ATE320793T1 - Verabreichung von einer chemoschützenden verbindung,welche eine thiolgruppe enthält - Google Patents
Verabreichung von einer chemoschützenden verbindung,welche eine thiolgruppe enthältInfo
- Publication number
- ATE320793T1 ATE320793T1 AT01927472T AT01927472T ATE320793T1 AT E320793 T1 ATE320793 T1 AT E320793T1 AT 01927472 T AT01927472 T AT 01927472T AT 01927472 T AT01927472 T AT 01927472T AT E320793 T1 ATE320793 T1 AT E320793T1
- Authority
- AT
- Austria
- Prior art keywords
- administration
- compound containing
- thiol
- chemoprotectant agent
- intra
- Prior art date
Links
- YTPLMLYBLZKORZ-UHFFFAOYSA-N Thiophene Chemical group C=1C=CSC=1 YTPLMLYBLZKORZ-UHFFFAOYSA-N 0.000 title 1
- 230000001767 chemoprotection Effects 0.000 title 1
- 150000001875 compounds Chemical class 0.000 title 1
- 238000000034 method Methods 0.000 abstract 3
- PWKSKIMOESPYIA-BYPYZUCNSA-N L-N-acetyl-Cysteine Chemical compound CC(=O)N[C@@H](CS)C(O)=O PWKSKIMOESPYIA-BYPYZUCNSA-N 0.000 abstract 2
- 229960004308 acetylcysteine Drugs 0.000 abstract 2
- 239000003795 chemical substances by application Substances 0.000 abstract 2
- AKHNMLFCWUSKQB-UHFFFAOYSA-L sodium thiosulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=S AKHNMLFCWUSKQB-UHFFFAOYSA-L 0.000 abstract 2
- 235000019345 sodium thiosulphate Nutrition 0.000 abstract 2
- 150000003573 thiols Chemical class 0.000 abstract 2
- 208000003174 Brain Neoplasms Diseases 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 208000027418 Wounds and injury Diseases 0.000 abstract 1
- 231100000433 cytotoxic Toxicity 0.000 abstract 1
- 230000001472 cytotoxic effect Effects 0.000 abstract 1
- 230000006378 damage Effects 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 208000014674 injury Diseases 0.000 abstract 1
- 238000001361 intraarterial administration Methods 0.000 abstract 1
- 210000004185 liver Anatomy 0.000 abstract 1
- 230000000116 mitigating effect Effects 0.000 abstract 1
- 208000025440 neoplasm of neck Diseases 0.000 abstract 1
- 238000011275 oncology therapy Methods 0.000 abstract 1
- 210000000056 organ Anatomy 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/04—Sulfur, selenium or tellurium; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/095—Sulfur, selenium, or tellurium compounds, e.g. thiols
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
- A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/28—Compounds containing heavy metals
- A61K31/282—Platinum compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/661—Phosphorus acids or esters thereof not having P—C bonds, e.g. fosfosal, dichlorvos, malathion or mevinphos
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
- A61K33/243—Platinum; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/06—Tripeptides
- A61K38/063—Glutathione
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Inorganic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Dermatology (AREA)
- Toxicology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US19993600P | 2000-04-26 | 2000-04-26 | |
US22987000P | 2000-08-30 | 2000-08-30 |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE320793T1 true ATE320793T1 (de) | 2006-04-15 |
Family
ID=26895307
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT01927472T ATE320793T1 (de) | 2000-04-26 | 2001-04-26 | Verabreichung von einer chemoschützenden verbindung,welche eine thiolgruppe enthält |
Country Status (13)
Country | Link |
---|---|
US (6) | US7022315B2 (de) |
EP (1) | EP1328253B1 (de) |
JP (1) | JP5242877B2 (de) |
KR (1) | KR20030014208A (de) |
CN (1) | CN1443064A (de) |
AT (1) | ATE320793T1 (de) |
AU (2) | AU2001253919B2 (de) |
BR (1) | BR0110403A (de) |
CA (1) | CA2406081C (de) |
DE (1) | DE60118172T2 (de) |
ES (1) | ES2261399T3 (de) |
IL (1) | IL152433A0 (de) |
WO (1) | WO2001080832A2 (de) |
Families Citing this family (39)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP5242877B2 (ja) | 2000-04-26 | 2013-07-24 | オレゴン ヘルス アンド サイエンス ユニバーシティー | チオールをベースとする化学保護剤の投与 |
EP1609468A3 (de) * | 2000-11-22 | 2006-01-25 | Rxkinetix, Inc. | Eine Zusammensetzung auf der Basis eines Schwefel enthaltenden Antioxidans wie dessen Verwendung zur Herstellung eines Medikaments für die Behandlung von Mucositis |
US20040062764A1 (en) * | 2001-08-30 | 2004-04-01 | Neuwelt Edward A | Chemoprotectant for gastric toxicity |
WO2003045334A2 (en) | 2001-11-29 | 2003-06-05 | Sound Pharmaceuticals Incorporated | Methods and compositions for ameliorating the undesirable effects of chemotherapy |
US6815434B2 (en) | 2002-01-04 | 2004-11-09 | Sound Pharmaceuticals Incorporated | Methods for treating hearing loss |
WO2003057012A2 (en) * | 2002-01-07 | 2003-07-17 | Board Of Regents, The University Of Texas System | S-dimethylarsino-thiosuccinic acid s-dimethylarsino-2-thiobenzoic acid s-(dimethylarsino) glutathione as treatments for cancer |
US20030235571A1 (en) * | 2002-06-19 | 2003-12-25 | Gabriel Gojon-Romanillos | Systemic treatment of pathological conditions resulting from oxidative stress and/or redox imbalance |
US6669929B1 (en) | 2002-12-30 | 2003-12-30 | Colgate Palmolive Company | Dentifrice containing functional film flakes |
US20040229815A1 (en) | 2003-01-03 | 2004-11-18 | Nagasawa Herbert T. | Methods for reducing oxidative stress in a cell with a sulfhydryl protected glutathione prodrug |
US20040198841A1 (en) * | 2003-03-13 | 2004-10-07 | Oregon Health & Science University | Use of thiol-based compositions in ameliorating mucosal injury |
US20050118261A1 (en) * | 2003-06-12 | 2005-06-02 | Oien Hal J. | Compositions and methods of administering doxepin to mucosal tissue |
TW201440760A (zh) * | 2004-07-16 | 2014-11-01 | Texas A & M Univ Sys | 有機砷化合物、其用於治療癌症之用途及包含其之醫藥組成物 |
US20070148154A1 (en) * | 2004-12-17 | 2007-06-28 | Universite Rene Descartes (Paris V) | Use of superoxide dismutase mimetics and reductase gultatione in the form of anticancer drugs |
US7968738B2 (en) | 2005-07-29 | 2011-06-28 | Ziopharm Oncology, Inc. | Compounds and methods for the treatment of cancer |
US8148356B2 (en) | 2005-08-24 | 2012-04-03 | Cumberland Pharmaceuticals, Inc. | Acetylcysteine composition and uses therefor |
DK1965787T3 (da) * | 2005-11-30 | 2013-06-03 | Endo Pharmaceuticals Inc | Behandling af xerostomi med en svovlindeholdende antioxidant |
WO2008021550A2 (en) * | 2006-08-16 | 2008-02-21 | Oregon Health & Science University | Thiol-based agents for reducing toxicities associated with medical procedures employing radiographic contrast agents |
TW200829261A (en) * | 2006-09-29 | 2008-07-16 | Ziopharm Oncology Inc | Method for controlling angiogenesis in animals |
US20100266501A1 (en) * | 2006-11-07 | 2010-10-21 | University Of Vermont and State Agricltural College | Methods and compositions for organ protection |
ES2392737T3 (es) * | 2007-11-02 | 2012-12-13 | Ziopharm Oncology, Inc. | Terapia combinada con compuestos arsenicales orgánicos |
BRPI0821002A2 (pt) * | 2007-12-12 | 2015-06-16 | Ziopharm Oncology Inc | Compostos e métodos para o tratamento de câncer |
US8227517B2 (en) * | 2008-02-12 | 2012-07-24 | Tosk, Incorporated | Doxorubicin adjuvants to reduce toxicity and methods for using the same |
DK3388111T3 (da) | 2008-08-20 | 2021-12-06 | Solasia Pharma K K | Organoarsenforbindelse til behandlingen af kræft |
US20100183748A1 (en) * | 2009-01-21 | 2010-07-22 | Ikaria, Inc. | Methods for Treating or Preventing Radiocontrast Agent Induced Kidney Injury |
CA2767168C (en) | 2009-07-08 | 2019-04-09 | Hope Medical Enterprises, Inc. D.B.A. Hope Pharmaceuticals | Sodium thiosulfate-containing pharmaceutical compositions |
DE102011006425A1 (de) | 2010-03-31 | 2011-10-06 | Awd.Pharma Gmbh & Co. Kg | Pharmazeutische Zubereitung und deren Verwendung |
CN105392478A (zh) * | 2013-07-31 | 2016-03-09 | 味之素株式会社 | 癌症化学疗法时的副作用降低剂 |
AU2015259362B2 (en) | 2014-05-12 | 2018-02-15 | The Johns Hopkins University | Engineering synthetic brain penetrating gene vectors |
US11173135B2 (en) | 2016-03-17 | 2021-11-16 | Thiogenesis Therapeutics, Inc. | Compositions for controlled release of cysteamine and systemic treatment of cysteamine sensitive disorders |
JP7416622B2 (ja) | 2017-03-08 | 2024-01-17 | ホープ メディカル エンタープライズ インコーポレイテッド ディー.ビー.エー. ホープ ファーマシューティカルズ | チオ硫酸ナトリウムの透析中の使用 |
EP3684418A4 (de) * | 2017-09-20 | 2021-06-16 | Thiogenesis Therapeutics, Inc. | Verfahren zur behandlung von cysteaminempfindlichen erkrankungen |
US10596190B2 (en) * | 2017-11-29 | 2020-03-24 | Oregon Health & Science University | Method for reducing ototoxicity in pediatric patients receiving platinum-based chemotherapy |
AU2019218232A1 (en) | 2018-02-09 | 2020-09-24 | Decibel Therapeutics, Inc. | Hypertonic pharmaceutical compositions containing an anti-platinum chemoprotectant agent |
AU2019299216A1 (en) | 2018-07-03 | 2021-01-07 | Fennec Pharmaceuticals, Inc. | Anhydrous sodium thiosulfate and formulations thereof |
WO2020140029A1 (en) * | 2018-12-27 | 2020-07-02 | Montefiore Medical Center | Nucleophilic chemicals useful in the treatment of cisplatin-induced sensory neuropathy and ototoxicity |
US10813947B1 (en) | 2019-05-31 | 2020-10-27 | Decibel Therapeutics, Inc. | Methods of otoprotection against platinum-based antineoplastic agents |
FR3099051A1 (fr) * | 2019-07-25 | 2021-01-29 | Laboratoires Grimberg | Composition pour pulvérisation nasale ou buccale contenant du soufre |
EP4090238A4 (de) * | 2020-01-16 | 2024-04-10 | The United States of America, as represented by the Secretary, Department of Health and Human Services | Echtzeit-überwachung von freien radikalfängern in vivo durch hyperpolarisierte n-acetyl-cystein-isotope |
CN114848836B (zh) * | 2021-07-06 | 2023-09-15 | 中山大学孙逸仙纪念医院 | 一种偶联物及其在治疗内耳疾病上的应用 |
Family Cites Families (22)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4474759A (en) * | 1982-07-22 | 1984-10-02 | Vojislav Petrovich | Method of treating bacterial, viral or parasitic diseases |
US4961926A (en) * | 1987-11-19 | 1990-10-09 | Sloan-Kettering Institute For Cancer Research | Methods for prevention and treatment of mucositis with granulocyte colony stimulating factor |
WO1992008448A1 (en) | 1990-11-09 | 1992-05-29 | Cell Technology, Inc. | Method for preventing drug-induced or radiation myelosuppression |
IT1258781B (it) * | 1992-01-16 | 1996-02-29 | Zambon Spa | Composizione farmaceutica oftalmica contenente n-acetilcisteina e polivinilalcol |
US5618823A (en) | 1992-06-24 | 1997-04-08 | Boehringer Mannheim Italia S.P.A. | Glutathione as chemoprotective agent |
US5424471A (en) | 1992-07-31 | 1995-06-13 | U.S. Bioscience, Inc. | Crystalline amifostine compositions and methods of the preparation and use of same |
DE4228455A1 (de) * | 1992-08-26 | 1994-09-15 | Beiersdorf Ag | Kosmetische und dermatologische Lichtschutzformulierungen mit einem Gehalt an Thiolen und/oder Thiolderivaten |
US6214345B1 (en) | 1993-05-14 | 2001-04-10 | Bristol-Myers Squibb Co. | Lysosomal enzyme-cleavable antitumor drug conjugates |
US5843481A (en) * | 1994-01-18 | 1998-12-01 | Mount Sinai Hospital Corporation | Treatment of proliferative disorders, metastasaes, and drug resistant tumors with vanadate compounds and derivatives or analogues thereof |
US5789000A (en) | 1994-11-14 | 1998-08-04 | Bionumerik Pharmaceuticals, Inc. | Sterile aqueous parenteral formulations of cis-diammine dichloro platinum |
US5846958A (en) | 1995-02-17 | 1998-12-08 | U.S. Bioscience, Inc. | Methods of using aminothiols to promote hematopoietic progenitor cell growth |
US5643853A (en) | 1995-02-28 | 1997-07-01 | Purdue Research Foundation | Thiol activation of cytotoxic and auxin-herbicidal agents and root formation stimulation |
US6110891A (en) * | 1996-06-21 | 2000-08-29 | Alizyme Therapeutics Ltd. | Lectin compositions and uses thereof |
ES2170414T3 (es) | 1996-09-23 | 2002-08-01 | Bionumerik Pharmaceuticals Inc | Reduccion de efectos toxicos del carboplatino usando ditioeteres. |
US6573253B2 (en) | 1997-02-12 | 2003-06-03 | Medimmune Oncology Inc. | Methods for the administration of amifostine and related compounds |
US6051563A (en) * | 1997-02-12 | 2000-04-18 | U.S. Bioscience, Inc. | Methods for the administration of amifostine and related compounds |
US5994409A (en) * | 1997-12-09 | 1999-11-30 | U.S. Bioscience, Inc. | Methods for treatment of neuro--and nephro--disorders and therapeutic toxicities using aminothiol compounds |
US6231889B1 (en) * | 1998-09-21 | 2001-05-15 | Chronorx, Llc | Unit dosage forms for the treatment of herpes simplex |
JP5242877B2 (ja) | 2000-04-26 | 2013-07-24 | オレゴン ヘルス アンド サイエンス ユニバーシティー | チオールをベースとする化学保護剤の投与 |
US6759061B2 (en) * | 2001-08-31 | 2004-07-06 | Renew Life, Inc. | Liver function improvement formulation |
WO2003045334A2 (en) | 2001-11-29 | 2003-06-05 | Sound Pharmaceuticals Incorporated | Methods and compositions for ameliorating the undesirable effects of chemotherapy |
WO2004039336A2 (en) | 2002-10-31 | 2004-05-13 | Oregon Health & Science University | Use of thiol-based compositions in treating chemotherapeutic agent-induced thrombocytopenia |
-
2001
- 2001-04-26 JP JP2001577932A patent/JP5242877B2/ja not_active Expired - Lifetime
- 2001-04-26 AU AU2001253919A patent/AU2001253919B2/en not_active Ceased
- 2001-04-26 BR BR0110403-9A patent/BR0110403A/pt not_active Application Discontinuation
- 2001-04-26 IL IL15243301A patent/IL152433A0/xx unknown
- 2001-04-26 US US10/257,879 patent/US7022315B2/en not_active Expired - Lifetime
- 2001-04-26 WO PCT/US2001/040624 patent/WO2001080832A2/en not_active Application Discontinuation
- 2001-04-26 DE DE60118172T patent/DE60118172T2/de not_active Expired - Lifetime
- 2001-04-26 ES ES01927472T patent/ES2261399T3/es not_active Expired - Lifetime
- 2001-04-26 CA CA002406081A patent/CA2406081C/en not_active Expired - Lifetime
- 2001-04-26 AT AT01927472T patent/ATE320793T1/de not_active IP Right Cessation
- 2001-04-26 AU AU5391901A patent/AU5391901A/xx active Pending
- 2001-04-26 EP EP01927472A patent/EP1328253B1/de not_active Expired - Lifetime
- 2001-04-26 CN CN01810176A patent/CN1443064A/zh active Pending
- 2001-04-26 KR KR1020027014454A patent/KR20030014208A/ko not_active Application Discontinuation
-
2005
- 2005-11-14 US US11/273,723 patent/US20060177523A1/en not_active Abandoned
-
2015
- 2015-07-29 US US14/812,782 patent/US20160184353A1/en not_active Abandoned
-
2016
- 2016-10-04 US US15/284,950 patent/US20170182089A1/en not_active Abandoned
-
2018
- 2018-02-28 US US15/907,941 patent/US20180289737A1/en not_active Abandoned
-
2019
- 2019-02-07 US US16/269,989 patent/US20200000844A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
US20170182089A1 (en) | 2017-06-29 |
WO2001080832A2 (en) | 2001-11-01 |
EP1328253A2 (de) | 2003-07-23 |
CN1443064A (zh) | 2003-09-17 |
US20030176359A1 (en) | 2003-09-18 |
US20160184353A1 (en) | 2016-06-30 |
DE60118172D1 (de) | 2006-05-11 |
DE60118172T2 (de) | 2007-03-08 |
JP2003531164A (ja) | 2003-10-21 |
US20060177523A1 (en) | 2006-08-10 |
CA2406081C (en) | 2009-12-22 |
EP1328253B1 (de) | 2006-03-22 |
AU5391901A (en) | 2001-11-07 |
JP5242877B2 (ja) | 2013-07-24 |
AU2001253919B2 (en) | 2006-12-14 |
ES2261399T3 (es) | 2006-11-16 |
US20180289737A1 (en) | 2018-10-11 |
US7022315B2 (en) | 2006-04-04 |
WO2001080832A3 (en) | 2003-05-15 |
CA2406081A1 (en) | 2001-11-01 |
KR20030014208A (ko) | 2003-02-15 |
IL152433A0 (en) | 2003-05-29 |
BR0110403A (pt) | 2004-02-25 |
US20200000844A1 (en) | 2020-01-02 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ATE320793T1 (de) | Verabreichung von einer chemoschützenden verbindung,welche eine thiolgruppe enthält | |
BR0009647A (pt) | Docetaxel em combinação com rhumab her2 para o tratamento de cânceres | |
BR0209147A (pt) | Terapia combinada que usa anticorpos anti-egfr e agentes anti-hormonais | |
WO2000041726A3 (en) | Noninvasive vascular therapy | |
BR0209365A (pt) | Usos farmacêuticos de bisfosfonatos | |
BR9815442A (pt) | Liberação terapêutica dirigida de compostos de vitamina d | |
BR0014525A (pt) | Processo de tratamento de distúrbios metabólicos, especialmente diabetes, ou uma doença ou condição associada com diabetes | |
NO993393D0 (no) | Fotokjemoterapeutiske blandinger | |
MX9302038A (es) | Metodo para el tratamiento del cancer por una terapia conjunta con derivados de 2-halometilideno y un agente antineoplasico especifico de fase m o fase s. | |
BRPI0517953A (pt) | uso de zd 6474, ou de um sal farmaceuticamente aceitável do mesmo, e de um antiandrógeno, composição farmacêutica, kit, e, método para a produção de um efeito da redução da permeabilidade vascular e/ou antiangiogênico em um animal de sangue quente | |
AR011133A1 (es) | MICROGRÁNULOS DE LIBERACIoN CONTROLADA QUE CONTIENEN CISPLATINO , PROCEDIMIENTO DE SU PREPARACIoN, COMPOSICIoN FARMACÉUTICA Y UTILIZACIoN EN LA FABRICACIoN DE UN MEDICAMENTO POLIQUIMIOTERAPIA O EN ASOCIACIoN CON UNA RADIOTERAPIA. | |
BR0207316A (pt) | Derivados de epotilona para o tratamento de tumores refratários | |
BR0313117A (pt) | Método para a produção de um efeito redutor de permeabilidade vascular e/ou antiangiogênico em um animal de sangue quente tal como um humano, método para o tratamento de um câncer em um animal de sangue quente tal como um humano, composição farmacêutica, kit, e, uso de zd6474 ou de um seu sal farmaceuticamente aceitável e de zd1839 ou de um seu sal farmaceuticamente aceitável | |
BR9813318A (pt) | Processo de tratamento de tumores e degeneração macular em paciente humano ou veterinário, composição farmacêutica para tratamento de tumores e degeneração macular em um paciente humano ou veterinário | |
IL140848A0 (en) | Treatment regimen for administration of phenylacetylacetylglutamine, phenylacetylisoglutamine and/or phenylacetate | |
SE7612534L (sv) | Forfarande for framstellning av farmaceutiska preparat for behandling av storningar i kalciumemnesomsettning | |
SE8602743L (sv) | Bruksferdiga injektionslosningar innehallande en antitumorantracyklinglykosid | |
BR9814419A (pt) | "combinação de compostos de benzociclo-heptapiridina e drogas antineopláticas para tratamento de doenças proliferativas" | |
DE69835435D1 (de) | Anti-arrhythmische zusammensetzungen und behandlungsverfahren | |
BR0110150A (pt) | Método e composição para o tratamento de câncer por meio da administração de agentes quimioterápicos indutores da apoptose | |
Cheli et al. | Photodynamic therapy of spontaneous animal tumors using the active component of hematoporphyrin derivative (DHE) as photosensitizing drug: Clincal results | |
Kaplan et al. | Mitomycin and fluorouracil with concomitant radiotherapy in head and neck cancer | |
KR927002224A (ko) | 항종양효과증강제 및 항종양제 | |
GB2356347B (en) | Pharmaceutical compositions and their use | |
ID28035A (id) | Kegunaan turunan antrasiklin untuk pengobatan tumor hati |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |