ATE335201T1 - Reversibel immobilisierung von liganden an metalloberflächen, deren herstellung und verwendung als biosensoren - Google Patents

Reversibel immobilisierung von liganden an metalloberflächen, deren herstellung und verwendung als biosensoren

Info

Publication number
ATE335201T1
ATE335201T1 AT00932451T AT00932451T ATE335201T1 AT E335201 T1 ATE335201 T1 AT E335201T1 AT 00932451 T AT00932451 T AT 00932451T AT 00932451 T AT00932451 T AT 00932451T AT E335201 T1 ATE335201 T1 AT E335201T1
Authority
AT
Austria
Prior art keywords
ligands
biosensors
production
metal surfaces
reversible immobilization
Prior art date
Application number
AT00932451T
Other languages
English (en)
Inventor
Jamie E Ramirez-Vick
Original Assignee
Iris Biotechnologies Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Iris Biotechnologies Inc filed Critical Iris Biotechnologies Inc
Application granted granted Critical
Publication of ATE335201T1 publication Critical patent/ATE335201T1/de

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54353—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals with ligand attached to the carrier via a chemical coupling agent
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/551—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being inorganic
    • G01N33/553—Metal or metal coated
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00497—Features relating to the solid phase supports
    • B01J2219/00527—Sheets
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
    • B01J2219/00612—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports the surface being inorganic
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
    • B01J2219/00623—Immobilisation or binding
    • B01J2219/0063—Other, e.g. van der Waals forces, hydrogen bonding
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
    • B01J2219/00632—Introduction of reactive groups to the surface
    • B01J2219/00637—Introduction of reactive groups to the surface by coating it with another layer
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00659—Two-dimensional arrays
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00718—Type of compounds synthesised
    • B01J2219/0072—Organic compounds
    • B01J2219/00722—Nucleotides
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00718—Type of compounds synthesised
    • B01J2219/0072—Organic compounds
    • B01J2219/00725—Peptides
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00718—Type of compounds synthesised
    • B01J2219/0072—Organic compounds
    • B01J2219/0074—Biological products

Landscapes

  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Cell Biology (AREA)
  • Pathology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • General Physics & Mathematics (AREA)
  • Inorganic Chemistry (AREA)
  • Peptides Or Proteins (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
AT00932451T 1999-05-14 2000-05-15 Reversibel immobilisierung von liganden an metalloberflächen, deren herstellung und verwendung als biosensoren ATE335201T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US13411099P 1999-05-14 1999-05-14

Publications (1)

Publication Number Publication Date
ATE335201T1 true ATE335201T1 (de) 2006-08-15

Family

ID=22461813

Family Applications (1)

Application Number Title Priority Date Filing Date
AT00932451T ATE335201T1 (de) 1999-05-14 2000-05-15 Reversibel immobilisierung von liganden an metalloberflächen, deren herstellung und verwendung als biosensoren

Country Status (11)

Country Link
US (1) US7108971B2 (de)
EP (1) EP1214594B1 (de)
AT (1) ATE335201T1 (de)
AU (1) AU5017200A (de)
CA (1) CA2409442C (de)
CY (1) CY1105128T1 (de)
DE (1) DE60029802T2 (de)
DK (1) DK1214594T3 (de)
ES (1) ES2269147T3 (de)
PT (1) PT1214594E (de)
WO (1) WO2000070345A1 (de)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7270954B1 (en) * 2000-06-30 2007-09-18 Iris Biotechnologies, Inc. Hybridization of target DNA with immobilized nucleic acid analogs
US20030068655A1 (en) * 2001-09-12 2003-04-10 Protiveris, Inc. Microcantilever apparatus and methods for detection of enzymes
EP1413886A1 (de) * 2002-10-25 2004-04-28 Interuniversitair Microelektronica Centrum ( Imec) Sensoroberfläche
US20140302113A1 (en) * 2011-09-30 2014-10-09 Sparkmed Research, Llc Systems, devices, and methods for embedding drug molecules into medical catheters or tubes
JP6590837B2 (ja) 2014-02-14 2019-10-16 ルール−ウニベルシタット ボーフム 立体構造および二次構造解析のためのバイオセンサー
ES2834484T3 (es) 2016-11-21 2021-06-17 Univ Ruhr Bochum Método para la preselección de fármacos para enfermedades de plegamiento incorrecto de proteínas
US20200141866A1 (en) 2017-05-29 2020-05-07 RUHR-UNIVERSITäT BOCHUM Biosensor for Conformation and Secondary Structure Analysis

