ATE273005T1 - Taxane mit carbonaten in c-4 - Google Patents
Taxane mit carbonaten in c-4Info
- Publication number
- ATE273005T1 ATE273005T1 AT00980427T AT00980427T ATE273005T1 AT E273005 T1 ATE273005 T1 AT E273005T1 AT 00980427 T AT00980427 T AT 00980427T AT 00980427 T AT00980427 T AT 00980427T AT E273005 T1 ATE273005 T1 AT E273005T1
- Authority
- AT
- Austria
- Prior art keywords
- compounds
- formula
- taxanes
- carbonates
- 3cch2
- Prior art date
Links
- BVKZGUZCCUSVTD-UHFFFAOYSA-L Carbonate Chemical compound [O-]C([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-L 0.000 title 1
- 229940123237 Taxane Drugs 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 2
- 125000002941 2-furyl group Chemical group O1C([*])=C([H])C([H])=C1[H] 0.000 abstract 1
- 239000002246 antineoplastic agent Substances 0.000 abstract 1
- -1 cyclobutyl- Chemical group 0.000 abstract 1
- 125000002933 cyclohexyloxy group Chemical group C1(CCCCC1)O* 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 abstract 1
- 229940126701 oral medication Drugs 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- DKPFODGZWDEEBT-QFIAKTPHSA-N taxane Chemical class C([C@]1(C)CCC[C@@H](C)[C@H]1C1)C[C@H]2[C@H](C)CC[C@@H]1C2(C)C DKPFODGZWDEEBT-QFIAKTPHSA-N 0.000 abstract 1
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
- C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Epoxy Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Carbon And Carbon Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US17996500P | 2000-02-03 | 2000-02-03 | |
| PCT/US2000/031484 WO2001056565A1 (en) | 2000-02-03 | 2000-11-16 | C-4 carbonate taxanes |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE273005T1 true ATE273005T1 (de) | 2004-08-15 |
Family
ID=22658728
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT00980427T ATE273005T1 (de) | 2000-02-03 | 2000-11-16 | Taxane mit carbonaten in c-4 |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US6750246B1 (enExample) |
| EP (1) | EP1251846B1 (enExample) |
| JP (1) | JP2003523971A (enExample) |
| AT (1) | ATE273005T1 (enExample) |
| AU (1) | AU778284B2 (enExample) |
| CA (1) | CA2399116A1 (enExample) |
| CZ (1) | CZ20022956A3 (enExample) |
| DE (1) | DE60012988T2 (enExample) |
| DK (1) | DK1251846T3 (enExample) |
| ES (1) | ES2226954T3 (enExample) |
| HK (1) | HK1047891B (enExample) |
| MY (1) | MY129310A (enExample) |
| NZ (1) | NZ521136A (enExample) |
| PE (1) | PE20020747A1 (enExample) |
| PT (1) | PT1251846E (enExample) |
| RU (1) | RU2243223C2 (enExample) |
| TR (1) | TR200402454T4 (enExample) |
| TW (2) | TWI245041B (enExample) |
| WO (1) | WO2001056565A1 (enExample) |
| ZA (1) | ZA200207037B (enExample) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6750246B1 (en) | 2000-02-03 | 2004-06-15 | Bristol-Myers Squibb Company | C-4 carbonate taxanes |
| US6916942B2 (en) * | 2000-02-03 | 2005-07-12 | Bristol-Myers Squibb Company | Process for the preparation of C-4 carbonate taxanes |
| SI1372636T1 (sl) * | 2001-02-28 | 2006-12-31 | Bristol Myers Squibb Co | Metronomsko odmerjanje taksanov za inhibiranje tumorske rasti |
| UY27185A1 (es) * | 2001-02-28 | 2002-09-30 | Bristol Myers Squibb Co | Dosificación metronómica de taxanos |
| US7063977B2 (en) * | 2001-08-21 | 2006-06-20 | Bristol-Myers Squibb Company | Enzymatic resolution of t-butyl taxane derivatives |
| IL162118A0 (en) * | 2001-12-20 | 2005-11-20 | Bristol Myers Squibb Co | Pharmaceutical compositions containing an orally active taxane derivative |
| US20070105944A1 (en) * | 2002-10-25 | 2007-05-10 | Comezoglu S N | Taxane metabolites |
| US7371759B2 (en) * | 2003-09-25 | 2008-05-13 | Bristol-Myers Squibb Company | HMG-CoA reductase inhibitors and method |
| TW200533339A (en) * | 2004-03-16 | 2005-10-16 | Bristol Myers Squibb Co | Therapeutic synergy of anti-cancer compounds |
| US7459562B2 (en) * | 2004-04-23 | 2008-12-02 | Bristol-Myers Squibb Company | Monocyclic heterocycles as kinase inhibitors |
| TW200538453A (en) * | 2004-04-26 | 2005-12-01 | Bristol Myers Squibb Co | Bicyclic heterocycles as kinase inhibitors |
| US7432373B2 (en) * | 2004-06-28 | 2008-10-07 | Bristol-Meyers Squibb Company | Processes and intermediates useful for preparing fused heterocyclic kinase inhibitors |
| US7439246B2 (en) * | 2004-06-28 | 2008-10-21 | Bristol-Myers Squibb Company | Fused heterocyclic kinase inhibitors |
| US7173031B2 (en) | 2004-06-28 | 2007-02-06 | Bristol-Myers Squibb Company | Pyrrolotriazine kinase inhibitors |
| US20060116420A1 (en) * | 2004-11-23 | 2006-06-01 | Ramakrishnan Chidambaram | Crystalline forms of 3'-tert-Butyl-3'-N-tert-butyloxycarbonyl-4-deacetyl-3'-dephenyl-3'-N-debenzoyl-4-O-methoxycarbonyl-paclitaxel |
| US20060258736A1 (en) * | 2005-05-12 | 2006-11-16 | Bristol-Myers Squibb Company | Dosing regimen |
| US20080221135A1 (en) * | 2005-05-13 | 2008-09-11 | Bristol-Myers Squibb Company | Combination therapy |
| US7348325B2 (en) | 2005-11-30 | 2008-03-25 | Bristol-Myers Squibb Company | Pyrrolotriazine kinase inhibitors |
| PL217731B1 (pl) | 2006-06-01 | 2014-08-29 | Tomasz Byrski | Sposób wykrywania genetycznie uwarunkowanej obniżonej odpowiedzi na chemioterapię cytostatykiem taksanowym, zastosowanie mutacji założycielskiej oraz zestawu do wykrywania takiej odpowiedzi |
| HUE035059T2 (hu) | 2009-11-05 | 2018-05-02 | Rhizen Pharmaceuticals S A | Új benzopirán-kinát modulátorok |
Family Cites Families (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MY110249A (en) | 1989-05-31 | 1998-03-31 | Univ Florida State | Method for preparation of taxol using beta lactam |
| US5399726A (en) | 1993-01-29 | 1995-03-21 | Florida State University | Process for the preparation of baccatin III analogs bearing new C2 and C4 functional groups |
| US6335362B1 (en) | 1991-09-23 | 2002-01-01 | Florida State University | Taxanes having an alkyl substituted side-chain and pharmaceutical compositions containing them |
| US5284865A (en) | 1991-09-23 | 1994-02-08 | Holton Robert A | Cyclohexyl substituted taxanes and pharmaceutical compositions containing them |
| US5283253A (en) | 1991-09-23 | 1994-02-01 | Florida State University | Furyl or thienyl carbonyl substituted taxanes and pharmaceutical compositions containing them |
| US6521660B2 (en) | 1991-09-23 | 2003-02-18 | Florida State University | 3′-alkyl substituted taxanes and pharmaceutical compositions containing them |
| RU2059631C1 (ru) * | 1991-11-29 | 1996-05-10 | Дзе Юниверсити оф Канзас | Производные таксола и фармацевтическая композиция, обладающая противоопухолевой активностью |
| FR2698871B1 (fr) * | 1992-12-09 | 1995-02-24 | Rhone Poulenc Rorer Sa | Nouveau taxoïdes, leur préparation et les compositions pharmaceutiques qui les contiennent. |
| DE69333905T2 (de) | 1992-12-23 | 2006-08-03 | Bristol-Myers Squibb Co. | Seitenkette tragende Taxane und deren Zwischenprodukte |
| US5973160A (en) | 1992-12-23 | 1999-10-26 | Poss; Michael A. | Methods for the preparation of novel sidechain-bearing taxanes |
| US5475011A (en) * | 1993-03-26 | 1995-12-12 | The Research Foundation Of State University Of New York | Anti-tumor compounds, pharmaceutical compositions, methods for preparation thereof and for treatment |
| US5567592A (en) | 1994-02-02 | 1996-10-22 | Regents Of The University Of California | Screening method for the identification of bioenhancers through the inhibition of P-glycoprotein transport in the gut of a mammal |
| FR2721024B1 (fr) * | 1994-06-09 | 1996-07-12 | Rhone Poulenc Rorer Sa | Nouveaux taxoïdes, leur préparation et les compositions pharmaceutiques qui les contiennent. |
| CA2192373A1 (en) | 1994-06-09 | 1995-12-14 | Hirofumi Terasawa | Deacetoxytaxol derivative |
| FR2726272B1 (fr) * | 1994-10-26 | 1996-12-06 | Rhone Poulenc Rorer Sa | Nouveaux taxoides, leur preparation et les compositions pharmaceutiques qui les contiennent |
| US5840929A (en) | 1995-04-14 | 1998-11-24 | Bristol-Myers Squibb Company | C4 methoxy ether derivatives of paclitaxel |
| TW354293B (en) | 1995-06-06 | 1999-03-11 | Bristol Myers Squibb Co | Prodrugs of paclitaxel derivatives |
| US6245805B1 (en) | 1995-10-26 | 2001-06-12 | Baker Norton Pharmaceuticals, Inc. | Method, compositions and kits for increasing the oral bioavailability of pharmaceutical agents |
| US6964946B1 (en) | 1995-10-26 | 2005-11-15 | Baker Norton Pharmaceuticals, Inc. | Oral pharmaceutical compositions containing taxanes and methods of treatment employing the same |
| US5739359A (en) * | 1997-01-24 | 1998-04-14 | Virginia Tech Intellectual Properties, Inc. | Methods for preparing 1-deoxy paclitaxels |
| HUP0101457A3 (en) | 1997-12-31 | 2003-01-28 | Bristol Myers Squibb Co | Antitumor 2-aroyl-4-acyl paclitaxel analogs and medicaments containing them , their intermediates and method for producing them |
| MXPA01011046A (es) | 1999-05-17 | 2002-07-22 | Squibb Bristol Myers Co | Novedosas condiciones de reaccion para la escicion de teres de sililo en la preparacion de paclitaxel (taxol, marca registrada) y analogos de paclitaxel. |
| WO2001010856A1 (en) | 1999-08-11 | 2001-02-15 | Bristol-Myers Squibb Company | Process for the preparation of a paclitaxel c-4 methyl carbonate analog |
| JP2003512443A (ja) | 1999-10-27 | 2003-04-02 | ベーカー ノートン ファーマシューティカルズ インコーポレイテッド | タキサンをヒト患者に経口投与するための方法及び組成物 |
| US6750246B1 (en) | 2000-02-03 | 2004-06-15 | Bristol-Myers Squibb Company | C-4 carbonate taxanes |
| WO2002064132A2 (en) | 2001-01-18 | 2002-08-22 | Pharmacia & Upjohn Company | Chemotherapeutic microemulsion compositions of paclitaxel with improved oral bioavailability |
| UY27185A1 (es) | 2001-02-28 | 2002-09-30 | Bristol Myers Squibb Co | Dosificación metronómica de taxanos |
| DE10154464B4 (de) | 2001-11-08 | 2005-10-20 | Max Delbrueck Centrum | Oral verabreichbare pharmazeutische Zubereitung umfassend liposomal verkapseltes Taxol |
| WO2003045357A1 (en) | 2001-11-27 | 2003-06-05 | Transform Pharmaceuticals, Inc. | Oral pharmaceutical formulations comprising paclitaxel, derivatives and methods of administration thereof |
-
2000
- 2000-11-14 US US09/712,352 patent/US6750246B1/en not_active Expired - Lifetime
- 2000-11-16 CA CA002399116A patent/CA2399116A1/en not_active Abandoned
- 2000-11-16 RU RU2002123641/04A patent/RU2243223C2/ru not_active IP Right Cessation
- 2000-11-16 WO PCT/US2000/031484 patent/WO2001056565A1/en not_active Ceased
- 2000-11-16 ES ES00980427T patent/ES2226954T3/es not_active Expired - Lifetime
- 2000-11-16 TR TR2004/02454T patent/TR200402454T4/xx unknown
- 2000-11-16 AU AU17692/01A patent/AU778284B2/en not_active Ceased
- 2000-11-16 DE DE60012988T patent/DE60012988T2/de not_active Expired - Lifetime
- 2000-11-16 EP EP00980427A patent/EP1251846B1/en not_active Expired - Lifetime
- 2000-11-16 CZ CZ20022956A patent/CZ20022956A3/cs unknown
- 2000-11-16 HK HK03100017.6A patent/HK1047891B/en not_active IP Right Cessation
- 2000-11-16 NZ NZ521136A patent/NZ521136A/en unknown
- 2000-11-16 PT PT00980427T patent/PT1251846E/pt unknown
- 2000-11-16 JP JP2001556256A patent/JP2003523971A/ja active Pending
- 2000-11-16 DK DK00980427T patent/DK1251846T3/da active
- 2000-11-16 AT AT00980427T patent/ATE273005T1/de active
-
2001
- 2001-01-29 TW TW090101690A patent/TWI245041B/zh not_active IP Right Cessation
- 2001-01-29 TW TW094114392A patent/TWI245042B/zh not_active IP Right Cessation
- 2001-01-29 MY MYPI20010372A patent/MY129310A/en unknown
- 2001-02-02 PE PE2001000117A patent/PE20020747A1/es not_active Application Discontinuation
-
2002
- 2002-09-02 ZA ZA200207037A patent/ZA200207037B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP1251846A1 (en) | 2002-10-30 |
| DE60012988T2 (de) | 2005-08-25 |
| ZA200207037B (en) | 2003-12-02 |
| CA2399116A1 (en) | 2001-08-09 |
| JP2003523971A (ja) | 2003-08-12 |
| RU2243223C2 (ru) | 2004-12-27 |
| EP1251846A4 (en) | 2003-03-12 |
| AU1769201A (en) | 2001-08-14 |
| TW200526613A (en) | 2005-08-16 |
| MY129310A (en) | 2007-03-30 |
| TR200402454T4 (tr) | 2004-12-21 |
| PE20020747A1 (es) | 2002-08-17 |
| AU778284B2 (en) | 2004-11-25 |
| CZ20022956A3 (cs) | 2003-02-12 |
| ES2226954T3 (es) | 2005-04-01 |
| DK1251846T3 (da) | 2004-11-29 |
| US6750246B1 (en) | 2004-06-15 |
| HK1047891B (en) | 2005-01-28 |
| NZ521136A (en) | 2004-05-28 |
| EP1251846B1 (en) | 2004-08-11 |
| TWI245041B (en) | 2005-12-11 |
| RU2002123641A (ru) | 2004-01-10 |
| PT1251846E (pt) | 2004-11-30 |
| WO2001056565A1 (en) | 2001-08-09 |
| DE60012988D1 (en) | 2004-09-16 |
| TWI245042B (en) | 2005-12-11 |
| HK1047891A1 (en) | 2003-03-14 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ATE273005T1 (de) | Taxane mit carbonaten in c-4 | |
| DE60144392D1 (de) | Antivirale mittel | |
| EA201000643A1 (ru) | Замещенное производное этилендиамина для лечения микобактериальных заболеваний и фармацевтическая композиция на его основе | |
| DE60122193D1 (de) | Glucopyranosyloxybenzylbenzol derivate und medizinische zusammensetzungen, die diese verbindungen enthalten | |
| CY1110914T1 (el) | Δικυκλο-πυραζολες δραστικες ως αναστολεις kinασων, διεργασια για την παρασκευη τους και φαρμακευτικες συνθεσεις που τις περιλαμβανουν | |
| DE60206911D1 (de) | Imidazol-2-carbonsäureamid derivate als raf-kinase-inhibitoren | |
| ATE452129T1 (de) | N-phenyl-2-pyrimidine-amine derivatives | |
| DE60324155D1 (de) | Indol-3-carbinol metaboliten als chemotherapeutische und chemopräventive wirkstoffen | |
| CY1108874T1 (el) | ΧΡΗΣΗ ΤΩΝ ΑΝΑΣΤΟΛΕΩΝ Ι κΒ- ΚΙΝΑΣΗΣ ΣΤΗ ΘΕΡΑΠΕΙΑ ΤΟΥ ΠΟΝΟΥ | |
| MA27040A1 (fr) | Nucleosides substitues en 4' | |
| CR7743A (es) | Nuevos compuestos de oxazol y tiazol como inhibidorea del factor de crecimiento transformador (tgf) | |
| CY1108522T1 (el) | Μεθοδος συνθεσης της περινδοπριλης και των φαρμακευτικως αποδεκτων αλατων της | |
| CY1111851T1 (el) | Αρωματικες ενωσεις ως αντι-φλεγμονωδεις, ανοσορυθμιστικοι και αντι-πολλαπλασιαστικοι παραγοντες | |
| CY1107815T1 (el) | 1,3 - διϋποκατεστημεναι και 1,3,3 -τριϋποκατεστημεναι πυρρολιδιναι ως συνδεσμικα μεσα υποδοχεως ισταμινης -3, και θεραπευτικαι εφαρμογαι των | |
| CY1107939T1 (el) | Συνεργικοι φαρμακευτικοι συνδυασμοι για την προληψη ή την αγωγη του διαβητη | |
| SE0400043D0 (sv) | New compounds | |
| SE0102055D0 (sv) | New Compounds | |
| DE602004031410D1 (de) | Inden derivate als pharmazeutika | |
| BR0014687A (pt) | Compostos de taxano pentacìclico | |
| IT1307786B1 (it) | Analoghi di ceramidi, processo per la loro preparazione e loro usocome antitumorali. | |
| PE20030236A1 (es) | Derivados de bencimidazol 1-aril-2-n,s- u o-sustituidos, obtencion de medicamentos y preparados farmaceuticos que contienen estos derivados | |
| DE60119514D1 (de) | Amidderivate der 2-amino-3-hydroxy-4-tert-leucyl-amino-5-phenyl-pentansäure | |
| SE0004827D0 (sv) | Therapeutic compounds | |
| EE200200688A (et) | Akrüloüüldistamütsiini derivaati, mikrotuubulivastast toimeainet ja/või antimetaboliiti sisaldav farmatseutiline kompositsioon, derivaadi kasutamine tuumorivastase ravimi valmistamiseks ning kombineeritud ravimpreparaat | |
| TH51266A (th) | C-4 คาร์บอเนทแทกเซน |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
Ref document number: 1251846 Country of ref document: EP |