ATE299136T1 - Verfahren zur asymmetrischen hydrierung von hexahydrochinolinsalzen - Google Patents
Verfahren zur asymmetrischen hydrierung von hexahydrochinolinsalzenInfo
- Publication number
- ATE299136T1 ATE299136T1 AT03744359T AT03744359T ATE299136T1 AT E299136 T1 ATE299136 T1 AT E299136T1 AT 03744359 T AT03744359 T AT 03744359T AT 03744359 T AT03744359 T AT 03744359T AT E299136 T1 ATE299136 T1 AT E299136T1
- Authority
- AT
- Austria
- Prior art keywords
- salts
- methoxybenzyl
- hexahydrochinoline
- asymmetric hydrogenation
- hexahydroisoquinolinium
- Prior art date
Links
- JCWLOGAMQQPDKR-UHFFFAOYSA-N 1,2,3,4,4a,5-hexahydroquinoline Chemical class C1=CCC2CCCNC2=C1 JCWLOGAMQQPDKR-UHFFFAOYSA-N 0.000 title 1
- 238000009876 asymmetric hydrogenation reaction Methods 0.000 title 1
- 238000000034 method Methods 0.000 title 1
- 150000003839 salts Chemical class 0.000 abstract 2
- IYZRINJHKVQAQC-UHFFFAOYSA-N 1-[(4-methoxyphenyl)methyl]-3,4,5,6,7,8-hexahydroisoquinoline Chemical class C1=CC(OC)=CC=C1CC1=NCCC2=C1CCCC2 IYZRINJHKVQAQC-UHFFFAOYSA-N 0.000 abstract 1
- AOBQMWZNCPVXEM-UHFFFAOYSA-N 3,4,5,6,7,8-hexahydroisoquinoline Chemical compound C1CN=CC2=C1CCCC2 AOBQMWZNCPVXEM-UHFFFAOYSA-N 0.000 abstract 1
- MKXZASYAUGDDCJ-SZMVWBNQSA-N LSM-2525 Chemical compound C1CCC[C@H]2[C@@]3([H])N(C)CC[C@]21C1=CC(OC)=CC=C1C3 MKXZASYAUGDDCJ-SZMVWBNQSA-N 0.000 abstract 1
- 239000003434 antitussive agent Substances 0.000 abstract 1
- 229940124584 antitussives Drugs 0.000 abstract 1
- 239000003054 catalyst Substances 0.000 abstract 1
- 229960001985 dextromethorphan Drugs 0.000 abstract 1
- 238000005984 hydrogenation reaction Methods 0.000 abstract 1
- 239000013067 intermediate product Substances 0.000 abstract 1
- 229910052741 iridium Inorganic materials 0.000 abstract 1
- GKOZUEZYRPOHIO-UHFFFAOYSA-N iridium atom Chemical compound [Ir] GKOZUEZYRPOHIO-UHFFFAOYSA-N 0.000 abstract 1
- 239000003446 ligand Substances 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 230000003287 optical effect Effects 0.000 abstract 1
- 229910052703 rhodium Inorganic materials 0.000 abstract 1
- 239000010948 rhodium Substances 0.000 abstract 1
- MHOVAHRLVXNVSD-UHFFFAOYSA-N rhodium atom Chemical compound [Rh] MHOVAHRLVXNVSD-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
- C07D217/18—Aralkyl radicals
- C07D217/20—Aralkyl radicals with oxygen atoms directly attached to the aromatic ring of said aralkyl radical, e.g. papaverine
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Catalysts (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP02006124 | 2002-03-19 | ||
| PCT/EP2003/002610 WO2003078399A1 (en) | 2002-03-19 | 2003-03-13 | Process for asymmetric hydrogenation of hexahydroquinoline salts |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE299136T1 true ATE299136T1 (de) | 2005-07-15 |
Family
ID=27838017
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT03744359T ATE299136T1 (de) | 2002-03-19 | 2003-03-13 | Verfahren zur asymmetrischen hydrierung von hexahydrochinolinsalzen |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US20050148776A1 (de) |
| EP (1) | EP1485357B1 (de) |
| JP (1) | JP2005527527A (de) |
| CN (1) | CN1639127A (de) |
| AT (1) | ATE299136T1 (de) |
| AU (1) | AU2003227057A1 (de) |
| CA (1) | CA2478275A1 (de) |
| DE (1) | DE60300985D1 (de) |
| TW (1) | TW200305569A (de) |
| WO (1) | WO2003078399A1 (de) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7629470B2 (en) | 2004-07-08 | 2009-12-08 | Merck & Co., Inc. | Formation of tetra-substituted enamides and stereoselective reduction thereof |
| CN111333573B (zh) * | 2020-04-10 | 2021-09-28 | 浙江工业大学 | 一种右美沙芬中间体的制备工艺 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH11508903A (ja) * | 1995-07-11 | 1999-08-03 | ロンザ アーゲー | 光学活性１−（ｐ−メトキシベンジル）−１，２，３，４，５，６，７，８−オクタヒドロイソキノリンの製造方法 |
| US5880285A (en) * | 1996-12-23 | 1999-03-09 | Roche Vitamins Inc. | Process for manufacture of optically active isochinole compounds |
-
2003
- 2003-03-13 WO PCT/EP2003/002610 patent/WO2003078399A1/en not_active Ceased
- 2003-03-13 AU AU2003227057A patent/AU2003227057A1/en not_active Abandoned
- 2003-03-13 CN CN03804515.XA patent/CN1639127A/zh active Pending
- 2003-03-13 AT AT03744359T patent/ATE299136T1/de not_active IP Right Cessation
- 2003-03-13 CA CA002478275A patent/CA2478275A1/en not_active Abandoned
- 2003-03-13 US US10/507,940 patent/US20050148776A1/en not_active Abandoned
- 2003-03-13 DE DE60300985T patent/DE60300985D1/de not_active Expired - Lifetime
- 2003-03-13 EP EP03744359A patent/EP1485357B1/de not_active Expired - Lifetime
- 2003-03-13 JP JP2003576405A patent/JP2005527527A/ja not_active Withdrawn
- 2003-03-14 TW TW092105623A patent/TW200305569A/zh unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP1485357B1 (de) | 2005-07-06 |
| EP1485357A1 (de) | 2004-12-15 |
| CN1639127A (zh) | 2005-07-13 |
| DE60300985D1 (de) | 2005-08-11 |
| AU2003227057A1 (en) | 2003-09-29 |
| JP2005527527A (ja) | 2005-09-15 |
| CA2478275A1 (en) | 2003-09-25 |
| TW200305569A (en) | 2003-11-01 |
| US20050148776A1 (en) | 2005-07-07 |
| WO2003078399A1 (en) | 2003-09-25 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |