ATE273302T1 - Diazocinderivate und deren verwendung als tryptase inhibitoren - Google Patents

Diazocinderivate und deren verwendung als tryptase inhibitoren

Info

Publication number
ATE273302T1
ATE273302T1 AT02704674T AT02704674T ATE273302T1 AT E273302 T1 ATE273302 T1 AT E273302T1 AT 02704674 T AT02704674 T AT 02704674T AT 02704674 T AT02704674 T AT 02704674T AT E273302 T1 ATE273302 T1 AT E273302T1
Authority
AT
Austria
Prior art keywords
tryptase inhibitors
diazocine
derivatives
diazocine derivatives
inhibitors
Prior art date
Application number
AT02704674T
Other languages
English (en)
Inventor
Wolf-Ruediger Ulrich
Thomas Baer
Thomas Martin
Josef Stadlwieser
Stefan-Lutz Wollin
Karl Zech
Christian P Sommerhoff
Original Assignee
Altana Pharma Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Altana Pharma Ag filed Critical Altana Pharma Ag
Application granted granted Critical
Publication of ATE273302T1 publication Critical patent/ATE273302T1/de

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/02Nasal agents, e.g. decongestants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/06Antiasthmatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/10Drugs for disorders of the urinary system of the bladder
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/02Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/06Antipsoriatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/02Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • A61P27/14Decongestants or antiallergics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/06Immunosuppressants, e.g. drugs for graft rejection
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/08Antiallergic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Dermatology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Urology & Nephrology (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Transplantation (AREA)
  • Otolaryngology (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Ophthalmology & Optometry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Non-Silver Salt Photosensitive Materials And Non-Silver Salt Photography (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
AT02704674T 2001-01-31 2002-01-26 Diazocinderivate und deren verwendung als tryptase inhibitoren ATE273302T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP01102098 2001-01-31
PCT/EP2002/000831 WO2002060895A1 (en) 2001-01-31 2002-01-26 Diazocine derivatives and their use as tryptase inhibitors

Publications (1)

Publication Number Publication Date
ATE273302T1 true ATE273302T1 (de) 2004-08-15

Family

ID=8176347

Family Applications (1)

Application Number Title Priority Date Filing Date
AT02704674T ATE273302T1 (de) 2001-01-31 2002-01-26 Diazocinderivate und deren verwendung als tryptase inhibitoren

Country Status (12)

Country Link
US (1) US6924305B2 (de)
EP (1) EP1358182B1 (de)
JP (1) JP2004517943A (de)
AT (1) ATE273302T1 (de)
AU (1) AU2002238522B8 (de)
CA (1) CA2438594A1 (de)
DE (1) DE60200935T2 (de)
DK (1) DK1358182T3 (de)
ES (1) ES2225758T3 (de)
PT (1) PT1358182E (de)
SI (1) SI1358182T1 (de)
WO (1) WO2002060895A1 (de)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2278928T3 (es) 2001-06-19 2007-08-16 Altana Pharma Ag Inhibidores de triptasa.
WO2006044133A1 (en) * 2004-09-24 2006-04-27 Axys Pharmaceuticals, Inc. Active ketone inhibitors of tryptase

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH10501238A (ja) 1994-06-01 1998-02-03 アリス ファーマシューティカル コーポレイション 肥満細胞媒介症状を治療するための組成物及び方法
SI9520101A (en) * 1994-09-23 1997-12-31 Arris Pharm Corp Compositions and methods for treating mast-cell inflammatory condition
CZ29799A3 (cs) 1996-07-30 1999-06-16 Arris Pharmaceutical Corporation Disubstituovaná cyklická sloučenina, způsob její výroby, farmaceutický přípravek a způsob léčení onemocnění živočicha
WO1999012918A1 (fr) 1997-09-05 1999-03-18 Yoshitomi Pharmaceutical Industries, Ltd. Inhibiteur de la tryptase
EP1030844A1 (de) 1997-11-10 2000-08-30 Array Biopharma Inc. Verbindungen, die die aktivität von tryptase hemmen
US6221914B1 (en) 1997-11-10 2001-04-24 Array Biopharma Inc. Sulfonamide bridging compounds that inhibit tryptase activity
ES2233025T3 (es) 1998-02-06 2005-06-01 Max-Planck-Gesellschaft Zur Forderung Der Wissenschaften E.V. Agente inhibidores de la triptasa.
EP1060171A2 (de) 1998-02-06 2000-12-20 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Tryptase-inhibitoren
AU5625499A (en) 1998-09-04 2000-03-27 Altana Pharma Ag Novel pyranoses
DE19937721A1 (de) 1999-08-10 2001-02-15 Max Planck Gesellschaft Neue Diketopiperazine
DE60014932T2 (de) 1999-08-10 2005-10-13 Altana Pharma Ag Diazocindionderivate und ihre verwendung als tryptase inhibitoren
AU778965B2 (en) 1999-09-14 2004-12-23 Altana Pharma Ag Tryptase inhibitors
CA2392127A1 (en) 1999-12-20 2001-06-28 Byk Gulden Lomberg Chemische Fabrik Gmbh Tryptase inhibitors
TR200402322T4 (tr) 1999-12-20 2004-12-21 Altana Pharma Ag Triptaz inhibitörler

Also Published As

Publication number Publication date
CA2438594A1 (en) 2002-08-08
US6924305B2 (en) 2005-08-02
DE60200935T2 (de) 2005-09-01
SI1358182T1 (en) 2005-02-28
AU2002238522B8 (en) 2007-01-18
ES2225758T3 (es) 2005-03-16
DE60200935D1 (de) 2004-09-16
AU2002238522A1 (en) 2002-08-12
EP1358182B1 (de) 2004-08-11
WO2002060895A1 (en) 2002-08-08
JP2004517943A (ja) 2004-06-17
US20040072762A1 (en) 2004-04-15
EP1358182A1 (de) 2003-11-05
PT1358182E (pt) 2004-12-31
AU2002238522B2 (en) 2006-12-21
DK1358182T3 (da) 2004-12-20

Similar Documents

Publication Publication Date Title
DE60310576D1 (en) 2-hydroxy-6-phenylphenanthridine als pde-4-hemmer
ATE353217T1 (de) 3-hydroxy-6-phenylphenanthridine als pde-4 inhibitoren
BRPI0608886B8 (pt) derivados de n-sulfonilpirróis e seus usos
DE69910831D1 (de) Epothilonderivate und ihre verwendung als antitumormittel
HRP20050228A2 (en) Novel phenanthridines
ES2186874T3 (es) Analogos de m-amidinofenilo como inhibidores del factor xa.
DE60105418D1 (de) Serinprotease-inhibitoren
PT1086096E (pt) Benzamidas com substituintes etra-hidrofuraniloxi como inibidores da fosfodiesterase 4
ATE391715T1 (de) Heterozyklische mutilinester und deren verwendung als bakterizide
TR200201128T2 (tr) PDE4 inhibitörleri olarak tetrahidrotiyopiranfitalazinon türevleri.
NO20064417L (no) Nye isoamidosubstituertehydroksy-6-fenylfenantridiner
ATE343582T1 (de) Derivate von (6, 7-dihydro -5h-imidazo(1,2 - a)imidazol -3 -sulfonylamino)-propionamid und deren verwendung als inhibitoren der interaktion von cams und leukointreginen
DE60202669D1 (de) 6-phenylbenzonaphthyidine
EA200301101A1 (ru) Производные пиперазина и их применение в качестве ингибиторов pde4
ATE371662T1 (de) Siliziumverbindungen und deren verwendung
DE69810629D1 (de) Beta-alkoxyacrylate gegen malaria
DK1244643T3 (da) Tryptaseinhibitorer
ATE508130T1 (de) 3-oxa-10-aza-phenanthrene als pde4- oder pde3/4- inhibitoren
DE60200935D1 (de) Diazocinderivate und deren verwendung als tryptase inhibitoren
DK1244614T3 (da) Tryptase-inhibitorer
ATE348803T1 (de) Tryptase-inhibitoren
ATE279398T1 (de) Diazocindionderivate und ihre verwendung als tryptase inhibitoren
DE602004009313D1 (de) Organosiliziumverbindungen und deren verwendung
ATE321760T1 (de) N-aryl-2-oxazolidinone und deren derivate
DE60311000D1 (de) Indolderivate und deren verwendung als 5-ht liganden

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification

Ref document number: 1358182

Country of ref document: EP

REN Ceased due to non-payment of the annual fee