ATE342736T1 - Intravaskuläre verabreichung von nukleinsäuren - Google Patents

Intravaskuläre verabreichung von nukleinsäuren

Info

Publication number
ATE342736T1
ATE342736T1 AT00976999T AT00976999T ATE342736T1 AT E342736 T1 ATE342736 T1 AT E342736T1 AT 00976999 T AT00976999 T AT 00976999T AT 00976999 T AT00976999 T AT 00976999T AT E342736 T1 ATE342736 T1 AT E342736T1
Authority
AT
Austria
Prior art keywords
nucleic acids
intravascular administration
cell
polynucleotide
genetic material
Prior art date
Application number
AT00976999T
Other languages
English (en)
Inventor
Jon A Wolff
Original Assignee
Mirus Bio Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mirus Bio Corp filed Critical Mirus Bio Corp
Application granted granted Critical
Publication of ATE342736T1 publication Critical patent/ATE342736T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Biochemistry (AREA)
  • Epidemiology (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Physics & Mathematics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
AT00976999T 1999-11-05 2000-11-06 Intravaskuläre verabreichung von nukleinsäuren ATE342736T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US16371999P 1999-11-05 1999-11-05
US70707000A 2000-11-05 2000-11-05
PCT/US2000/030562 WO2001032223A1 (en) 1999-11-05 2000-11-06 Intravascular delivery of nucleic acid

Publications (1)

Publication Number Publication Date
ATE342736T1 true ATE342736T1 (de) 2006-11-15

Family

ID=26859887

Family Applications (1)

Application Number Title Priority Date Filing Date
AT00976999T ATE342736T1 (de) 1999-11-05 2000-11-06 Intravaskuläre verabreichung von nukleinsäuren

Country Status (7)

Country Link
US (1) US7396821B1 (de)
EP (1) EP1246649B1 (de)
AT (1) ATE342736T1 (de)
DE (1) DE60031442T2 (de)
ES (1) ES2269199T3 (de)
PT (1) PT1246649E (de)
WO (1) WO2001032223A1 (de)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7642248B2 (en) 1999-11-05 2010-01-05 Roche Madison Inc Devices and processes for distribution of genetic material to mammalian limb
US10590418B2 (en) 2001-07-23 2020-03-17 The Board Of Trustees Of The Leland Stanford Junior University Methods and compositions for RNAi mediated inhibition of gene expression in mammals
DK1409506T3 (da) 2001-07-23 2012-08-06 Univ Leland Stanford Junior Fremgangsmåder og sammensætninger til RNAi-formidlet inhibering af genekspression i pattedyr
RU2019128427A (ru) 2017-03-13 2021-04-14 Филип Эндрю РАДОВИЧ Нервно-мышечный токсин для применения при лечении нарушения первого плюснефалангового сустава стопы

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5693622A (en) * 1989-03-21 1997-12-02 Vical Incorporated Expression of exogenous polynucleotide sequences cardiac muscle of a mammal
US5703055A (en) 1989-03-21 1997-12-30 Wisconsin Alumni Research Foundation Generation of antibodies through lipid mediated DNA delivery
US5698531A (en) * 1989-03-31 1997-12-16 The Regents Of The University Of Michigan Treatment of diseases by site-specific instillation of cells or site-specific transformation of cells and kits therefor
US5521291A (en) 1991-09-30 1996-05-28 Boehringer Ingelheim International, Gmbh Conjugates for introducing nucleic acid into higher eucaryotic cells
US5583020A (en) 1992-11-24 1996-12-10 Ribozyme Pharmaceuticals, Inc. Permeability enhancers for negatively charged polynucleotides
JP3626187B2 (ja) * 1993-06-07 2005-03-02 バイカル インコーポレイテッド 遺伝子治療に適するプラスミド
US6133242A (en) * 1993-10-15 2000-10-17 Thomas Jefferson Univerisity Inhibition of extracellular matrix synthesis by antisense compounds directed to nuclear proto-oncogenes
US5922687A (en) 1995-05-04 1999-07-13 Board Of Trustees Of The Leland Stanford Junior University Intracellular delivery of nucleic acids using pressure
US6265387B1 (en) * 1995-10-11 2001-07-24 Mirus, Inc. Process of delivering naked DNA into a hepatocyte via bile duct
US6627616B2 (en) * 1995-12-13 2003-09-30 Mirus Corporation Intravascular delivery of non-viral nucleic acid
DE69738316T2 (de) * 1997-06-20 2008-09-25 Mirus Bio Corp., Madison Verfahren zur verabreichung eines polynukleotids über das gefä system
CA2290736A1 (en) * 1997-07-11 1999-01-21 Introgene B.V. Interleukin-3 gene therapy for cancer

