ATE374526T1 - Lösung und verfahren zur wiederbelebung und heilung von ischämisch beschädigtem gewebe - Google Patents

Lösung und verfahren zur wiederbelebung und heilung von ischämisch beschädigtem gewebe

Info

Publication number
ATE374526T1
ATE374526T1 AT97925571T AT97925571T ATE374526T1 AT E374526 T1 ATE374526 T1 AT E374526T1 AT 97925571 T AT97925571 T AT 97925571T AT 97925571 T AT97925571 T AT 97925571T AT E374526 T1 ATE374526 T1 AT E374526T1
Authority
AT
Austria
Prior art keywords
tissue
organ
solution
function
resuscitation solution
Prior art date
Application number
AT97925571T
Other languages
English (en)
Inventor
Lauren Brasile
Original Assignee
Breonics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=24603829&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE374526(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Breonics Inc filed Critical Breonics Inc
Application granted granted Critical
Publication of ATE374526T1 publication Critical patent/ATE374526T1/de

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/3683Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix subjected to a specific treatment prior to implantation, e.g. decellularising, demineralising, grinding, cellular disruption/non-collagenous protein removal, anti-calcification, crosslinking, supercritical fluid extraction, enzyme treatment
    • A61L27/3691Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix subjected to a specific treatment prior to implantation, e.g. decellularising, demineralising, grinding, cellular disruption/non-collagenous protein removal, anti-calcification, crosslinking, supercritical fluid extraction, enzyme treatment characterised by physical conditions of the treatment, e.g. applying a compressive force to the composition, pressure cycles, ultrasonic/sonication or microwave treatment, lyophilisation
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01NPRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N1/00Preservation of bodies of humans or animals, or parts thereof
    • A01N1/02Preservation of living parts
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01NPRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N1/00Preservation of bodies of humans or animals, or parts thereof
    • A01N1/02Preservation of living parts
    • A01N1/0205Chemical aspects
    • A01N1/021Preservation or perfusion media, liquids, solids or gases used in the preservation of cells, tissue, organs or bodily fluids
    • A01N1/0226Physiologically active agents, i.e. substances affecting physiological processes of cells and tissue to be preserved, e.g. anti-oxidants or nutrients
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/3683Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix subjected to a specific treatment prior to implantation, e.g. decellularising, demineralising, grinding, cellular disruption/non-collagenous protein removal, anti-calcification, crosslinking, supercritical fluid extraction, enzyme treatment
    • A61L27/3687Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix subjected to a specific treatment prior to implantation, e.g. decellularising, demineralising, grinding, cellular disruption/non-collagenous protein removal, anti-calcification, crosslinking, supercritical fluid extraction, enzyme treatment characterised by the use of chemical agents in the treatment, e.g. specific enzymes, detergents, capping agents, crosslinkers, anticalcification agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M31/00Devices for introducing or retaining media, e.g. remedies, in cavities of the body
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P41/00Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2202/00Special media to be introduced, removed or treated
    • A61M2202/04Liquids
    • A61M2202/0468Liquids non-physiological
    • A61M2202/0476Oxygenated solutions

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Transplantation (AREA)
  • Botany (AREA)
  • Epidemiology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Dermatology (AREA)
  • Molecular Biology (AREA)
  • Environmental Sciences (AREA)
  • Dentistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Anesthesiology (AREA)
  • Biophysics (AREA)
  • Hematology (AREA)
  • Physiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Surgery (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AT97925571T 1996-05-17 1997-05-16 Lösung und verfahren zur wiederbelebung und heilung von ischämisch beschädigtem gewebe ATE374526T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/649,200 US5843024A (en) 1996-05-17 1996-05-17 Solution and process for resuscitation and preparation of ischemically damaged tissue

Publications (1)

Publication Number Publication Date
ATE374526T1 true ATE374526T1 (de) 2007-10-15

Family

ID=24603829

Family Applications (1)

Application Number Title Priority Date Filing Date
AT97925571T ATE374526T1 (de) 1996-05-17 1997-05-16 Lösung und verfahren zur wiederbelebung und heilung von ischämisch beschädigtem gewebe

Country Status (12)

Country Link
US (1) US5843024A (de)
EP (1) EP1021084B2 (de)
JP (1) JP4259614B2 (de)
CN (1) CN1163125C (de)
AT (1) ATE374526T1 (de)
AU (1) AU723424B2 (de)
CA (1) CA2255657C (de)
DE (1) DE69738184T2 (de)
ES (1) ES2296310T5 (de)
HK (1) HK1021925A1 (de)
RU (1) RU2199310C2 (de)
WO (1) WO1997043899A1 (de)

Families Citing this family (82)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060003447A1 (en) * 2003-12-30 2006-01-05 Richard Fike Dry powder cells and cell culture reagents and methods of production thereof
US8409846B2 (en) 1997-09-23 2013-04-02 The United States Of America As Represented By The Department Of Veteran Affairs Compositions, methods and devices for maintaining an organ
US6736790B2 (en) 1998-02-25 2004-05-18 Denise R. Barbut Method and system for selective or isolated integrate cerebral perfusion and cooling
WO2000006174A1 (en) * 1998-07-31 2000-02-10 Massachusetts Institute Of Technology Methods for increasing cytidine levels in vivo and treating cytidine-dependent human diseases
US8314064B2 (en) * 1998-07-31 2012-11-20 Massachusetts Institute Of Technology Uridine administration stimulates membrane production
US20050203053A1 (en) * 1999-07-30 2005-09-15 Wurtman Richard J. Uridine administration improves phosphatide synthesis, synaptic transmission and cogntive function
US8143234B2 (en) 1998-07-31 2012-03-27 Massachusetts Institute Of Technology Uridine administration improves phosphatide synthesis, synaptic transmission and cognitive function
US8518882B2 (en) * 1998-07-31 2013-08-27 Massachusetts Institute Of Technology Methods and compositions for ameliorating or inhibiting decline in memory or intelligence or improving same
US6977140B1 (en) 1998-09-29 2005-12-20 Organ Recovery Systems, Inc. Method for maintaining and/or restoring viability of organs
US6673594B1 (en) 1998-09-29 2004-01-06 Organ Recovery Systems Apparatus and method for maintaining and/or restoring viability of organs
US7749693B2 (en) 1998-09-29 2010-07-06 Lifeline Scientific, Inc. Method of determining that an organ is not suitable for transplantation and using it for testing substances
AU6274899A (en) * 1998-09-29 2000-04-17 Organ Recovery Systems, Inc. Apparatus and method for maintaining and/or restoring viability of organs
US6485959B1 (en) 1998-10-07 2002-11-26 Cedars Sinai Medical Center Cell preconditioning and cryopresevation medium
US20040038192A1 (en) * 1999-04-14 2004-02-26 Breonics, Inc. System for exsanguinous metabolic support of an organ or tissue
US20070166292A1 (en) * 1999-04-14 2007-07-19 Breonics, Inc. System for exsanguinous metabolic support of an organ or tissue
WO2000061166A1 (en) * 1999-04-14 2000-10-19 Breonics, Inc. System for exsanguinous metabolic support of an organ or tissue
US6846842B2 (en) * 1999-10-07 2005-01-25 Beth Israel Deconess Medical Center, Inc. Pyruvate ester composition and method of use for resuscitation after events of ischemia and reperfusion
US20020039786A1 (en) 2000-01-19 2002-04-04 Reid Lola M. Liver tissue source
US6492103B1 (en) 2000-01-31 2002-12-10 Organ Recovery Systems, Inc. System for organ and tissue preservation and hypothermic blood substitution
CA2420182A1 (en) * 2000-08-25 2002-03-07 Organ Recovery Systems, Inc. Methods of thrombolytic organ treatment and repair
WO2002035929A1 (en) 2000-11-03 2002-05-10 Vitrolife Ab Evaluation and preservation solution
AU3240602A (en) * 2000-11-06 2002-05-15 Invitrogen Corp Dry powder cells and cell culture reagents and methods of production thereof
