ATE296289T1 - Verfahren zur herstellung von aryl-pyridinyl verbindungen - Google Patents
Verfahren zur herstellung von aryl-pyridinyl verbindungenInfo
- Publication number
- ATE296289T1 ATE296289T1 AT00969824T AT00969824T ATE296289T1 AT E296289 T1 ATE296289 T1 AT E296289T1 AT 00969824 T AT00969824 T AT 00969824T AT 00969824 T AT00969824 T AT 00969824T AT E296289 T1 ATE296289 T1 AT E296289T1
- Authority
- AT
- Austria
- Prior art keywords
- aryl
- halopyridine
- pph3
- diphenylphosphine
- oac
- Prior art date
Links
- 238000004519 manufacturing process Methods 0.000 title 1
- KDLHZDBZIXYQEI-UHFFFAOYSA-N Palladium Chemical compound [Pd] KDLHZDBZIXYQEI-UHFFFAOYSA-N 0.000 abstract 4
- VNDYJBBGRKZCSX-UHFFFAOYSA-L zinc bromide Chemical compound Br[Zn]Br VNDYJBBGRKZCSX-UHFFFAOYSA-L 0.000 abstract 3
- 230000003197 catalytic effect Effects 0.000 abstract 2
- 150000005748 halopyridines Chemical class 0.000 abstract 2
- 229910052763 palladium Inorganic materials 0.000 abstract 2
- RIOQSEWOXXDEQQ-UHFFFAOYSA-N triphenylphosphine Chemical compound C1=CC=CC=C1P(C=1C=CC=CC=1)C1=CC=CC=C1 RIOQSEWOXXDEQQ-UHFFFAOYSA-N 0.000 abstract 2
- 150000003751 zinc Chemical class 0.000 abstract 2
- LVEYOSJUKRVCCF-UHFFFAOYSA-N 1,3-bis(diphenylphosphino)propane Chemical compound C=1C=CC=CC=1P(C=1C=CC=CC=1)CCCP(C=1C=CC=CC=1)C1=CC=CC=C1 LVEYOSJUKRVCCF-UHFFFAOYSA-N 0.000 abstract 1
- BCJVBDBJSMFBRW-UHFFFAOYSA-N 4-diphenylphosphanylbutyl(diphenyl)phosphane Chemical compound C=1C=CC=CC=1P(C=1C=CC=CC=1)CCCCP(C=1C=CC=CC=1)C1=CC=CC=C1 BCJVBDBJSMFBRW-UHFFFAOYSA-N 0.000 abstract 1
- 101100030361 Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) pph-3 gene Proteins 0.000 abstract 1
- NFHFRUOZVGFOOS-UHFFFAOYSA-N Pd(PPh3)4 Substances [Pd].C1=CC=CC=C1P(C=1C=CC=CC=1)C1=CC=CC=C1.C1=CC=CC=C1P(C=1C=CC=CC=1)C1=CC=CC=C1.C1=CC=CC=C1P(C=1C=CC=CC=1)C1=CC=CC=C1.C1=CC=CC=C1P(C=1C=CC=CC=1)C1=CC=CC=C1 NFHFRUOZVGFOOS-UHFFFAOYSA-N 0.000 abstract 1
- 229910007339 Zn(OAc)2 Inorganic materials 0.000 abstract 1
- 125000005418 aryl aryl group Chemical group 0.000 abstract 1
- 150000004792 aryl magnesium halides Chemical class 0.000 abstract 1
- 238000006243 chemical reaction Methods 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 238000006880 cross-coupling reaction Methods 0.000 abstract 1
- -1 for example Chemical class 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- YJVFFLUZDVXJQI-UHFFFAOYSA-L palladium(ii) acetate Chemical compound [Pd+2].CC([O-])=O.CC([O-])=O YJVFFLUZDVXJQI-UHFFFAOYSA-L 0.000 abstract 1
- 150000003003 phosphines Chemical class 0.000 abstract 1
- DJWUNCQRNNEAKC-UHFFFAOYSA-L zinc acetate Chemical compound [Zn+2].CC([O-])=O.CC([O-])=O DJWUNCQRNNEAKC-UHFFFAOYSA-L 0.000 abstract 1
- 239000011592 zinc chloride Substances 0.000 abstract 1
- 235000005074 zinc chloride Nutrition 0.000 abstract 1
- JIAARYAFYJHUJI-UHFFFAOYSA-L zinc dichloride Chemical compound [Cl-].[Cl-].[Zn+2] JIAARYAFYJHUJI-UHFFFAOYSA-L 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/44—Radicals substituted by doubly-bound oxygen, sulfur, or nitrogen atoms, or by two such atoms singly-bound to the same carbon atom
- C07D213/53—Nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/44—Radicals substituted by doubly-bound oxygen, sulfur, or nitrogen atoms, or by two such atoms singly-bound to the same carbon atom
- C07D213/46—Oxygen atoms