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4895955A (en) * 1988-05-27 1990-01-23 Lifecodes Corporation Non-radioactive carbodiimide precursor to nucleic acid probes
US5077210A (en) * 1989-01-13 1991-12-31 Eigler Frances S Immobilization of active agents on substrates with a silane and heterobifunctional crosslinking agent
US5491097A (en) * 1989-06-15 1996-02-13 Biocircuits Corporation Analyte detection with multilayered bioelectronic conductivity sensors
US5622828A (en) * 1990-06-11 1997-04-22 Nexstar Pharmaceuticals, Inc. High-affinity oligonucleotide ligands to secretory phospholipase A2 (sPLA2)
IL103674A0 (en) * 1991-11-19 1993-04-04 Houston Advanced Res Center Method and apparatus for molecule detection
US5412087A (en) * 1992-04-24 1995-05-02 Affymax Technologies N.V. Spatially-addressable immobilization of oligonucleotides and other biological polymers on surfaces
US5248772A (en) * 1992-01-29 1993-09-28 Coulter Corporation Formation of colloidal metal dispersions using aminodextrans as reductants and protective agents
US5465151A (en) * 1993-01-21 1995-11-07 State Of Oregon Acting By And Through The State Board Of Higher Education On Behalf Of The University Of Oregon Sensors employing interference of electromagnetic waves passing through waveguides having functionalized surfaces
US5985548A (en) * 1993-02-04 1999-11-16 E. I. Du Pont De Nemours And Company Amplification of assay reporters by nucleic acid replication
US5620850A (en) * 1994-09-26 1997-04-15 President And Fellows Of Harvard College Molecular recognition at surfaces derivatized with self-assembled monolayers
DE4444893A1 (de) * 1994-12-16 1996-06-20 Merck Patent Gmbh Peptide und synthetische Zellmembranen
US5622826A (en) * 1994-12-22 1997-04-22 Houston Advanced Research Center Method for immobilization of molecules on platinum solid support surfaces
EP0813610A1 (de) 1995-03-04 1997-12-29 Roche Diagnostics GmbH Sequenzspezifischer nachweis von nukleinsäuren
US6613508B1 (en) 1996-01-23 2003-09-02 Qiagen Genomics, Inc. Methods and compositions for analyzing nucleic acid molecules utilizing sizing techniques
US5942397A (en) * 1996-12-11 1999-08-24 Tarlov; Michael J. Surface immobilization of biopolymers
US5837860A (en) * 1997-03-05 1998-11-17 Molecular Tool, Inc. Covalent attachment of nucleic acid molecules onto solid-phases via disulfide bonds
US5760130A (en) * 1997-05-13 1998-06-02 Molecular Dynamics, Inc. Aminosilane/carbodiimide coupling of DNA to glass substrate
WO1999020649A1 (de) * 1997-10-22 1999-04-29 Merck Patent Gmbh Spacer peptides and membranes containing same
US6203758B1 (en) 1997-11-10 2001-03-20 Bio-Pixel Ltd. Micro-circuit system with array of functionalized micro-electrodes
US6338968B1 (en) * 1998-02-02 2002-01-15 Signature Bioscience, Inc. Method and apparatus for detecting molecular binding events
EP1055004A2 (de) 1998-02-20 2000-11-29 Wolfbeis, Otto Samuel Vorrichtung zur detektion von oligo- und/oder polynukleotid-hybridisierungen
US6500609B1 (en) 1999-02-11 2002-12-31 Scynexis Chemistry & Automation, Inc. Method and apparatus for synthesizing characterizing and assaying combinatorial libraries
US6174683B1 (en) 1999-04-26 2001-01-16 Biocept, Inc. Method of making biochips and the biochips resulting therefrom

Also Published As

Publication number Publication date
DK1214594T3 (da) 2006-11-13
WO2000070345A1 (en) 2000-11-23
CY1105128T1 (el) 2010-03-03
EP1214594B1 (de) 2006-08-02
US20040091858A9 (en) 2004-05-13
CA2409442C (en) 2009-12-08
US20020160391A1 (en) 2002-10-31
DE60029802D1 (de) 2006-09-14
DE60029802T2 (de) 2007-01-18
EP1214594A1 (de) 2002-06-19
ES2269147T3 (es) 2007-04-01
AU5017200A (en) 2000-12-05
CA2409442A1 (en) 2000-11-23
US7108971B2 (en) 2006-09-19
PT1214594E (pt) 2006-11-30

Similar Documents

Publication Publication Date Title
ATE258963T1 (de) Farbstoff-markierte imidazochinolinverbindungen
DE69518820D1 (de) Rotogranulat und Beschichtung von Acetaminophen, Pseudoephedrin, Chlorpheniramin und, gegebenenfalls, Dextromethorphan
DK1042458T3 (da) Fremgangsmåde til immobilisering af enzymer
NZ337202A (en) Method for providing enhanced photosynthesis for horticultural crops by applying highly reflective particulate materials
ATE154526T1 (de) Aktivierte trägermaterialien, ihre herstellung und verwendung
DE3773318D1 (de) Titanoxid-katalysator, verfahren zu dessen herstellung und dessen verwendung fuer die herstellung von linearen polyaethylenpolyaminen.
ATE335201T1 (de) Reversibel immobilisierung von liganden an metalloberflächen, deren herstellung und verwendung als biosensoren
LV10304A (lv) Struktureti kristali ka jauna fermentu imobilizacijas forma
SE9701783D0 (sv) In situ synthesis of oligonucleotides of inverse orientation
TR200001333T2 (tr) Kiral amin oksazolinil ligandlara dayanan geçiş metali katalizlenmiş tepkimeler
DE69412815D1 (de) Künstliche rezeptoren, antikörper und enzyme
FR2763617B3 (fr) Element de retenue mobile pour elements de construction en forme de plaque
ATE248820T1 (de) Haftvermittler
TR199802019T2 (xx) Terap�tik amidleri stereoselektif olarak haz�rlamak i�in enzimatik y�ntem.
DE60120729D1 (de) 5-trityloxymethyl-2-oxazolidinon und verfahren zu dessen herstellung
DK1083990T3 (da) Oxidationskatalysator og fremgangsmåde til katalytisk oxidation
DE69940743D1 (de) Kunststoff-geträgerte phosphorliganden verwendbar in der katalyse
ATE513285T1 (de) Sicherheitsanordnung
NO20053818L (no) Hydrogeneringskatalysator.
FR2804129B1 (fr) Procedes de synthese et d'immobilisation d'acides nucleiques sur un support solide silanise
DE69720785D1 (de) Verminderung von stickoxid
DE60021373D1 (de) Verfahren der zellkultivierung
SE9904749D0 (sv) Polycrystalline diamond microstructures
PT1252029E (pt) Metodo para o tratamento ornamental de objectos
DK1200592T3 (da) Mammalske cytokiner og relaterede reagenser

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification

Ref document number: 1214594

Country of ref document: EP

REN Ceased due to non-payment of the annual fee