ATE339506T1 - Rifamycin biosynthese genkluster - Google Patents

Rifamycin biosynthese genkluster

Info

Publication number
ATE339506T1
ATE339506T1 AT97938923T AT97938923T ATE339506T1 AT E339506 T1 ATE339506 T1 AT E339506T1 AT 97938923 T AT97938923 T AT 97938923T AT 97938923 T AT97938923 T AT 97938923T AT E339506 T1 ATE339506 T1 AT E339506T1
Authority
AT
Austria
Prior art keywords
rifamycin
gene
gene cluster
dna
biosynthesis
Prior art date
Application number
AT97938923T
Other languages
English (en)
Inventor
Thomas Schupp
Christiane Toupet
Nathalie Engel
Original Assignee
Novartis Pharma Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Pharma Gmbh filed Critical Novartis Pharma Gmbh
Application granted granted Critical
Publication of ATE339506T1 publication Critical patent/ATE339506T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/93—Ligases (6)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/10—Nitrogen as only ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
    • C12P17/188—Heterocyclic compound containing in the condensed system at least one hetero ring having nitrogen atoms and oxygen atoms as the only ring heteroatoms
    • C12P17/189—Heterocyclic compound containing in the condensed system at least one hetero ring having nitrogen atoms and oxygen atoms as the only ring heteroatoms containing the rifamycin nucleus

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Medicinal Chemistry (AREA)
  • Plant Pathology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Plant Substances (AREA)
AT97938923T 1996-08-20 1997-08-18 Rifamycin biosynthese genkluster ATE339506T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP96810551 1996-08-20

Publications (1)

Publication Number Publication Date
ATE339506T1 true ATE339506T1 (de) 2006-10-15

Family

ID=8225680

Family Applications (1)

Application Number Title Priority Date Filing Date
AT97938923T ATE339506T1 (de) 1996-08-20 1997-08-18 Rifamycin biosynthese genkluster

Country Status (8)

Country Link
US (1) US6924106B2 (de)
EP (1) EP0929681B1 (de)
AT (1) ATE339506T1 (de)
AU (1) AU4119597A (de)
DE (1) DE69736673T2 (de)
ES (1) ES2271973T3 (de)
PT (1) PT929681E (de)
WO (1) WO1998007868A1 (de)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6495348B1 (en) * 1993-10-07 2002-12-17 Regents Of The University Of Minnesota Mitomycin biosynthetic gene cluster
US6121029A (en) 1998-06-18 2000-09-19 Novartis Ag Genes for the biosynthesis of epothilones
CA2330543A1 (en) * 1998-06-23 1999-12-29 Biosearch Italia S.P.A. Methods for transferring the capability to produce a natural product into a suitable production host
US6265202B1 (en) 1998-06-26 2001-07-24 Regents Of The University Of Minnesota DNA encoding methymycin and pikromycin
WO2000044888A2 (en) * 1999-01-26 2000-08-03 University College London Dimethylarginine dimethylaminohydrolases
ES2335385T3 (es) 1999-10-13 2010-03-26 The Board Of Trustees Of The Leland Stanford Junior University Biosintesis de sustratos de policetido sintasa.
JP2014508516A (ja) 2011-01-28 2014-04-10 アミリス， インコーポレイテッド ゲルに封入されたマイクロコロニーのスクリーニング
MX2013013065A (es) 2011-05-13 2013-12-02 Amyris Inc Metodos y composiciones para detectar la produccion microbiana de compuestos inmiscibles em agua.
CN104540949B (zh) 2012-08-07 2018-05-29 阿迈瑞斯公司 用于稳定乙酰-辅酶a衍生化合物生成的方法
AU2014227811C1 (en) 2013-03-15 2018-09-27 Amyris, Inc. Use of phosphoketolase and phosphotransacetylase for production of acetyl-coenzyme a derived compounds
CA2918891C (en) 2013-08-07 2023-03-14 Amyris, Inc. Methods for stabilizing production of acetyl-coenzyme a derived compounds
WO2016210343A1 (en) 2015-06-25 2016-12-29 Amyris, Inc. Maltose dependent degrons, maltose-responsive promoters, stabilization constructs, and their use in production of non-catabolic compounds

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0463707A1 (de) * 1985-12-17 1992-01-02 Lubrizol Genetics Inc. Herstellung von Polyketid-Antibiotika
US5763569A (en) * 1991-08-23 1998-06-09 The Brigham And Women's Hospital, Inc Calcium receptor-active molecules
ES2164713T3 (es) * 1993-09-20 2002-03-01 Univ Leland Stanford Junior Produccion recombinante de nuevos poliquetidos.

Also Published As

Publication number Publication date
US6924106B2 (en) 2005-08-02
ES2271973T3 (es) 2007-04-16
PT929681E (pt) 2007-01-31
WO1998007868A1 (en) 1998-02-26
EP0929681A1 (de) 1999-07-21
DE69736673D1 (en) 2006-10-26
DE69736673T2 (de) 2007-09-13
AU4119597A (en) 1998-03-06
EP0929681B1 (de) 2006-09-13
US20050053927A1 (en) 2005-03-10

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