ATE266388T1 - Verfahren zur herstellung von formulierungen zur direkttablettierung - Google Patents

Verfahren zur herstellung von formulierungen zur direkttablettierung

Info

Publication number
ATE266388T1
ATE266388T1 AT01121128T AT01121128T ATE266388T1 AT E266388 T1 ATE266388 T1 AT E266388T1 AT 01121128 T AT01121128 T AT 01121128T AT 01121128 T AT01121128 T AT 01121128T AT E266388 T1 ATE266388 T1 AT E266388T1
Authority
AT
Austria
Prior art keywords
weight
excipient
direct tableting
pharmaceutically
producing formulations
Prior art date
Application number
AT01121128T
Other languages
English (en)
Inventor
Ta-Shuong Yeh
Daniel Hungting Yeh
Original Assignee
Wei Ming Pharmaceutical Mfg Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wei Ming Pharmaceutical Mfg Co filed Critical Wei Ming Pharmaceutical Mfg Co
Application granted granted Critical
Publication of ATE266388T1 publication Critical patent/ATE266388T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2095—Tabletting processes; Dosage units made by direct compression of powders or specially processed granules, by eliminating solvents, by melt-extrusion, by injection molding, by 3D printing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1611—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1635—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2009—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
AT01121128T 2001-05-01 2001-09-04 Verfahren zur herstellung von formulierungen zur direkttablettierung ATE266388T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US09/847,017 US6761905B2 (en) 2001-05-01 2001-05-01 Process for the preparation of direct tabletting formulations and aids

Publications (1)

Publication Number Publication Date
ATE266388T1 true ATE266388T1 (de) 2004-05-15

Family

ID=25299560

Family Applications (1)

Application Number Title Priority Date Filing Date
AT01121128T ATE266388T1 (de) 2001-05-01 2001-09-04 Verfahren zur herstellung von formulierungen zur direkttablettierung

Country Status (11)

Country Link
US (1) US6761905B2 (de)
EP (1) EP1256338B1 (de)
CN (1) CN1309375C (de)
AT (1) ATE266388T1 (de)
DE (1) DE60103247T2 (de)
DK (1) DK1256338T3 (de)
ES (1) ES2220640T3 (de)
HK (1) HK1050147A1 (de)
PT (1) PT1256338E (de)
TR (1) TR200401489T4 (de)
TW (1) TWI284541B (de)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040221631A1 (en) * 2002-09-05 2004-11-11 Kerrigan Kurt J. Composition for fertilizer tablet
NZ565108A (en) * 2005-07-07 2011-10-28 Farnam Co Inc Sustained release pharmaceutical compositions for highly water soluble drugs
US8951562B2 (en) 2006-11-10 2015-02-10 Atacama Labs Oy Method and apparatus or dry granulation
WO2008127794A2 (en) * 2007-04-13 2008-10-23 Dow Global Technologies Inc. Granular material for dosage forms
NZ584521A (en) * 2007-10-10 2011-03-31 Avantor Performance Mat Inc Directly compressible high functionality granular microcrystalline cellulose based excipient, manufacturing process and use thereof
US20100055180A1 (en) * 2007-10-10 2010-03-04 Mallinckrodt Baker, Inc. Directly Compressible Granular Microcrystalline Cellulose Based Excipient, Manufacturing Process and Use Thereof
EP2365799A1 (de) * 2008-11-20 2011-09-21 Avantor Performance Materials, Inc. Direkt komprimierbarer hochfunktionaler granulatförmiger gleichzeitig aufbereiteter hilfsstoff auf basis von dibasischem calciumphosphat
CN102448444B (zh) * 2009-04-01 2016-05-25 巴尔-波特拉及康邦亚股份有限公司 包括硝基儿茶酚衍生物的药物制剂及其制备方法
ES2401007T3 (es) 2009-06-26 2013-04-16 Taris Biomedical, Inc. Dispositivos de administración de fármaco implantables y procedimientos de fabricación de los mismos
BR112012011265B1 (pt) 2009-11-11 2020-12-01 Borealis Ag cabo e processo de produção do mesmo
ES2601884T3 (es) * 2010-03-19 2017-02-16 Daiichi Sankyo Company, Limited Procedimiento para mejorar la capacidad de disolución de un anticoagulante
CA2937365C (en) 2016-03-29 2018-09-18 F. Hoffmann-La Roche Ag Granulate formulation of 5-methyl-1-phenyl-2-(1h)-pyridone and method of making the same
CN111374953A (zh) * 2018-12-31 2020-07-07 上海鼎雅药物化学科技有限公司 对乙酰氨基酚片及其制备工艺
GB2595203A (en) 2020-03-03 2021-11-24 Alkaloid Ad Skopje Formulation
CN112076166A (zh) * 2020-09-21 2020-12-15 湖州展望药业有限公司 一种直压淀粉及其生产方法
CN116808013A (zh) * 2020-11-23 2023-09-29 武汉武药科技有限公司 卡谷氨酸原料药和卡谷氨酸固体制剂及其制备方法

