ATE317009T1 - Chimäre phagen - Google Patents

Chimäre phagen

Info

Publication number
ATE317009T1
ATE317009T1 AT02743959T AT02743959T ATE317009T1 AT E317009 T1 ATE317009 T1 AT E317009T1 AT 02743959 T AT02743959 T AT 02743959T AT 02743959 T AT02743959 T AT 02743959T AT E317009 T1 ATE317009 T1 AT E317009T1
Authority
AT
Austria
Prior art keywords
phages
protein
phage
helper
coat
Prior art date
Application number
AT02743959T
Other languages
English (en)
Inventor
Erwin Houtzager
Ton Logtenberg
Kruif Cornelis Adriaan De
Original Assignee
Crucell Holland Bv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from EP01202304A external-priority patent/EP1266963A1/de
Priority claimed from US09/882,621 external-priority patent/US7070926B2/en
Application filed by Crucell Holland Bv filed Critical Crucell Holland Bv
Application granted granted Critical
Publication of ATE317009T1 publication Critical patent/ATE317009T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00—Libraries per se, e.g. arrays, mixtures
    • C40B40/02—Libraries contained in or displayed by microorganisms, e.g. bacteria or animal cells; Libraries contained in or displayed by vectors, e.g. plasmids; Libraries containing only microorganisms or vectors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C12N15/1037—Screening libraries presented on the surface of microorganisms, e.g. phage display, E. coli display
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2795/00—Bacteriophages
    • C12N2795/00011—Details
    • C12N2795/10011—Details dsDNA Bacteriophages
    • C12N2795/10021—Viruses as such, e.g. new isolates, mutants or their genomic sequences
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2795/00—Bacteriophages
    • C12N2795/00011—Details
    • C12N2795/10011—Details dsDNA Bacteriophages
    • C12N2795/10022—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Biochemistry (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Virology (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Immunology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Holo Graphy (AREA)
AT02743959T 2001-06-15 2002-06-14 Chimäre phagen ATE317009T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP01202304A EP1266963A1 (de) 2001-06-15 2001-06-15 Chimäre Phagen
US09/882,621 US7070926B2 (en) 2001-06-15 2001-06-15 Chimaeric phages

Publications (1)

Publication Number Publication Date
ATE317009T1 true ATE317009T1 (de) 2006-02-15

Family

ID=26076931

Family Applications (1)

Application Number Title Priority Date Filing Date
AT02743959T ATE317009T1 (de) 2001-06-15 2002-06-14 Chimäre phagen

Country Status (10)

Country Link
US (2) US7329530B2 (de)
EP (1) EP1402025B1 (de)
AT (1) ATE317009T1 (de)
AU (1) AU2002345421B2 (de)
CA (1) CA2449071C (de)
DE (1) DE60209010T2 (de)
DK (1) DK1402025T3 (de)
ES (1) ES2257560T3 (de)
NZ (1) NZ529465A (de)
WO (1) WO2002103012A1 (de)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK1402025T3 (da) * 2001-06-15 2006-06-06 Crucell Holland Bv Kimære fager
US7070926B2 (en) 2001-06-15 2006-07-04 Crucell Holland B.V. Chimaeric phages
WO2003052053A2 (en) * 2001-12-17 2003-06-26 Ribapharm Inc. Nucleoside libraries and compounds by mcc combinatorial strategies on solid support
CA2872136C (en) 2002-07-18 2017-06-20 Merus B.V. Recombinant production of mixtures of antibodies
USRE47770E1 (en) 2002-07-18 2019-12-17 Merus N.V. Recombinant production of mixtures of antibodies
CA2527694C (en) 2003-05-30 2015-07-14 Hendricus Renerus Jacobus Mattheus Hoogenboom Fab library for the preparation of anti vegf and anti rabies virus fabs
US20100069614A1 (en) 2008-06-27 2010-03-18 Merus B.V. Antibody producing non-human mammals
CA2526284C (en) 2003-06-25 2014-11-18 Crucell Holland B.V. Binding molecules for the treatment of myeloid cell malignancies
CA2568162C (en) 2004-05-27 2013-04-16 Crucell Holland B.V. Binding molecules capable of neutralizing rabies virus and uses thereof
EP1799259B1 (de) * 2004-10-12 2012-12-05 Crucell Holland B.V. Bindende moleküle für den nachweis von krebs
EP1812067B1 (de) 2004-11-11 2012-03-21 Crucell Holland B.V. Zusammensetzungen gegen das sars-coronavirus und ihre verwendungen
CA2591665C (en) 2004-12-20 2015-05-05 Crucell Holland B.V. Binding molecules capable of neutralizing west nile virus and uses thereof
US20060235795A1 (en) * 2005-04-19 2006-10-19 Microsoft Corporation Secure network commercial transactions
AU2006245734C1 (en) 2005-05-12 2012-05-24 Crucell Holland B.V. Host cell specific binding molecules capable of neutralizing viruses and uses thereof
US8642513B2 (en) 2005-09-15 2014-02-04 Crucell Holland B.V. Method for preparing immunoglobulin libraries
WO2007064462A1 (en) * 2005-11-29 2007-06-07 The Trustees Of The University Of Pennsylvania Phage particle diagnostic reagents
US8227242B2 (en) * 2005-12-07 2012-07-24 Los Alamos National Security, Llc Plasmids and packaging cell lines for use in phage display
EA018030B1 (ru) 2006-06-06 2013-05-30 Круселл Холланд Б.В. Связывающие молекулы человека, имеющие убивающую активность против стафилококков, и их применения
EP2024394B1 (de) 2006-06-06 2014-11-05 Crucell Holland B.V. Humane bindungsmoleküle mit abtötender wirkung auf enterokokken und staphylococcus aureus und anwendungen davon
WO2008028946A2 (en) 2006-09-07 2008-03-13 Crucell Holland B.V. Human binding molecules capable of neutralizing influenza virus h5n1 and uses thereof
BRPI0716983B8 (pt) 2006-09-07 2021-05-25 Crucell Holland Bv anticorpo humano isolado, ou fragmento de ligação ao antígeno do mesmo,capaz de reconhecer e se ligar a um epítopo da subunidade ha2 da proteína hemaglutinina de influenza (ha), molécula de ácido nucleico e composição farmacêutica.
CA2704494A1 (en) 2007-11-02 2009-05-14 The Scripps Research Institute Directed evolution using proteins comprising unnatural amino acids
US8470327B2 (en) 2009-05-11 2013-06-25 Crucell Holland B.V. Human binding molecules capable of neutralizing influenza virus H3N2 and uses thereof
EA027054B1 (ru) 2011-07-14 2017-06-30 Круселл Холланд Б.В. Связывающие молекулы человека, способные нейтрализовать вирусы гриппа a филогенетической группы 1 и филогенетической группы 2 и вирусы гриппа b
CA2791109C (en) 2011-09-26 2021-02-16 Merus B.V. Generation of binding molecules
MX360056B (es) 2012-03-08 2018-10-19 Janssen Vaccines & Prevention Bv Moléculas de unión humanas que pueden unirse a los virus de la influenza b y neutralizarlos, y sus usos.
ES2743399T3 (es) 2012-04-20 2020-02-19 Merus Nv Métodos y medios para la producción de moléculas heterodiméricas similares a Ig
CN108350436B (zh) * 2015-11-25 2021-07-16 伊莱利利公司 噬菌体展示载体和使用方法
US20220259585A1 (en) * 2019-03-04 2022-08-18 The Texas A&M University System Methods of making and utilizing amber-obligated phage display libraries

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9500851D0 (en) * 1995-01-17 1995-03-08 Bionvent International Ab Method of selecting specific bacteriophages
EP1266963A1 (de) 2001-06-15 2002-12-18 Crucell Holland B.V. Chimäre Phagen
US7070926B2 (en) 2001-06-15 2006-07-04 Crucell Holland B.V. Chimaeric phages
DK1402025T3 (da) 2001-06-15 2006-06-06 Crucell Holland Bv Kimære fager

Also Published As

Publication number Publication date
DK1402025T3 (da) 2006-06-06
CA2449071A1 (en) 2002-12-27
WO2002103012A1 (en) 2002-12-27
EP1402025B1 (de) 2006-02-01
US7901919B2 (en) 2011-03-08
US7329530B2 (en) 2008-02-12
DE60209010D1 (de) 2006-04-13
AU2002345421B2 (en) 2006-11-16
NZ529465A (en) 2005-05-27
EP1402025A1 (de) 2004-03-31
US20050014261A1 (en) 2005-01-20
US20090017521A1 (en) 2009-01-15
ES2257560T3 (es) 2006-08-01
DE60209010T2 (de) 2006-09-28
CA2449071C (en) 2008-12-16

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