GB2374018A - Ultrasound therapy - Google Patents

Ultrasound therapy Download PDF

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Publication number
GB2374018A
GB2374018A GB0213631A GB0213631A GB2374018A GB 2374018 A GB2374018 A GB 2374018A GB 0213631 A GB0213631 A GB 0213631A GB 0213631 A GB0213631 A GB 0213631A GB 2374018 A GB2374018 A GB 2374018A
Authority
GB
United Kingdom
Prior art keywords
ultrasound
nucleated cell
electric field
cell
disrupt
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
GB0213631A
Other versions
GB0213631D0 (en
GB2374018B (en
Inventor
Roger Kingdon Craig
Anthony Patrick Michale
Ana Maria Rollan-Haro
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Gendel Ltd
Original Assignee
Gendel Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0028121A external-priority patent/GB0028121D0/en
Priority claimed from GB0105643A external-priority patent/GB0105643D0/en
Priority claimed from GB0120582A external-priority patent/GB0120582D0/en
Application filed by Gendel Ltd filed Critical Gendel Ltd
Publication of GB0213631D0 publication Critical patent/GB0213631D0/en
Publication of GB2374018A publication Critical patent/GB2374018A/en
Application granted granted Critical
Publication of GB2374018B publication Critical patent/GB2374018B/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N7/00—Ultrasound therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A61K41/0028—Disruption, e.g. by heat or ultrasounds, sonophysical or sonochemical activation, e.g. thermosensitive or heat-sensitive liposomes, disruption of calculi with a medicinal preparation and ultrasounds
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M47/00—Means for after-treatment of the produced biomass or of the fermentation or metabolic products, e.g. storage of biomass
    • C12M47/06—Hydrolysis; Cell lysis; Extraction of intracellular or cell wall material

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Biomedical Technology (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • Sustainable Development (AREA)
  • Microbiology (AREA)
  • Radiology & Medical Imaging (AREA)
  • Molecular Biology (AREA)
  • Cell Biology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Dental Tools And Instruments Or Auxiliary Dental Instruments (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

We describe the combined use of an electric field and ultrasound to ablate a cell or tissue, the use of ultrasound to, disrupt a nucleated cell which has previously been electrosensitised by exposure to an electric field, and the use of an electric field for sensitising a nucleated cell to ultrasound. We furthermore disclose the use of electricity to disrupt a nucleated cell which has previously been sensitised by exposure of ultrasound, and the use of ultrasound for sensitising a nucleated cell to electricity.

Description

',UK Patent Application 'g,GB.,,2 374 018 PA (43) Date of Printing by UK
Office 09.10.2002 (21) Application No 0213631.5 (51) INTCL7 A61 N 1/00
(22) Date of Filing 16.11.2001 (52) UK CL (Edition T) (30) Priority Data A5R RHXT (31) 0028121 (32) 17.11.2000 (33) GB
(31) 0105643 (32) 07.03.2001 (56) Documents Cited by ISA (31) 60279812 (32) 29.03.2001 (33) US WO1997/040679A1 WO1997/018855A1
(31) 0120582 (32) 23.08.2001 (33) GB US 6041253 A
(31) 60322388 (32) 14.09.2001 (33) US
(58) Field of Search by ISA
(86) InternationalApplicationData INTCL7 A61B,A61N PCT/GB2001/005065 En 16.11.2001 ONLINE: WPI EPODOC JAPIO (87) International Publication Data W02002/040093 En 23.05.2002 (72) Inventor(s) Roger Kingdon Craig Anthony Patrick Michale (71) Applicant(s) Ana Maria Rollan-Haro Gendel Limited llncorporated in the Unrted Kingdom) (74) Agent and/or Address for Service Science Innovation Centre, Science Research Park, D Young & Co Crogmore Road, COLERAINE, Co.Londonderry, 21 New Fetter Lane, LONDON, EC4A IDA, BT52 1ST, United Kingdom United Kingdom (54) Abstract Title Ultrasound therapy (57) We describe the combined use of an electric field and ultrasound to ablate a cell or tissue, the use of
ultrasound to, disrupt a nucleated cell which has previously been electrosensitised by exposure to an electric field, and the use of an electric field for sensitizing a nucleated cell to ultrasound. We furthermore disclose the
use of electricity to disrupt a nucleated cell which has previously been sensitised by exposure of ultrasound, and the use of ultrasound for sensitising a nucleated cell to electricity.
good ES cells 75- it\ Control 50- \ \ o.0 0.5 1 0 t 5 2.0 1) Ultrasound ower density (W/cm floor 30 sec.), Go This international application has entered the national phase early. As an international search had not been established D at early entry a search has been made under section 17.
GB0213631A 2000-11-17 2001-11-16 Ultrasound therapy Expired - Fee Related GB2374018B (en)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
GB0028121A GB0028121D0 (en) 2000-11-17 2000-11-17 Ultrasound therapy
GB0105643A GB0105643D0 (en) 2001-03-07 2001-03-07 Ultrasound therapy
US27981201P 2001-03-29 2001-03-29
GB0120582A GB0120582D0 (en) 2001-08-23 2001-08-23 Ultrasound therapy
US32238801P 2001-09-14 2001-09-14
PCT/GB2001/005065 WO2002040093A2 (en) 2000-11-17 2001-11-16 Ablation of cells using combined electric field and ultrasound therapy

Publications (3)

Publication Number Publication Date
GB0213631D0 GB0213631D0 (en) 2002-07-24
GB2374018A true GB2374018A (en) 2002-10-09
GB2374018B GB2374018B (en) 2003-11-19

Family

ID=27515991

Family Applications (1)

Application Number Title Priority Date Filing Date
GB0213631A Expired - Fee Related GB2374018B (en) 2000-11-17 2001-11-16 Ultrasound therapy

Country Status (4)

Country Link
EP (1) EP1353723A2 (en)
AU (1) AU2002215115A1 (en)
GB (1) GB2374018B (en)
WO (1) WO2002040093A2 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7052493B2 (en) 1996-10-22 2006-05-30 Epicor Medical, Inc. Methods and devices for ablation
JP2005526579A (en) * 2002-05-23 2005-09-08 ジェンデル・リミテッド Shochu device
US8932208B2 (en) 2005-05-26 2015-01-13 Maquet Cardiovascular Llc Apparatus and methods for performing minimally-invasive surgical procedures
JP2010540160A (en) 2007-10-05 2010-12-24 マッケ カーディオバスキュラー，エルエルシー Apparatus and method for minimally invasive surgical procedures

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997018855A1 (en) * 1995-11-21 1997-05-29 Eduard Naumovich Lerner Device for enhanced delivery of biologically active substances and compounds in an organism
WO1997040679A1 (en) * 1996-05-01 1997-11-06 Imarx Pharmaceutical Corp. Methods for delivering compounds into a cell
US6041253A (en) * 1995-12-18 2000-03-21 Massachusetts Institute Of Technology Effect of electric field and ultrasound for transdermal drug delivery

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3732131A1 (en) 1987-09-24 1989-04-06 Wolf Gmbh Richard FOCUSING ULTRASONIC transducer
JP2651740B2 (en) * 1990-07-26 1997-09-10 ハウス食品株式会社 Sterilization method by high voltage pulse
DE19507478C1 (en) 1995-03-03 1996-05-15 Siemens Ag Therapy device for treatment with focused ultrasound
US5895356A (en) 1995-11-15 1999-04-20 American Medical Systems, Inc. Apparatus and method for transurethral focussed ultrasound therapy
US5676692A (en) 1996-03-28 1997-10-14 Indianapolis Center For Advanced Research, Inc. Focussed ultrasound tissue treatment method
JP4664450B2 (en) 1997-06-30 2011-04-06 アンステイテユ・ギユスタブ・ルシー Improved methods for introducing nucleic acids into multicellular eukaryotic cells and combinations thereof
DE69826124T3 (en) 1997-06-30 2007-10-11 Institut Gustave Roussy ADMINISTRATION OF NUCLEIC ACID IN CROSS-LINKED MUSCLES
US6055453A (en) 1997-08-01 2000-04-25 Genetronics, Inc. Apparatus for addressing needle array electrodes for electroporation therapy
US6007499A (en) 1997-10-31 1999-12-28 University Of Washington Method and apparatus for medical procedures using high-intensity focused ultrasound
WO1999022809A1 (en) 1997-11-04 1999-05-14 Genetronics, Inc. Combined electroporation and iontophoresis apparatus for drug and gene delivery
DE69941447D1 (en) * 1998-01-05 2009-11-05 Univ Washington INCREASED TRANSPORT USING MEMBRANE-DAMAGED SUBSTANCES
GB9917416D0 (en) * 1999-07-23 1999-09-22 Univ Ulster
GB0002856D0 (en) * 2000-02-08 2000-03-29 Gendel Limited Ultrasound sensitisation

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997018855A1 (en) * 1995-11-21 1997-05-29 Eduard Naumovich Lerner Device for enhanced delivery of biologically active substances and compounds in an organism
US6041253A (en) * 1995-12-18 2000-03-21 Massachusetts Institute Of Technology Effect of electric field and ultrasound for transdermal drug delivery
WO1997040679A1 (en) * 1996-05-01 1997-11-06 Imarx Pharmaceutical Corp. Methods for delivering compounds into a cell

Also Published As

Publication number Publication date
GB0213631D0 (en) 2002-07-24
WO2002040093A3 (en) 2003-08-07
WO2002040093A2 (en) 2002-05-23
GB2374018B (en) 2003-11-19
AU2002215115A1 (en) 2002-05-27
EP1353723A2 (en) 2003-10-22

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PCNP Patent ceased through non-payment of renewal fee

Effective date: 20151116