Also Published As

Publication number Publication date
EP1246649A1 (de) 2002-10-09
ES2269199T3 (es) 2007-04-01
DE60031442D1 (de) 2006-11-30
DE60031442T2 (de) 2007-03-29
PT1246649E (pt) 2007-01-31
US7396821B1 (en) 2008-07-08
EP1246649B1 (de) 2006-10-18
EP1246649A4 (de) 2002-11-27
WO2001032223A1 (en) 2001-05-10

Similar Documents

Publication Publication Date Title
EA199600103A1 (ru) Способ лечения болезни сердца, фильтрованный инъекционный препарат аденовирусного вектора, способ получения вирусного штамма, рекомбинантный вектор, клетка-хозяин, способ получения рекомбинантного аденовирусного вектора, способ лечения болезни периферических сосудов и способ ограничения доставки трансгена и его экспрессии в одном органе или структуре
DE69512219D1 (de) Gezielte spaltung von rns mittels gezielter bindung der ribonuklease p und spaltungssequenzen
ATE240401T1 (de) Expression von exogenen polynukleotidsequenzen in wirbeltieren
AU690733B2 (en) Genetic therapy of vascular diseases with a cell-specific active substance which is dependent on the cell cycle
HUP9801207A2 (hu) Nukleinsavat tartalmazó készítmények, előállításuk és alkalmazásuk
ES2094159T3 (es) Produccion de factor de crecimiento de celulas endoteliales vasculares.
ES2140096T3 (es) Procedimiento de tratamiento que utiliza la administracion mediada por electroporacion de farmacos y genes
BG101103A (bg) Теломераза при бозайници
ATE445417T1 (de) Ex vivo verfahren und zusammensetzungen zur nukleinsäureverabreichung
DE69838147D1 (de) Verbindungen und methoden zur modulierung von occludin-abhängiger gewebepermeabilität
DK592186A (da) Fremgangsmaade til udvinding af proteiner
BR0010648A (pt) Utilização de microesferas biodegradáveis que liberam um agente anticanceroso radiossensibilizador, processo de preparação de microesferas biodegradáveis, e, suspensão constituìda de uma solução estéril
DE69334257D1 (de) Methode zur Einführung von genetischem Material in Zellen
ES8606903A1 (es) Un metodo para entregar un agente seleccionado a un lugar biologico caracterizado por la presencia de una secuencia de adn seleccionada.
WO2005007811A3 (en) Injection of bone marrow-derived cells and medium for angiogenesis
ATE397461T1 (de) Auf tgf-beta 1 ansprechende knochenmarkzellen
NO20033144D0 (no) Modulore transfeksjonssystemer
DK1171165T3 (da) Injektion af autolog knoglemarv i myokardiet
SE9202208L (sv) Vävnadsförstärkning
DE60031442D1 (de) Intravaskuläre verabreichung von nukleinsäuren
BR9811014A (pt) "região concentrada reguladora de gene especìfica para semente precoce"
WO2000066732A3 (en) Laminin 8 and methods for its use
Hovanessian et al. Protein kinase in human plasma analogous to that present in control and interferon-treated HeLa cells
AU1248602A (en) Formulations comprising dextrin polymers in combination with sugars for the delivery of nucleic acids
UA10281C2 (uk) Спосіб отримання речовини для лікування захворювань підшлункової залози

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification

Ref document number: 1246649

Country of ref document: EP