JP2004527529A (ja) * 2001-04-04 2004-09-09 クリティカル セラピューティックス インコーポレイテッド 急性腎不全を予防するための方法
WO2003048313A2 (en) * 2001-11-30 2003-06-12 Invitrogen Corporation Cell culture media
WO2003088955A1 (en) * 2002-04-17 2003-10-30 Critical Therapeutics, Inc. Pharmaceutical composition comprising an alpha-ketoalkanoic acid ester or -amine and lactic acid or a lactic acid salt
WO2004039248A2 (en) * 2002-10-31 2004-05-13 The General Hospital Corporation Repairing or replacing tissues or organs
EP1613152B1 (de) 2003-04-04 2018-07-04 Organ Recovery Systems, Inc. Vorrichtung zur trennung von gasen von fliessenden flüssigkeiten
US7678563B2 (en) 2003-04-04 2010-03-16 Organ Recovery Systems, Inc. Method and apparatus for controlling air pressure in an organ or tissue container
EP1475434A1 (de) 2003-05-09 2004-11-10 Oncoscience AG Verfahren zur Lagerung von Tumorzellen
EP1625861A4 (de) 2003-05-21 2012-04-11 Jms Co Ltd Behälter für die serumproduktion und diesen verwendendes verfahren der regenerativen medizin
US7504201B2 (en) * 2004-04-05 2009-03-17 Organ Recovery Systems Method for perfusing an organ and for isolating cells from the organ
CA3178010A1 (en) 2004-10-07 2006-04-20 Transmedics, Inc. Systems and methods for ex-vivo organ care
US12010987B2 (en) 2004-10-07 2024-06-18 Transmedics, Inc. Systems and methods for ex-vivo organ care and for using lactate as an indication of donor organ status
US9301519B2 (en) 2004-10-07 2016-04-05 Transmedics, Inc. Systems and methods for ex-vivo organ care
US8304181B2 (en) 2004-10-07 2012-11-06 Transmedics, Inc. Method for ex-vivo organ care and for using lactate as an indication of donor organ status
US20060079479A1 (en) * 2004-10-13 2006-04-13 Italo Biaggioni Methods of inducing vasodilation
BRPI0517333A (pt) * 2004-11-12 2008-10-07 Doorzand Airdrive B V solução de conservação e perfusão de órgãos para manter a viabilidade do órgão doador, e, método para conservar um órgão
US20060160062A1 (en) * 2005-01-14 2006-07-20 Young Lindon H Perfusion and/or preservation solution for organs
US20060204482A1 (en) * 2005-03-14 2006-09-14 Deolden James Methods of islet isolation and transplantation
US9078428B2 (en) * 2005-06-28 2015-07-14 Transmedics, Inc. Systems, methods, compositions and solutions for perfusing an organ
US20070169779A1 (en) 2006-01-24 2007-07-26 Freeman Gary A Reperfusion protection in resuscitation
US10071218B2 (en) 2006-01-24 2018-09-11 Zoll Medical Corporation Reperfusion protection in resuscitation
US8535934B2 (en) 2006-04-19 2013-09-17 Transmedics, Inc. Systems and methods for ex vivo organ care
US9457179B2 (en) 2007-03-20 2016-10-04 Transmedics, Inc. Systems for monitoring and applying electrical currents in an organ perfusion system
DE102007038121A1 (de) * 2007-07-31 2009-02-05 Novalung Gmbh Konditionierung von Blut eines Patienten durch Gase
CN105510850A (zh) 2007-11-02 2016-04-20 麻省理工学院 尿苷饮食添加顺应性方法及其用途
US9247728B2 (en) 2008-01-31 2016-02-02 Transmedics, Inc. Systems and methods for ex vivo lung care
CN102083443B (zh) * 2008-04-09 2014-01-15 北卡罗来纳大学查珀尔希尔分校 调节肌动蛋白细胞骨架重排和细胞间间隙形成的方法
US8394355B2 (en) * 2009-08-10 2013-03-12 P2 Science Aps Use of UTP for the diagnosis of stenoses and other conditions of restricted blood flow
US9320269B2 (en) 2009-09-25 2016-04-26 John Brassil Organ preservation system
DE102009045589A1 (de) 2009-10-12 2011-04-14 Universitätsklinikum Freiburg Vorrichtung zur Behandlung eines Individuums mit Herzminderleistung, Herzstillstand oder Schlaganfall
US9834756B2 (en) 2010-07-16 2017-12-05 Lifeline Scientific, Inc. Methods for increasing isolation yields of cellular products
CN103429733B (zh) 2010-10-22 2015-11-25 细胞与组织系统股份有限公司 培养的胰岛
WO2012078968A2 (en) 2010-12-10 2012-06-14 Lifeline Scientific, Inc. Machine perfusion with complement inhibitors
US9867368B2 (en) 2011-03-15 2018-01-16 Paragonix Technologies, Inc. System for hypothermic transport of samples
US9426979B2 (en) 2011-03-15 2016-08-30 Paragonix Technologies, Inc. Apparatus for oxygenation and perfusion of tissue for organ preservation
US20210392873A1 (en) 2011-03-15 2021-12-23 Paragonix Technologies, Inc. System for hypothermic transport of samples
US11178866B2 (en) 2011-03-15 2021-11-23 Paragonix Technologies, Inc. System for hypothermic transport of samples
WO2012125782A2 (en) 2011-03-15 2012-09-20 Paragonix Technologies, Inc. Apparatus for oxygenation and perfusion of tissue for organ preservation
US9253976B2 (en) 2011-03-15 2016-02-09 Paragonix Technologies, Inc. Methods and devices for preserving tissues
US8828710B2 (en) 2011-03-15 2014-09-09 Paragonix Technologies, Inc. System for hypothermic transport of samples
ES2913104T3 (es) 2011-04-14 2022-05-31 Transmedics Inc Solución de cuidado de órganos para perfusión en máquina ex-vivo de pulmones de donantes
WO2012170633A1 (en) 2011-06-09 2012-12-13 Lifeline Scientific, Inc. Data record for organ transport and/or storage, comprising biomarker and events information
US20120330438A1 (en) 2011-06-22 2012-12-27 Shaf Keshavjee Repaired organ and method for making the same
US8785116B2 (en) 2012-08-10 2014-07-22 Paragonix Technologies, Inc. Methods for evaluating the suitability of an organ for transplant
US9560846B2 (en) 2012-08-10 2017-02-07 Paragonix Technologies, Inc. System for hypothermic transport of biological samples
ES2728480T3 (es) 2012-09-08 2019-10-24 Organ Technologies Inc Método para mantener un órgano o tejido para su uso para trasplante durante un largo período
US10420337B2 (en) 2013-03-15 2019-09-24 Lifeline Scientific, Inc. Transporter with a glucose sensor for determining viability of an organ or tissue
US20140278468A1 (en) 2013-03-15 2014-09-18 I.D. Therapeutics Llc Apparatus and method for optimizing treatment using medication compliance patterns and glucose sensor
CN113287600B (zh) 2014-06-02 2022-08-19 特兰斯迈迪茨公司 对离体肝脏灌注的灌注回路和系统以及对其保存的系统
US9994811B2 (en) 2014-10-09 2018-06-12 Lauren Brasile Reducing the immunogenicity of allografts
CA2970117A1 (en) 2014-12-12 2016-06-16 Darren FREED Apparatus and method for organ perfusion
GB201511207D0 (en) * 2015-06-25 2015-08-12 Xvivo Perfusion Ab Isolated organ evaluation and treatment
JP6934005B2 (ja) 2015-09-09 2021-09-08 トランスメディクス,インコーポレイテッド エキソビボ臓器管理システムのための大動脈カニューレ
CN105918308A (zh) * 2016-04-28 2016-09-07 上海市胸科医院 一种用于移植供肺灌流的肺灌流液及其制备方法
US10091986B2 (en) 2016-05-09 2018-10-09 Xor-Labs Toronto Inc. Organ perfusion device and method
CA3066625A1 (en) 2017-06-07 2018-12-13 Paragonix Technologies, Inc. Apparatus for tissue transport and preservation
JP2020002062A (ja) * 2018-06-28 2020-01-09 株式会社Screenホールディングス 灌流装置および灌流方法
CA3151433C (en) * 2019-09-27 2023-05-16 Virginia Commonwealth University Compositions and methods for restoring or increasing tissue perfusion
US11632951B2 (en) 2020-01-31 2023-04-25 Paragonix Technologies, Inc. Apparatus for tissue transport and preservation
WO2022233642A1 (en) * 2021-05-06 2022-11-10 Xvivo Perfusion Ab Methods for removing leucocytes from isolated organs
USD1031028S1 (en) 2022-09-08 2024-06-11 Paragonix Technologies, Inc. Tissue suspension adaptor

Family Cites Families (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5331209B2 (de) 1973-10-05 1978-09-01
US4110474A (en) 1977-08-26 1978-08-29 Suntech, Inc. Tetramethylpentane blood substitutes
US4187252A (en) 1977-08-26 1980-02-05 Suntech, Inc. Tetramethylpentane blood substitutes
US4186253A (en) 1978-10-10 1980-01-29 The Green Cross Corporation Perfusate for preserving organ to be transplanted and preserving method
US4252827A (en) 1979-05-23 1981-02-24 The Green Cross Corporation Oxygen-transferable fluorocarbon emulsion
US5085630A (en) * 1980-04-14 1992-02-04 Thomas Jefferson University Oxygenated fluorocarbon nutrient solution
US4686085A (en) * 1980-04-14 1987-08-11 Thomas Jefferson University Stroke treatment utilizing extravascular circulation of oxygenated synthetic nutrients to treat tissue hypoxic and ischemic disorders
US4443480A (en) 1982-04-12 1984-04-17 Children's Hospital Medical Center Artificial blood and other gas transport agents
US4423077A (en) 1982-07-27 1983-12-27 The University Of Pennsylvania Perfluorochemical emulsion artificial blood
US4534978A (en) 1982-12-28 1985-08-13 The Green Cross Corporation Perfluorocycloamines
US4868318A (en) 1985-02-01 1989-09-19 The Green Cross Corporation Perfluoro chemicals and polyfluorinated compounds
US4686024A (en) 1985-02-01 1987-08-11 The Green Cross Corporation Novel perfluoro chemicals and polyfluorinated compounds and process for production of the same
US4865836A (en) 1986-01-14 1989-09-12 Fluoromed Pharmaceutical, Inc. Brominated perfluorocarbon emulsions for internal animal use for contrast enhancement and oxygen transport
US4866096A (en) 1987-03-20 1989-09-12 Air Products And Chemicals, Inc. Stable fluorochemical aqueous emulsions
US5130230A (en) * 1988-05-02 1992-07-14 Cryomedical Sciences, Inc. Blood substitute
US5011469A (en) * 1988-08-29 1991-04-30 Shiley, Inc. Peripheral cardiopulmonary bypass and coronary reperfusion system
US5584804A (en) * 1990-10-10 1996-12-17 Life Resuscitation Technologies, Inc. Brain resuscitation and organ preservation device and method for performing the same
US5395314A (en) * 1990-10-10 1995-03-07 Life Resuscitation Technologies, Inc. Brain resuscitation and organ preservation device and method for performing the same
US5137510A (en) * 1990-12-14 1992-08-11 Mallinckrodt Medical, Inc. System and method for oxygenation of the heart using subpericardial fluids
US5290766A (en) * 1991-02-18 1994-03-01 The National Heart Foundation Of New Zealand Cardioplegic compositions
CA2066374C (en) * 1991-04-19 2002-01-29 Paul E. Segall Solution for perfusing primates
US5409688A (en) 1991-09-17 1995-04-25 Sonus Pharmaceuticals, Inc. Gaseous ultrasound contrast media
US5403575A (en) 1991-12-12 1995-04-04 Hemagen/Pfc Highly fluorinated, chloro-substituted organic compound-containing emulsions and methods of using them
US5552267A (en) * 1992-04-03 1996-09-03 The Trustees Of Columbia University In The City Of New York Solution for prolonged organ preservation
US5370989A (en) * 1992-04-03 1994-12-06 The Trustees Of Columbia University In The City Of New York Solution for prolonged organ preservation
US5362622A (en) * 1993-03-11 1994-11-08 Board Of Regents, The University Of Texas System Combined perfusion and oxygenation apparatus
WO1994021116A1 (en) * 1993-03-16 1994-09-29 Alliance Pharmaceutical Corp. Preservation solution and method for warm organ preservation
US5405742A (en) * 1993-07-16 1995-04-11 Cyromedical Sciences, Inc. Solutions for tissue preservation and bloodless surgery and methods using same
AU2595195A (en) 1994-05-20 1995-12-18 Vec Tec, Inc. Method and apparatus monitoring viability of transplantable organs

Also Published As

Publication number Publication date
CA2255657A1 (en) 1997-11-27
ES2296310T3 (es) 2008-04-16
WO1997043899A1 (en) 1997-11-27
DE69738184T2 (de) 2008-07-24
RU2199310C2 (ru) 2003-02-27
DE69738184D1 (de) 2007-11-15
HK1021925A1 (en) 2000-07-21
CN1226132A (zh) 1999-08-18
EP1021084B1 (de) 2007-10-03
ES2296310T5 (es) 2016-06-24
EP1021084B9 (de) 2008-02-27
AU723424B2 (en) 2000-08-24
US5843024A (en) 1998-12-01
JP2000511531A (ja) 2000-09-05
EP1021084B2 (de) 2016-03-09
EP1021084A1 (de) 2000-07-26
EP1021084A4 (de) 2004-10-13
CN1163125C (zh) 2004-08-25
AU3067197A (en) 1997-12-09
CA2255657C (en) 2009-09-01
JP4259614B2 (ja) 2009-04-30

Similar Documents

Publication Publication Date Title
ATE374526T1 (de) Lösung und verfahren zur wiederbelebung und heilung von ischämisch beschädigtem gewebe
DE69701152D1 (de) Ein blasenkatheter-set mit einem gebrauchsfertigem katheter
DK1487431T3 (da) Forebyggelse og/eller behandling af cardiovaskulær sygdom og/eller dermed associeret hjertefejl
ATE111361T1 (de) Methode für behandlung von transplantaten vor transplantationen.
ES2180653T3 (es) Tratamiento de material biologico antes de la implantacion.
ES2169128T3 (es) Procedimientos para el tratamiento de enfermedades utilizando celulas de sertoli y aloinjertos o xenoinjertos.
NZ334190A (en) Method for improved selectivity in photo-activation of molecular agents
BRPI0418326A (pt) método de regeneração de tecidos
DE60026146D1 (de) Verwendung von dapoxetin, a selektiver serotonin-aufnahme inhibitor mit schnellem wirkungseintritt, zur behandlung von sexueller dysfunction
ATE208209T1 (de) Die kombination des wachstumhormones und des insulinähnlichen wachstumsfaktors-i zur behandlung von kongestivem herzversagen
DE60001555D1 (de) Wässrige lösung zum konservieren von gewebe und organen
ATE162078T1 (de) Morphogeninduzierte regenerierung der leber
ATE108658T1 (de) Verwendung von tetracycline zur herstellung eines arzneimittels zum herabsetzen des augendrucks.
NO830041L (no) Fremgangsmaate til behandling av azykli hos sauer eller storfe
ATE251462T1 (de) Verfahren zur behandlung von narbengewebe
ATE221310T1 (de) Neues verfahren zur kryokonservierung von pflanzen
ATE306278T1 (de) Behandlung von knochenleiden mit adrenomedullin
RU93014633A (ru) Способ лечения острого панкреатита
DE60024114D1 (de) Zusammensetzung zur behandlung von atherosklerose, welche ein statin und ex-vivo behandeltes blut enthält
RU92012993A (ru) Способ коррекции явлений тиреотоксикоза
RU99122312A (ru) Способ лечения больных, оперированных по поводу неспецифических заболеваний легких
BG101472A (en) Vascular transplant and method for its preparation
Heiner et al. The effect of inadequate venous or arterial blood supply on the survival of abdominal islands flaps in rats
RU92015103A (ru) Способ аутовенозной пластики внешнепеченочных желчных протоков
MX9504896A (es) Pericardio bovino tratado con glutaraldehido, como bioprotesis de pared toracoabdominal, tejido pulmonar y bronquial.

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification

Ref document number: 1021084

Country of ref document: EP

REN Ceased due to non-payment of the annual fee