ATE414700T1 - Verfahren zur herstellung von 6-ä(4,5-dihydro-1h- imidazol-2-yl)amino-ü-7-methyl-1h-benzimidazol- - carbonitrile und dessen bevorzugte salzform - Google Patents
Verfahren zur herstellung von 6-ä(4,5-dihydro-1h- imidazol-2-yl)amino-ü-7-methyl-1h-benzimidazol- - carbonitrile und dessen bevorzugte salzformInfo
- Publication number
- ATE414700T1 ATE414700T1 AT04713336T AT04713336T ATE414700T1 AT E414700 T1 ATE414700 T1 AT E414700T1 AT 04713336 T AT04713336 T AT 04713336T AT 04713336 T AT04713336 T AT 04713336T AT E414700 T1 ATE414700 T1 AT E414700T1
- Authority
- AT
- Austria
- Prior art keywords
- carbonitriles
- imidazol
- benzimidazole
- dihydro
- amino
- Prior art date
Links
- 238000004519 manufacturing process Methods 0.000 title abstract 2
- -1 4,5-DIHYDRO-1H-IMIDAZOL-2-YL Chemical class 0.000 title 1
- 150000003839 salts Chemical group 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 4
- CWYNVVGOOAEACU-UHFFFAOYSA-N Fe2+ Chemical compound [Fe+2] CWYNVVGOOAEACU-UHFFFAOYSA-N 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 239000003054 catalyst Substances 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 239000000852 hydrogen donor Substances 0.000 abstract 1
- 238000005984 hydrogenation reaction Methods 0.000 abstract 1
- 239000002184 metal Substances 0.000 abstract 1
- 238000007363 ring formation reaction Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US44881103P | 2003-02-20 | 2003-02-20 | |
| US10/386,958 US20040167194A1 (en) | 2003-02-20 | 2003-03-12 | Methods of making 6-[(4,5-Dihydro-1H-imidazol-2-yl)amino-]-7-methyl-1H-benzimidazole-4-carbonitrile and its preferred salt form |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE414700T1 true ATE414700T1 (de) | 2008-12-15 |
Family
ID=32871636
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT04713336T ATE414700T1 (de) | 2003-02-20 | 2004-02-20 | Verfahren zur herstellung von 6-ä(4,5-dihydro-1h- imidazol-2-yl)amino-ü-7-methyl-1h-benzimidazol- - carbonitrile und dessen bevorzugte salzform |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US20040167194A1 (de) |
| EP (2) | EP1953146B1 (de) |
| AT (1) | ATE414700T1 (de) |
| AU (1) | AU2004213458B2 (de) |
| CA (1) | CA2517002C (de) |
| CY (1) | CY1108809T1 (de) |
| DE (1) | DE602004017838D1 (de) |
| ES (2) | ES2482167T3 (de) |
| WO (1) | WO2004074279A1 (de) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7456219B2 (en) * | 2002-03-04 | 2008-11-25 | Merck Hdac Research, Llc | Polymorphs of suberoylanilide hydroxamic acid |
| KR101053816B1 (ko) * | 2003-02-20 | 2011-08-03 | 론자 아게 | Ｎ-치환된 포름아미드의 제조 방법 |
| CA2649660A1 (en) * | 2006-05-10 | 2007-11-22 | Teva Pharmaceutical Industries Ltd. | Methods for reducing 7/9-nitrotetracycline derivatives |
| WO2010084067A2 (en) | 2009-01-22 | 2010-07-29 | Syngenta Participations Ag | Insecticidal compounds |
| CN102120731B (zh) * | 2010-01-09 | 2015-01-07 | 浙江华海药业股份有限公司 | 一种制备4-(3-氯-4-氟苯基胺基)-7-甲氧基-6-(3-吗啉丙氧基)喹唑啉的新方法 |
| US20150133516A1 (en) * | 2013-11-13 | 2015-05-14 | Brian K. Adams | Methods and Compositions for Treating ADHD |
| CN105418519B (zh) * | 2015-11-25 | 2018-10-02 | 高小春 | 具有抗肿瘤活性的吩嗪酰胺类化合物的合成及其应用 |
| WO2018228984A1 (en) * | 2017-06-14 | 2018-12-20 | Bayer Aktiengesellschaft | Process for preparing 3,4-dichloro-n-(2-cyanophenyl)-5-isothiazolecarboxamide |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5478858A (en) * | 1993-12-17 | 1995-12-26 | The Procter & Gamble Company | 5-(2-imidazolinylamino) benzimidazole compounds useful as alpha-2 adrenoceptor agonists |
| DE4422370A1 (de) | 1994-06-27 | 1996-01-04 | Nsm Ag | System zum bargeldlosen Spielen an geldbetätigten Unterhaltungsautomaten |
| EP0775134A4 (de) * | 1994-08-04 | 1997-08-13 | Synaptic Pharma Corp | Neue benzimidazolderivate |
| CZ183599A3 (cs) | 1996-11-25 | 1999-10-13 | The Procter & Gamble Company | Způsob přípravy derivátů 2-amino-2-imidazolinu guanidinu a 2-amino-3,4,5,6-tetrahydropyrimidinu |
| ID24081A (id) * | 1997-04-15 | 2000-07-06 | Procter & Gamble | Senyawa-senyawa 5-(2-imidazolinilamino) benzimidazol yang berguna sebagai agonis-agonis alfa-2-adrenoseptor |
| SK7792000A3 (en) | 1997-11-24 | 2001-01-18 | Procter & Gamble | 5-(2-imidazolinylamino)-benzimidazole derivatives, their preparation and their use as alpha-adrenoceptor agonists with improved metabolic stability |
| US6066740A (en) * | 1997-11-25 | 2000-05-23 | The Procter & Gamble Company | Process for making 2-amino-2-imidazoline, guanidine and 2-amino-3,4,5,6-tetrahydropyrimidine derivatives |
-
2003
- 2003-03-12 US US10/386,958 patent/US20040167194A1/en not_active Abandoned
-
2004
- 2004-02-20 ES ES08008259.7T patent/ES2482167T3/es not_active Expired - Lifetime
- 2004-02-20 EP EP08008259.7A patent/EP1953146B1/de not_active Expired - Lifetime
- 2004-02-20 ES ES04713336T patent/ES2318272T3/es not_active Expired - Lifetime
- 2004-02-20 CA CA2517002A patent/CA2517002C/en not_active Expired - Fee Related
- 2004-02-20 WO PCT/US2004/005084 patent/WO2004074279A1/en not_active Ceased
- 2004-02-20 DE DE602004017838T patent/DE602004017838D1/de not_active Expired - Lifetime
- 2004-02-20 AU AU2004213458A patent/AU2004213458B2/en not_active Ceased
- 2004-02-20 EP EP04713336A patent/EP1594862B1/de not_active Expired - Lifetime
- 2004-02-20 AT AT04713336T patent/ATE414700T1/de active
-
2006
- 2006-01-17 US US11/332,998 patent/US7304084B2/en not_active Expired - Fee Related
-
2009
- 2009-02-18 CY CY20091100189T patent/CY1108809T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP1594862A1 (de) | 2005-11-16 |
| US7304084B2 (en) | 2007-12-04 |
| ES2318272T3 (es) | 2009-05-01 |
| CY1108809T1 (el) | 2014-04-09 |
| US20040167194A1 (en) | 2004-08-26 |
| AU2004213458A1 (en) | 2004-09-02 |
| CA2517002C (en) | 2014-07-08 |
| DE602004017838D1 (de) | 2009-01-02 |
| CA2517002A1 (en) | 2004-09-02 |
| AU2004213458B2 (en) | 2010-03-04 |
| ES2482167T3 (es) | 2014-08-01 |
| EP1594862B1 (de) | 2008-11-19 |
| EP1953146B1 (de) | 2014-04-30 |
| AU2010201757A1 (en) | 2010-05-20 |
| US20060122248A1 (en) | 2006-06-08 |
| WO2004074279A1 (en) | 2004-09-02 |
| EP1953146A1 (de) | 2008-08-06 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
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