) 2009-12-03 2015-05-13 Opko健康公司 超硫酸化双糖制剂
EP3417865A1 (de) * 2011-07-19 2018-12-26 Baxalta GmbH Resorptionsförderer als additive zur verbesserung der oralen formulierung nicht-antikoagulierender sulfatierter polysaccharide

Family Cites Families (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4141973A (en) 1975-10-17 1979-02-27 Biotrics, Inc. Ultrapure hyaluronic acid and the use thereof
US4301067A (en) * 1979-06-05 1981-11-17 Kureha Kagaku Kogyo Kabushiki Kaisha Chitin containing poly-ion complex
US4424346A (en) 1981-06-04 1984-01-03 Canadian Patents And Development Ltd. Derivatives of chitins, chitosans and other polysaccharides
US4570629A (en) 1982-03-17 1986-02-18 University Of Illinois Foundation Hydrophilic biopolymeric copolyelectrolytes, and biodegradable wound dressing comprising same
US4659700A (en) 1984-03-02 1987-04-21 Johnson & Johnson Products, Inc. Chitosan-glycerol-water gel
US4619913A (en) 1984-05-29 1986-10-28 Matrix Pharmaceuticals, Inc. Treatments employing drug-containing matrices for introduction into cellular lesion areas
SE456346B (sv) 1984-07-23 1988-09-26 Pharmacia Ab Gel for att forhindra adhesion mellan kroppsvevnader och sett for dess framstellning
US4619995A (en) 1984-12-24 1986-10-28 Nova Chem Limited N,O-carboxymethyl chitosan and preparative method therefor
US4868113A (en) 1986-03-03 1989-09-19 Rorer Biotechnology, Inc. Recombinant DNA vector encoding human endothelial cell growth factor
US5460939A (en) 1986-04-18 1995-10-24 Advanced Tissue Sciences, Inc. Temporary living skin replacement
US4946870A (en) 1986-06-06 1990-08-07 Union Carbide Chemicals And Plastics Company Inc. Delivery systems for pharmaceutical or therapeutic actives
US4819617A (en) 1986-09-04 1989-04-11 University Of Florida Viscoelastic material for ophthalmic surgery
US5080893A (en) 1988-05-31 1992-01-14 University Of Florida Method for preventing surgical adhesions using a dilute solution of polymer
NZ226171A (en) 1987-09-18 1990-06-26 Ethicon Inc Gel formulation containing polypeptide growth factor
US4978332A (en) 1987-09-28 1990-12-18 Matrix Pharmaceutical, Inc. Treatments employing vasoconstrictive substances in combination with cytotoxic agents for introduction into cellular lesion areas
DK505488D0 (da) 1987-12-21 1988-09-09 Bar Shalom Daniel Middel og anvendelse af samme
US5023090A (en) 1989-08-16 1991-06-11 Levin Robert H Topical compositions containing LYCD and other topically active medicinal ingredients for the treatment of ACNE
US5140016A (en) 1988-05-31 1992-08-18 University Of Florida Method and composition for preventing surgical adhesions using a dilute solution of polymer
US5470829A (en) 1988-11-17 1995-11-28 Prisell; Per Pharmaceutical preparation
US5234915A (en) 1989-03-09 1993-08-10 Micro Vesicular Systems, Inc. Biodegradable gel
US5093319A (en) 1989-10-31 1992-03-03 Pfizer Hospital Products Group, Inc. Use of derivatives of chitin soluble in aqueous solutions for preventing adhesions
US5462990A (en) 1990-10-15 1995-10-31 Board Of Regents, The University Of Texas System Multifunctional organic polymers
US5412084A (en) 1991-10-09 1995-05-02 Nova Chem Limited N-O-carboxymethylchitosonium carboxylate salts
AU3235593A (en) 1991-12-20 1993-07-28 Howmedica Inc. Process for insolubilizing N-carboxyalkyl derivatives of chitosan
US5474765A (en) * 1992-03-23 1995-12-12 Ut Sw Medical Ctr At Dallas Preparation and use of steroid-polyanionic polymer-based conjugates targeted to vascular endothelial cells
JPH06211903A (ja) * 1993-01-19 1994-08-02 Shin Etsu Chem Co Ltd 硫酸化キトサンの製造方法およびキトサンの硫酸化剤
EP0637450A3 (de) 1993-08-04 1995-04-05 Collagen Corp Verfahren und Zusammensetzung zur Wiederbelebung von Nerbgewebe.
US5411988A (en) 1993-10-27 1995-05-02 Bockow; Barry I. Compositions and methods for inhibiting inflammation and adhesion formation
DE4337152A1 (de) 1993-10-30 1995-05-04 Merck Patent Gmbh Verfahren zur Herstellung von wäßrigen Chitosan-Lösungen und -Gelen
EP0665022A1 (de) 1994-01-28 1995-08-02 Prodex, Inc. Viskoelastische Lösung aus N,O-Carboxymethylchitosan zur opthalmischen Verwendung
GB9421653D0 (en) 1994-10-27 1994-12-14 Innovative Tech Ltd Wound dressing
GB9421969D0 (en) 1994-10-28 1994-12-21 Innovative Tech Ltd Wound treatment composition
US5510102A (en) 1995-01-23 1996-04-23 The Regents Of The University Of California Plasma and polymer containing surgical hemostatic adhesives
US5679658A (en) 1995-05-08 1997-10-21 Chitogenics, Inc. N,O-carbonxymethylchitosan for prevention of surgical adhesions
JPH09143199A (ja) * 1995-11-17 1997-06-03 Nippon Chem Res Kk 血小板第４因子の製造方法
US6146847A (en) * 1996-11-01 2000-11-14 Genespan Corporation Stabilized transient gene expression
US6730735B2 (en) * 1997-07-03 2004-05-04 West Pharmaceutical Services Drug Delivery & Clinical Research Centre Limited Conjugate of polyethylene glycol and chitosan
WO2001010421A1 (en) * 1999-08-06 2001-02-15 Board Of Regents, The University Of Texas System Drug releasing biodegradable fiber implant
EP1095650A1 (de) 1999-10-29 2001-05-02 Universiteit Leiden Zweiphasensystem mit kontrollierter Freigabe
WO2003086297A2 (en) * 2002-04-08 2003-10-23 Lavipharm Laboratories, Inc. Multi-layer mucoadhesive drug delivery device with bursting release layer
US7265097B2 (en) * 2002-08-20 2007-09-04 Chitogenics, Inc. Methods of drug delivery using sulphated chitinous polymers

Also Published As

Publication number Publication date
DE60316970D1 (de) 2007-11-29
US20040038870A1 (en) 2004-02-26
US8017595B2 (en) 2011-09-13
EP1546216A2 (de) 2005-06-29
DE60316970T2 (de) 2008-07-17
WO2004018010A3 (en) 2004-07-08
AU2003256882A8 (en) 2004-03-11
AU2003256882A1 (en) 2004-03-11
WO2004018010A2 (en) 2004-03-04
US7265097B2 (en) 2007-09-04
CA2496376C (en) 2013-05-07
US20080076704A1 (en) 2008-03-27
CA2496376A1 (en) 2004-03-04
EP1546216A4 (de) 2006-05-10
EP1546216B1 (de) 2007-10-17

Similar Documents

Publication Publication Date Title
ATE458021T1 (de) Biologisch abbaubare kationische polymere
TW200728329A (en) Preparation and application of high refraction polymers
BRPI0507680A (pt) partìculas de fosfato de cálcio terapêuticas e métodos de fabricação e uso das mesmas
EA201000747A1 (ru) Система и способ трансдермальной доставки и способ получения системы трансдермальной доставки
CY1105877T1 (el) Οφθαλμικες συνθεσεις πepιεχουσες συνepγιστικο συνδυασμο τριων πολυμepων
MXPA06011924A (es) Dispositivo de liberacion continua base polimeros.
BRPI0516857A (pt) dispositivos biomédicos que contêm copolìmeros de bloco anfifìlico
DK1543063T3 (da) Medikament levering
CL2003002277A1 (es) Composicion farmaceutica inyectable, de deposito de liberacion prolongada, que comprende un agente beneficioso disuelto o disperso en un gel constituido por un polimero bioerosionable y biocompatible; y un solvente.
DK1585470T3 (da) Transdermal afgivelse af fentanyl
BRPI0518187A (pt) formulações de olanzapina em nanopartìcula injetáveis
ATE288256T1 (de) Dermale zusammensetzungen
MXPA05012776A (es) Sistemas de reticulacion para polimeros de hidroxilo.
DOP2010000234A (es) Antagonistas n,n-disustituidos de aminoalquilbifenilo de receptores d2 de prostaglandina
BR0111257A (pt) Formulação, e, uso de uma formulação
AR054937A1 (es) Goma de mascar biodegradable
ATE417833T1 (de) Triazinderivate mit carbamatfunktion
BRPI0607351A2 (pt) métodos para tratamento de linfomas empregando uma combinação de agente quimioterapêutico e il-2 e opcionalmente um anticorpo anti-cd20
ATE376004T1 (de) Arzneistoffzufuhrverfahren unter verwendung von sulfatierten chitinösen polymeren
BR0308486A (pt) Composição tópica compreendendo um ciclofrutano, um veìculo e uma droga
WO2019055996A8 (en) Polymer nanodiscs for biotechnology and medical applications
ATE405605T1 (de) Verfahren zur herstellung absorbierender verbundstoffe
DE602007005146D1 (de) Ammensetzung
ATE497991T1 (de) Phosphitester enthaltende stabilisatorzusammensetzung
ATE448807T1 (de) Verfahren zur herstellung von gelzusammensetzungen für abgabevorrichtungen

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification

Ref document number: 1546216

Country of ref document: EP

REN Ceased due to non-payment of the annual fee