ATE337337T1 - Modifizierte derivate von cck-8 - Google Patents
Modifizierte derivate von cck-8Info
- Publication number
- ATE337337T1 ATE337337T1 AT02704898T AT02704898T ATE337337T1 AT E337337 T1 ATE337337 T1 AT E337337T1 AT 02704898 T AT02704898 T AT 02704898T AT 02704898 T AT02704898 T AT 02704898T AT E337337 T1 ATE337337 T1 AT E337337T1
- Authority
- AT
- Austria
- Prior art keywords
- sup
- cck
- asp
- peptide
- obesity
- Prior art date
Links
- IZTQOLKUZKXIRV-YRVFCXMDSA-N sincalide Chemical class C([C@@H](C(=O)N[C@@H](CCSC)C(=O)NCC(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC=1C=CC=CC=1)C(N)=O)NC(=O)[C@@H](N)CC(O)=O)C1=CC=C(OS(O)(=O)=O)C=C1 IZTQOLKUZKXIRV-YRVFCXMDSA-N 0.000 title abstract 5
- 108010087230 Sincalide Proteins 0.000 abstract 4
- 238000010609 cell counting kit-8 assay Methods 0.000 abstract 4
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 3
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 abstract 2
- 208000008589 Obesity Diseases 0.000 abstract 2
- 239000008103 glucose Substances 0.000 abstract 2
- 235000020824 obesity Nutrition 0.000 abstract 2
- 208000001072 type 2 diabetes mellitus Diseases 0.000 abstract 2
- 150000001408 amides Chemical class 0.000 abstract 1
- 239000008280 blood Substances 0.000 abstract 1
- 210000004369 blood Anatomy 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 230000037406 food intake Effects 0.000 abstract 1
- 235000012631 food intake Nutrition 0.000 abstract 1
- 230000003914 insulin secretion Effects 0.000 abstract 1
- 230000004048 modification Effects 0.000 abstract 1
- 238000012986 modification Methods 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
- 230000036186 satiety Effects 0.000 abstract 1
- 235000019627 satiety Nutrition 0.000 abstract 1
- 238000006467 substitution reaction Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/595—Gastrins; Cholecystokinins [CCK]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Diabetes (AREA)
- Gastroenterology & Hepatology (AREA)
- General Health & Medical Sciences (AREA)
- Endocrinology (AREA)
- Animal Behavior & Ethology (AREA)
- Biophysics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Obesity (AREA)
- Pharmacology & Pharmacy (AREA)
- Hematology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Biochemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Emergency Medicine (AREA)
- Child & Adolescent Psychology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Saccharide Compounds (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0105069.9A GB0105069D0 (en) | 2001-03-01 | 2001-03-01 | Modified peptide |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE337337T1 true ATE337337T1 (de) | 2006-09-15 |
Family
ID=9909777
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT02704898T ATE337337T1 (de) | 2001-03-01 | 2002-02-28 | Modifizierte derivate von cck-8 |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US7402663B2 (de) |
| EP (1) | EP1363945B1 (de) |
| AT (1) | ATE337337T1 (de) |
| AU (1) | AU2002238701B2 (de) |
| CA (1) | CA2439598C (de) |
| DE (1) | DE60214135T2 (de) |
| ES (1) | ES2271218T3 (de) |
| GB (1) | GB0105069D0 (de) |
| NZ (1) | NZ528031A (de) |
| WO (1) | WO2002070546A2 (de) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20090281032A1 (en) * | 2001-03-01 | 2009-11-12 | Peter Raymond Flatt | Modified CCK peptides |
| DE602005026014D1 (de) * | 2004-07-15 | 2011-03-03 | Univ Queensland | Proteinartige verbindungen und anwendungen davon |
| US20080254108A1 (en) * | 2004-08-23 | 2008-10-16 | Mark Rosenberg | Formulations and Methods for Modulating Satiety |
| AU2005305036B2 (en) * | 2004-11-01 | 2011-03-10 | Amylin Pharmaceuticals, Llc | Treatment of obesity and related disorders |
| WO2007055728A1 (en) * | 2005-11-01 | 2007-05-18 | Amylin Pharmaceuticals, Inc. | Treatment of obesity and related disorders |
| US8394765B2 (en) * | 2004-11-01 | 2013-03-12 | Amylin Pharmaceuticals Llc | Methods of treating obesity with two different anti-obesity agents |
| EP2286837A3 (de) * | 2004-11-01 | 2013-09-04 | Amylin Pharmaceuticals, LLC | Behandlung von Fettleibigkeit und von verwandten Krankheiten |
| GB0514463D0 (en) * | 2005-01-31 | 2005-08-17 | Loders Croklaan Bv | Use of pinolenic acid |
| WO2007055743A2 (en) * | 2005-11-01 | 2007-05-18 | Amylin Pharmaceuticals, Inc. | Treatment of obesity and related disorders |
| BRPI0722276A2 (pt) * | 2007-11-14 | 2014-04-22 | Amylin Pharmaceuticals Inc | Métodos para tratar obesidade e doenças e distúrbios relacionados à obesidade |
| WO2011116139A2 (en) * | 2010-03-16 | 2011-09-22 | Chiasma Inc. | Improved pharmaceutical compositions and methods of delivery |
| MX363522B (es) | 2013-03-21 | 2019-03-26 | Sanofi Aventis Deutschland | Síntesis de productos peptídicos que contienen hidantoína. |
| MX365465B (es) | 2013-03-21 | 2019-06-04 | Sanofi Aventis Deutschland | Sintesis de productos peptidicos que contienen imida ciclica. |
| WO2014165607A2 (en) * | 2013-04-02 | 2014-10-09 | Stealth Peptides International, Inc. | Aromatic-cationic peptide formulations, compositions and methods of use |
| US20170008928A1 (en) * | 2015-07-06 | 2017-01-12 | Novo Nordisk A/S | Novel peptides and peptide derivatives and uses thereof |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE276482C (de) | ||||
| US3579494A (en) | 1968-07-18 | 1971-05-18 | Squibb & Sons Inc | C-sulfonated tyrosyl peptides related to cholecystokinin-pan-creozymin (cck-pz) |
| FR2611722B1 (fr) * | 1987-03-02 | 1989-08-11 | Inst Nat Sante Rech Med | Nouveaux peptides derives de la cck8, leur preparation et les compositions pharmaceutiques qui les contiennent |
| NZ228855A (en) * | 1988-04-25 | 1992-08-26 | Hoffmann La Roche | Tyrosine analogues and peptides containing them especially cholecystokinin (cck) analogues |
| DD276482B5 (de) * | 1988-10-25 | 1996-08-08 | Charite Med Fakultaet | Verfahren zur Herstellung neuer Cholecystokininsequenzen |
| US5631230A (en) | 1989-09-21 | 1997-05-20 | Arizona Technology Development Corporation | Receptor selective analogues of cholecystokinin-8 |
| US5128448A (en) * | 1990-01-10 | 1992-07-07 | Hoffman-La Roche Inc. | CCK analogs with appetite regulating activity |
| AU1879892A (en) * | 1991-04-24 | 1992-12-21 | Warner-Lambert Company | Cck analogs containing alpha-substituted amino acids |
| US6924264B1 (en) * | 1999-04-30 | 2005-08-02 | Amylin Pharmaceuticals, Inc. | Modified exendins and exendin agonists |
| GB2355009A (en) * | 1999-07-30 | 2001-04-11 | Univ Glasgow | Peptides conjugated to bile acids/salts |
-
2001
- 2001-03-01 GB GBGB0105069.9A patent/GB0105069D0/en not_active Ceased
-
2002
- 2002-02-28 AU AU2002238701A patent/AU2002238701B2/en not_active Ceased
- 2002-02-28 ES ES02704898T patent/ES2271218T3/es not_active Expired - Lifetime
- 2002-02-28 NZ NZ528031A patent/NZ528031A/en unknown
- 2002-02-28 US US10/469,655 patent/US7402663B2/en not_active Expired - Fee Related
- 2002-02-28 CA CA2439598A patent/CA2439598C/en not_active Expired - Fee Related
- 2002-02-28 EP EP02704898A patent/EP1363945B1/de not_active Expired - Lifetime
- 2002-02-28 WO PCT/GB2002/000827 patent/WO2002070546A2/en not_active Ceased
- 2002-02-28 AT AT02704898T patent/ATE337337T1/de not_active IP Right Cessation
- 2002-02-28 DE DE60214135T patent/DE60214135T2/de not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| WO2002070546A3 (en) | 2002-12-05 |
| US20040116657A1 (en) | 2004-06-17 |
| GB0105069D0 (en) | 2001-04-18 |
| ES2271218T3 (es) | 2007-04-16 |
| US7402663B2 (en) | 2008-07-22 |
| CA2439598C (en) | 2011-08-16 |
| DE60214135T2 (de) | 2007-07-19 |
| DE60214135D1 (de) | 2006-10-05 |
| EP1363945A2 (de) | 2003-11-26 |
| NZ528031A (en) | 2005-08-26 |
| EP1363945B1 (de) | 2006-08-23 |
| CA2439598A1 (en) | 2002-09-12 |
| WO2002070546A2 (en) | 2002-09-12 |
| AU2002238701B2 (en) | 2008-01-24 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
Ref document number: 1363945 Country of ref document: EP |
|
| REN | Ceased due to non-payment of the annual fee |