ATE270549T1 - Substituierte trizyklische pyrazolderivate mit protein kinase aktivität - Google Patents

Substituierte trizyklische pyrazolderivate mit protein kinase aktivität

Info

Publication number
ATE270549T1
ATE270549T1 AT99920103T AT99920103T ATE270549T1 AT E270549 T1 ATE270549 T1 AT E270549T1 AT 99920103 T AT99920103 T AT 99920103T AT 99920103 T AT99920103 T AT 99920103T AT E270549 T1 ATE270549 T1 AT E270549T1
Authority
AT
Austria
Prior art keywords
pyrazole
dihydro
indazole
chemical compounds
derivatives
Prior art date
Application number
AT99920103T
Other languages
English (en)
Inventor
Lee Arnold
Paul Rafferty
Michael Hockley
Allyson Turner
Original Assignee
Abbott Gmbh & Co Kg
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbott Gmbh & Co Kg filed Critical Abbott Gmbh & Co Kg
Application granted granted Critical
Publication of ATE270549T1 publication Critical patent/ATE270549T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A61K31/4162—1,2-Diazoles condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
AT99920103T 1998-04-30 1999-04-28 Substituierte trizyklische pyrazolderivate mit protein kinase aktivität ATE270549T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US8364898P 1998-04-30 1998-04-30
PCT/US1999/009185 WO1999055335A1 (en) 1998-04-30 1999-04-28 Substituted tricyclic pyrazole derivatives with protein kinase activity

Publications (1)

Publication Number Publication Date
ATE270549T1 true ATE270549T1 (de) 2004-07-15

Family

ID=22179779

Family Applications (1)

Application Number Title Priority Date Filing Date
AT99920103T ATE270549T1 (de) 1998-04-30 1999-04-28 Substituierte trizyklische pyrazolderivate mit protein kinase aktivität

Country Status (8)

Country Link
EP (1) EP1073435B1 (de)
JP (1) JP2002512962A (de)
CN (1) CN1311678A (de)
AT (1) ATE270549T1 (de)
DE (1) DE69918542T2 (de)
ES (1) ES2224650T3 (de)
PT (1) PT1073435E (de)
WO (1) WO1999055335A1 (de)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2289791T3 (es) 1997-08-22 2008-02-01 Astrazeneca Ab Derivados de oxindolilquinazolina como inhibidores de la angiogenesis.
BR9915139A (pt) * 1998-11-06 2001-08-07 Basf Ag Método de inibir a hiperpermeabilidade vascular, e de inibir um processo ou estado fisiológico em um indivìduo
EP1229925A2 (de) * 1999-11-19 2002-08-14 Axxima Pharmaceuticals Aktiengesellschaft Hemmstoffe gegen helicobacter pylori verursachte gastrointestinale krankheiten
US6849409B2 (en) 2000-10-16 2005-02-01 Axxima Pharmaceuticals Ag Cellular kinases involved in Cytomegalovirus infection and their inhibition
DE10134196B4 (de) * 2001-07-13 2005-08-18 Forschungszentrum Karlsruhe Gmbh Technik Und Umwelt Pharmazeutische Zusammensetzung zur Hemmung der unkontrollierten Vermehrung und/oder Induzierung der Apoptose von Zellen
WO2003024936A1 (en) 2001-09-19 2003-03-27 Pharmacia Corporation Substituted pyrazolo compounds for the treatment of inflammation
ATE495741T1 (de) * 2001-09-26 2011-02-15 Pfizer Italia Srl Aminoindazolderivate mit kinaseinhibierender wirkung, verfahren zu deren herstellung und diese enthaltende pharmazeutische zusammensetzungen
CA2476822A1 (en) * 2002-02-19 2003-08-28 Pharmacia Italia S.P.A. Tricyclic pyrazole derivatives, process for their preparation and their use as antitumor agents
US7166293B2 (en) * 2002-03-29 2007-01-23 Carlsbad Technology, Inc. Angiogenesis inhibitors
AR045037A1 (es) 2003-07-10 2005-10-12 Aventis Pharma Sa Tetrahidro-1h-pirazolo [3,4-c] piridinas sustituidas, composiciones que las contienen y su utilizacion.
DE602005023587D1 (de) * 2004-01-21 2010-10-28 Univ Emory Zusammensetzungen und verwendung von tyrosinkinase-hemmern zur behandlung von pathogenen infektionen
WO2007132307A1 (en) 2006-05-09 2007-11-22 Pfizer Products Inc. Cycloalkylamino acid derivatives and pharmaceutical compositions thereof
AP2527A (en) 2006-10-31 2012-12-06 Pfizer Prod Inc Pyrazoline compounds as mineralocorticoid receptorantagonists
CN101434595B (zh) * 2008-12-19 2014-06-25 沈阳药科大学 抗真菌剂-硫色满酮缩氨基(硫)脲系列物
JP2012524058A (ja) * 2009-04-15 2012-10-11 フォンダツィオーネ アイアールシーシーエス イスティトゥト ナツィオナーレ デイ トゥモリ 血管透過性亢進の治療におけるマルチキナーゼ阻害剤の使用
CN102086212B (zh) * 2009-12-03 2013-06-12 沈阳药科大学 抗真菌剂-2，3，4，5-四氢-4H-苯并[b]噻喃并[4，3-c]吡唑-2-甲酰胺衍生物
US8853207B2 (en) 2012-04-12 2014-10-07 Development Center For Biotechnology Heterocyclic pyrazole compounds, method for preparing the same and use thereof
RU2674447C1 (ru) * 2017-12-19 2018-12-10 Федеральное государственное бюджетное образовательное учреждение высшего образования "Дальневосточный государственный медицинский университет" Министерства здравоохранения Российской Федерации (ФГБОУ ВО ДВГМУ Минздрава России) Способ лечения синдрома избыточного бактериального роста в тонком кишечнике у больных сахарным диабетом 2 типа в сочетании с гастродуоденальным хеликобактериозом

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE789948A (fr) * 1971-10-13 1973-04-11 Sandoz Sa Nouveaux derives du pyrazole, leur preparation et leur application comme medicaments
US3816438A (en) * 1972-12-22 1974-06-11 Sandoz Ag 2h(1)-benzothiepino(5,4-c)-pyrazoles and(1)-benzothiopyrano(4,3-c)-pyrazoles
US3816437A (en) * 1972-12-22 1974-06-11 Sandoz Ag Thieno(2,3-g)indazoles
US3843664A (en) * 1973-02-20 1974-10-22 Sandoz Ag Substituted naphtho pyrazoles
US3843666A (en) * 1973-05-29 1974-10-22 Sandoz Ag Process for preparing substituted indeno,naphtho and cyclohepta pyrazoles
CA2146018A1 (en) * 1992-10-23 1994-05-11 Paul David Leeson Dopamine receptor subtype ligands
EP0724572B1 (de) * 1993-09-15 1998-12-16 MERCK SHARP & DOHME LTD. Kondensierte tricyclische heteroaromatische derivate als liganden des dopamin-rezeptor-subtyps
IL112249A (en) * 1994-01-25 2001-11-25 Warner Lambert Co Pharmaceutical compositions containing di and tricyclic pyrimidine derivatives for inhibiting tyrosine kinases of the epidermal growth factor receptor family and some new such compounds
PT1023063E (pt) * 1997-10-06 2004-02-27 Abbott Gmbh & Co Kg Derivados de indeno¬1,2-c|- nafto¬1,2-c|- e benzo¬6,7|ciclo-hepta¬1,2-c|pirazole

Also Published As

Publication number Publication date
EP1073435A1 (de) 2001-02-07
PT1073435E (pt) 2004-10-29
JP2002512962A (ja) 2002-05-08
WO1999055335A1 (en) 1999-11-04
EP1073435B1 (de) 2004-07-07
DE69918542D1 (de) 2004-08-12
CN1311678A (zh) 2001-09-05
ES2224650T3 (es) 2005-03-01
DE69918542T2 (de) 2005-08-18

Similar Documents

Publication Publication Date Title
ATE270549T1 (de) Substituierte trizyklische pyrazolderivate mit protein kinase aktivität
NL980011I1 (nl) 7-Piperazinyl- of 7-morfolino-4-oxo-chinoline-3-carbonzuurderivaten, hun bereiding en hun gebruik als anti-microbiële middelen.
DK1051972T3 (da) Nitrogenoxiddonorsammensætning og fremgangsmåde til behandling af anale lidelser
DE69818083D1 (de) INDENO[1,2-c]-,NAPHTHO[1,2-C]-UND BENZO[6,7]CYCLOHEPTA[1,2-c]PYRAZOLDERIVATE
IT1123636B (it) Derivati dell'1,2,4-triazolo,loro preparazione e loro impiego come antiparassitari
BG105346A (en) Pyrolopyrimidines as protein kinase inhibitors
DK71387A (da) Terapeutisk middel til behandling af psoriasis
IT1221826B (it) Preparato per uso topico per il trattamento terapeutico dell impotentia coeundi
IT7826674A0 (it) Derivati dell'acido glicil-metil-fosfinico, loro preparazione e loro impiego.
IT8448772A1 (it) Derivati dell'etanolo loro preparazione e loro impiego come fungicidi
IT7922662A0 (it) Acidi 2-sostituiti-4-aril-5-tiazolcarbossilici e loro derivati quali agenti di salvaguardia in colture di riso.
NO173184C (no) Analogifremgangsmaate for fremstilling av terapeutisk aktive pyridin-2,4- og 2,5-dikarboksylsyrederivater
AU756175C (en) Catalytic domain of the human effector cell cycle checkpoint protein kinase, Chk1, materials and methods for identification of inhibitors thereof
MX26142A (es) Derivados de acido benzoico para tratar enfermedades relacionadas con leucotrieno.
IT1090352B (it) Acidi ftalamici e acidi nicotinici e loro uso come regolatori della crescita delle piante
DK178489D0 (da) Anthralin-sterol-komplekser, deres fremstilling og anvendelse
IT1258315B (it) Derivati del flavone
IT8268039A0 (it) Derivati dell acido penem 3 carbossilico loro preparazione ed uso come agenti antimicrobici
IT1219653B (it) Composti eterociclici,loro preparazione e loro impiego come erbicidi
Tolstoy The Elephant King
Melin Nelson John Popko: Users Council President
ASHWORTH January LA Council Meeting
Lorant CORROSION OF SILVER SINGLE CRYSTALS
Glover et al. Bloom Mill Yield Control.(Retroactive Coverage)
Olson Wet Disks? Try This

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification

Ref document number: 1073435

Country of ref document: EP

REN Ceased due to non-payment of the annual fee