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4072535A (en) 1970-12-28 1978-02-07 A. E. Staley Manufacturing Company Precompacted-starch binder-disintegrant-filler material for direct compression tablets and dry dosage capsules
DE3447422A1 (de) 1984-12-24 1986-06-26 Basf Ag, 6700 Ludwigshafen Verfahren zur herstellung von ascorbinsaeure-granulat
DE3505433A1 (de) 1985-02-16 1986-08-21 Basf Ag, 6700 Ludwigshafen Direkttablettierhilfsmittel
DE3506276C1 (de) 1985-02-22 1986-04-24 Meggle Milchindustrie Gmbh & Co Kg, 8094 Reitmehring Direkttablettiermittel
US4757090A (en) 1986-07-14 1988-07-12 Mallinckrodt, Inc. Direct tableting acetaminophen compositions
ES2039226T3 (es) 1986-12-30 1993-09-16 American Cyanamid Company Procedimiento para preparar composiciones que contienen policarbofil.
US5200193A (en) 1987-04-22 1993-04-06 Mcneilab, Inc. Pharmaceutical sustained release matrix and process
US4968509A (en) 1987-07-27 1990-11-06 Mcneilab, Inc. Oral sustained release acetaminophen formulation and process
DE69013689T2 (de) * 1990-11-29 1995-03-02 Wei Ming Pharmaceutical Mfg Co Hilfsträger für direkte Verpressung.
AU3136293A (en) 1991-11-15 1993-06-15 Isp Investments Inc. Pharmaceutical tablet with pvp having an enhanced drug dissolution rate
DE4418837A1 (de) 1994-05-30 1995-12-07 Bayer Ag Thermisches Granulierverfahren
US6083430A (en) 1994-10-28 2000-07-04 Fuisz Technologies Ltd. Method of preparing a dosage unit by direct tableting and product therefrom
US5585115A (en) 1995-01-09 1996-12-17 Edward H. Mendell Co., Inc. Pharmaceutical excipient having improved compressability
DE19628617A1 (de) 1996-07-16 1998-01-22 Basf Ag Direkttablettierhilfsmittel
IT1301966B1 (it) 1998-07-30 2000-07-20 Zambon Spa Composizioni farmaceutiche ad attivita' analgesica
US6350751B1 (en) * 1999-10-11 2002-02-26 Pfizer Inc. Therapeutic agents

Also Published As

Publication number Publication date
CN1383813A (zh) 2002-12-11
DE60103247D1 (de) 2004-06-17
EP1256338B1 (de) 2004-05-12
DK1256338T3 (da) 2004-09-06
TWI284541B (en) 2007-08-01
US20030017198A1 (en) 2003-01-23
PT1256338E (pt) 2004-09-30
ES2220640T3 (es) 2004-12-16
US6761905B2 (en) 2004-07-13
HK1050147A1 (en) 2003-06-13
TR200401489T4 (tr) 2004-07-21
CN1309375C (zh) 2007-04-11
EP1256338A3 (de) 2003-01-29
DE60103247T2 (de) 2005-05-04
EP1256338A2 (de) 2002-11-13

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