WO2002040093A3 - Ablation of cells using combined electric field and ultrasound therapy - Google Patents

Ablation of cells using combined electric field and ultrasound therapy Download PDF

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Publication number
WO2002040093A3
WO2002040093A3 PCT/GB2001/005065 GB0105065W WO0240093A3 WO 2002040093 A3 WO2002040093 A3 WO 2002040093A3 GB 0105065 W GB0105065 W GB 0105065W WO 0240093 A3 WO0240093 A3 WO 0240093A3
Authority
WO
WIPO (PCT)
Prior art keywords
electric field
ultrasound
ablation
cells
ultrasound therapy
Prior art date
Application number
PCT/GB2001/005065
Other languages
French (fr)
Other versions
WO2002040093A2 (en
Inventor
Roger Kingdon Craig
Anthony Patrick Mchale
Ana Maria Rollan-Haro
Original Assignee
Gendel Ltd
Kingdon Craig R
Anthony Patrick Mchale
Ana Maria Rollan-Haro
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0028121A external-priority patent/GB0028121D0/en
Priority claimed from GB0105643A external-priority patent/GB0105643D0/en
Priority claimed from GB0120582A external-priority patent/GB0120582D0/en
Application filed by Gendel Ltd, Kingdon Craig R, Anthony Patrick Mchale, Ana Maria Rollan-Haro filed Critical Gendel Ltd
Priority to EP01983692A priority Critical patent/EP1353723A2/en
Priority to AU2002215115A priority patent/AU2002215115A1/en
Priority to GB0213631A priority patent/GB2374018B/en
Priority to US10/113,173 priority patent/US6821274B2/en
Publication of WO2002040093A2 publication Critical patent/WO2002040093A2/en
Priority to US10/439,470 priority patent/US7481781B2/en
Publication of WO2002040093A3 publication Critical patent/WO2002040093A3/en
Priority to US10/940,888 priority patent/US20050043726A1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N7/00—Ultrasound therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A61K41/0028—Disruption, e.g. by heat or ultrasounds, sonophysical or sonochemical activation, e.g. thermosensitive or heat-sensitive liposomes, disruption of calculi with a medicinal preparation and ultrasounds
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M47/00—Means for after-treatment of the produced biomass or of the fermentation or metabolic products, e.g. storage of biomass
    • C12M47/06—Hydrolysis; Cell lysis; Extraction of intracellular or cell wall material

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Biomedical Technology (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • Sustainable Development (AREA)
  • Microbiology (AREA)
  • Radiology & Medical Imaging (AREA)
  • Molecular Biology (AREA)
  • Cell Biology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Dental Tools And Instruments Or Auxiliary Dental Instruments (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

We describe the combined use of an electric field and ultrasound to ablate a cell or tissue, the use of ultrasound to disrupt a nucleated cell which has previously been electrosensitised by exposure to an electric field, and the use of an electric field for sensitising a nucleated cell to ultrasound. We furthermore disclose the use of electricity to disrupt a nucleated cell which has previously been sensitised by exposure of ultrasound, and the use of ultrasound for sensitising a nucleated cell to electricity.
PCT/GB2001/005065 2000-11-17 2001-11-16 Ablation of cells using combined electric field and ultrasound therapy WO2002040093A2 (en)

Priority Applications (6)

Application Number Priority Date Filing Date Title
EP01983692A EP1353723A2 (en) 2000-11-17 2001-11-16 Ablation of cells using combined electric field and ultrasound therapy
AU2002215115A AU2002215115A1 (en) 2000-11-17 2001-11-16 Ablation of cells using combined electric field and ultrasound therapy
GB0213631A GB2374018B (en) 2000-11-17 2001-11-16 Ultrasound therapy
US10/113,173 US6821274B2 (en) 2001-03-07 2002-03-29 Ultrasound therapy for selective cell ablation
US10/439,470 US7481781B2 (en) 2000-11-17 2003-05-16 Ultrasound therapy
US10/940,888 US20050043726A1 (en) 2001-03-07 2004-09-13 Device II

Applications Claiming Priority (10)

Application Number Priority Date Filing Date Title
GB0028121A GB0028121D0 (en) 2000-11-17 2000-11-17 Ultrasound therapy
GB0028121.2 2000-11-17
GB0105643A GB0105643D0 (en) 2001-03-07 2001-03-07 Ultrasound therapy
GB0105643.1 2001-03-07
US27981201P 2001-03-29 2001-03-29
US60/279,812 2001-03-29
GB0120582.2 2001-08-23
GB0120582A GB0120582D0 (en) 2001-08-23 2001-08-23 Ultrasound therapy
US32238801P 2001-09-14 2001-09-14
US60/322,388 2001-09-14

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
US10/113,173 Continuation-In-Part US6821274B2 (en) 2000-11-17 2002-03-29 Ultrasound therapy for selective cell ablation

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US10/439,470 Continuation-In-Part US7481781B2 (en) 2000-11-17 2003-05-16 Ultrasound therapy

Publications (2)

Publication Number Publication Date
WO2002040093A2 WO2002040093A2 (en) 2002-05-23
WO2002040093A3 true WO2002040093A3 (en) 2003-08-07

Family

ID=27515991

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB2001/005065 WO2002040093A2 (en) 2000-11-17 2001-11-16 Ablation of cells using combined electric field and ultrasound therapy

Country Status (4)

Country Link
EP (1) EP1353723A2 (en)
AU (1) AU2002215115A1 (en)
GB (1) GB2374018B (en)
WO (1) WO2002040093A2 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8932208B2 (en) 2005-05-26 2015-01-13 Maquet Cardiovascular Llc Apparatus and methods for performing minimally-invasive surgical procedures

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7052493B2 (en) 1996-10-22 2006-05-30 Epicor Medical, Inc. Methods and devices for ablation
JP2005526579A (en) * 2002-05-23 2005-09-08 ジェンデル・リミテッド Shochu device
JP2010540160A (en) 2007-10-05 2010-12-24 マッケ カーディオバスキュラー，エルエルシー Apparatus and method for minimally invasive surgical procedures

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999034831A1 (en) * 1998-01-05 1999-07-15 University Of Washington Enhanced transport using membrane disruptive agents
WO2001007011A1 (en) * 1999-07-23 2001-02-01 Gendel Limited Method for releasing an agent from a red blood cell
WO2001058431A1 (en) * 2000-02-08 2001-08-16 Gendel Limited Method for loading a red blood cell with an agent

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DE3732131A1 (en) 1987-09-24 1989-04-06 Wolf Gmbh Richard FOCUSING ULTRASONIC transducer
JP2651740B2 (en) * 1990-07-26 1997-09-10 ハウス食品株式会社 Sterilization method by high voltage pulse
DE19507478C1 (en) 1995-03-03 1996-05-15 Siemens Ag Therapy device for treatment with focused ultrasound
US6041253A (en) * 1995-12-18 2000-03-21 Massachusetts Institute Of Technology Effect of electric field and ultrasound for transdermal drug delivery
US5895356A (en) 1995-11-15 1999-04-20 American Medical Systems, Inc. Apparatus and method for transurethral focussed ultrasound therapy
WO1997018855A1 (en) * 1995-11-21 1997-05-29 Eduard Naumovich Lerner Device for enhanced delivery of biologically active substances and compounds in an organism
US5676692A (en) 1996-03-28 1997-10-14 Indianapolis Center For Advanced Research, Inc. Focussed ultrasound tissue treatment method
CA2252617A1 (en) * 1996-05-01 1997-11-06 Imarx Pharmaceutical Corp. Methods for delivering compounds into a cell
JP4664450B2 (en) 1997-06-30 2011-04-06 アンステイテユ・ギユスタブ・ルシー Improved methods for introducing nucleic acids into multicellular eukaryotic cells and combinations thereof
DE69826124T3 (en) 1997-06-30 2007-10-11 Institut Gustave Roussy ADMINISTRATION OF NUCLEIC ACID IN CROSS-LINKED MUSCLES
US6055453A (en) 1997-08-01 2000-04-25 Genetronics, Inc. Apparatus for addressing needle array electrodes for electroporation therapy
US6007499A (en) 1997-10-31 1999-12-28 University Of Washington Method and apparatus for medical procedures using high-intensity focused ultrasound
WO1999022809A1 (en) 1997-11-04 1999-05-14 Genetronics, Inc. Combined electroporation and iontophoresis apparatus for drug and gene delivery

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Publication number Priority date Publication date Assignee Title
WO1999034831A1 (en) * 1998-01-05 1999-07-15 University Of Washington Enhanced transport using membrane disruptive agents
WO2001007011A1 (en) * 1999-07-23 2001-02-01 Gendel Limited Method for releasing an agent from a red blood cell
WO2001058431A1 (en) * 2000-02-08 2001-08-16 Gendel Limited Method for loading a red blood cell with an agent

Non-Patent Citations (13)

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EVA NILSSON: "Modelling of the electrochemical treatment of tumours", KTH DISSERTATIONS, 3 October 2000 (2000-10-03), Kungl Tekniska Högskolan, Stockholm, SE, XP002237874, Retrieved from the Internet <URL:http://media.lib.kth.se:8080/dissengrefhit.asp?dissnr=2933> [retrieved on 20030410] *
GILL INDERBIR S ET AL: "Laparoscopic and percutaneous radiofrequency ablation of the kidney: Acute and chronic porcine study.", UROLOGY, vol. 56, no. 2, August 2000 (2000-08-01), pages 197 - 200, XP002237876, ISSN: 0090-4295 *
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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8932208B2 (en) 2005-05-26 2015-01-13 Maquet Cardiovascular Llc Apparatus and methods for performing minimally-invasive surgical procedures

Also Published As

Publication number Publication date
GB0213631D0 (en) 2002-07-24
WO2002040093A2 (en) 2002-05-23
GB2374018A (en) 2002-10-09
GB2374018B (en) 2003-11-19
AU2002215115A1 (en) 2002-05-27
EP1353723A2 (en) 2003-10-22

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