ATE298585T1 - Verwendung von fibrinolytischen metallproteinasen zur behandlung von blutgerinseln - Google Patents
Verwendung von fibrinolytischen metallproteinasen zur behandlung von blutgerinselnInfo
- Publication number
- ATE298585T1 ATE298585T1 AT00988099T AT00988099T ATE298585T1 AT E298585 T1 ATE298585 T1 AT E298585T1 AT 00988099 T AT00988099 T AT 00988099T AT 00988099 T AT00988099 T AT 00988099T AT E298585 T1 ATE298585 T1 AT E298585T1
- Authority
- AT
- Austria
- Prior art keywords
- fibrinolytic
- metalproteinases
- blood clots
- treat blood
- treat
- Prior art date
Links
- 208000007536 Thrombosis Diseases 0.000 title abstract 2
- 239000003527 fibrinolytic agent Substances 0.000 title 1
- 230000003480 fibrinolytic effect Effects 0.000 title 1
- 101000774685 Agkistrodon contortrix contortrix Snake venom metalloproteinase fibrolase Proteins 0.000 abstract 1
- 101000851165 Bothrops pirajai Snake venom metalloproteinase BpirMP Proteins 0.000 abstract 1
- 102000009123 Fibrin Human genes 0.000 abstract 1
- 108010073385 Fibrin Proteins 0.000 abstract 1
- BWGVNKXGVNDBDI-UHFFFAOYSA-N Fibrin monomer Chemical compound CNC(=O)CNC(=O)CN BWGVNKXGVNDBDI-UHFFFAOYSA-N 0.000 abstract 1
- 239000008280 blood Substances 0.000 abstract 1
- 210000004369 blood Anatomy 0.000 abstract 1
- 229950003499 fibrin Drugs 0.000 abstract 1
- 230000003472 neutralizing effect Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
- A61K38/4886—Metalloendopeptidases (3.4.24), e.g. collagenase
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Epidemiology (AREA)
- Vascular Medicine (AREA)
- Diabetes (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Enzymes And Modification Thereof (AREA)
- Medicinal Preparation (AREA)
- Chemical Or Physical Treatment Of Fibers (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/466,276 US6455269B1 (en) | 1999-12-17 | 1999-12-17 | Method for localized administration of fibrinolytic metalloproteinases |
| PCT/US2000/034143 WO2001043765A2 (en) | 1999-12-17 | 2000-12-15 | Method for localized administration of fibrinolytic metalloproteinases |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE298585T1 true ATE298585T1 (de) | 2005-07-15 |
Family
ID=23851165
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT00988099T ATE298585T1 (de) | 1999-12-17 | 2000-12-15 | Verwendung von fibrinolytischen metallproteinasen zur behandlung von blutgerinseln |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US6455269B1 (enExample) |
| EP (2) | EP1239873B1 (enExample) |
| JP (1) | JP2003517020A (enExample) |
| AT (1) | ATE298585T1 (enExample) |
| AU (1) | AU784252B2 (enExample) |
| CA (1) | CA2394613A1 (enExample) |
| DE (1) | DE60021111T2 (enExample) |
| DK (1) | DK1239873T3 (enExample) |
| ES (1) | ES2242655T3 (enExample) |
| HK (1) | HK1050845B (enExample) |
| MX (1) | MXPA02006024A (enExample) |
| PT (1) | PT1239873E (enExample) |
| SG (1) | SG172474A1 (enExample) |
| WO (1) | WO2001043765A2 (enExample) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6440414B1 (en) * | 1999-10-01 | 2002-08-27 | Amgen Inc. | Pharmaceutical compositions of fibrinolytic agent |
| US6261820B1 (en) * | 1999-10-01 | 2001-07-17 | Amgen Inc. | Fibronolytically active polypeptide |
| US6455269B1 (en) * | 1999-12-17 | 2002-09-24 | Amgen, Inc. | Method for localized administration of fibrinolytic metalloproteinases |
| US7033776B2 (en) * | 1999-12-17 | 2006-04-25 | Amgen Inc. | Method for treatment of indwelling catheter occlusion using fibrinolytic metalloproteinases |
| US20090254062A1 (en) * | 2008-04-03 | 2009-10-08 | Mcglothlin Mark W | Infusion catheters with slit valves and of simplified construction |
| US9414752B2 (en) | 2012-11-09 | 2016-08-16 | Elwha Llc | Embolism deflector |
| US20140328892A1 (en) * | 2013-04-04 | 2014-11-06 | Jullia Y. Lee | Use of alfimeprase in the treatment of thrombosis |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4447236A (en) | 1982-02-05 | 1984-05-08 | Cordis Corporation | Infusion catheter system |
| US4610879A (en) * | 1984-01-06 | 1986-09-09 | University Of Southern California | Fibrinolytic enzyme from snake vernom |
| US5000185A (en) | 1986-02-28 | 1991-03-19 | Cardiovascular Imaging Systems, Inc. | Method for intravascular two-dimensional ultrasonography and recanalization |
| ZA889415B (en) | 1987-12-18 | 1989-09-27 | Chiron Corp | Compositions and method for recombinant production of crotalidus venum fibrolase |
| WO1990007352A1 (en) | 1989-01-04 | 1990-07-12 | Boston Scientific Corporation | Angioplasty catheter |
| US5709676A (en) | 1990-02-14 | 1998-01-20 | Alt; Eckhard | Synergistic treatment of stenosed blood vessels using shock waves and dissolving medication |
| US5260060A (en) * | 1991-08-09 | 1993-11-09 | University Of Southern California | Fibrinolytic enzymes |
| US5626564A (en) | 1995-03-31 | 1997-05-06 | Creighton University | Adjustable sideholes catheter |
| US6020181A (en) * | 1995-05-17 | 2000-02-01 | New York Blood, Inc. | Inhibition of thrombus formation by medical related apparatus comprising treating with fibrinolytic matrix metalloproteinase |
| US5830468A (en) | 1995-05-17 | 1998-11-03 | The New York Blood Center, Inc. | Fibrin(ogen) degradation by fibrinolytic matrix metalloproteinase |
| US5741779A (en) * | 1996-05-10 | 1998-04-21 | Xoma Corporation | Antithrombotic materials and methods |
| US5951981A (en) * | 1996-12-02 | 1999-09-14 | Diatide, Inc. | Thrombolytic agents with antithrombotic activity |
| US6440414B1 (en) | 1999-10-01 | 2002-08-27 | Amgen Inc. | Pharmaceutical compositions of fibrinolytic agent |
| US6261820B1 (en) | 1999-10-01 | 2001-07-17 | Amgen Inc. | Fibronolytically active polypeptide |
| US6455269B1 (en) * | 1999-12-17 | 2002-09-24 | Amgen, Inc. | Method for localized administration of fibrinolytic metalloproteinases |
-
1999
- 1999-12-17 US US09/466,276 patent/US6455269B1/en not_active Expired - Fee Related
-
2000
- 2000-12-15 EP EP00988099A patent/EP1239873B1/en not_active Expired - Lifetime
- 2000-12-15 DK DK00988099T patent/DK1239873T3/da active
- 2000-12-15 PT PT00988099T patent/PT1239873E/pt unknown
- 2000-12-15 AT AT00988099T patent/ATE298585T1/de not_active IP Right Cessation
- 2000-12-15 CA CA002394613A patent/CA2394613A1/en not_active Abandoned
- 2000-12-15 EP EP05013933A patent/EP1645282A1/en not_active Withdrawn
- 2000-12-15 AU AU24346/01A patent/AU784252B2/en not_active Ceased
- 2000-12-15 ES ES00988099T patent/ES2242655T3/es not_active Expired - Lifetime
- 2000-12-15 JP JP2001544901A patent/JP2003517020A/ja not_active Withdrawn
- 2000-12-15 WO PCT/US2000/034143 patent/WO2001043765A2/en not_active Ceased
- 2000-12-15 DE DE60021111T patent/DE60021111T2/de not_active Expired - Fee Related
- 2000-12-15 MX MXPA02006024A patent/MXPA02006024A/es active IP Right Grant
- 2000-12-15 HK HK03101990.5A patent/HK1050845B/en not_active IP Right Cessation
-
2003
- 2003-06-23 SG SG2006088561A patent/SG172474A1/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ES2242655T3 (es) | 2005-11-16 |
| AU784252B2 (en) | 2006-03-02 |
| EP1645282A1 (en) | 2006-04-12 |
| US6455269B1 (en) | 2002-09-24 |
| WO2001043765A2 (en) | 2001-06-21 |
| CA2394613A1 (en) | 2001-06-21 |
| AU2434601A (en) | 2001-06-25 |
| WO2001043765A3 (en) | 2002-01-17 |
| PT1239873E (pt) | 2005-10-31 |
| DE60021111D1 (de) | 2005-08-04 |
| EP1239873B1 (en) | 2005-06-29 |
| JP2003517020A (ja) | 2003-05-20 |
| HK1050845B (en) | 2005-11-04 |
| DK1239873T3 (da) | 2005-08-29 |
| EP1239873A2 (en) | 2002-09-18 |
| SG172474A1 (en) | 2011-07-28 |
| MXPA02006024A (es) | 2002-12-05 |
| DE60021111T2 (de) | 2006-05-11 |
| HK1050845A1 (en) | 2003-07-11 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
Ref document number: 1239873 Country of ref document: EP |
|
| REN | Ceased due to non-payment of the annual fee |