ATE322508T1 - Verwendung des antikörpers 271.14d9.f8 (dsm acc2331) um die bindung zwischen alphavbeta6- integrin und fibronectin in vitro zu hemmen - Google Patents

Verwendung des antikörpers 271.14d9.f8 (dsm acc2331) um die bindung zwischen alphavbeta6- integrin und fibronectin in vitro zu hemmen

Info

Publication number
ATE322508T1
ATE322508T1 AT99907361T AT99907361T ATE322508T1 AT E322508 T1 ATE322508 T1 AT E322508T1 AT 99907361 T AT99907361 T AT 99907361T AT 99907361 T AT99907361 T AT 99907361T AT E322508 T1 ATE322508 T1 AT E322508T1
Authority
AT
Austria
Prior art keywords
integrin
fibronectin
vitro
antibody
inhibit
Prior art date
Application number
AT99907361T
Other languages
English (en)
Inventor
Simon Goodman
Beate Diefenbach
Francesc Mitjans
Ana Carceller
Elisabet Rosell-Vives
Original Assignee
Merck Patent Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent Gmbh filed Critical Merck Patent Gmbh
Application granted granted Critical
Publication of ATE322508T1 publication Critical patent/ATE322508T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2839—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the integrin superfamily
    • C07K16/2848—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the integrin superfamily against integrin beta3-subunit-containing molecules, e.g. CD41, CD51, CD61
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
AT99907361T 1998-01-23 1999-01-11 Verwendung des antikörpers 271.14d9.f8 (dsm acc2331) um die bindung zwischen alphavbeta6- integrin und fibronectin in vitro zu hemmen ATE322508T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP98101108 1998-01-23

Publications (1)

Publication Number Publication Date
ATE322508T1 true ATE322508T1 (de) 2006-04-15

Family

ID=8231295

Family Applications (1)

Application Number Title Priority Date Filing Date
AT99907361T ATE322508T1 (de) 1998-01-23 1999-01-11 Verwendung des antikörpers 271.14d9.f8 (dsm acc2331) um die bindung zwischen alphavbeta6- integrin und fibronectin in vitro zu hemmen

Country Status (17)

Country Link
EP (1) EP1049718B1 (de)
JP (1) JP2002501086A (de)
KR (1) KR20010034327A (de)
CN (1) CN1168741C (de)
AR (1) AR014464A1 (de)
AT (1) ATE322508T1 (de)
AU (1) AU2716399A (de)
BR (1) BR9907218A (de)
CA (1) CA2319160A1 (de)
DE (1) DE69930723T2 (de)
HU (1) HUP0101151A3 (de)
ID (1) ID27810A (de)
NO (1) NO20003767D0 (de)
PL (1) PL341569A1 (de)
SK (1) SK10772000A3 (de)
WO (1) WO1999037683A1 (de)
ZA (1) ZA99453B (de)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2601882T5 (es) 1999-04-09 2021-06-07 Kyowa Kirin Co Ltd Procedimiento para controlar la actividad de una molécula inmunofuncional
US6946292B2 (en) 2000-10-06 2005-09-20 Kyowa Hakko Kogyo Co., Ltd. Cells producing antibody compositions with increased antibody dependent cytotoxic activity
CA2444821C (en) 2001-04-24 2012-07-10 Merck Patent Gesellschaft Mit Beschraenkter Haftung Combination therapy using anti-angiogenic agents and tnfa
US7829087B2 (en) 2001-07-09 2010-11-09 Elan Pharmaceuticals, Inc. Methods of treating cognitive impairment
AU2002312566A1 (en) 2001-07-09 2003-01-29 Elan Pharmaceuticals, Inc. Methods of inhibiting amyloid toxicity
CA2478833C (en) 2002-03-13 2015-11-10 Biogen, Inc. Anti-.alpha.v.beta.6 antibodies
CN104072614B (zh) * 2005-07-08 2017-04-26 生物基因Ma公司 抗-αvβ6 抗体及其用途
EA201200560A1 (ru) 2006-01-18 2012-09-28 Мерк Патент Гмбх Специфическая терапия, использующая интегриновые лиганды для лечения рака
CA2646611A1 (en) 2006-03-21 2008-05-22 Genentech, Inc. Combinatorial therapy
EP2046374A4 (de) 2006-07-10 2010-05-05 Biogen Idec Inc Zusammensetzungen und verfahren zur wachstumshemmung von smad4-defizienten tumoren
CN103524619B (zh) 2006-08-03 2016-10-05 阿斯利康(瑞典)有限公司 针对αVβ6的抗体及其应用
EP2441464B1 (de) 2007-01-18 2014-04-09 Merck Patent GmbH Integrin-liganden zur verwendung in der behandlung von darmkrebs
HUE027911T2 (en) 2007-09-26 2016-11-28 Genentech Inc New antibodies
EP2730282A1 (de) 2007-11-08 2014-05-14 The General Hospital Corporation Verfahren und Zusammensetzung zur Behandlung von Proteinurie-Erkrankungen
CN102365297B (zh) 2009-03-25 2014-10-29 霍夫曼-拉罗奇有限公司 新型抗-α5β1抗体及其应用
EP2445534A2 (de) 2009-05-25 2012-05-02 Merck Patent GmbH Kontinuierliche verabreichung von cilengitid in der krebstherapie
RU2565539C2 (ru) * 2010-02-18 2015-10-20 Те Риджентс Оф Те Юниверсити Оф Калифорния АНТИТЕЛА, НЕЙТРАЛИЗУЮЩИЕ ИНТЕГРИН ανβ8
US10035859B2 (en) 2013-03-15 2018-07-31 Biogen Ma Inc. Anti-alpha V beta 6 antibodies and uses thereof
WO2014143739A2 (en) 2013-03-15 2014-09-18 Biogen Idec Ma Inc. Anti-alpha v beta 6 antibodies and uses thereof

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69531187T2 (de) * 1994-12-20 2004-04-22 Merck Patent Gmbh Monoklonaler Antikörper gegen das Alpha-V-Integrin

Also Published As

Publication number Publication date
ID27810A (id) 2001-04-26
KR20010034327A (ko) 2001-04-25
CN1288469A (zh) 2001-03-21
HUP0101151A2 (hu) 2001-08-28
NO20003767L (no) 2000-07-21
HUP0101151A3 (en) 2004-06-28
AU2716399A (en) 1999-08-09
WO1999037683A1 (de) 1999-07-29
EP1049718A1 (de) 2000-11-08
NO20003767D0 (no) 2000-07-21
EP1049718B1 (de) 2006-04-05
BR9907218A (pt) 2000-10-24
DE69930723T2 (de) 2006-11-16
DE69930723D1 (de) 2006-05-18
JP2002501086A (ja) 2002-01-15
CA2319160A1 (en) 1999-07-29
SK10772000A3 (sk) 2001-01-18
PL341569A1 (en) 2001-04-23
AR014464A1 (es) 2001-02-28
ZA99453B (en) 1999-07-21
CN1168741C (zh) 2004-09-29

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