ATE366745T1 - Mutant er-alpha und nachweissysteme für transaktivierung - Google Patents
Mutant er-alpha und nachweissysteme für transaktivierungInfo
- Publication number
- ATE366745T1 ATE366745T1 AT00981647T AT00981647T ATE366745T1 AT E366745 T1 ATE366745 T1 AT E366745T1 AT 00981647 T AT00981647 T AT 00981647T AT 00981647 T AT00981647 T AT 00981647T AT E366745 T1 ATE366745 T1 AT E366745T1
- Authority
- AT
- Austria
- Prior art keywords
- eralpha
- mutant
- test
- transactivation
- diagnosing
- Prior art date
Links
- 230000023603 positive regulation of transcription initiation, DNA-dependent Effects 0.000 title abstract 3
- 238000001514 detection method Methods 0.000 title 1
- 102000007594 Estrogen Receptor alpha Human genes 0.000 abstract 10
- 108010007005 Estrogen Receptor alpha Proteins 0.000 abstract 10
- 238000000034 method Methods 0.000 abstract 7
- 102000040430 polynucleotide Human genes 0.000 abstract 3
- 108091033319 polynucleotide Proteins 0.000 abstract 3
- 239000002157 polynucleotide Substances 0.000 abstract 3
- 108700008625 Reporter Genes Proteins 0.000 abstract 2
- 230000000694 effects Effects 0.000 abstract 2
- 238000012216 screening Methods 0.000 abstract 2
- 239000000592 Artificial Cell Substances 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 230000001419 dependent effect Effects 0.000 abstract 1
- 230000001076 estrogenic effect Effects 0.000 abstract 1
- 239000003446 ligand Substances 0.000 abstract 1
- 239000008177 pharmaceutical agent Substances 0.000 abstract 1
- 230000002103 transcriptional effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/72—Receptors; Cell surface antigens; Cell surface determinants for hormones
- C07K14/721—Steroid/thyroid hormone superfamily, e.g. GR, EcR, androgen receptor, oestrogen receptor
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Cell Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Toxicology (AREA)
- Endocrinology (AREA)
- Immunology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Mushroom Cultivation (AREA)
Applications Claiming Priority (8)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP34802299 | 1999-12-07 | ||
| JP37066799 | 1999-12-27 | ||
| JP2000207011 | 2000-07-07 | ||
| JP2000220508 | 2000-07-21 | ||
| JP2000234053 | 2000-08-02 | ||
| JP2000235461 | 2000-08-03 | ||
| JP2000235463 | 2000-08-03 | ||
| JP2000235460 | 2000-08-03 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE366745T1 true ATE366745T1 (de) | 2007-08-15 |
Family
ID=27573667
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT00981647T ATE366745T1 (de) | 1999-12-07 | 2000-12-01 | Mutant er-alpha und nachweissysteme für transaktivierung |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US7582476B2 (enExample) |
| EP (1) | EP1237925B1 (enExample) |
| JP (1) | JP4742483B2 (enExample) |
| AT (1) | ATE366745T1 (enExample) |
| AU (1) | AU782142B2 (enExample) |
| CA (1) | CA2393045A1 (enExample) |
| DE (1) | DE60035522T2 (enExample) |
| WO (1) | WO2001042307A1 (enExample) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2002057283A1 (en) * | 2001-01-19 | 2002-07-25 | Baylor College Of Medecine | Methods and compositions in breast cancer diagnosis and therapeutics |
| EP1533368A4 (en) * | 2002-07-02 | 2006-06-21 | Astellas Pharma Inc | SCREENING METHOD FOR A DRUG TO IMPROVE INSULIN RESISTANCE |
