ATE303380T1 - Oxindolderivate als cdk-1 inhibitoren und deren verwendung in therapie - Google Patents
Oxindolderivate als cdk-1 inhibitoren und deren verwendung in therapieInfo
- Publication number
- ATE303380T1 ATE303380T1 AT02704891T AT02704891T ATE303380T1 AT E303380 T1 ATE303380 T1 AT E303380T1 AT 02704891 T AT02704891 T AT 02704891T AT 02704891 T AT02704891 T AT 02704891T AT E303380 T1 ATE303380 T1 AT E303380T1
- Authority
- AT
- Austria
- Prior art keywords
- compound
- formula
- alkyl
- directed
- cell
- Prior art date
Links
- 101150012716 CDK1 gene Proteins 0.000 title 1
- JYGFTBXVXVMTGB-UHFFFAOYSA-N indolin-2-one Chemical class C1=CC=C2NC(=O)CC2=C1 JYGFTBXVXVMTGB-UHFFFAOYSA-N 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
- 238000002560 therapeutic procedure Methods 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 5
- -1 5-imidazolyl Chemical group 0.000 abstract 3
- 206010028980 Neoplasm Diseases 0.000 abstract 2
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 1
- 125000002941 2-furyl group Chemical group O1C([*])=C([H])C([H])=C1[H] 0.000 abstract 1
- 125000000389 2-pyrrolyl group Chemical group [H]N1C([*])=C([H])C([H])=C1[H] 0.000 abstract 1
- 125000003349 3-pyridyl group Chemical group N1=C([H])C([*])=C([H])C([H])=C1[H] 0.000 abstract 1
- 229910006074 SO2NH2 Inorganic materials 0.000 abstract 1
- 230000006907 apoptotic process Effects 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 230000035755 proliferation Effects 0.000 abstract 1
- 125000004528 pyrimidin-5-yl group Chemical group N1=CN=CC(=C1)* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0102624A FR2821358B1 (fr) | 2001-02-27 | 2001-02-27 | Oxindoles inhibiteurs de cdk-1 et leur application en therapeutique |
| PCT/FR2002/000681 WO2002068411A1 (fr) | 2001-02-27 | 2002-02-25 | Oxindoles inhibiteurs de cdk-1 et leur application en therapeutique |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE303380T1 true ATE303380T1 (de) | 2005-09-15 |
Family
ID=8860477
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT02704891T ATE303380T1 (de) | 2001-02-27 | 2002-02-25 | Oxindolderivate als cdk-1 inhibitoren und deren verwendung in therapie |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US20040110770A1 (de) |
| EP (1) | EP1366038B1 (de) |
| AT (1) | ATE303380T1 (de) |
| DE (1) | DE60205872T2 (de) |
| DK (1) | DK1366038T3 (de) |
| ES (1) | ES2244751T3 (de) |
| FR (1) | FR2821358B1 (de) |
| PT (1) | PT1366038E (de) |
| WO (1) | WO2002068411A1 (de) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX2009008775A (es) * | 2007-02-13 | 2010-03-01 | Schering Corp | Agonistas de adrenorreceptores alfa2c funcionalmente selectivos. |
| DE102008022221A1 (de) * | 2008-05-06 | 2009-11-12 | Universität des Saarlandes | Inhibitoren der humanen Aldosteronsynthase CYP11B2 |
| US8541404B2 (en) * | 2009-11-09 | 2013-09-24 | Elexopharm Gmbh | Inhibitors of the human aldosterone synthase CYP11B2 |
| GB201014374D0 (en) * | 2010-08-27 | 2010-10-13 | Univ Greenwich | Novel hybrid compounds |
| CN102688234B (zh) * | 2011-03-21 | 2015-07-29 | 华东理工大学 | 吲哚酮衍生物作为rsk2抑制剂的合成与应用 |
| WO2016055454A1 (en) * | 2014-10-06 | 2016-04-14 | International Society For Drug Development S.R.L. | Pharmaceutical combination for the treatment of tumors |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5880141A (en) * | 1995-06-07 | 1999-03-09 | Sugen, Inc. | Benzylidene-Z-indoline compounds for the treatment of disease |
| AU4155697A (en) * | 1996-08-23 | 1998-03-06 | Sugen, Inc. | Indolinone combinatorial libraries and related products and methods for the treatment of disease |
| ES2239393T3 (es) * | 1997-05-07 | 2005-09-16 | Sugen, Inc. | Derivados de 2-indolinona utilizados como moduladores de la actividad de la proteina-quinasa. |
| US6316429B1 (en) * | 1997-05-07 | 2001-11-13 | Sugen, Inc. | Bicyclic protein kinase inhibitors |
| US6133305A (en) * | 1997-09-26 | 2000-10-17 | Sugen, Inc. | 3-(substituted)-2-indolinones compounds and use thereof as inhibitors of protein kinase activity |
| ES2194468T3 (es) * | 1998-05-29 | 2003-11-16 | Centre Nat Rech Scient | Uso de derivados del bisindol indigoide para la fabricacion de un medicamento para inhibir quinasas dependientes de ciclinas. |
| US6313310B1 (en) * | 1999-12-15 | 2001-11-06 | Hoffmann-La Roche Inc. | 4-and 5-alkynyloxindoles and 4-and 5-alkenyloxindoles |
-
2001
- 2001-02-27 FR FR0102624A patent/FR2821358B1/fr not_active Expired - Fee Related
-
2002
- 2002-02-25 ES ES02704891T patent/ES2244751T3/es not_active Expired - Lifetime
- 2002-02-25 DE DE60205872T patent/DE60205872T2/de not_active Expired - Fee Related
- 2002-02-25 WO PCT/FR2002/000681 patent/WO2002068411A1/fr not_active Application Discontinuation
- 2002-02-25 PT PT02704891T patent/PT1366038E/pt unknown
- 2002-02-25 EP EP02704891A patent/EP1366038B1/de not_active Expired - Lifetime
- 2002-02-25 DK DK02704891T patent/DK1366038T3/da active
- 2002-02-25 AT AT02704891T patent/ATE303380T1/de not_active IP Right Cessation
-
2003
- 2003-08-20 US US10/644,411 patent/US20040110770A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| DK1366038T3 (da) | 2005-12-19 |
| ES2244751T3 (es) | 2005-12-16 |
| DE60205872D1 (de) | 2005-10-06 |
| EP1366038A1 (de) | 2003-12-03 |
| WO2002068411A1 (fr) | 2002-09-06 |
| US20040110770A1 (en) | 2004-06-10 |
| FR2821358B1 (fr) | 2006-04-07 |
| FR2821358A1 (fr) | 2002-08-30 |
| PT1366038E (pt) | 2005-11-30 |
| EP1366038B1 (de) | 2005-08-31 |
| DE60205872T2 (de) | 2006-06-08 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
Ref document number: 1366038 Country of ref document: EP |
|
| REN | Ceased due to non-payment of the annual fee |