ATE330606T1 - Verfahren zur vorbeugung von nmda-rezeptor vermittelten neuronalen schäden - Google Patents
Verfahren zur vorbeugung von nmda-rezeptor vermittelten neuronalen schädenInfo
- Publication number
- ATE330606T1 ATE330606T1 AT93923724T AT93923724T ATE330606T1 AT E330606 T1 ATE330606 T1 AT E330606T1 AT 93923724 T AT93923724 T AT 93923724T AT 93923724 T AT93923724 T AT 93923724T AT E330606 T1 ATE330606 T1 AT E330606T1
- Authority
- AT
- Austria
- Prior art keywords
- nmda receptor
- neuronal damage
- mediated neuronal
- mammal
- preventing nmda
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/44—Oxidoreductases (1)
- A61K38/446—Superoxide dismutase (1.15)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/28—Compounds containing heavy metals
- A61K31/295—Iron group metal compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/06—Tripeptides
- A61K38/063—Glutathione
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/44—Oxidoreductases (1)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
- A61K38/49—Urokinase; Tissue plasminogen activator
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/55—Protease inhibitors
- A61K38/556—Angiotensin converting enzyme inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biomedical Technology (AREA)
- Dermatology (AREA)
- Vascular Medicine (AREA)
- Neurosurgery (AREA)
- Emergency Medicine (AREA)
- Neurology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US07/949,342 US5234956A (en) | 1991-04-19 | 1992-09-22 | Method of preventing NMDA receptor complex-mediated neuronal damage |
US08/025,028 US5455279A (en) | 1991-04-19 | 1993-03-02 | Regimen method of mediating neuronal damage using nitroglycerine |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE330606T1 true ATE330606T1 (de) | 2006-07-15 |
Family
ID=26699179
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT93923724T ATE330606T1 (de) | 1992-09-22 | 1993-09-22 | Verfahren zur vorbeugung von nmda-rezeptor vermittelten neuronalen schäden |
Country Status (8)
Country | Link |
---|---|
US (3) | US5455279A (de) |
EP (1) | EP0661973B1 (de) |
AT (1) | ATE330606T1 (de) |
AU (1) | AU5348194A (de) |
DE (1) | DE69334035T2 (de) |
DK (1) | DK0661973T3 (de) |
ES (1) | ES2264122T3 (de) |
WO (1) | WO1994006428A1 (de) |
Families Citing this family (55)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1991002810A1 (en) * | 1989-08-09 | 1991-03-07 | The Children's Medical Center Corporation | Nmda oxidizing agents for protecting neurons from injury |
US5922773A (en) * | 1992-12-04 | 1999-07-13 | The Children's Medical Center Corp. | Glaucoma treatment |
ES2182843T3 (es) | 1993-04-20 | 2003-03-16 | Merck & Co Inc | Subunidades de receptor humano de n-metil-d-aspartato, acidos nucleicos que codifican las mismas y su uso. |
FR2714828B1 (fr) * | 1994-01-12 | 1996-02-02 | Rhone Poulenc Rorer Sa | Application du riluzole dans le traitement des maladies mitochondriales. |
JPH08208511A (ja) * | 1995-01-31 | 1996-08-13 | Samu Kenkyusho:Kk | 抗運動ニューロン疾患剤 |
RU2106864C1 (ru) | 1995-10-23 | 1998-03-20 | Николай Серафимович Зефиров | Средство для лечения болезни альцгеймера |
US6140309A (en) * | 1996-03-12 | 2000-10-31 | University Of South Florida | Vasoactive effects and free radical generation by β-amyloid peptides |
US5807847A (en) * | 1996-06-04 | 1998-09-15 | Queen's University At Kingston | Nitrate esters |
US20050137191A1 (en) * | 1996-06-04 | 2005-06-23 | Thatcher Gregory R. | Nitrate esters and their use for mitigating cellular damage |
US6310052B1 (en) | 1996-06-04 | 2001-10-30 | Queen's University At Kingston | Nitrate esters and their use for neurological conditions |
US5872124A (en) * | 1996-07-31 | 1999-02-16 | Thomas Jefferson University | Treatment of diseases of the central nervous system using uric acid as a scavenger of peroxynitrite |
AU4030097A (en) * | 1996-09-03 | 1998-03-26 | Yeda Research And Development Co. Ltd. | Central nervous system-derived immune privilege factor and uses thereof |
US6126939A (en) * | 1996-09-03 | 2000-10-03 | Yeda Research And Development Co. Ltd. | Anti-inflammatory dipeptide and pharmaceutical composition thereof |
EP0979073A4 (de) * | 1997-03-31 | 2004-04-07 | Childrens Medical Center | Nitrosylierung zur inaktivierung apoptotischer enzyme |
US6057373A (en) * | 1997-05-22 | 2000-05-02 | Synchroneuron, Llc | Methods of treating tardive dyskinesia and other movement disorders using NMDA receptor antagonists |
US5866585A (en) * | 1997-05-22 | 1999-02-02 | Synchroneuron, Llc | Methods of treating tardive dyskinesia using NMDA receptor antagonists |
US6277891B1 (en) | 1997-07-11 | 2001-08-21 | The Johns Hopkins University | Nitric oxide inhibits rhinovirus infection |
US6436996B1 (en) * | 1997-09-30 | 2002-08-20 | Duke University | Modulation of nitric oxide production |
US5952389A (en) * | 1998-01-13 | 1999-09-14 | Synchroneuron | Methods of treating tardive dyskinesia and other movement disorders |
US6294583B1 (en) | 1998-01-13 | 2001-09-25 | Synchroneuron, Llc | Methods of treating tardive dyskinesia and other movement disorders |
JPH11217330A (ja) * | 1998-01-30 | 1999-08-10 | Sumitomo Pharmaceut Co Ltd | 神経栄養因子分泌促進剤 |
EP1013272A1 (de) * | 1998-12-23 | 2000-06-28 | Biomedical Primate Research Centre (BPRC) | Beeinflussung der Aktivität eines Stickoxidradikalherstellungsweges zur Behandlung von mit freien Sauerstoffradikalen verbundenen Krankheiten |
US6482854B1 (en) | 1999-03-25 | 2002-11-19 | Massachusetts Eye And Ear Infirmary | Glaucoma treatment |
FR2791571B1 (fr) * | 1999-04-02 | 2002-10-04 | Sod Conseils Rech Applic | Association inhibiteur(s) de no synthase et antioxydant(s) metabolique(s) |
US6255280B1 (en) | 1999-04-08 | 2001-07-03 | University Of Kentucky Research Foundation | Protection against traumatic brain injury |
GB9908175D0 (en) * | 1999-04-09 | 1999-06-02 | Lilly Co Eli | Method of treating neurological disorders |
US6432434B1 (en) * | 1999-04-22 | 2002-08-13 | The United States Of America As Represented By The Secretary Of The Army | Treatment of and/or prophylaxis against brain and spinal cord injury |
US6417227B1 (en) | 1999-04-28 | 2002-07-09 | Cg And Associates | Methods of delivery of cetyl myristoleate |
WO2000074672A1 (en) * | 1999-06-09 | 2000-12-14 | Department Of The Army, U.S. Government | Method and compositions for treating and preventing retinal damage |
US6444702B1 (en) | 2000-02-22 | 2002-09-03 | Neuromolecular, Inc. | Aminoadamantane derivatives as therapeutic agents |
CA2414941C (en) | 2000-08-11 | 2010-12-14 | David R. Whitlock | Compositions including ammonia oxidizing bacteria to increase production of nitric oxide and nitric oxide precursors and methods of using same |
JP2004515477A (ja) * | 2000-12-07 | 2004-05-27 | ニューロモレキュラー インコーポレイテッド | Nmdaレセプターアンタゴニストを用いて神経精神医学的障害を処置するための方法 |
EP1852113A3 (de) * | 2000-12-07 | 2008-03-12 | Neuromolecular Inc. | Verfahren zur Behandlung neuropsychiatrischer Erkrankungen mit NMDA-Rezeptorantagonisten |
US20020072512A1 (en) * | 2000-12-08 | 2002-06-13 | Metaphore Pharmaceuticals, Inc | Method of preventing and treating HIV-mediated central nervous system damage |
US20030045449A1 (en) * | 2001-08-15 | 2003-03-06 | Pfizer, Inc. | Pharmaceutical combinations for the treatment of neurodegenerative diseases |
US20030232739A1 (en) * | 2001-08-15 | 2003-12-18 | Pfizer Inc. | Pharmaceutical combinations comprising a NOS inhibitor and an NMDA receptor antagonist |
CN1308438C (zh) * | 2002-01-11 | 2007-04-04 | 大卫·R·怀特洛克 | 含有氨氧化细菌的化合物以及使用的方法 |
AU2003269810A1 (en) * | 2002-04-04 | 2004-02-16 | Children's Medical Center Corporation | Pyrroloquinoline quinone drugs as a neuroprotectant and methods of use thereof |
US20050148673A1 (en) * | 2002-07-11 | 2005-07-07 | Harbut Ronald E. | Prolonged administration of NMDA antagonist and safener drug to alter neuropathic pain condition |
US7086532B2 (en) * | 2003-07-16 | 2006-08-08 | Allergan, Inc. | Titration/compliance pack with increasing doses |
EP1667646A4 (de) * | 2003-09-26 | 2007-07-04 | David R Whitlock | Verfahren zur verwendung von ammoniak-oxidierenden bakterien |
AR046314A1 (es) | 2003-11-05 | 2005-11-30 | Merz Pharma Gmbh & Co Kgaa | Composiciones que comprenden ciclohexilaminas y aminoadamantanos |
CN101389315A (zh) | 2004-06-17 | 2009-03-18 | 莫茨药物股份两合公司 | 美金刚口服剂型即释制剂 |
US7619007B2 (en) | 2004-11-23 | 2009-11-17 | Adamas Pharmaceuticals, Inc. | Method and composition for administering an NMDA receptor antagonist to a subject |
KR101406456B1 (ko) | 2005-04-06 | 2014-06-20 | 아다마스 파마슈티칼스, 인코포레이티드 | Cns 장애의 치료를 위한 방법 및 조성물 |
WO2007116458A1 (ja) * | 2006-03-30 | 2007-10-18 | Tohru Hasegawa | 神経変性疾患治療薬 |
US20100190815A1 (en) * | 2006-09-08 | 2010-07-29 | Kyowa Hakko Bio Co., Ltd. | Hypertension-ameliorating agent |
EP2111858A1 (de) | 2008-04-25 | 2009-10-28 | EPFL Ecole Polytechnique Fédérale de Lausanne | Neue Behandlung für Morbus Alzheimer |
IT1398507B1 (it) * | 2009-01-13 | 2013-03-01 | Giellepi Chemicals S P A | Composizione per il trattamento di neuropatie |
US9023890B2 (en) * | 2009-12-02 | 2015-05-05 | The Charlotte-Mecklenburg Hospital Authority | Nitrate esters and their use for the treatment of muscle and muscle related diseases |
SG182522A1 (en) | 2010-01-27 | 2012-08-30 | Takeda Pharmaceutical | Compounds for suppressing a peripheral nerve disorder induced by an anti - cancer agent |
US9452117B2 (en) | 2011-06-01 | 2016-09-27 | The Charlotte-Mecklenburg Hospital Authority | Nitrate esters and their use for the treatment of muscle and muscle related diseases |
EP2948135B1 (de) | 2013-01-25 | 2019-01-02 | Case Western Reserve University | Zusammensetzungen und verfahren zur behandlung von erkrankungen mit pervasiver entwicklung |
AU2015247710B2 (en) | 2014-04-15 | 2021-09-09 | Aobiome Llc | Ammonia-oxidizing Nitrosomonas eutropha strain D23 |
US11225640B2 (en) | 2014-04-15 | 2022-01-18 | Aobiome Llc | Ammonia oxidizing bacteria for treatment of psoriasis |
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US3328251A (en) * | 1965-12-30 | 1967-06-27 | Du Pont | Pharmaceutical compositions and methods utilizing 2-aminoadamantane and its derivatives |
US3391142A (en) * | 1966-02-09 | 1968-07-02 | Lilly Co Eli | Adamantyl secondary amines |
ES413944A1 (es) * | 1972-04-20 | 1976-06-01 | Merz & Co | Procedimiento para la preparacion de compuestos de adamen- tano trisustituidos en las posiciones 1,3,5. |
US4064139A (en) * | 1975-04-07 | 1977-12-20 | Merck & Co., Inc. | Substituted 9,10-dihydroanthracen-9,10-imines |
US4399141A (en) * | 1977-09-19 | 1983-08-16 | Merck & Co., Inc. | 5-Alkyl or hydroxyalkyl substituted-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5,10-imines and anticonvulsant use thereof |
US4374838A (en) * | 1977-09-19 | 1983-02-22 | Merck & Co., Inc. | Dibenzo[a,d]cycloocten-5,12-(and 6,12)-imines |
DE2856393C2 (de) * | 1978-12-27 | 1983-04-28 | Merz + Co GmbH & Co, 6000 Frankfurt | Arzneimittel zur Behandlung von Morbus Parkinson |
US4513137A (en) * | 1981-04-09 | 1985-04-23 | The University Of Akron | Iodonium salts |
US4351847A (en) * | 1981-06-26 | 1982-09-28 | Pennwalt Corporation | Antiviral alpha, alpha-dialkyl adamantylethylamines |
GB8600783D0 (en) * | 1986-01-14 | 1986-02-19 | Merck Sharp & Dohme | N-methyl-d-aspartate receptor antagonists |
US4736048A (en) * | 1986-06-04 | 1988-04-05 | Dow Corning Corporation | Pressure sensitive adhesive release liner and fluorosilicone compounds, compositions and method therefor |
US4806543A (en) * | 1986-11-25 | 1989-02-21 | Board Of Trustees Of The Leland Stanford Junior University | Method and compositions for reducing neurotoxic injury |
EP0341264A4 (en) * | 1987-01-23 | 1991-03-20 | The General Hospital Corporation | Atriopeptins, guanylate cyclase activators, and phosphodiesterase inhibitors as treatment for glaucoma, hydrocephalus and cerebral edema (cranial fluid volume dysfunction) |
US4898920A (en) * | 1987-10-15 | 1990-02-06 | Dow Corning Corporation | Adhesive compositions, controlled release compositions and transdermal delivery device |
ATE94384T1 (de) * | 1989-04-14 | 1993-10-15 | Merz & Co Gmbh & Co | Verwendung von adamantan-derivaten zur praevention und behandlung der cerebralen ischaemie. |
WO1991002810A1 (en) * | 1989-08-09 | 1991-03-07 | The Children's Medical Center Corporation | Nmda oxidizing agents for protecting neurons from injury |
US5521215A (en) * | 1989-11-07 | 1996-05-28 | Ramot University Authority For Applied Research And Industrial Development Ltd. | NMDA-blocking pharmaceuticals |
US5559095A (en) * | 1989-11-22 | 1996-09-24 | Neurex Corporation | Delayed treatment method of reducing ischemia-related neuronal damage |
US5264371A (en) * | 1989-11-22 | 1993-11-23 | Neurex Corporation | Screening method for neuroprotective compounds |
US5091391A (en) * | 1990-08-16 | 1992-02-25 | University Of Pittsburgh Of The Commonwealth System Of Higher Education | Method of resisting neurodegenerative disorders |
EP0581856B1 (de) * | 1991-04-19 | 1999-07-14 | The Children's Medical Center Corporation | Verfahren zur vorbeugung nmda-rezeptorkomplex-vermittelter neuronaler schäden |
-
1993
- 1993-03-02 US US08/025,028 patent/US5455279A/en not_active Expired - Lifetime
- 1993-09-22 AU AU53481/94A patent/AU5348194A/en not_active Abandoned
- 1993-09-22 DK DK93923724T patent/DK0661973T3/da active
- 1993-09-22 AT AT93923724T patent/ATE330606T1/de active
- 1993-09-22 WO PCT/US1993/009019 patent/WO1994006428A1/en active IP Right Grant
- 1993-09-22 DE DE69334035T patent/DE69334035T2/de not_active Expired - Lifetime
- 1993-09-22 ES ES93923724T patent/ES2264122T3/es not_active Expired - Lifetime
- 1993-09-22 EP EP93923724A patent/EP0661973B1/de not_active Expired - Lifetime
-
1995
- 1995-03-22 US US08/407,973 patent/US5747545A/en not_active Expired - Lifetime
- 1995-06-07 US US08/482,365 patent/US5801203A/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
EP0661973A4 (de) | 1999-12-22 |
US5747545A (en) | 1998-05-05 |
US5455279A (en) | 1995-10-03 |
EP0661973B1 (de) | 2006-06-21 |
DK0661973T3 (da) | 2006-10-30 |
ES2264122T3 (es) | 2006-12-16 |
DE69334035D1 (de) | 2006-08-03 |
EP0661973A1 (de) | 1995-07-12 |
WO1994006428A1 (en) | 1994-03-31 |
AU5348194A (en) | 1994-04-12 |
US5801203A (en) | 1998-09-01 |
DE69334035T2 (de) | 2006-12-28 |
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Legal Events
Date | Code | Title | Description |
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UEP | Publication of translation of european patent specification |
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