ATE288447T1 - Methode zur behandlung von alzheimer mit einem von einer gliazelllinie stammenden neurotrophen protein (gdnf) - Google Patents
Methode zur behandlung von alzheimer mit einem von einer gliazelllinie stammenden neurotrophen protein (gdnf)Info
- Publication number
- ATE288447T1 ATE288447T1 AT96932325T AT96932325T ATE288447T1 AT E288447 T1 ATE288447 T1 AT E288447T1 AT 96932325 T AT96932325 T AT 96932325T AT 96932325 T AT96932325 T AT 96932325T AT E288447 T1 ATE288447 T1 AT E288447T1
- Authority
- AT
- Austria
- Prior art keywords
- gdnf
- cell line
- glial cell
- derived
- treating alzheimer
- Prior art date
Links
- 102000034615 Glial cell line-derived neurotrophic factor Human genes 0.000 title abstract 3
- 108091010837 Glial cell line-derived neurotrophic factor Proteins 0.000 title abstract 3
- 108010025020 Nerve Growth Factor Proteins 0.000 title 1
- 102000007072 Nerve Growth Factors Human genes 0.000 title 1
- 210000004498 neuroglial cell Anatomy 0.000 title 1
- 239000003900 neurotrophic factor Substances 0.000 title 1
- 208000024827 Alzheimer disease Diseases 0.000 abstract 1
- 208000027418 Wounds and injury Diseases 0.000 abstract 1
- 210000002932 cholinergic neuron Anatomy 0.000 abstract 1
- 230000006378 damage Effects 0.000 abstract 1
- 230000007850 degeneration Effects 0.000 abstract 1
- 208000014674 injury Diseases 0.000 abstract 1
- 210000004129 prosencephalon Anatomy 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
- A61K38/185—Nerve growth factor [NGF]; Brain derived neurotrophic factor [BDNF]; Ciliary neurotrophic factor [CNTF]; Glial derived neurotrophic factor [GDNF]; Neurotrophins, e.g. NT-3
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Psychology (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/535,682 US5731284A (en) | 1995-09-28 | 1995-09-28 | Method for treating Alzheimer's disease using glial line-derived neurotrophic factor (GDNF) protein product |
| PCT/US1996/015305 WO1997011965A1 (en) | 1995-09-28 | 1996-09-23 | Method for treating alzheimer's disease using glial cell line-derived neurotrophic factor (gdnf) protein product |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE288447T1 true ATE288447T1 (de) | 2005-02-15 |
Family
ID=24135315
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT96932325T ATE288447T1 (de) | 1995-09-28 | 1996-09-23 | Methode zur behandlung von alzheimer mit einem von einer gliazelllinie stammenden neurotrophen protein (gdnf) |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US5731284A (de) |
| EP (1) | EP0852585B1 (de) |
| JP (1) | JP4761409B2 (de) |
| AT (1) | ATE288447T1 (de) |
| AU (1) | AU711053B2 (de) |
| CA (1) | CA2232789C (de) |
| DE (1) | DE69634301T2 (de) |
| DK (1) | DK0852585T3 (de) |
| ES (1) | ES2237775T3 (de) |
| NZ (1) | NZ319040A (de) |
| PT (1) | PT852585E (de) |
| SI (1) | SI0852585T1 (de) |
| WO (1) | WO1997011965A1 (de) |
Families Citing this family (54)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6184200B1 (en) * | 1995-09-28 | 2001-02-06 | Amgen Inc. | Truncated glial cell line-derived neurotrophic factor |
| US6677135B1 (en) | 1996-05-08 | 2004-01-13 | Biogen, Inc. | Ret ligand (RetL) for stimulating neutral and renal growth |
| EP1011683A4 (de) * | 1997-05-22 | 2003-06-11 | Cephalon Inc | Vitamin d analoge und der wirkung auf neuronen |
| ES2214743T3 (es) * | 1997-09-19 | 2004-09-16 | Biopharm Gesellschaft Zur Biotechnologischen Entwicklung Von Pharmaka Mbh | Combinacion de citocinas con actividad neurotrofica. |
| US6761888B1 (en) | 2000-05-26 | 2004-07-13 | Neuralab Limited | Passive immunization treatment of Alzheimer's disease |
| US6787523B1 (en) * | 1997-12-02 | 2004-09-07 | Neuralab Limited | Prevention and treatment of amyloidogenic disease |
| US20080050367A1 (en) * | 1998-04-07 | 2008-02-28 | Guriq Basi | Humanized antibodies that recognize beta amyloid peptide |
| US7964192B1 (en) | 1997-12-02 | 2011-06-21 | Janssen Alzheimer Immunotherapy | Prevention and treatment of amyloidgenic disease |
| TWI239847B (en) * | 1997-12-02 | 2005-09-21 | Elan Pharm Inc | N-terminal fragment of Abeta peptide and an adjuvant for preventing and treating amyloidogenic disease |
| US7790856B2 (en) * | 1998-04-07 | 2010-09-07 | Janssen Alzheimer Immunotherapy | Humanized antibodies that recognize beta amyloid peptide |
| US7588766B1 (en) | 2000-05-26 | 2009-09-15 | Elan Pharma International Limited | Treatment of amyloidogenic disease |
| US20050059802A1 (en) * | 1998-04-07 | 2005-03-17 | Neuralab Ltd | Prevention and treatment of amyloidogenic disease |
| JP2002512805A (ja) | 1998-04-29 | 2002-05-08 | オクラホマ メディカル リサーチ ファウンデーション | アデノウイルスベクターおよびレトロウイルスベクターからのレトロウイルスプロデューサー細胞の構築 |
| AU1822000A (en) * | 1998-11-20 | 2000-06-13 | Yale University | Effects of gdnf and ngf on sodium channels in drg neurons |
| CA2408255A1 (en) | 2000-05-05 | 2001-11-15 | Marie T. Filbin | Methods for stimulating nervous system regeneration and repair by regulating arginase 1 and polyamine synthesis |
| WO2002005634A2 (en) | 2000-07-13 | 2002-01-24 | University Of South Florida | Transgenic animal and methods |
| TWI255272B (en) * | 2000-12-06 | 2006-05-21 | Guriq Basi | Humanized antibodies that recognize beta amyloid peptide |
| US7700751B2 (en) | 2000-12-06 | 2010-04-20 | Janssen Alzheimer Immunotherapy | Humanized antibodies that recognize β-amyloid peptide |
| KR20050021026A (ko) * | 2001-06-15 | 2005-03-07 | 주식회사 장생도라지 | 장생도라지 추출물을 포함하는 면역계의 이상으로부터발생하는 질병의 예방 및 치료용 약제학적 조성물 |
| US7150737B2 (en) * | 2001-07-13 | 2006-12-19 | Sci/Med Life Systems, Inc. | Methods and apparatuses for navigating the subarachnoid space |
| US7455666B2 (en) | 2001-07-13 | 2008-11-25 | Board Of Regents, The University Of Texas System | Methods and apparatuses for navigating the subarachnoid space |
| MY139983A (en) * | 2002-03-12 | 2009-11-30 | Janssen Alzheimer Immunotherap | Humanized antibodies that recognize beta amyloid peptide |
| WO2004021992A2 (en) * | 2002-09-06 | 2004-03-18 | The General Hospital Corporation | Delivery of therapeutics to the brain and spinal cord |
| MXPA05008156A (es) * | 2003-02-01 | 2005-09-30 | Neuralab Ltd | Inmunizacion activa para generar anticuerpos para beta-a soluble. |
| US20040209810A1 (en) * | 2003-02-24 | 2004-10-21 | Gill Steven S. | Method of treating Parkinson's disease in humans by intraputaminal infusion of glial cell-line derived neurotrophic factor |
| US8946151B2 (en) | 2003-02-24 | 2015-02-03 | Northern Bristol N.H.S. Trust Frenchay Hospital | Method of treating Parkinson's disease in humans by convection-enhanced infusion of glial cell-line derived neurotrophic factor to the putamen |
| TWI306458B (en) * | 2003-05-30 | 2009-02-21 | Elan Pharma Int Ltd | Humanized antibodies that recognize beta amyloid peptide |
| US20050225165A1 (en) * | 2004-04-13 | 2005-10-13 | Naik Sanjeev M | Brake by-wire control system |
| GB2414934A (en) * | 2004-06-11 | 2005-12-14 | Gill Steven Streatfield | Treatment of Parkinson's disease with GDNF |
| PE20061401A1 (es) * | 2004-12-15 | 2006-12-23 | Neuralab Ltd | ANTICUERPOS Aß PARA MEJORAR LA COGNICION |
| ES2434732T3 (es) * | 2004-12-15 | 2013-12-17 | Janssen Alzheimer Immunotherapy | Anticuerpos para beta-amiloide humanizados para su uso en mejorar la cognición |
| ES2396555T3 (es) | 2004-12-15 | 2013-02-22 | Janssen Alzheimer Immunotherapy | Anticuerpos que reconocen péptido beta amiloide |
| EP1940471A1 (de) * | 2005-10-28 | 2008-07-09 | NsGene A/S | Implantierbares biokompatibles immunisolatorisches vehikel zur abgabe von gdnf |
