ATE272121T1 - Gene manipulation und expression mittels genomischer elemente - Google Patents
Gene manipulation und expression mittels genomischer elementeInfo
- Publication number
- ATE272121T1 ATE272121T1 AT92911887T AT92911887T ATE272121T1 AT E272121 T1 ATE272121 T1 AT E272121T1 AT 92911887 T AT92911887 T AT 92911887T AT 92911887 T AT92911887 T AT 92911887T AT E272121 T1 ATE272121 T1 AT E272121T1
- Authority
- AT
- Austria
- Prior art keywords
- mammalian
- gene
- expression
- fragment
- homologous recombination
- Prior art date
Links
- 108090000623 proteins and genes Proteins 0.000 title abstract 7
- 239000012634 fragment Substances 0.000 abstract 3
- 230000006801 homologous recombination Effects 0.000 abstract 3
- 238000002744 homologous recombination Methods 0.000 abstract 3
- 240000004808 Saccharomyces cerevisiae Species 0.000 abstract 1
- 230000003321 amplification Effects 0.000 abstract 1
- 210000004027 cell Anatomy 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 230000002759 chromosomal effect Effects 0.000 abstract 1
- 238000001727 in vivo Methods 0.000 abstract 1
- 210000000415 mammalian chromosome Anatomy 0.000 abstract 1
- 102000035118 modified proteins Human genes 0.000 abstract 1
- 108091005573 modified proteins Proteins 0.000 abstract 1
- 238000002703 mutagenesis Methods 0.000 abstract 1
- 231100000350 mutagenesis Toxicity 0.000 abstract 1
- 238000003199 nucleic acid amplification method Methods 0.000 abstract 1
- 230000002103 transcriptional effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/53—Colony-stimulating factor [CSF]
- C07K14/535—Granulocyte CSF; Granulocyte-macrophage CSF
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/59—Follicle-stimulating hormone [FSH]; Chorionic gonadotropins, e.g.hCG [human chorionic gonadotropin]; Luteinising hormone [LH]; Thyroid-stimulating hormone [TSH]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
- C12N15/81—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2800/00—Nucleic acids vectors
- C12N2800/20—Pseudochromosomes, minichrosomosomes
- C12N2800/206—Pseudochromosomes, minichrosomosomes of yeast origin, e.g. YAC, 2u
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2840/00—Vectors comprising a special translation-regulating system
- C12N2840/44—Vectors comprising a special translation-regulating system being a specific part of the splice mechanism, e.g. donor, acceptor
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Gastroenterology & Hepatology (AREA)
- Microbiology (AREA)
- Endocrinology (AREA)
- Toxicology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Mycology (AREA)
- Medicinal Chemistry (AREA)
- Immunology (AREA)
- Reproductive Health (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US69621691A | 1991-05-06 | 1991-05-06 | |
| PCT/US1992/003686 WO1992019255A1 (en) | 1991-05-06 | 1992-05-05 | Gene manipulation and expression using genomic elements |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE272121T1 true ATE272121T1 (de) | 2004-08-15 |
Family
ID=24796175
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT92911887T ATE272121T1 (de) | 1991-05-06 | 1992-05-05 | Gene manipulation und expression mittels genomischer elemente |
Country Status (10)
| Country | Link |
|---|---|
| EP (1) | EP0584214B1 (de) |
| JP (2) | JPH06507550A (de) |
| KR (1) | KR100259933B1 (de) |
| AT (1) | ATE272121T1 (de) |
| AU (1) | AU671801B2 (de) |
| CA (2) | CA2102594C (de) |
| DE (1) | DE69233387T2 (de) |
| NO (1) | NO934011L (de) |
| SG (1) | SG93780A1 (de) |
| WO (1) | WO1992019255A1 (de) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6048729A (en) | 1987-05-01 | 2000-04-11 | Transkaryotic Therapies, Inc. | In vivo protein production and delivery system for gene therapy |
| US6692737B1 (en) | 1991-11-05 | 2004-02-17 | Transkaryotic Therapies, Inc. | In vivo protein production and delivery system for gene therapy |
| NZ245015A (en) | 1991-11-05 | 1995-12-21 | Transkaryotic Therapies Inc | Delivery of human growth hormone through the administration of transfected cell lines encoding human growth hormone, which are physically protected from host immune response; the transfected cells and their production |
| US5968502A (en) * | 1991-11-05 | 1999-10-19 | Transkaryotic Therapies, Inc. | Protein production and protein delivery |
| US5641670A (en) * | 1991-11-05 | 1997-06-24 | Transkaryotic Therapies, Inc. | Protein production and protein delivery |
| US6063630A (en) | 1991-11-05 | 2000-05-16 | Transkaryotic Therapies, Inc. | Targeted introduction of DNA into primary or secondary cells and their use for gene therapy |
| US6054288A (en) * | 1991-11-05 | 2000-04-25 | Transkaryotic Therapies, Inc. | In vivo protein production and delivery system for gene therapy |
| US6531124B1 (en) | 1992-07-10 | 2003-03-11 | Transkaryotic Therapies, Inc. | In vivo production and delivery of insulinotropin for gene therapy |
| US6670178B1 (en) | 1992-07-10 | 2003-12-30 | Transkaryotic Therapies, Inc. | In Vivo production and delivery of insulinotropin for gene therapy |
| EP0742285A1 (de) * | 1995-05-10 | 1996-11-13 | Rijksuniversiteit Leiden | Verfahren zur Isolierung von exonischen Genteile von Eukaryonten gene, und exonische Vektoren |
| US6897066B1 (en) | 1997-09-26 | 2005-05-24 | Athersys, Inc. | Compositions and methods for non-targeted activation of endogenous genes |
| US7316923B1 (en) | 1997-09-26 | 2008-01-08 | Athersys, Inc. | Compositions and methods for non-targeted activation of endogenous genes |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4656134A (en) * | 1982-01-11 | 1987-04-07 | Board Of Trustees Of Leland Stanford Jr. University | Gene amplification in eukaryotic cells |
| US4740461A (en) * | 1983-12-27 | 1988-04-26 | Genetics Institute, Inc. | Vectors and methods for transformation of eucaryotic cells |
| US4889806A (en) * | 1987-04-15 | 1989-12-26 | Washington University | Large DNA cloning system based on yeast artificial chromosomes |
| CA2045175C (en) * | 1989-11-06 | 2003-03-18 | Arthur I. Skoultchi | Production of proteins using homologous recombination |
| EP0779362B2 (de) * | 1989-12-22 | 2012-06-13 | Laboratoires Serono SA | DNS-Konstrukten zur Aktivierung und Veränderung der Expression von endogenen Genen |
-
1992
- 1992-05-05 KR KR1019930703372A patent/KR100259933B1/ko not_active IP Right Cessation
- 1992-05-05 CA CA002102594A patent/CA2102594C/en not_active Expired - Fee Related
- 1992-05-05 SG SG9604228A patent/SG93780A1/en unknown
- 1992-05-05 CA CA002102628A patent/CA2102628A1/en not_active Abandoned
- 1992-05-05 AT AT92911887T patent/ATE272121T1/de not_active IP Right Cessation
- 1992-05-05 EP EP92911887A patent/EP0584214B1/de not_active Revoked
- 1992-05-05 AU AU19732/92A patent/AU671801B2/en not_active Ceased
- 1992-05-05 JP JP4511157A patent/JPH06507550A/ja not_active Withdrawn
- 1992-05-05 DE DE69233387T patent/DE69233387T2/de not_active Revoked
- 1992-05-05 WO PCT/US1992/003686 patent/WO1992019255A1/en active IP Right Grant
-
1993
- 1993-11-05 NO NO934011A patent/NO934011L/no unknown
-
2007
- 2007-12-07 JP JP2007317755A patent/JP2008086326A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| DE69233387T2 (de) | 2005-07-21 |
| KR100259933B1 (ko) | 2000-06-15 |
| AU671801B2 (en) | 1996-09-12 |
| SG93780A1 (en) | 2003-01-21 |
| NO934011D0 (no) | 1993-11-05 |
| WO1992019255A1 (en) | 1992-11-12 |
| NO934011L (no) | 1994-01-05 |
| JP2008086326A (ja) | 2008-04-17 |
| AU1973292A (en) | 1992-12-21 |
| EP0584214A4 (de) | 1995-04-19 |
| CA2102594A1 (en) | 1992-11-07 |
| EP0584214A1 (de) | 1994-03-02 |
| JPH06507550A (ja) | 1994-09-01 |
| CA2102628A1 (en) | 1992-11-07 |
| CA2102594C (en) | 2007-07-17 |
| DE69233387D1 (de) | 2004-09-02 |
| EP0584214B1 (de) | 2004-07-28 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |