ATE356179T1 - Chemilumineszente markierungsverbindungen - Google Patents
Chemilumineszente markierungsverbindungenInfo
- Publication number
- ATE356179T1 ATE356179T1 AT99919759T AT99919759T ATE356179T1 AT E356179 T1 ATE356179 T1 AT E356179T1 AT 99919759 T AT99919759 T AT 99919759T AT 99919759 T AT99919759 T AT 99919759T AT E356179 T1 ATE356179 T1 AT E356179T1
- Authority
- AT
- Austria
- Prior art keywords
- compounds
- chemiluminescent
- conjugates
- labeled
- assays
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 6
- 238000003556 assay Methods 0.000 abstract 2
- 238000002372 labelling Methods 0.000 abstract 2
- HJCUTNIGJHJGCF-UHFFFAOYSA-N 9,10-dihydroacridine Chemical group C1=CC=C2CC3=CC=CC=C3NC2=C1 HJCUTNIGJHJGCF-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 239000012491 analyte Substances 0.000 abstract 1
- 239000007800 oxidant agent Substances 0.000 abstract 1
- 230000001590 oxidative effect Effects 0.000 abstract 1
- 230000009870 specific binding Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
- C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
- C07D221/04—Ortho- or peri-condensed ring systems
- C07D221/06—Ring systems of three rings
- C07D221/08—Aza-anthracenes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D219/00—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems
- C07D219/02—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems with only hydrogen, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the ring system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
- C07F7/1804—Compounds having Si-O-C linkages
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/06—Phosphorus compounds without P—C bonds
- C07F9/08—Esters of oxyacids of phosphorus
- C07F9/09—Esters of phosphoric acids
- C07F9/113—Esters of phosphoric acids with unsaturated acyclic alcohols
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
- C07F9/576—Six-membered rings
- C07F9/64—Acridine or hydrogenated acridine ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having sulfur atoms, with or without selenium or tellurium atoms, as the only ring hetero atoms
- C07F9/655363—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having sulfur atoms, with or without selenium or tellurium atoms, as the only ring hetero atoms the sulfur atom being part of a six-membered ring
- C07F9/655372—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having sulfur atoms, with or without selenium or tellurium atoms, as the only ring hetero atoms the sulfur atom being part of a six-membered ring condensed with carbocyclic rings or carbocyclic ring systems
-
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09K—MATERIALS FOR MISCELLANEOUS APPLICATIONS, NOT PROVIDED FOR ELSEWHERE
- C09K11/00—Luminescent, e.g. electroluminescent, chemiluminescent materials
- C09K11/06—Luminescent, e.g. electroluminescent, chemiluminescent materials containing organic luminescent materials
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/531—Production of immunochemical test materials
- G01N33/532—Production of labelled immunochemicals
- G01N33/533—Production of labelled immunochemicals with fluorescent label
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
- G01N33/582—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with fluorescent label
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Hematology (AREA)
- Biomedical Technology (AREA)
- Urology & Nephrology (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Microbiology (AREA)
- Cell Biology (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Biotechnology (AREA)
- Pathology (AREA)
- General Physics & Mathematics (AREA)
- Materials Engineering (AREA)
- Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Luminescent Compositions (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/099,657 US6126870A (en) | 1997-09-12 | 1998-06-17 | Chemiluminescent labeling compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE356179T1 true ATE356179T1 (de) | 2007-03-15 |
Family
ID=22276034
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT99919759T ATE356179T1 (de) | 1998-06-17 | 1999-05-03 | Chemilumineszente markierungsverbindungen |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US6126870A (de) |
| EP (1) | EP1029016B1 (de) |
| JP (1) | JP2002518410A (de) |
| AT (1) | ATE356179T1 (de) |
| AU (1) | AU760023C (de) |
| CA (1) | CA2301120A1 (de) |
| DE (1) | DE69935408T2 (de) |
| ES (1) | ES2283111T3 (de) |
| WO (1) | WO1999066005A1 (de) |
Families Citing this family (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1999014220A1 (en) * | 1997-09-12 | 1999-03-25 | Lumigen, Inc. | Novel compounds for generating chemiluminescence with a peroxidase |
| EP1186886A3 (de) * | 2000-09-04 | 2004-01-07 | Fuji Photo Film Co., Ltd. | Verfahren zur biochemischen Analyse und dazu geeignetes Gerät |
| US6872828B2 (en) * | 2001-12-20 | 2005-03-29 | Lumigen, Inc. | Compounds for generating chemiluminescence with a peroxidase |
| US7247726B2 (en) * | 2001-02-26 | 2007-07-24 | Lumigen, Inc. | Compounds for generating chemiluminescence with a peroxidase |
| KR100496776B1 (ko) * | 2001-06-21 | 2005-06-22 | 삼성토탈 주식회사 | 에틸렌 중합 및 공중합용 촉매 |
| US7560556B2 (en) * | 2001-12-20 | 2009-07-14 | Lumigen, Inc. | Assay methods using chemiluminescent detection of peroxidase |
| AU2002352881B2 (en) * | 2001-12-20 | 2008-11-06 | Lumigen, Inc. | Improved compounds for generating chemiluminescence with a peroxidase |
| DE10212805A1 (de) * | 2002-03-22 | 2003-10-02 | Leica Microsystems Schweiz Ag | Operationsmikroskop mit Informationssystem |
| US7390670B2 (en) | 2003-02-20 | 2008-06-24 | Lumigen, Inc. | Signalling compounds and methods for detecting hydrogen peroxide |
| US7846676B2 (en) | 2004-07-19 | 2010-12-07 | Cell Biosciences, Inc. | Methods and devices for analyte detection |
| US7935479B2 (en) | 2004-07-19 | 2011-05-03 | Cell Biosciences, Inc. | Methods and devices for analyte detection |
| EP1776581B1 (de) | 2004-07-19 | 2015-05-06 | ProteinSimple | Verfahren zum Nachweis von Proteinen |
| US7682839B2 (en) | 2005-03-14 | 2010-03-23 | Lumigen, Inc. | Methods using novel chemiluminescent labels |
| US20060205094A1 (en) * | 2005-03-14 | 2006-09-14 | Lumigen, Inc. | Methods using novel chemiluminescent labels |
| WO2006116687A2 (en) * | 2005-04-27 | 2006-11-02 | The Trustees Of The University Of Pennsylvania | Nanoassays |
| WO2006116686A2 (en) * | 2005-04-27 | 2006-11-02 | The Trustees Of The University Of Pennsylvania | Nanostructure enhanced luminescent devices |
| US7879575B2 (en) * | 2005-04-27 | 2011-02-01 | The Trustees Of The University Of Pennsylvania | Nanostructures that provide a modified nanoenvironment for the enhancement of luminescence |
| US8945361B2 (en) | 2005-09-20 | 2015-02-03 | ProteinSimple | Electrophoresis standards, methods and kits |
| US7799534B2 (en) * | 2006-05-09 | 2010-09-21 | Beckman Coulter, Inc. | Nonseparation assay methods |
| DE202007010668U1 (de) | 2007-07-30 | 2008-12-18 | Follmann & Co. Gesellschaft Für Chemie-Werkstoffe Und -Verfahrenstechnik Mbh & Co. Kg | Verbesserte Mikrokapseln |
| US8778624B2 (en) * | 2009-11-16 | 2014-07-15 | Siemens Healthcare Diagnostics Inc. | Zwitterion-containing acridinium compounds |
| US20150093757A1 (en) | 2013-09-27 | 2015-04-02 | Protein Simple | Methods. apparatus and systems for detection of total protein using capillary electrophoresis |
| US9766206B2 (en) | 2013-09-27 | 2017-09-19 | ProteinSimple | Apparatus, systems, and methods for capillary electrophoresis |
| JP7107842B6 (ja) | 2016-01-13 | 2023-08-18 | プロテインシンプル | システム |
| CN106749404B (zh) * | 2016-12-07 | 2019-01-04 | 湖南远璟生物技术有限公司 | 一种与碱性磷酸酶反应产生化学发光的化合物的制备方法 |
| US11782023B2 (en) | 2018-12-19 | 2023-10-10 | Regeneron Pharmaceuticals, Inc. | Ce-western applications for antibody development |
| WO2020237095A1 (en) | 2019-05-21 | 2020-11-26 | Regeneron Pharmaceuticals, Inc. | Methods for identifying and quantitating host cell protein |
| US11420202B1 (en) | 2021-08-31 | 2022-08-23 | ProteinSimple | Systems and methods for fractionation and collection of analytes in a sample |
| US20230075533A1 (en) | 2021-09-03 | 2023-03-09 | ProteinSimple | Methods and systems for analysis of samples containing particles used for gene delivery |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3279029D1 (en) * | 1981-12-11 | 1988-10-20 | Welsh Nat School Med | Luminescent labelling materials and procedures |
| US4745181A (en) * | 1986-10-06 | 1988-05-17 | Ciba Corning Diagnostics Corp. | Polysubstituted aryl acridinium esters |
| ATE236177T1 (de) * | 1996-01-16 | 2003-04-15 | Lumigen Inc | Verbindungen, zusammensetzungen und methoden zur erzeugung von chemilumineszenz mit phosphatase- enzymen |
| US5840963A (en) * | 1997-05-13 | 1998-11-24 | Lumigen, Inc. | Chemiluminescent reactions using dihydroxyaromatic compounds and heterocyclic enol phosphates |
| US5772926A (en) * | 1997-05-13 | 1998-06-30 | Lumigen, Inc. | Chemiluminescent reactions using dihydroxyaromatic compounds and heterocyclic enol phosphates |
| US5922558A (en) * | 1997-09-12 | 1999-07-13 | Lumigen, Inc. | Methods and compositions for generating chemiluminescence with a peroxidase |
-
1998
- 1998-06-17 US US09/099,657 patent/US6126870A/en not_active Expired - Lifetime
-
1999
- 1999-05-03 CA CA002301120A patent/CA2301120A1/en not_active Abandoned
- 1999-05-03 ES ES99919759T patent/ES2283111T3/es not_active Expired - Lifetime
- 1999-05-03 AT AT99919759T patent/ATE356179T1/de not_active IP Right Cessation
- 1999-05-03 WO PCT/US1999/006561 patent/WO1999066005A1/en active IP Right Grant
- 1999-05-03 DE DE69935408T patent/DE69935408T2/de not_active Expired - Lifetime
- 1999-05-03 JP JP2000554815A patent/JP2002518410A/ja active Pending
- 1999-05-03 AU AU37409/99A patent/AU760023C/en not_active Expired
- 1999-05-03 EP EP99919759A patent/EP1029016B1/de not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| AU760023C (en) | 2003-12-04 |
| CA2301120A1 (en) | 1999-12-23 |
| DE69935408D1 (de) | 2007-04-19 |
| JP2002518410A (ja) | 2002-06-25 |
| ES2283111T3 (es) | 2007-10-16 |
| US6126870A (en) | 2000-10-03 |
| AU760023B2 (en) | 2003-05-08 |
| EP1029016A4 (de) | 2003-06-25 |
| WO1999066005A1 (en) | 1999-12-23 |
| EP1029016B1 (de) | 2007-03-07 |
| EP1029016A1 (de) | 2000-08-23 |
| AU3740999A (en) | 2000-01-05 |
| DE69935408T2 (de) | 2007-11-08 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ATE356179T1 (de) | Chemilumineszente markierungsverbindungen | |
| ATE280241T1 (de) | Chemilumineszierende zusammensetzungen und entsprechende verfahren | |
| EP2186910A3 (de) | Verfahren und Zusammensetzungen für verbesserte Lumineszenztests unter Verwendung von Mikropartikeln | |
| DE3883478T2 (de) | Peridinin-Chlorophyll-Komplex als fluoreszierende Erkennungszeichen. | |
| DE3575789D1 (de) | Gleichseitige mehrfache proben und in denselben zu verwendende zusammensetzungen. | |
| EE05650B1 (et) | Antikehade radioaktiivse mrgistamise komplekt ja seostamistest | |
| ATE447712T1 (de) | Immunoassay mit doppelter standardkurve | |
| AU1706892A (en) | Assay methods utilizing induced luminescence | |
| ES2093634T3 (es) | Inmunoensayos heterogeneos. | |
| SG155923A1 (en) | Fluorescent dye compounds, conjugates and uses thereof | |
| EP1489418A4 (de) | Neue fluoreszenzmarkierungsverbindungen | |
| FI950764A0 (fi) | Biotinyloidut kemiluminesenssileimat, konjugaatit, analyysit, analyysipakkaukset | |
| MXPA04001730A (es) | Metodo para determinacion de multiples analitos. | |
| ITRM910503A1 (it) | Metodo per rivelare macromolecole immobilizzate su una matrice | |
| EP1005649A4 (de) | Nicht-enzymatische methoden zur erzeugung von chemilumineszenz bei acridan-alkenen | |
| FR2853077B1 (fr) | Procedes immunochromatographiques en phase solide | |
| ATE371747T1 (de) | Dendritische chemilumineszierende substrate | |
| DE69927240D1 (de) | Messung von hydriden mit hilfe chemilumineszierender acridiniumverbindungen | |
| ATE177208T1 (de) | Nichttrennender chemilumineszenzassay durch spezifische bindung | |
| ATE533053T1 (de) | Nicht-elispot-test | |
| ATE259424T1 (de) | Enzym-substrate und assay mit intramolekularen fret | |
| DE60027002D1 (de) | Chemilumineszenz redox-assay zur quantifizierung von analyten in biologischen proben | |
| DK0497870T3 (da) | Enzymassay og assaysæt til måling af cellulær aktivering | |
| DE60116124D1 (de) | Elektrochemilumineszenz von acridanzusammensetzungen | |
| ES2070715B1 (es) | Substratos de aminopeptidasas como sustancias de utilidad diagnosticas. |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |