ATE335841T1 - Assay zur detektion der transferaseenzymaktivität beim screening von medikamenten - Google Patents

Assay zur detektion der transferaseenzymaktivität beim screening von medikamenten

Info

Publication number
ATE335841T1
ATE335841T1 AT01938911T AT01938911T ATE335841T1 AT E335841 T1 ATE335841 T1 AT E335841T1 AT 01938911 T AT01938911 T AT 01938911T AT 01938911 T AT01938911 T AT 01938911T AT E335841 T1 ATE335841 T1 AT E335841T1
Authority
AT
Austria
Prior art keywords
activity
zym
assay
drug screening
transferase
Prior art date
Application number
AT01938911T
Other languages
English (en)
Inventor
Sunita Maria Desousa
Suresh Solapure
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Application granted granted Critical
Publication of ATE335841T1 publication Critical patent/ATE335841T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/48—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/02—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms
    • C12Q1/18—Testing for antimicrobial activity of a material
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/92—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving lipids, e.g. cholesterol, lipoproteins, or their receptors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/195—Assays involving biological materials from specific organisms or of a specific nature from bacteria
    • G01N2333/24—Assays involving biological materials from specific organisms or of a specific nature from bacteria from Enterobacteriaceae (F), e.g. Citrobacter, Serratia, Proteus, Providencia, Morganella, Yersinia
    • G01N2333/245—Escherichia (G)

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Cell Biology (AREA)
  • Endocrinology (AREA)
  • Toxicology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
AT01938911T 2000-06-08 2001-06-05 Assay zur detektion der transferaseenzymaktivität beim screening von medikamenten ATE335841T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IN439MA2000 2000-06-08

Publications (1)

Publication Number Publication Date
ATE335841T1 true ATE335841T1 (de) 2006-09-15

Family

ID=11097174

Family Applications (1)

Application Number Title Priority Date Filing Date
AT01938911T ATE335841T1 (de) 2000-06-08 2001-06-05 Assay zur detektion der transferaseenzymaktivität beim screening von medikamenten

Country Status (10)

Country Link
US (4) US20030143635A1 (de)
EP (2) EP1292702A1 (de)
JP (2) JP2003535598A (de)
AT (1) ATE335841T1 (de)
AU (2) AU2001264482A1 (de)
CA (2) CA2407718A1 (de)
DE (1) DE60122141T2 (de)
ES (1) ES2269413T3 (de)
WO (2) WO2001094622A1 (de)
ZA (2) ZA200208624B (de)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2370469A1 (en) * 1999-04-22 2000-11-02 Astrazeneca Ab Assay for detecting phospho-n-acetylmuramyl-pentapeptide translocase activity
ATE335841T1 (de) * 2000-06-08 2006-09-15 Astrazeneca Ab Assay zur detektion der transferaseenzymaktivität beim screening von medikamenten
SE0104101D0 (sv) * 2001-12-05 2001-12-05 Astrazeneca Ab New assay
SE0104102D0 (sv) 2001-12-05 2001-12-05 Astrazeneca Ab New assay
WO2004072607A2 (en) * 2003-02-05 2004-08-26 Merck & Co. Inc. High speed assay for glycosyl transferases
US9115358B2 (en) 2006-08-11 2015-08-25 President And Fellows Of Harvard College Moenomycin biosynthesis-related compositions and methods of use thereof
US8604004B2 (en) * 2007-10-04 2013-12-10 President And Fellows Of Harvard College Moenomycin analogs, methods of synthesis, and uses thereof
WO2013151697A1 (en) 2012-04-06 2013-10-10 President And Fellows Of Harvard College Methods and compounds for identifying glycosyltransferase inhibitors
US9273084B2 (en) 2012-04-06 2016-03-01 President And Fellows Of Harvard College Moenomycin analogs, methods of synthesis, and uses thereof
US9902985B2 (en) 2012-04-06 2018-02-27 President And Fellows Of Harvard College Chemoenzymatic methods for synthesizing moenomycin analogs

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4568649A (en) * 1983-02-22 1986-02-04 Immunex Corporation Immediate ligand detection assay
SE9404072D0 (sv) * 1994-11-24 1994-11-24 Astra Ab Novel polypeptides
US5861318A (en) * 1994-11-16 1999-01-19 Pharmacia & Upjohn Company Scintillation proximity assay for N-acetylgalactosaminyltransferase activity
US6153381A (en) * 1997-08-28 2000-11-28 Millennium Pharmaceuticals, Inc. Screening for antibiotics
AU2574199A (en) * 1998-02-02 1999-08-16 Princeton University Substrate analogs for murg, methods of making same and assays using same
EP1076719A1 (de) * 1998-05-15 2001-02-21 AstraZeneca AB Ein scintillationsannäherungsversuchsaufbau zur bestimmung von peptidoglykansynthese
US20010049117A1 (en) * 1998-08-20 2001-12-06 Helena R. Axelrod Analogs of udp-murnac peptides, assays, kits and related methods of their use
ATE335841T1 (de) * 2000-06-08 2006-09-15 Astrazeneca Ab Assay zur detektion der transferaseenzymaktivität beim screening von medikamenten

Also Published As

Publication number Publication date
EP1292701A1 (de) 2003-03-19
JP2003535598A (ja) 2003-12-02
WO2001094623A1 (en) 2001-12-13
US20060228766A1 (en) 2006-10-12
WO2001094622A1 (en) 2001-12-13
DE60122141D1 (de) 2006-09-21
US20030108969A1 (en) 2003-06-12
JP2003535597A (ja) 2003-12-02
AU2001264483A1 (en) 2001-12-17
ZA200208625B (en) 2003-08-04
DE60122141T2 (de) 2007-06-28
ES2269413T3 (es) 2007-04-01
ZA200208624B (en) 2003-08-04
CA2407718A1 (en) 2001-12-13
US20030143635A1 (en) 2003-07-31
EP1292701B1 (de) 2006-08-09
US20060172361A1 (en) 2006-08-03
EP1292702A1 (de) 2003-03-19
CA2407934A1 (en) 2001-12-13
AU2001264482A1 (en) 2001-12-17

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Legal Events

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