| AU2003298605B2 (en) | 2002-10-16 | 2007-10-18 | Gen-Probe Incorporated | Compositions and methods for detecting west nile virus |
| US7927840B2 (en) * | 2006-09-11 | 2011-04-19 | Gen Probe Incorporated | Method for detecting West Nile Virus nucleic acids in the 3′ non-coding region |
| AU2003280793A1 (en) * | 2002-11-15 | 2004-06-15 | Sumitomo Chemical Company, Limited | MUTANT ESTROGEN RECEPTOR-Alpha AND GENE THEREOF |
| US20070087346A1 (en) * | 2003-10-24 | 2007-04-19 | Gennaro Ciliberto | Orthogonal gene switches |
| FR2863275B1 (fr) * | 2003-12-09 | 2007-08-10 | Biomerieux Sa | Procede pour le diagnostic/pronostic du cancer du sein |
| WO2005071080A2 (en) | 2004-01-20 | 2005-08-04 | Isis Pharmaceuticals, Inc. | Modulation of glucocorticoid receptor expression |
| JP2006153656A (ja) * | 2004-11-29 | 2006-06-15 | Olympus Corp | 反応カプセル、反応カプセルを使用した検査方法およびシステム |
| AU2012328680A1 (en) | 2011-10-25 | 2014-05-01 | Ionis Pharmaceuticals, Inc. | Antisense modulation of GCCR expression |
| BR112015030595A2 (pt) | 2013-06-19 | 2017-07-25 | Seragon Pharmaceuticals Inc | moduladores de receptor de estrogênio de azetidina e usos dos mesmos |
| EA031077B1 (ru) | 2013-06-19 | 2018-11-30 | Серагон Фармасьютикалз, Инк. | Модулятор рецептора эстрогена и его применения |
| MA39740A (fr) | 2014-03-13 | 2017-01-18 | Hoffmann La Roche | Méthodes et compositions pour moduler des mutants du récepteur des oestrogènes |
| JP6768711B2 (ja) | 2015-05-26 | 2020-10-14 | エフ・ホフマン−ラ・ロシュ・アクチェンゲゼルシャフト | 複素環式エストロゲン受容体モジュレーター及びその使用 |
| US10179676B1 (en) | 2017-07-26 | 2019-01-15 | William Hagan Taylor | Dispenser with self-closing cap |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0258401A4 (en) | 1986-02-20 | 1989-06-13 | California Biotechnology Inc | Eucaryotic expression of steroid receptor proteins. |
| FR2634495B1 (fr) * | 1988-07-01 | 1990-10-26 | Chambon Pierre | Procede de preparation d'une proteine par des levures utilisant un systeme inductible, vecteurs et souches transformees correspondantes |
| JPH06510363A (ja) * | 1990-10-29 | 1994-11-17 | ディカルブ プラント ジェネティクス | 磁気性粒子を使用する生物学的材料の単離 |
-
2000
- 2000-12-01 EP EP00981647A patent/EP1237925B1/en not_active Expired - Lifetime
- 2000-12-01 AT AT00981647T patent/ATE366745T1/de not_active IP Right Cessation
- 2000-12-01 US US10/148,835 patent/US7582476B2/en not_active Expired - Fee Related
- 2000-12-01 AU AU18868/01A patent/AU782142B2/en not_active Ceased
- 2000-12-01 DE DE60035522T patent/DE60035522T2/de not_active Expired - Lifetime
- 2000-12-01 JP JP2001543602A patent/JP4742483B2/ja not_active Expired - Fee Related
- 2000-12-01 WO PCT/JP2000/008553 patent/WO2001042307A1/en not_active Ceased
- 2000-12-01 CA CA002393045A patent/CA2393045A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| US7582476B2 (en) | 2009-09-01 |
| EP1237925B1 (en) | 2007-07-11 |
| EP1237925A1 (en) | 2002-09-11 |
| AU782142B2 (en) | 2005-07-07 |
| JP2003516137A (ja) | 2003-05-13 |
| WO2001042307A1 (en) | 2001-06-14 |
| DE60035522D1 (de) | 2007-08-23 |
| US20030207380A1 (en) | 2003-11-06 |
| CA2393045A1 (en) | 2001-06-14 |
| JP4742483B2 (ja) | 2011-08-10 |
| AU1886801A (en) | 2001-06-18 |
| DE60035522T2 (de) | 2008-03-20 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |