ATE318581T1 - Sensibilisierung von roten blutkörperchen gegenüber ultraschall durch einwirkung eines elektrischen feldes - Google Patents

Sensibilisierung von roten blutkörperchen gegenüber ultraschall durch einwirkung eines elektrischen feldes

Info

Publication number
ATE318581T1
ATE318581T1 AT00948142T AT00948142T ATE318581T1 AT E318581 T1 ATE318581 T1 AT E318581T1 AT 00948142 T AT00948142 T AT 00948142T AT 00948142 T AT00948142 T AT 00948142T AT E318581 T1 ATE318581 T1 AT E318581T1
Authority
AT
Austria
Prior art keywords
red blood
ultrasound
sensitization
effect
blood cells
Prior art date
Application number
AT00948142T
Other languages
German (de)
English (en)
Inventor
Haro Ana Maria Rollan
Anthony Patrick Mchale
Roger Craig
Original Assignee
Uutech Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Uutech Ltd filed Critical Uutech Ltd
Application granted granted Critical
Publication of ATE318581T1 publication Critical patent/ATE318581T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5063—Compounds of unknown constitution, e.g. material from plants or animals
    • A61K9/5068—Cell membranes or bacterial membranes enclosing drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A61K41/0028—Disruption, e.g. by heat or ultrasounds, sonophysical or sonochemical activation, e.g. thermosensitive or heat-sensitive liposomes, disruption of calculi with a medicinal preparation and ultrasounds
    • A61K41/0033—Sonodynamic cancer therapy with sonochemically active agents or sonosensitizers, having their cytotoxic effects enhanced through application of ultrasounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6901—Conjugates being cells, cell fragments, viruses, ghosts, red blood cells or viral vectors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
    • A61K9/0009—Galenical forms characterised by the drug release technique; Application systems commanded by energy involving or responsive to electricity, magnetism or acoustic waves; Galenical aspects of sonophoresis, iontophoresis, electroporation or electroosmosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Cell Biology (AREA)
  • Virology (AREA)
  • Biophysics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Molecular Biology (AREA)
  • Botany (AREA)
  • Zoology (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AT00948142T 1999-07-23 2000-07-24 Sensibilisierung von roten blutkörperchen gegenüber ultraschall durch einwirkung eines elektrischen feldes ATE318581T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9917416.1A GB9917416D0 (https=) 1999-07-23 1999-07-23
US14655699P 1999-07-30 1999-07-30

Publications (1)

Publication Number Publication Date
ATE318581T1 true ATE318581T1 (de) 2006-03-15

Family

ID=10857882

Family Applications (1)

Application Number Title Priority Date Filing Date
AT00948142T ATE318581T1 (de) 1999-07-23 2000-07-24 Sensibilisierung von roten blutkörperchen gegenüber ultraschall durch einwirkung eines elektrischen feldes

Country Status (8)

Country Link
EP (1) EP1196143B1 (https=)
JP (1) JP2003505409A (https=)
AT (1) ATE318581T1 (https=)
AU (1) AU6171000A (https=)
CA (1) CA2378377A1 (https=)
GB (1) GB9917416D0 (https=)
MX (1) MXPA02000792A (https=)
WO (1) WO2001007011A1 (https=)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0002856D0 (en) * 2000-02-08 2000-03-29 Gendel Limited Ultrasound sensitisation
CA2412544A1 (en) * 2000-07-24 2002-01-31 Gendel Limited Polypeptide delivery ii-2
WO2002040093A2 (en) 2000-11-17 2002-05-23 Gendel Limited Ablation of cells using combined electric field and ultrasound therapy
US6821274B2 (en) 2001-03-07 2004-11-23 Gendel Ltd. Ultrasound therapy for selective cell ablation
CA2438500C (en) * 2001-02-19 2009-09-08 Pola Chemical Industries Inc. Composition for electroporation
AU2003227960B2 (en) 2002-05-23 2008-10-30 Gendel Limited Ablation device
CA2929970C (en) 2013-12-20 2020-05-12 F. Hoffmann-La Roche Ag Method of immobilizing a cell on a support using compounds comprising a polyethylene glycol moiety
JP6629736B2 (ja) 2013-12-20 2020-01-15 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ １以上の疎水性ドメインおよびｐｅｇ部分を含む親水性ドメインを含む、細胞を結合するのに有用な化合物
CN105917226B (zh) * 2013-12-20 2018-06-01 豪夫迈·罗氏有限公司 包含两个或多个疏水结构域和一个含有peg部分的亲水结构域的化合物用于稳定细胞的用途
CN110090309B (zh) * 2019-05-28 2022-05-31 上海大学 功能基化红细胞膜的制备方法
CN113088494B (zh) * 2021-04-13 2022-08-05 武汉大学 一种用于释放被红细胞仿生材料捕获的肿瘤细胞的方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2655801C2 (de) * 1976-12-09 1986-06-26 Kernforschungsanlage Jülich GmbH, 5170 Jülich Injizierbare Suspension von Membranvesikeln aus Erythrozyten und Verfahren zur Herstellung der Suspension
US4935223A (en) * 1988-08-04 1990-06-19 Board Of Regents, The University Of Texas System Labeled cells for use in imaging
US5236835A (en) * 1988-10-05 1993-08-17 Hapgood, C.V. Electro insertion of proteins into red cell membranes
JPH02121931A (ja) * 1988-10-29 1990-05-09 Res Inst For Prod Dev 濃縮ヘモグロビンの製造方法
CA2248158A1 (en) * 1996-03-12 1997-09-18 The Board Of Regents Of The University Of Nebraska Targeted site specific drug delivery compositions and method of use
EP0882448B1 (en) * 1997-05-05 2005-01-12 DIDECO S.r.l. Method of encapsulating biologically active agents within erythrocytes and apparatus therefor
DE19735460A1 (de) * 1997-08-16 1999-02-18 Rolf Prof Dr Med Zander Spül- oder Lagerungsflüssigkeit für Blutzellen

Also Published As

Publication number Publication date
MXPA02000792A (es) 2003-07-14
EP1196143B1 (en) 2006-03-01
JP2003505409A (ja) 2003-02-12
GB9917416D0 (https=) 1999-09-22
CA2378377A1 (en) 2001-02-01
AU6171000A (en) 2001-02-13
WO2001007011A1 (en) 2001-02-01
EP1196143A1 (en) 2002-04-17

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