DE60209010D1 - Chimäre phagen - Google Patents

Chimäre phagen

Info

Publication number
DE60209010D1
DE60209010D1 DE60209010T DE60209010T DE60209010D1 DE 60209010 D1 DE60209010 D1 DE 60209010D1 DE 60209010 T DE60209010 T DE 60209010T DE 60209010 T DE60209010 T DE 60209010T DE 60209010 D1 DE60209010 D1 DE 60209010D1
Authority
DE
Germany
Prior art keywords
phages
protein
phage
helper
coat
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60209010T
Other languages
English (en)
Other versions
DE60209010T2 (de
Inventor
Erwin Houtzager
Ton Logtenberg
Kruif Adriaan De
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Janssen Vaccines and Prevention BV
Original Assignee
Crucell Holand BV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from EP01202304A external-priority patent/EP1266963A1/de
Priority claimed from US09/882,621 external-priority patent/US7070926B2/en
Application filed by Crucell Holand BV filed Critical Crucell Holand BV
Application granted granted Critical
Publication of DE60209010D1 publication Critical patent/DE60209010D1/de
Publication of DE60209010T2 publication Critical patent/DE60209010T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00—Libraries per se, e.g. arrays, mixtures
    • C40B40/02—Libraries contained in or displayed by microorganisms, e.g. bacteria or animal cells; Libraries contained in or displayed by vectors, e.g. plasmids; Libraries containing only microorganisms or vectors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C12N15/1037—Screening libraries presented on the surface of microorganisms, e.g. phage display, E. coli display
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2795/00—Bacteriophages
    • C12N2795/00011—Details
    • C12N2795/10011—Details dsDNA Bacteriophages
    • C12N2795/10021—Viruses as such, e.g. new isolates, mutants or their genomic sequences
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2795/00—Bacteriophages
    • C12N2795/00011—Details
    • C12N2795/10011—Details dsDNA Bacteriophages
    • C12N2795/10022—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Virology (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Plant Pathology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Holo Graphy (AREA)
DE60209010T 2001-06-15 2002-06-14 Chimäre phagen Expired - Lifetime DE60209010T2 (de)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US882621 2001-06-15
EP01202304A EP1266963A1 (de) 2001-06-15 2001-06-15 Chimäre Phagen
US09/882,621 US7070926B2 (en) 2001-06-15 2001-06-15 Chimaeric phages
EP01202304 2001-06-15
PCT/NL2002/000391 WO2002103012A1 (en) 2001-06-15 2002-06-14 Chimaeric phages

Publications (2)

Publication Number Publication Date
DE60209010D1 true DE60209010D1 (de) 2006-04-13
DE60209010T2 DE60209010T2 (de) 2006-09-28

Family

ID=26076931

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60209010T Expired - Lifetime DE60209010T2 (de) 2001-06-15 2002-06-14 Chimäre phagen

Country Status (10)

Country Link
US (2) US7329530B2 (de)
EP (1) EP1402025B1 (de)
AT (1) ATE317009T1 (de)
AU (1) AU2002345421B2 (de)
CA (1) CA2449071C (de)
DE (1) DE60209010T2 (de)
DK (1) DK1402025T3 (de)
ES (1) ES2257560T3 (de)
NZ (1) NZ529465A (de)
WO (1) WO2002103012A1 (de)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE60209010T2 (de) * 2001-06-15 2006-09-28 Crucell Holland B.V. Chimäre phagen
US7070926B2 (en) 2001-06-15 2006-07-04 Crucell Holland B.V. Chimaeric phages
AU2002349905A1 (en) * 2001-12-17 2003-06-30 Ribapharm Inc. Nucleoside libraries and compounds by mcc combinatorial strategies on solid support
CA2872136C (en) 2002-07-18 2017-06-20 Merus B.V. Recombinant production of mixtures of antibodies
USRE47770E1 (en) 2002-07-18 2019-12-17 Merus N.V. Recombinant production of mixtures of antibodies
AU2004242614B2 (en) 2003-05-30 2011-09-22 Merus N.V. Fab library for the preparation of anti vegf and anti rabies virus fabs
US20100069614A1 (en) 2008-06-27 2010-03-18 Merus B.V. Antibody producing non-human mammals
AU2004251890B2 (en) 2003-06-25 2010-09-23 Crucell Holland B.V. Binding molecules for the treatment of myeloid cell malignancies
CN102139106B (zh) 2004-05-27 2014-10-08 克鲁塞尔荷兰公司 能中和狂犬病病毒的结合分子及其应用
JP4852046B2 (ja) * 2004-10-12 2012-01-11 クルセル ホランド ベー ヴェー 癌の治療及び検出に用いる結合分子
KR101255861B1 (ko) 2004-11-11 2013-04-17 크루셀 홀란드 비.브이. 사스-코로나바이러스에 대한 조성물 및 그것의 용도
WO2006067122A2 (en) 2004-12-20 2006-06-29 Crucell Holland B.V. Binding molecules capable of neutralizing west nile virus and uses thereof
US20060235795A1 (en) * 2005-04-19 2006-10-19 Microsoft Corporation Secure network commercial transactions
US8052974B2 (en) 2005-05-12 2011-11-08 Crucell Holland B.V. Host cell specific binding molecules capable of neutralizing viruses and uses thereof
EP1928914A2 (de) 2005-09-15 2008-06-11 Crucell Holland B.V. Verfahren zur herstellung von immunoglobulinbibliotheken
EP1963494B1 (de) * 2005-11-29 2014-10-08 The Trustees of The University of Pennsylvania Diagnostische phagenpartikelreagentien
US8227242B2 (en) * 2005-12-07 2012-07-24 Los Alamos National Security, Llc Plasmids and packaging cell lines for use in phage display
US7960518B2 (en) 2006-06-06 2011-06-14 Crucell Holland B.V. Human binding molecules having killing activity against enterococci and uses thereof
CA2654712C (en) 2006-06-06 2015-05-05 Crucell Holland B.V. Human binding molecules having killing activity against staphylococci and uses thereof
EA017203B1 (ru) 2006-09-07 2012-10-30 Круселл Холланд Б.В. Связывающие молекулы человека, способные нейтрализовать вирус гриппа h5n1, и их применение
RS52688B (sr) 2006-09-07 2013-08-30 Crucell Holland B.V. Humani vezni molekuli sposobni da neutrališu virus influence h5n1 i njihova upotreba
BRPI0819092A2 (pt) * 2007-11-02 2014-10-14 Scripps Research Inst Evolução direcionada usando proteínas que compreendem aminoácidos não naturais.
CA2761648C (en) 2009-05-11 2019-03-12 Crucell Holland B.V. Human binding molecules capable of neutralizing influenza virus h3n2 and uses thereof
WO2013007770A1 (en) 2011-07-14 2013-01-17 Crucell Holland B.V. Human binding molecules capable of neutralizing influenza a viruses of phylogenetic group 1 and phylogenetic group 2 and influenza b viruses
CA2791109C (en) 2011-09-26 2021-02-16 Merus B.V. Generation of binding molecules
EP2822968B1 (de) 2012-03-08 2018-01-10 Janssen Vaccines & Prevention B.V. Humane bindungsmoleküle mit fähigkeit zur bindung an influenza-b-viren und zu deren neutralisierung sowie ihre verwendungen
CN114163530B (zh) 2012-04-20 2025-04-29 美勒斯公司 用于产生免疫球蛋白样分子的方法和手段
JP6530863B2 (ja) * 2015-11-25 2019-06-12 イーライ リリー アンド カンパニー ファージディスプレイベクター及び使用方法
EP3935166A4 (de) * 2019-03-04 2022-11-23 The Texas A&M University System Verfahren zur herstellung und verwendung von bernstein-verpflichteten phagen-anzeige-bibliotheken

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9500851D0 (en) * 1995-01-17 1995-03-08 Bionvent International Ab Method of selecting specific bacteriophages
DE60209010T2 (de) 2001-06-15 2006-09-28 Crucell Holland B.V. Chimäre phagen
EP1266963A1 (de) 2001-06-15 2002-12-18 Crucell Holland B.V. Chimäre Phagen
US7070926B2 (en) * 2001-06-15 2006-07-04 Crucell Holland B.V. Chimaeric phages

Also Published As

Publication number Publication date
CA2449071A1 (en) 2002-12-27
AU2002345421B2 (en) 2006-11-16
EP1402025B1 (de) 2006-02-01
NZ529465A (en) 2005-05-27
US20050014261A1 (en) 2005-01-20
US7329530B2 (en) 2008-02-12
US20090017521A1 (en) 2009-01-15
ATE317009T1 (de) 2006-02-15
EP1402025A1 (de) 2004-03-31
CA2449071C (en) 2008-12-16
WO2002103012A1 (en) 2002-12-27
DE60209010T2 (de) 2006-09-28
DK1402025T3 (da) 2006-06-06
US7901919B2 (en) 2011-03-08
ES2257560T3 (es) 2006-08-01

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