ATE297393T1 - Carbamoyltetrahydropyridin-derivate - Google Patents
Carbamoyltetrahydropyridin-derivateInfo
- Publication number
- ATE297393T1 ATE297393T1 AT00907999T AT00907999T ATE297393T1 AT E297393 T1 ATE297393 T1 AT E297393T1 AT 00907999 T AT00907999 T AT 00907999T AT 00907999 T AT00907999 T AT 00907999T AT E297393 T1 ATE297393 T1 AT E297393T1
- Authority
- AT
- Austria
- Prior art keywords
- group
- atom
- derivatives
- alkyl group
- carbamoyltetrahydropyridine
- Prior art date
Links
- KTXSODKVFJNBQU-UHFFFAOYSA-N 3,4-dihydro-2h-pyridine-1-carboxamide Chemical class NC(=O)N1CCCC=C1 KTXSODKVFJNBQU-UHFFFAOYSA-N 0.000 title abstract 2
- 125000006527 (C1-C5) alkyl group Chemical group 0.000 abstract 3
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- 150000004944 pyrrolopyrimidines Chemical class 0.000 abstract 2
- ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical group [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 abstract 1
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical group [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000004414 alkyl thio group Chemical group 0.000 abstract 1
- 229910052801 chlorine Inorganic materials 0.000 abstract 1
- 125000001309 chloro group Chemical group Cl* 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 229910052740 iodine Inorganic materials 0.000 abstract 1
- 125000000876 trifluoromethoxy group Chemical group FC(F)(F)O* 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/10—Antioedematous agents; Diuretics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Epidemiology (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Immunology (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Hospice & Palliative Care (AREA)
- Psychology (AREA)
- Vascular Medicine (AREA)
- Rheumatology (AREA)
- Addiction (AREA)
- Dermatology (AREA)
- Diabetes (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Hydrogenated Pyridines (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP6500499 | 1999-03-11 | ||
| JP18562899 | 1999-06-30 | ||
| JP25835399 | 1999-09-13 | ||
| PCT/JP2000/001468 WO2000053604A1 (fr) | 1999-03-11 | 2000-03-10 | Derives de carbamoyl tetrahydropyridine |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE297393T1 true ATE297393T1 (de) | 2005-06-15 |
Family
ID=27298632
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT00907999T ATE297393T1 (de) | 1999-03-11 | 2000-03-10 | Carbamoyltetrahydropyridin-derivate |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US6600038B1 (de) |
| EP (2) | EP1176146B1 (de) |
| KR (1) | KR20010102544A (de) |
| CN (1) | CN1174984C (de) |
| AT (1) | ATE297393T1 (de) |
| AU (1) | AU756702B2 (de) |
| CA (1) | CA2366642A1 (de) |
| DE (1) | DE60020692T2 (de) |
| ES (1) | ES2239592T3 (de) |
| HK (1) | HK1046683A1 (de) |
| WO (1) | WO2000053604A1 (de) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AR028782A1 (es) * | 2000-07-05 | 2003-05-21 | Taisho Pharmaceutical Co Ltd | Derivados heterociclicos tetrahidropiridino o piperidino |
| CA2507763A1 (en) * | 2002-12-04 | 2004-06-17 | Eisai Co., Ltd. | Fused 1,3-dihydro-imidazole ring compounds |
| TWI270549B (en) | 2002-12-26 | 2007-01-11 | Taisho Pharmaceutical Co Ltd | Pyrrolopyrimidine and pyrrolopyridine derivatives substituted with cyclic amino group |
| US7030145B2 (en) | 2003-04-18 | 2006-04-18 | Bristol-Myers Squibb Company | Pyridinyl derivatives for the treatment of depression |
| US7112585B2 (en) | 2003-04-18 | 2006-09-26 | Bristol-Myers Squibb Company | Pyrimidine derivatives as corticotropin releasing factor inhibitors |
| CA2552598A1 (en) * | 2004-01-06 | 2005-07-21 | Taisho Pharmaceutical Co., Ltd. | Thienopyrimidine and thienopyridine derivatives substituted with cyclic amino group |
| WO2005066142A2 (en) * | 2004-01-06 | 2005-07-21 | Taisho Pharmaceutical Co., Ltd. | Pyrrolopyrimidine and pyrrolotriazine derivatives as crf receptor antagonists |
| ES2282986T3 (es) | 2004-01-06 | 2007-10-16 | Taisho Pharmaceutical Co., Ltd | Derivados de triaza-ciclopenta(cd)indeno. |
| EP1725562A1 (de) * | 2004-03-05 | 2006-11-29 | Taisho Pharmaceutical Co., Ltd | Pyrrolopyrimidinderivate |
| JP2007161585A (ja) | 2004-06-25 | 2007-06-28 | Taisho Pharmaceut Co Ltd | 環状アミノ基で置換されているピロロピリミジン及びピロロピリジン誘導体 |
| RU2007102683A (ru) * | 2004-06-25 | 2008-07-27 | Тайсо Фармасьютикал Ко., Лтд. (Jp) | Производные пирролпиримидина и пирролпиридина, замещенные тетрагидропиридином, в качестве антагонистов crf |
| EP1814885A4 (de) * | 2004-11-23 | 2009-12-16 | Us Therapeutics Inc Reddy | Neue bicyclische heterocyclische verbindungen, verfahren zu ihrer herstellung und zusammensetzungen damit |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2818676A1 (de) * | 1978-04-27 | 1979-11-08 | Troponwerke Gmbh & Co Kg | Substituierte 5,6-dimethylpyrrolo 2,3-d pyrimidine, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel |
| US6765008B1 (en) | 1992-12-17 | 2004-07-20 | Pfizer Inc | Pyrrolopyrimidines as CRF antagonists |
| EP0976745B1 (de) | 1997-03-26 | 2003-08-13 | Taisho Pharmaceutical Co., Ltd | 4-tetrahydropyridylpyrimidin-derivate |
| JPH11335376A (ja) * | 1998-05-25 | 1999-12-07 | Taisho Pharmaceut Co Ltd | アリールテトラヒドロピリジン誘導体 |
| JP2000086663A (ja) | 1998-09-09 | 2000-03-28 | Taisho Pharmaceut Co Ltd | アリールテトラヒドロピリジン誘導体 |
-
2000
- 2000-03-10 AT AT00907999T patent/ATE297393T1/de not_active IP Right Cessation
- 2000-03-10 KR KR1020017011455A patent/KR20010102544A/ko not_active Application Discontinuation
- 2000-03-10 EP EP00907999A patent/EP1176146B1/de not_active Expired - Lifetime
- 2000-03-10 CN CNB008074542A patent/CN1174984C/zh not_active Expired - Fee Related
- 2000-03-10 US US09/914,534 patent/US6600038B1/en not_active Expired - Fee Related
- 2000-03-10 EP EP04005593A patent/EP1449843A1/de not_active Withdrawn
- 2000-03-10 ES ES00907999T patent/ES2239592T3/es not_active Expired - Lifetime
- 2000-03-10 WO PCT/JP2000/001468 patent/WO2000053604A1/ja not_active Application Discontinuation
- 2000-03-10 CA CA002366642A patent/CA2366642A1/en not_active Abandoned
- 2000-03-10 DE DE60020692T patent/DE60020692T2/de not_active Expired - Fee Related
- 2000-03-10 AU AU29414/00A patent/AU756702B2/en not_active Ceased
-
2002
- 2002-11-13 HK HK02108223A patent/HK1046683A1/xx not_active IP Right Cessation
-
2003
- 2003-01-21 US US10/347,288 patent/US6894168B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| ES2239592T3 (es) | 2005-10-01 |
| US20030191122A1 (en) | 2003-10-09 |
| EP1449843A1 (de) | 2004-08-25 |
| CA2366642A1 (en) | 2000-09-14 |
| AU2941400A (en) | 2000-09-28 |
| US6600038B1 (en) | 2003-07-29 |
| EP1176146A1 (de) | 2002-01-30 |
| DE60020692T2 (de) | 2006-03-23 |
| KR20010102544A (ko) | 2001-11-15 |
| WO2000053604A1 (fr) | 2000-09-14 |
| EP1176146B1 (de) | 2005-06-08 |
| AU756702B2 (en) | 2003-01-23 |
| US6894168B2 (en) | 2005-05-17 |
| DE60020692D1 (de) | 2005-07-14 |
| CN1350536A (zh) | 2002-05-22 |
| EP1176146A4 (de) | 2003-07-09 |
| CN1174984C (zh) | 2004-11-10 |
| HK1046683A1 (en) | 2003-01-24 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |