ATE352561T1 - Pgc-1, ein neuartiger ppar-gamma-koaktivator aus braunem fettgewebe - Google Patents

Pgc-1, ein neuartiger ppar-gamma-koaktivator aus braunem fettgewebe

Info

Publication number
ATE352561T1
ATE352561T1 AT98925051T AT98925051T ATE352561T1 AT E352561 T1 ATE352561 T1 AT E352561T1 AT 98925051 T AT98925051 T AT 98925051T AT 98925051 T AT98925051 T AT 98925051T AT E352561 T1 ATE352561 T1 AT E352561T1
Authority
AT
Austria
Prior art keywords
pgc
nucleic acid
acid molecules
brown
ati
Prior art date
Application number
AT98925051T
Other languages
English (en)
Inventor
Bruce M Spiegelman
Pere Puigserver
Zhidan Wu
Original Assignee
Dana Farber Cancer Inst Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dana Farber Cancer Inst Inc filed Critical Dana Farber Cancer Inst Inc
Application granted granted Critical
Publication of ATE352561T1 publication Critical patent/ATE352561T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/5759—Products of obesity genes, e.g. leptin, obese (OB), tub, fat
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/07—Animals genetically altered by homologous recombination
    • A01K2217/075—Animals genetically altered by homologous recombination inducing loss of function, i.e. knock out
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2799/00—Uses of viruses
    • C12N2799/02—Uses of viruses as vector
    • C12N2799/021—Uses of viruses as vector for the expression of a heterologous nucleic acid
    • C12N2799/026—Uses of viruses as vector for the expression of a heterologous nucleic acid where the vector is derived from a baculovirus

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Diabetes (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Obesity (AREA)
  • Public Health (AREA)
  • Child & Adolescent Psychology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Endocrinology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Toxicology (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Emergency Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Detergent Compositions (AREA)
AT98925051T 1997-05-30 1998-05-29 Pgc-1, ein neuartiger ppar-gamma-koaktivator aus braunem fettgewebe ATE352561T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US4810797P 1997-05-30 1997-05-30

Publications (1)

Publication Number Publication Date
ATE352561T1 true ATE352561T1 (de) 2007-02-15

Family

ID=21952777

Family Applications (1)

Application Number Title Priority Date Filing Date
AT98925051T ATE352561T1 (de) 1997-05-30 1998-05-29 Pgc-1, ein neuartiger ppar-gamma-koaktivator aus braunem fettgewebe

Country Status (7)

Country Link
US (1) US6166192A (de)
EP (1) EP1003777B1 (de)
JP (2) JP4495787B2 (de)
AT (1) ATE352561T1 (de)
CA (1) CA2290944C (de)
DE (1) DE69836963T2 (de)
WO (1) WO1998054220A1 (de)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6426411B1 (en) * 1997-05-30 2002-07-30 Dana-Farber Cancer Institute PGC-1, a novel brown fat pparγ coactivator
US6166192A (en) * 1997-05-30 2000-12-26 Dana-Farber Cancer Institute PGC-1, a novel brown fat PPARγ coactivator
DE60005973T2 (de) * 1999-08-27 2004-05-13 Eli Lilly And Co., Indianapolis Biaryl-oxa(thia)zolderivate und ihre verwendung als ppars modulatoren
WO2001035096A2 (en) * 1999-11-10 2001-05-17 Mitokor Diseases associated with altered mitochondrial function
JP5002105B2 (ja) * 1999-12-28 2012-08-15 リボノミックス， インコーポレイテッド 内因性のｍＲＮＡタンパク質（ｍＲＮＰ）複合体の単離および特徴付けの方法
US8815517B2 (en) * 1999-12-28 2014-08-26 Ribonomics, Inc. Methods for identifying functionally related genes and drug targets
GB0022670D0 (en) * 2000-09-15 2000-11-01 Astrazeneca Ab Molecules
ATE403665T1 (de) * 2001-02-05 2008-08-15 Dana Farber Cancer Inst Inc Verfahren und zusammensetzungen zur modulierung der gluconeogenese mit pgc-1
WO2002090576A1 (en) * 2001-05-09 2002-11-14 Millennium Pharmaceuticals, Inc. Methods and compositions for the treatment and diagnosis of body weight disorders
EP1264841A1 (de) * 2001-06-08 2002-12-11 Novo Nordisk A/S DNS für einen mutanten Coaktivator PGC-1 des Peroxisomproliferator-aktivierten Rezeptors (PPAR-gamma), Nachweismethoden und Testsatz dazu
WO2003000715A1 (en) * 2001-06-22 2003-01-03 Ceres, Inc. Chimeric histone acetyltransferase polypeptides
WO2003004067A1 (en) * 2001-07-05 2003-01-16 Millenium Pharmaceuticals, Inc. Methods and compositions for the treatment and diagnosis of body weight disorders
AU2002320301A1 (en) 2001-07-05 2003-01-21 Dana-Farber Cancer Institute, Inc. Novel pgc-1 isoforms and uses therefor
WO2003026576A2 (en) * 2001-09-24 2003-04-03 Board Of Supervisors Of Louisiana State Universityand Agricultural And Mechanical College Induction of brown adipocytes by transcription factor nfe2l2
EP1525323B1 (de) * 2001-11-09 2015-01-21 Dana-Farber Cancer Institute, Inc. Pgc-1beta, ein neues pgc-1-homolog, und verwendungen dafür
US20060035849A1 (en) * 2002-02-13 2006-02-16 Danafarber Cancer Institute, Inc Methods and composition for modulating type I muscle formation using pgc-1 alpha
US20040077566A9 (en) * 2002-05-09 2004-04-22 Millennium Pharmaceuticals, Inc. Methods and compositions for the treatment and diagnosis of body weight disorders
WO2004064500A2 (en) * 2003-01-21 2004-08-05 Posco Transcriptional coactivator asc-2
EP1774028A4 (de) 2004-07-07 2008-05-07 Dana Farber Cancer Inst Inc Verfahren und zusammensetzungen zur behandlung von obesität
US9181315B2 (en) 2009-01-08 2015-11-10 Dana-Farber Cancer Institute, Inc. Compositions and methods for induced brown fat differentiation
US20150004144A1 (en) * 2011-12-02 2015-01-01 The General Hospital Corporation Differentiation into brown adipocytes
NL2015957B1 (en) 2015-12-14 2017-06-29 Scala Pharma B V Compositions and methods for inducing beige or brown fat tissue.

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2231850A1 (en) * 1995-09-15 1997-03-20 Sergio Onate Steroid receptor coactivator compositions and methods of use
US6166192A (en) * 1997-05-30 2000-12-26 Dana-Farber Cancer Institute PGC-1, a novel brown fat PPARγ coactivator

Also Published As

Publication number Publication date
JP4495787B2 (ja) 2010-07-07
EP1003777B1 (de) 2007-01-24
US6166192A (en) 2000-12-26
DE69836963D1 (de) 2007-03-15
JP2009050265A (ja) 2009-03-12
JP4759605B2 (ja) 2011-08-31
EP1003777A1 (de) 2000-05-31
WO1998054220A1 (en) 1998-12-03
CA2290944A1 (en) 1998-12-03
JP2002502251A (ja) 2002-01-22
DE69836963T2 (de) 2007-10-25
CA2290944C (en) 2012-03-06

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