| US20090181008A1 (en) * | 2005-11-10 | 2009-07-16 | Satoris, Inc. | Methods of treating alzheimer's disease |
| US8784810B2 (en) * | 2006-04-18 | 2014-07-22 | Janssen Alzheimer Immunotherapy | Treatment of amyloidogenic diseases |
| PT2019683T (pt) * | 2006-04-25 | 2017-03-17 | Univ California | Administração de fatores de crescimento para o tratamento de distúrbios do snc |
| EP2023949A4 (de) * | 2006-04-26 | 2009-08-26 | Univ California | Zusammensetzungen und verfahren für konvektionsverstärkte freisetzung von neurotherapeutika mit hohem molekulargewicht |
| US20080292625A1 (en) * | 2007-04-18 | 2008-11-27 | Sally Schroeter | Prevention and treatment of cerebral amyloid angiopathy |
| US8003097B2 (en) * | 2007-04-18 | 2011-08-23 | Janssen Alzheimer Immunotherapy | Treatment of cerebral amyloid angiopathy |
| SI2182983T1 (sl) | 2007-07-27 | 2014-09-30 | Janssen Alzheimer Immunotherapy | Zdravljenje amiloidogenih bolezni s humaniziranimi protitelesi proti abeta |
| JO3076B1 (ar) * | 2007-10-17 | 2017-03-15 | Janssen Alzheimer Immunotherap | نظم العلاج المناعي المعتمد على حالة apoe |
| WO2009128057A2 (en) | 2008-04-18 | 2009-10-22 | UNIVERSITY COLLEGE DUBLIN, NATIONAL UNIVERSITY OF IRELAND, DUBLIN et al | Psycho-pharmaceuticals |
| US9067981B1 (en) | 2008-10-30 | 2015-06-30 | Janssen Sciences Ireland Uc | Hybrid amyloid-beta antibodies |
| US20110092955A1 (en) | 2009-10-07 | 2011-04-21 | Purdy Phillip D | Pressure-Sensing Medical Devices, Systems and Methods, and Methods of Forming Medical Devices |
| US11214610B2 (en) | 2010-12-01 | 2022-01-04 | H. Lundbeck A/S | High-purity production of multi-subunit proteins such as antibodies in transformed microbes such as Pichia pastoris |
| US9067988B2 (en) | 2010-12-01 | 2015-06-30 | Alderbio Holdings Llc | Methods of preventing or treating pain using anti-NGF antibodies |
| US9884909B2 (en) | 2010-12-01 | 2018-02-06 | Alderbio Holdings Llc | Anti-NGF compositions and use thereof |
| US9078878B2 (en) | 2010-12-01 | 2015-07-14 | Alderbio Holdings Llc | Anti-NGF antibodies that selectively inhibit the association of NGF with TrkA, without affecting the association of NGF with p75 |
| EP3434691A1 (de) | 2010-12-01 | 2019-01-30 | AlderBio Holdings LLC | Anti-ngf-zusammensetzengen und ihre verwendung |
| US9539324B2 (en) | 2010-12-01 | 2017-01-10 | Alderbio Holdings, Llc | Methods of preventing inflammation and treating pain using anti-NGF compositions |
| US20140302027A1 (en) * | 2011-09-26 | 2014-10-09 | University Of Louisville Research Foundation, Inc. | Methods of treating periodontal inflammation and periodontal bone loss |
| US8999927B2 (en) * | 2012-04-02 | 2015-04-07 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Glial cell line-derived neurotrophic factor (GDNF) compositions and use thereof |
| WO2018089702A1 (en) | 2016-11-10 | 2018-05-17 | Keros Therapeutics, Inc. | Gdnf fusion polypeptides and methods of use thereof |
| EP3628315A1 (de) | 2018-09-28 | 2020-04-01 | Université de Caen Normandie | Kombination aus acetylcholinesterase-inhibitor und 5-ht4-rezeptoragonist als neuroprotektives mittel zur behandlung von neurodegenerativen krankheiten |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4518584A (en) * | 1983-04-15 | 1985-05-21 | Cetus Corporation | Human recombinant interleukin-2 muteins |
| EP0154316B1 (de) * | 1984-03-06 | 1989-09-13 | Takeda Chemical Industries, Ltd. | Chemisch modifizierte Lymphokine und Verfahren zu ihrer Herstellung |
| US5106627A (en) * | 1987-11-17 | 1992-04-21 | Brown University Research Foundation | Neurological therapy devices |
| US5158881A (en) * | 1987-11-17 | 1992-10-27 | Brown University Research Foundation | Method and system for encapsulating cells in a tubular extrudate in separate cell compartments |
| US4892538A (en) * | 1987-11-17 | 1990-01-09 | Brown University Research Foundation | In vivo delivery of neurotransmitters by implanted, encapsulated cells |
| US5011472A (en) * | 1988-09-06 | 1991-04-30 | Brown University Research Foundation | Implantable delivery system for biological factors |
| CA2006596C (en) * | 1988-12-22 | 2000-09-05 | Rika Ishikawa | Chemically-modified g-csf |
| US5229500A (en) * | 1989-08-30 | 1993-07-20 | Regeneron Pharmaceuticals, Inc. | Brain derived neurotrophic factor |
| DE69034258D1 (de) * | 1989-10-16 | 2008-09-18 | Amgen Inc | Stamzellfaktor |
| WO1991010470A1 (en) * | 1990-01-08 | 1991-07-25 | Brown University Research Foundation | Devices and methods for enhanced delivery of active factors |
| US5202428A (en) * | 1990-06-20 | 1993-04-13 | The Salk Institute For Biological Studies | DNA encoding neurotropic growth factor |
| US5252714A (en) * | 1990-11-28 | 1993-10-12 | The University Of Alabama In Huntsville | Preparation and use of polyethylene glycol propionaldehyde |
| JP3385040B2 (ja) * | 1991-02-14 | 2003-03-10 | 武田薬品工業株式会社 | グリア活性化因子およびその製造法 |
| ATE275197T1 (de) * | 1991-09-20 | 2004-09-15 | Amgen Inc | Glial neurotrophe faktor |
| AU3129793A (en) * | 1991-11-08 | 1993-06-07 | General Hospital Corporation, The | Methods for the treatment of neuronal damage associated with ischemia, hypoxia or neurodegeneration |
| EP0802800B1 (de) * | 1993-08-12 | 2002-06-12 | Neurotech S.A. | Biokompatible immunoisolatorische Kapseln, die genetisch veränderte Zellen enthalten |
| WO1995017203A1 (en) * | 1993-12-22 | 1995-06-29 | The University Of Medicine And Dentistry Of New Jersey | Novel nucleic acid sequences isolated from glial cells |
| FR2717824B1 (fr) * | 1994-03-25 | 1996-04-26 | Rhone Poulenc Rorer Sa | Virus recombinants, préparation et utilisation en thérapie génique. |
| US5641750A (en) * | 1995-11-29 | 1997-06-24 | Amgen Inc. | Methods for treating photoreceptors using glial cell line-derived neurotrophic factor (GDNF) protein product |
| US5641749A (en) * | 1995-11-29 | 1997-06-24 | Amgen Inc. | Method for treating retinal ganglion cell injury using glial cell line-derived neurothrophic factor (GDNF) protein product |
-
1995
- 1995-09-28 US US08/535,682 patent/US5731284A/en not_active Expired - Lifetime
-
1996
- 1996-09-23 DE DE69634301T patent/DE69634301T2/de not_active Expired - Lifetime
- 1996-09-23 JP JP51357297A patent/JP4761409B2/ja not_active Expired - Lifetime
- 1996-09-23 AT AT96932325T patent/ATE288447T1/de active
- 1996-09-23 CA CA002232789A patent/CA2232789C/en not_active Expired - Lifetime
- 1996-09-23 WO PCT/US1996/015305 patent/WO1997011965A1/en not_active Ceased
- 1996-09-23 DK DK96932325T patent/DK0852585T3/da active
- 1996-09-23 PT PT96932325T patent/PT852585E/pt unknown
- 1996-09-23 AU AU71175/96A patent/AU711053B2/en not_active Expired
- 1996-09-23 NZ NZ319040A patent/NZ319040A/en not_active IP Right Cessation
- 1996-09-23 ES ES96932325T patent/ES2237775T3/es not_active Expired - Lifetime
- 1996-09-23 SI SI9630703T patent/SI0852585T1/xx unknown
- 1996-09-23 EP EP96932325A patent/EP0852585B1/de not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| CA2232789C (en) | 2001-02-27 |
| PT852585E (pt) | 2005-04-29 |
| JP4761409B2 (ja) | 2011-08-31 |
| DE69634301D1 (de) | 2005-03-10 |
| JPH11514860A (ja) | 1999-12-21 |
| ES2237775T3 (es) | 2005-08-01 |
| AU7117596A (en) | 1997-04-17 |
| DE69634301T2 (de) | 2005-06-09 |
| CA2232789A1 (en) | 1997-04-03 |
| DK0852585T3 (da) | 2005-05-09 |
| EP0852585A1 (de) | 1998-07-15 |
| EP0852585B1 (de) | 2005-02-02 |
| WO1997011965A1 (en) | 1997-04-03 |
| US5731284A (en) | 1998-03-24 |
| AU711053B2 (en) | 1999-10-07 |
| SI0852585T1 (en) | 2005-06-30 |
| NZ319040A (en) | 2001-02-23 |
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