ATE305934T1 - Verfahren zur herstellung von maytansinol - Google Patents
Verfahren zur herstellung von maytansinolInfo
- Publication number
- ATE305934T1 ATE305934T1 AT02726608T AT02726608T ATE305934T1 AT E305934 T1 ATE305934 T1 AT E305934T1 AT 02726608 T AT02726608 T AT 02726608T AT 02726608 T AT02726608 T AT 02726608T AT E305934 T1 ATE305934 T1 AT E305934T1
- Authority
- AT
- Austria
- Prior art keywords
- maytansinol
- producing
- preparing
- producing maytansinol
- unreduced
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D498/18—Bridged systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Solid-Sorbent Or Filter-Aiding Compositions (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US27679201P | 2001-03-16 | 2001-03-16 | |
PCT/US2002/007424 WO2002074775A1 (en) | 2001-03-16 | 2002-03-12 | Process for preparing maytansinol |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE305934T1 true ATE305934T1 (de) | 2005-10-15 |
Family
ID=23058083
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT02726608T ATE305934T1 (de) | 2001-03-16 | 2002-03-12 | Verfahren zur herstellung von maytansinol |
Country Status (7)
Country | Link |
---|---|
US (2) | US20020156274A1 (de) |
EP (1) | EP1373273B1 (de) |
JP (1) | JP2004526734A (de) |
AT (1) | ATE305934T1 (de) |
DE (1) | DE60206477T2 (de) |
ES (1) | ES2248550T3 (de) |
WO (1) | WO2002074775A1 (de) |
Families Citing this family (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6333410B1 (en) | 2000-08-18 | 2001-12-25 | Immunogen, Inc. | Process for the preparation and purification of thiol-containing maytansinoids |
US20100056762A1 (en) | 2001-05-11 | 2010-03-04 | Old Lloyd J | Specific binding proteins and uses thereof |
ATE446317T1 (de) | 2001-05-11 | 2009-11-15 | Ludwig Inst For Cancer Res Ltd | Spezifische bindungsproteine und ihre verwendung |
JP2005525423A (ja) * | 2002-05-13 | 2005-08-25 | スミスクライン・ビーチャム・コーポレイション | メイタンシノールの調製方法 |
US20050261493A1 (en) * | 2002-08-08 | 2005-11-24 | Mark Fulston | Methods for the isolation and purification of ansamitocins |
US7432088B2 (en) * | 2003-05-08 | 2008-10-07 | Immunogen Inc. | Methods for the production of ansamitocins |
US20090208556A1 (en) * | 2004-10-29 | 2009-08-20 | Regents Of The University Of California, The | Porous photonic crystals for drug delivery to the eye |
US20070135629A1 (en) * | 2005-12-08 | 2007-06-14 | Millennium Pharmaceuticals, Inc. | Isolation of ansamitocins |
JP5276017B2 (ja) | 2007-01-25 | 2013-08-28 | デイナ ファーバー キャンサー インスティチュート,インコーポレイテッド | Egfr変異体仲介性疾患の治療における抗egfr抗体の使用 |
CN101688229B (zh) | 2007-03-15 | 2013-06-12 | 路德维格癌症研究所 | 包含egfr抗体和src抑制剂的组合物及其在制备用于治疗哺乳动物癌症的药物中的用途 |
CN101896503B (zh) | 2007-08-14 | 2018-05-22 | 路德维格癌症研究所有限公司 | 靶向egf受体的单克隆抗体175及其衍生物和用途 |
CN102933231B (zh) | 2010-02-10 | 2015-07-29 | 伊缪诺金公司 | Cd20抗体及其用途 |
CN103604803B (zh) * | 2013-11-11 | 2015-11-25 | 深圳大学 | 一种快速检测红酒中铁离子含量的方法 |
JP6894423B2 (ja) | 2015-07-09 | 2021-06-30 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニアThe Regents Of The University Of California | 融合性リポソーム被覆多孔質ケイ素ナノ粒子 |
ES2949511T3 (es) * | 2019-03-01 | 2023-09-29 | Celgene Corp | Preparación de maitansinol |
JPWO2021107133A1 (de) | 2019-11-29 | 2021-06-03 |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4162940A (en) * | 1977-03-31 | 1979-07-31 | Takeda Chemical Industries, Ltd. | Method for producing Antibiotic C-15003 by culturing nocardia |
US4151042A (en) * | 1977-03-31 | 1979-04-24 | Takeda Chemical Industries, Ltd. | Method for producing maytansinol and its derivatives |
CA2006408A1 (en) * | 1988-12-27 | 1990-06-27 | Susumu Iwasa | Bispecific monoclonal antibody, its production and use |
US5208020A (en) * | 1989-10-25 | 1993-05-04 | Immunogen Inc. | Cytotoxic agents comprising maytansinoids and their therapeutic use |
US6333410B1 (en) * | 2000-08-18 | 2001-12-25 | Immunogen, Inc. | Process for the preparation and purification of thiol-containing maytansinoids |
US6441163B1 (en) * | 2001-05-31 | 2002-08-27 | Immunogen, Inc. | Methods for preparation of cytotoxic conjugates of maytansinoids and cell binding agents |
-
2002
- 2002-03-11 US US10/095,927 patent/US20020156274A1/en not_active Abandoned
- 2002-03-12 AT AT02726608T patent/ATE305934T1/de not_active IP Right Cessation
- 2002-03-12 JP JP2002573784A patent/JP2004526734A/ja active Pending
- 2002-03-12 DE DE60206477T patent/DE60206477T2/de not_active Expired - Fee Related
- 2002-03-12 EP EP02726608A patent/EP1373273B1/de not_active Expired - Lifetime
- 2002-03-12 WO PCT/US2002/007424 patent/WO2002074775A1/en active IP Right Grant
- 2002-03-12 ES ES02726608T patent/ES2248550T3/es not_active Expired - Lifetime
-
2004
- 2004-11-30 US US11/000,146 patent/US20050113571A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
EP1373273A4 (de) | 2004-07-14 |
EP1373273B1 (de) | 2005-10-05 |
EP1373273A1 (de) | 2004-01-02 |
ES2248550T3 (es) | 2006-03-16 |
US20020156274A1 (en) | 2002-10-24 |
US20050113571A1 (en) | 2005-05-26 |
DE60206477D1 (de) | 2006-02-16 |
WO2002074775A1 (en) | 2002-09-26 |
DE60206477T2 (de) | 2006-06-22 |
JP2004526734A (ja) | 2004-09-02 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |