ATE302649T1 - Verfahren zur synthese, reinigung und charakterisierung von kombinatorischen bibliotheken - Google Patents
Verfahren zur synthese, reinigung und charakterisierung von kombinatorischen bibliothekenInfo
- Publication number
- ATE302649T1 ATE302649T1 AT00907620T AT00907620T ATE302649T1 AT E302649 T1 ATE302649 T1 AT E302649T1 AT 00907620 T AT00907620 T AT 00907620T AT 00907620 T AT00907620 T AT 00907620T AT E302649 T1 ATE302649 T1 AT E302649T1
- Authority
- AT
- Austria
- Prior art keywords
- compounds
- tube
- configuration
- optionally
- purifying
- Prior art date
Links
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J19/0046—Sequential or parallel reactions, e.g. for the synthesis of polypeptides or polynucleotides; Apparatus and devices for combinatorial chemistry or for making molecular arrays
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00277—Apparatus
- B01J2219/00279—Features relating to reactor vessels
- B01J2219/00281—Individual reactor vessels
- B01J2219/00283—Reactor vessels with top opening
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00277—Apparatus
- B01J2219/00279—Features relating to reactor vessels
- B01J2219/00306—Reactor vessels in a multiple arrangement
- B01J2219/00308—Reactor vessels in a multiple arrangement interchangeably mounted in racks or blocks
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00277—Apparatus
- B01J2219/00452—Means for the recovery of reactants or products
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00277—Apparatus
- B01J2219/0054—Means for coding or tagging the apparatus or the reagents
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00583—Features relative to the processes being carried out
- B01J2219/00585—Parallel processes
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00583—Features relative to the processes being carried out
- B01J2219/00599—Solution-phase processes
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/0068—Means for controlling the apparatus of the process
- B01J2219/00686—Automatic
- B01J2219/00689—Automatic using computers
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/0068—Means for controlling the apparatus of the process
- B01J2219/00686—Automatic
- B01J2219/00691—Automatic using robots
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/0068—Means for controlling the apparatus of the process
- B01J2219/00693—Means for quality control
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/0068—Means for controlling the apparatus of the process
- B01J2219/00698—Measurement and control of process parameters
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/0068—Means for controlling the apparatus of the process
- B01J2219/00702—Processes involving means for analysing and characterising the products
- B01J2219/00704—Processes involving means for analysing and characterising the products integrated with the reactor apparatus
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/0068—Means for controlling the apparatus of the process
- B01J2219/00702—Processes involving means for analysing and characterising the products
- B01J2219/00707—Processes involving means for analysing and characterising the products separated from the reactor apparatus
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00718—Type of compounds synthesised
- B01J2219/0072—Organic compounds
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00718—Type of compounds synthesised
- B01J2219/0072—Organic compounds
- B01J2219/00722—Nucleotides
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00718—Type of compounds synthesised
- B01J2219/0072—Organic compounds
- B01J2219/00725—Peptides
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00718—Type of compounds synthesised
- B01J2219/00745—Inorganic compounds
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00718—Type of compounds synthesised
- B01J2219/00745—Inorganic compounds
- B01J2219/0075—Metal based compounds
- B01J2219/00754—Metal oxides
-
- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B40/00—Libraries per se, e.g. arrays, mixtures
- C40B40/04—Libraries containing only organic compounds
- C40B40/10—Libraries containing peptides or polypeptides, or derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B40/00—Libraries per se, e.g. arrays, mixtures
- C40B40/04—Libraries containing only organic compounds
- C40B40/14—Libraries containing macromolecular compounds and not covered by groups C40B40/06 - C40B40/12
-
- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B40/00—Libraries per se, e.g. arrays, mixtures
- C40B40/18—Libraries containing only inorganic compounds or inorganic materials
-
- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B50/00—Methods of creating libraries, e.g. combinatorial synthesis
- C40B50/08—Liquid phase synthesis, i.e. wherein all library building blocks are in liquid phase or in solution during library creation; Particular methods of cleavage from the liquid support
-
- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B70/00—Tags or labels specially adapted for combinatorial chemistry or libraries, e.g. fluorescent tags or bar codes
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N2035/00178—Special arrangements of analysers
- G01N2035/00207—Handling bulk quantities of analyte
- G01N2035/00217—Handling bulk quantities of analyte involving measurement of weight
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
- G01N35/028—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations having reaction cells in the form of microtitration plates
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Physical Or Chemical Processes And Apparatus (AREA)
- Detergent Compositions (AREA)
- Solid-Sorbent Or Filter-Aiding Compositions (AREA)
- Catalysts (AREA)
Applications Claiming Priority (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US11961999P | 1999-02-11 | 1999-02-11 | |
US09/248,541 US6500609B1 (en) | 1999-02-11 | 1999-02-11 | Method and apparatus for synthesizing characterizing and assaying combinatorial libraries |
US15637599P | 1999-09-28 | 1999-09-28 | |
US15719199P | 1999-09-30 | 1999-09-30 | |
US15747599P | 1999-10-01 | 1999-10-01 | |
PCT/EP2000/001525 WO2000047540A2 (en) | 1999-02-11 | 2000-02-11 | Method and apparatus for synthesizing, purifying and characterizing combinatorial libraries |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE302649T1 true ATE302649T1 (de) | 2005-09-15 |
Family
ID=27537559
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT00907620T ATE302649T1 (de) | 1999-02-11 | 2000-02-11 | Verfahren zur synthese, reinigung und charakterisierung von kombinatorischen bibliotheken |
Country Status (6)
Country | Link |
---|---|
EP (1) | EP1159063B1 (de) |
JP (1) | JP2002536653A (de) |
AT (1) | ATE302649T1 (de) |
DE (2) | DE60022168T2 (de) |
ES (1) | ES2186594T1 (de) |
WO (1) | WO2000047540A2 (de) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE10117275B4 (de) | 2001-04-06 | 2005-02-24 | Hte Ag The High Throughput Experimentation Company | Vorrichtung zur Archivierung und Analyse von Materialien |
DE10117274B4 (de) * | 2001-04-06 | 2005-03-03 | Hte Ag The High Throughput Experimentation Company | Verfahren zur Analyse und Archivierung von wenigstens einer Materialbibliothek |
CN101051043B (zh) | 2006-12-28 | 2011-11-16 | 深圳迈瑞生物医疗电子股份有限公司 | 生化分析仪用户个性化操作的实现方法和装置 |
US8314934B2 (en) | 2009-09-01 | 2012-11-20 | Alltech Associates, Inc. | Methods and apparatus for analyzing samples and collecting sample fractions |
EP3192583A1 (de) * | 2016-01-12 | 2017-07-19 | ETH Zurich | Vorrichtung und verfahren zur automatisierten chemischen synthese von verbindungen |
CN114002244A (zh) * | 2019-08-12 | 2022-02-01 | 山东第一医科大学附属肿瘤医院(山东省肿瘤防治研究院、山东省肿瘤医院) | 一种评价影像组学纹理特征稳定性的运动模块 |
WO2022209075A1 (ja) * | 2021-03-30 | 2022-10-06 | 株式会社島津製作所 | 分析システム及び分析システム用プログラム |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5324483B1 (en) * | 1992-10-08 | 1996-09-24 | Warner Lambert Co | Apparatus for multiple simultaneous synthesis |
US5716584A (en) * | 1995-09-07 | 1998-02-10 | Pathogenesis Corporation | Device for the synthesis of compounds in an array |
JPH11511381A (ja) * | 1995-09-22 | 1999-10-05 | バーレックス ラボラトリーズ,インコーポレイティド | 多重化学反応用装置および方法 |
WO1997045443A2 (en) * | 1996-05-10 | 1997-12-04 | Alanex Corp | Simultaneous chemical reaction apparatus |
WO1998015825A2 (en) * | 1996-10-07 | 1998-04-16 | Irori | Matrices with memories in automated drug discovery and units therefor |
US6673316B1 (en) * | 1996-10-30 | 2004-01-06 | Sumitomo Chemical Co., Ltd. | Synthesis experiment automating system, liquid separating treating apparatus and reaction vessel |
JP3338961B2 (ja) * | 1996-11-18 | 2002-10-28 | ロビンズ サイエンティフィック コーポレイション | 多ウエル式マイクロスケール合成のための装置 |
US6126904A (en) * | 1997-03-07 | 2000-10-03 | Argonaut Technologies, Inc. | Apparatus and methods for the preparation of chemical compounds |
JP2002504018A (ja) * | 1997-06-16 | 2002-02-05 | ケムスピード・リミテッド | 並行して複数の化学的、生化学的または物理的プロセスを行うデバイス |
CA2294941A1 (en) * | 1997-06-16 | 1998-12-23 | Chemspeed Ltd. | Reaction vessel holding device |
-
2000
- 2000-02-11 WO PCT/EP2000/001525 patent/WO2000047540A2/en active IP Right Grant
- 2000-02-11 DE DE60022168T patent/DE60022168T2/de not_active Expired - Lifetime
- 2000-02-11 AT AT00907620T patent/ATE302649T1/de not_active IP Right Cessation
- 2000-02-11 DE DE1159063T patent/DE1159063T1/de active Pending
- 2000-02-11 EP EP00907620A patent/EP1159063B1/de not_active Expired - Lifetime
- 2000-02-11 ES ES00907620T patent/ES2186594T1/es active Pending
- 2000-02-11 JP JP2000598462A patent/JP2002536653A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
DE60022168D1 (de) | 2005-09-29 |
EP1159063B1 (de) | 2005-08-24 |
JP2002536653A (ja) | 2002-10-29 |
WO2000047540A9 (en) | 2001-11-15 |
EP1159063A2 (de) | 2001-12-05 |
DE60022168T2 (de) | 2006-05-18 |
DE1159063T1 (de) | 2003-05-28 |
ES2186594T1 (es) | 2003-05-16 |
WO2000047540A3 (en) | 2001-04-12 |
WO2000047540A2 (en) | 2000-08-17 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ATE234149T1 (de) | Vorrichtung und verfahren zur trennung von flüssigen und festen phasen in organischen festphasensynthesen | |
WO2005026686A3 (en) | Multiplexed analytical platform | |
DK1068216T3 (da) | Bibliotek af oligomerer, der er mærket med forskellige markører | |
WO2002014838A8 (en) | Microarray detector and synthesizer | |
DE69330608D1 (de) | Positionelle sequenzierung durch hybridisierung | |
ATE265686T1 (de) | Molekularanalysator und verfahren zu seiner verwendung | |
FI971473A0 (fi) | Molekyylien merkintäjärjestelmä | |
DE69701612T2 (de) | Verfahren und zusammensetzungen zum analysieren von nukleinsäuremolekulen mittels bemessungstechniken | |
NO913000D0 (no) | Analyseelement og fremgangsmaate for fremstilling av dette. | |
ATE302649T1 (de) | Verfahren zur synthese, reinigung und charakterisierung von kombinatorischen bibliotheken | |
DK0729517T3 (da) | Fremgangsmåde til opnåelse af diagnostiske reagenser, assays og terapeutiske midler baseret på kliniske udtryk af en sygdom | |
EA200300475A1 (ru) | Способ работы компьютерной системы для осуществления дискретного субструктурного анализа | |
US6500609B1 (en) | Method and apparatus for synthesizing characterizing and assaying combinatorial libraries | |
WO2003019192A1 (en) | Apparatus, composition and method for proteome profiling | |
HUP0003261A2 (hu) | Több funkció- vagy mátrixelemen belül, továbbá ezek alkalmazásai | |
Fauchère et al. | Combinatorial chemistry for the generation of molecular diversity and the discovery of bioactive leads | |
Coates et al. | Successful implementation of automation in medicinal chemistry | |
JP2004174331A (ja) | 化合物の自動合成および評価システム | |
Park et al. | Improved loading and cleavage methods for solid-phase synthesis using chlorotrityl resins: synthesis and testing of a library of 144 discrete chemicals as potential farnesyltransferase inhibitors | |
Isbell et al. | Purifying the masses: integrating prepurification quality control, high-throughput LC/MS purification, and compound plating to feed high-throughput screening | |
JPH11500419A (ja) | 分類された大量の化学ライブラリの製造方法 | |
US20020081587A1 (en) | Biological microbalance array module chip | |
Saluz et al. | Fundamentals of DNA-chip/array technology for comparative gene-expression analysis | |
WO2002008155A2 (en) | Chemical constructs for solution phase chemistry | |
Uehling | New Software for HTS. |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |