ATE317703T1 - Polymer-wirkstoff-konjugate zur behandlung von krebs - Google Patents

Polymer-wirkstoff-konjugate zur behandlung von krebs

Info

Publication number
ATE317703T1
ATE317703T1 AT98928427T AT98928427T ATE317703T1 AT E317703 T1 ATE317703 T1 AT E317703T1 AT 98928427 T AT98928427 T AT 98928427T AT 98928427 T AT98928427 T AT 98928427T AT E317703 T1 ATE317703 T1 AT E317703T1
Authority
AT
Austria
Prior art keywords
polymer
cancer
treatment
drug
active conjugates
Prior art date
Application number
AT98928427T
Other languages
German (de)
English (en)
Inventor
Ruth Duncan
James Cassidy
Lisa German
Dale Hirst
Original Assignee
Innovata Plc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9712100.8A external-priority patent/GB9712100D0/en
Application filed by Innovata Plc filed Critical Innovata Plc
Application granted granted Critical
Publication of ATE317703T1 publication Critical patent/ATE317703T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/61—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule the organic macromolecular compound being a polysaccharide or a derivative thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
AT98928427T 1997-06-12 1998-06-12 Polymer-wirkstoff-konjugate zur behandlung von krebs ATE317703T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9712100.8A GB9712100D0 (en) 1997-06-12 1997-06-12 Biologically active materials
US5427797P 1997-07-30 1997-07-30

Publications (1)

Publication Number Publication Date
ATE317703T1 true ATE317703T1 (de) 2006-03-15

Family

ID=26311695

Family Applications (1)

Application Number Title Priority Date Filing Date
AT98928427T ATE317703T1 (de) 1997-06-12 1998-06-12 Polymer-wirkstoff-konjugate zur behandlung von krebs

Country Status (7)

Country Link
US (1) US6338843B1 (https=)
EP (1) EP0998303B1 (https=)
JP (1) JP2002508758A (https=)
AT (1) ATE317703T1 (https=)
AU (1) AU8025998A (https=)
DE (1) DE69833487T9 (https=)
WO (1) WO1998056424A1 (https=)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1191093C (zh) * 1998-10-30 2005-03-02 第一制药株式会社 Dds化合物及其测定方法
EP1198253A2 (en) * 1999-06-18 2002-04-24 ML Laboratories Plc Biologically active materials
EP1296719A2 (en) * 2000-07-01 2003-04-02 ML Laboratories Plc Dextrin - amphotericin conjugates and their methods of preparation
DE60131177T2 (de) * 2000-09-06 2008-08-07 AP Pharma, Inc., Redwood Abbaubare polyacetal-polymere
DE10112825A1 (de) 2001-03-16 2002-10-02 Fresenius Kabi De Gmbh HESylierung von Wirkstoffen in wässriger Lösung
DE10129369C1 (de) 2001-06-21 2003-03-06 Fresenius Kabi De Gmbh Wasserlösliches, einen Aminozucker aufweisendes Antibiotikum in Form eines Pol ysaccharid-Konjugats
DE10209821A1 (de) 2002-03-06 2003-09-25 Biotechnologie Ges Mittelhesse Kopplung von Proteinen an ein modifiziertes Polysaccharid
ITMI20020681A1 (it) * 2002-03-29 2003-09-29 Acs Dobfar Spa Procedimento per la produzione di nanoparticelle di paclitaxel ed albumina
US7538092B2 (en) 2002-10-08 2009-05-26 Fresenius Kabi Deutschland Gmbh Pharmaceutically active oligosaccharide conjugates
WO2004081538A2 (en) 2003-03-13 2004-09-23 Irm, Llc Compositions and methods of vinyl oxazolone polymerization
WO2005014655A2 (en) 2003-08-08 2005-02-17 Fresenius Kabi Deutschland Gmbh Conjugates of hydroxyalkyl starch and a protein
EP1734819A1 (en) * 2004-03-19 2006-12-27 Pro-Pharmaceuticals, Inc. Compositions and methods for targeting metastatic tumors using multivalent ligand-linked carbohydrate polymers
US11331392B2 (en) 2014-12-04 2022-05-17 The Trustees Of Columbia University In The City Of New York Biodegradable thermo-responsive polymers and uses thereof
GB2551979A (en) 2016-06-30 2018-01-10 Rs Arastirma Egitim Danismanlik Llac Sanayi Ticaret Ltd Cleavable polymer drug conjugates

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1044798B (it) 1974-10-15 1980-04-21 Ferruti Paolo Alti polimeri contenenti acido nicotinico processo per la loro preparazione e loro impiego
JPS5756500A (en) * 1980-09-22 1982-04-05 Otsuka Pharmaceut Co Ltd Novel bufadienolide-type steroid
US4496689A (en) * 1983-12-27 1985-01-29 Miles Laboratories, Inc. Covalently attached complex of alpha-1-proteinase inhibitor with a water soluble polymer
US5554386A (en) 1986-07-03 1996-09-10 Advanced Magnetics, Inc. Delivery of therapeutic agents to receptors using polysaccharides
US4793986A (en) * 1987-02-25 1988-12-27 Johnson Matthey, Inc. Macromolecular platinum antitumor compounds
GB9020861D0 (en) 1990-09-25 1990-11-07 Ml Lab Plc Pharmaceutical compositions
EP0540751A4 (en) 1991-05-20 1994-10-26 Eisai Co Ltd Steroid compound combined with polysaccharide
GB9217998D0 (en) * 1992-08-24 1992-10-07 Wellcome Found Methods of treating cancer
WO1995005199A1 (en) 1993-08-19 1995-02-23 Dextran Products Limited Pharmaceutical preparation and a process for making same

Also Published As

Publication number Publication date
DE69833487T9 (de) 2007-03-01
DE69833487D1 (de) 2006-04-20
EP0998303A1 (en) 2000-05-10
JP2002508758A (ja) 2002-03-19
AU8025998A (en) 1998-12-30
US6338843B1 (en) 2002-01-15
DE69833487T2 (de) 2006-10-12
EP0998303B1 (en) 2006-02-15
WO1998056424A1 (en) 1998-12-17

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Legal Events

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RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties