ATE32728T1 - Modifizierte protease-inhibitoren, verfahren zu ihrer herstellung und daraus bereitete pharmazeutische mittel. - Google Patents

Modifizierte protease-inhibitoren, verfahren zu ihrer herstellung und daraus bereitete pharmazeutische mittel.

Info

Publication number
ATE32728T1
ATE32728T1 AT84107861T AT84107861T ATE32728T1 AT E32728 T1 ATE32728 T1 AT E32728T1 AT 84107861 T AT84107861 T AT 84107861T AT 84107861 T AT84107861 T AT 84107861T AT E32728 T1 ATE32728 T1 AT E32728T1
Authority
AT
Austria
Prior art keywords
processes
production
protease inhibitors
pharmaceutical agents
prepared therefrom
Prior art date
Application number
AT84107861T
Other languages
German (de)
English (en)
Inventor
Ursula Dr Seemueller
Johannes Dodt
Hans Prof Dr Fritz
Original Assignee
Christensen Plantorgan Werk
Ciba Geigy Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Christensen Plantorgan Werk, Ciba Geigy Ag filed Critical Christensen Plantorgan Werk
Application granted granted Critical
Publication of ATE32728T1 publication Critical patent/ATE32728T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/815—Protease inhibitors from leeches, e.g. hirudin, eglin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Rheumatology (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Paper (AREA)
  • Pyrrole Compounds (AREA)
AT84107861T 1983-07-07 1984-07-05 Modifizierte protease-inhibitoren, verfahren zu ihrer herstellung und daraus bereitete pharmazeutische mittel. ATE32728T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE3324534A DE3324534A1 (de) 1983-07-07 1983-07-07 Modifizierte protease-inhibitoren, verfahren zu ihrer herstellung und daraus bereitete pharmazeutische mittel
EP84107861A EP0134479B1 (de) 1983-07-07 1984-07-05 Modifizierte Protease-Inhibitoren, Verfahren zu ihrer Herstellung und daraus bereitete pharmazeutische Mittel

Publications (1)

Publication Number Publication Date
ATE32728T1 true ATE32728T1 (de) 1988-03-15

Family

ID=6203414

Family Applications (1)

Application Number Title Priority Date Filing Date
AT84107861T ATE32728T1 (de) 1983-07-07 1984-07-05 Modifizierte protease-inhibitoren, verfahren zu ihrer herstellung und daraus bereitete pharmazeutische mittel.

Country Status (10)

Country Link
US (1) US4636489A (enExample)
EP (1) EP0134479B1 (enExample)
JP (1) JPH0670077B2 (enExample)
AT (1) ATE32728T1 (enExample)
CA (1) CA1230069A (enExample)
DE (2) DE3324534A1 (enExample)
DK (1) DK165988C (enExample)
ES (1) ES8601108A1 (enExample)
GR (1) GR82243B (enExample)
IE (1) IE57698B1 (enExample)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6342373B1 (en) * 1983-11-21 2002-01-29 Ucp Gen-Pharma Ag Process for preparing recombinant eglin, protease inhibitor
DE3506992A1 (de) * 1985-02-27 1986-08-28 Plantorgan Werk Heinrich G.E. Christensen, KG, 2903 Bad Zwischenahn Modifizierte hirudine, verfahren zu deren herstellung und pharmazeutische mittel, die diese wirkstoffe enthalten
US5166134A (en) * 1986-12-24 1992-11-24 John Lezdey Treatment of allergic rhinitis
EP0332576B1 (de) * 1988-03-07 1994-04-06 Ciba-Geigy Ag Modifizierte Proteine
US5180667A (en) * 1988-03-07 1993-01-19 Ciba-Geigy Corporation Genes encoding eglin C mutants
EP0416035B1 (en) * 1988-05-27 1994-12-07 The Children's Hospital Of Philadelphia Amphiphilic peptides and use thereof
US5114921A (en) * 1988-05-27 1992-05-19 The Children's Hospital Of Philadelphia Amphiphilic peptides and use thereof
ES2052062T3 (es) * 1988-06-11 1994-07-01 Ciba Geigy Ag Nuevos polipeptidos con actividad anticoagulante.
US5268296A (en) * 1988-06-11 1993-12-07 Ciba-Geigy Corporation DNA vector and recombinant host cell for production of hirullin P6 and P18
US5254535A (en) * 1989-04-17 1993-10-19 The Children's Hospital Of Pennsylvania Composition and treatment with biologically active peptides and antibiotic
US5792831A (en) * 1990-02-08 1998-08-11 Magainin Pharmaceuticals Inc. Analogues of magainin peptides containing D-amino acids
US5459237A (en) * 1990-02-08 1995-10-17 Magainin Pharmaceuticals Inc. Peptide compositions and uses therefor
JPH07504152A (ja) * 1990-02-08 1995-05-11 マゲイニン　ファーマスーティカルズ，　インコーポレーテッド 生物活性ペプチドおよび標的細胞、ウイルス、あるいはウイルス感染細胞の成長を抑制する方法
JPH05507273A (ja) * 1990-05-14 1993-10-21 マゲイニン　サイエンセズ　インコーポレーテッド Ｄアミノ酸残基を有する生物活性ペプチドの組成物およびそれによる治療方法
EP0559647A1 (en) * 1990-06-27 1993-09-15 Magainin Pharmaceuticals Inc. Composition and treatment with biologically active peptides and antibiotics which inhibit dna gyrase
US5208220A (en) * 1990-06-27 1993-05-04 Magainin Pharmaceuticals, Inc. Composition and treatment with biologically active peptides and antibiotics which inhibit DNA gyrase
AU655301B2 (en) * 1991-05-23 1994-12-15 Merrell Pharmaceuticals Inc. Inhibitors of cathepsin G and elastase for preventing connective tissue degradation
US5714470A (en) * 1991-08-22 1998-02-03 Merrell Pharmaceuticals, Inc. Orally-active elastase inhibitors
US5478811A (en) * 1991-08-22 1995-12-26 Merrell Dow Pharmaceuticals Inc. Orally-active elastase inhibitors
CA2120337A1 (en) * 1991-10-16 1993-04-17 Michael A. Zasloff Composition and treatment with biologically active peptides and antibiotic
NZ287604A (en) * 1994-06-02 1998-12-23 Merrell Pharma Inc Acylated enol derivatives as prodrugs of elastase inhibitors
AU690986B2 (en) * 1994-06-02 1998-05-07 Merrell Pharmaceuticals Inc. Perfluoroalkyl ketone inhibitors of elastase and processes for making the same
US6172044B1 (en) 1995-12-01 2001-01-09 Aventis Pharmaceuticals Inc. Acylated enol derivative of α-ketoesters and α-ketoamides
US5948886A (en) * 1996-11-20 1999-09-07 Hoechst Marion Roussel, Inc. Acylated enol derivatives of α-ketoesters and α-ketoamides
CA2266323A1 (en) 1996-09-24 1998-04-02 The Procter & Gamble Company Stabilized proteinaceous protease inhibitors and variants thereof
US7001884B2 (en) * 2001-06-18 2006-02-21 Regents Of The University Of Michigan Eglin c based drugs for treatment of disease
DE102005007313A1 (de) * 2005-02-17 2006-08-24 Wacker Chemie Ag Verfahren zur Herstellung von Entschäumerformulierungen
KR101237116B1 (ko) * 2010-11-12 2013-02-25 대한유화공업 주식회사 내충격성 및 내압특성이 우수한 폴리프로필렌 조성물
CN110551707A (zh) * 2019-10-17 2019-12-10 山西大学 一种纯化中性或碱性蛋白酶的方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2808396C2 (de) * 1978-02-27 1984-04-19 Plantorgan Werk Heinrich G.E. Christensen, KG, 2903 Bad Zwischenahn Protease-Inhibitoren
US4250086A (en) * 1979-11-19 1981-02-10 Ortho Pharmaceutical Corporation Method and composition for preparation of H-SAR-LYS-SAR-GLN-NH2

Also Published As

Publication number Publication date
DK332684D0 (da) 1984-07-06
CA1230069A (en) 1987-12-08
US4636489A (en) 1987-01-13
JPH0670077B2 (ja) 1994-09-07
JPS60105699A (ja) 1985-06-11
ES534098A0 (es) 1985-10-16
GR82243B (enExample) 1984-12-13
EP0134479A1 (de) 1985-03-20
DK165988C (da) 1993-07-26
IE841734L (en) 1985-01-07
ES8601108A1 (es) 1985-10-16
DK165988B (da) 1993-02-22
IE57698B1 (en) 1993-03-10
DE3324534A1 (de) 1985-01-17
DE3469534D1 (en) 1988-04-07
DK332684A (da) 1985-01-08
EP0134479B1 (de) 1988-03-02

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Legal Events

Date Code Title Description
EEIH Change in the person of patent owner
REN Ceased due to non-payment of the annual fee