- C07D213/48—Aldehydo radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/10—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing aromatic rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pyridine Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT1999MI002127A IT1313664B1 (it) | 1999-10-12 | 1999-10-12 | Processo per la preparazione di un composto aril-piridinico. |
| PCT/IT2000/000404 WO2001027083A1 (en) | 1999-10-12 | 2000-10-10 | Process for the preparation of aryl-pyridinyl compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE296289T1 true ATE296289T1 (de) | 2005-06-15 |
Family
ID=11383759
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT00969824T ATE296289T1 (de) | 1999-10-12 | 2000-10-10 | Verfahren zur herstellung von aryl-pyridinyl verbindungen |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US6765097B1 (de) |
| EP (1) | EP1274684B1 (de) |
| AT (1) | ATE296289T1 (de) |
| AU (1) | AU7946800A (de) |
| DE (1) | DE60020403T2 (de) |
| ES (1) | ES2242642T3 (de) |
| IT (1) | IT1313664B1 (de) |
| PT (1) | PT1274684E (de) |
| WO (1) | WO2001027083A1 (de) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6365745B1 (en) | 2000-07-14 | 2002-04-02 | Sumika Fine Chemicals Co., Ltd. | Method for producing hydrazine derivative |
| AU2002349814A1 (en) * | 2002-10-02 | 2004-05-13 | Euticals Prime European Therapeuticals Spa | Process for the preparation of aryl-piridyl compounds |
| EP1546104A1 (de) * | 2002-10-02 | 2005-06-29 | Euticals Prime European Therapeutical S.P.A | Verfahren zur herstellung von pyridyl-arylsulfonsäure derivate |
| EP2272831A1 (de) | 2009-06-26 | 2011-01-12 | Prime European Therapeuticals S.p.A. | Verfahren zur Herstellung von Arylpyridinylverbindungen |
| CN116987024B (zh) * | 2023-08-01 | 2026-02-13 | 浙江荣耀生物科技股份有限公司 | 一种阿扎那韦中间体的制备方法 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW409125B (en) | 1996-04-22 | 2000-10-21 | Novartis Ag | Antivirally active heterocyclic azahexane derivatives |
| DE19636995A1 (de) * | 1996-09-12 | 1998-03-19 | Basf Ag | Verfahren zur Herstellung substituierter Phenylpyridine |
| DE19831246A1 (de) * | 1998-07-11 | 2000-01-13 | Clariant Gmbh | Verfahren zur Herstellung von Arylpyridinen |
-
1999
- 1999-10-12 IT IT1999MI002127A patent/IT1313664B1/it active
-
2000
- 2000-10-10 PT PT00969824T patent/PT1274684E/pt unknown
- 2000-10-10 US US10/110,685 patent/US6765097B1/en not_active Expired - Lifetime
- 2000-10-10 ES ES00969824T patent/ES2242642T3/es not_active Expired - Lifetime
- 2000-10-10 WO PCT/IT2000/000404 patent/WO2001027083A1/en not_active Ceased
- 2000-10-10 DE DE60020403T patent/DE60020403T2/de not_active Expired - Fee Related
- 2000-10-10 AT AT00969824T patent/ATE296289T1/de not_active IP Right Cessation
- 2000-10-10 EP EP00969824A patent/EP1274684B1/de not_active Expired - Lifetime
- 2000-10-10 AU AU79468/00A patent/AU7946800A/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| DE60020403D1 (de) | 2005-06-30 |
| EP1274684B1 (de) | 2005-05-25 |
| EP1274684A1 (de) | 2003-01-15 |
| PT1274684E (pt) | 2005-10-31 |
| IT1313664B1 (it) | 2002-09-09 |
| AU7946800A (en) | 2001-04-23 |
| US6765097B1 (en) | 2004-07-20 |
| ITMI992127A1 (it) | 2001-04-12 |
| DE60020403T2 (de) | 2006-02-02 |
| ITMI992127A0 (it) | 1999-10-12 |
| ES2242642T3 (es) | 2005-11-16 |
| WO2001027083A1 (en) | 2001-04-19 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
Ref document number: 1274684 Country of ref document: EP |
|
| REN | Ceased due to non-payment of the annual fee |