ATE264862T1 - Chlorin- und bakteriochlorin-aminophenyldtpa konjugate als mr kontrastmittel und radiopharmazeutika - Google Patents

Chlorin- und bakteriochlorin-aminophenyldtpa konjugate als mr kontrastmittel und radiopharmazeutika

Info

Publication number
ATE264862T1
ATE264862T1 AT00128019T AT00128019T ATE264862T1 AT E264862 T1 ATE264862 T1 AT E264862T1 AT 00128019 T AT00128019 T AT 00128019T AT 00128019 T AT00128019 T AT 00128019T AT E264862 T1 ATE264862 T1 AT E264862T1
Authority
AT
Austria
Prior art keywords
compounds
usually
radioactive
aminophenyldtpa
bacteriochlorine
Prior art date
Application number
AT00128019T
Other languages
German (de)
English (en)
Inventor
Ravindra K Pandey
Zachary Grossman
Peter Kanter
Thomas J Dougherty
Original Assignee
Health Research Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Health Research Inc filed Critical Health Research Inc
Application granted granted Critical
Publication of ATE264862T1 publication Critical patent/ATE264862T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0474—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group
    • A61K51/0478—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group complexes from non-cyclic ligands, e.g. EDTA, MAG3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A61K41/0057—Photodynamic therapy with a photosensitizer, i.e. agent able to produce reactive oxygen species upon exposure to light or radiation, e.g. UV or visible light; photocleavage of nucleic acids with an agent
    • A61K41/0071—PDT with porphyrins having exactly 20 ring atoms, i.e. based on the non-expanded tetrapyrrolic ring system, e.g. bacteriochlorin, chlorin-e6, or phthalocyanines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/085—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier conjugated systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0474—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group
    • A61K51/0485—Porphyrins, texaphyrins wherein the nitrogen atoms forming the central ring system complex the radioactive metal
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/22—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed systems contains four or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/22—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains four or more hetero rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Optics & Photonics (AREA)
  • Physics & Mathematics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)
AT00128019T 1999-12-23 2000-12-20 Chlorin- und bakteriochlorin-aminophenyldtpa konjugate als mr kontrastmittel und radiopharmazeutika ATE264862T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US17196199P 1999-12-23 1999-12-23
US09/739,155 US6534040B2 (en) 1999-12-23 2000-12-18 Chlorin and bacteriochlorin-based aminophenyl DTPA and N2S2 conjugates for MR contrast media and radiopharmaceuticals

Publications (1)

Publication Number Publication Date
ATE264862T1 true ATE264862T1 (de) 2004-05-15

Family

ID=26867614

Family Applications (1)

Application Number Title Priority Date Filing Date
AT00128019T ATE264862T1 (de) 1999-12-23 2000-12-20 Chlorin- und bakteriochlorin-aminophenyldtpa konjugate als mr kontrastmittel und radiopharmazeutika

Country Status (8)

Country Link
US (1) US6534040B2 (US20010046983A1-20011129-C00021.png)
EP (1) EP1110963B1 (US20010046983A1-20011129-C00021.png)
JP (1) JP4885354B2 (US20010046983A1-20011129-C00021.png)
AT (1) ATE264862T1 (US20010046983A1-20011129-C00021.png)
AU (1) AU779361B2 (US20010046983A1-20011129-C00021.png)
CA (1) CA2329320C (US20010046983A1-20011129-C00021.png)
DE (1) DE60010028T2 (US20010046983A1-20011129-C00021.png)
DK (1) DK1110963T3 (US20010046983A1-20011129-C00021.png)

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USRE39094E1 (en) 1988-07-20 2006-05-09 Health Research, Inc. Pyropheophorbides and their use in photodynamic therapy
US6602274B1 (en) * 1999-01-15 2003-08-05 Light Sciences Corporation Targeted transcutaneous cancer therapy
WO2000041725A2 (en) * 1999-01-15 2000-07-20 Light Sciences Corporation Therapeutic compositions for metabolic bone disorders or bone metastases
US6454789B1 (en) * 1999-01-15 2002-09-24 Light Science Corporation Patient portable device for photodynamic therapy
JP2002534218A (ja) 1999-01-15 2002-10-15 ライト サイエンシーズ コーポレイション 非侵襲性の脈管療法
US20030114434A1 (en) * 1999-08-31 2003-06-19 James Chen Extended duration light activated cancer therapy
US7897140B2 (en) * 1999-12-23 2011-03-01 Health Research, Inc. Multi DTPA conjugated tetrapyrollic compounds for phototherapeutic contrast agents
US7078014B2 (en) * 1999-12-23 2006-07-18 Health Research, Inc. Method for using chlorin and bacteriochlorin-based aminophenyl DTPA and N2S2 conjugates for MR contrast media and radiopharmaceuticals
US7097826B2 (en) * 1999-12-23 2006-08-29 Health Research, Inc. Chlorin and bacteriochlorin-based difunctional aminophenyl DTPA and N2S2 conjugates for MR contrast media and radiopharmaceuticals
US6624187B1 (en) 2000-06-12 2003-09-23 Health Research, Inc. Long wave length absorbing bacteriochlorin alkyl ether analogs
US20030167033A1 (en) * 2002-01-23 2003-09-04 James Chen Systems and methods for photodynamic therapy
WO2004002476A2 (en) 2002-06-27 2004-01-08 Health Research, Inc. Fluorinated chlorin and bacteriochlorin photosensitizers for photodynamic therapy
US7053210B2 (en) * 2002-07-02 2006-05-30 Health Research, Inc. Efficient synthesis of pyropheophorbide a and its derivatives
US20040010218A1 (en) * 2002-07-11 2004-01-15 Henderson Barbara W. Photodynamic therapy for the enhancement of vascular permeability to aid in drug delivery to diseased tissues
AU2004207813B8 (en) * 2003-01-24 2010-04-22 Health Research, Inc. Use of photodynamic therapy therapeutic agents entrapped in ceramic nanoparticles
US20090076571A1 (en) * 2004-12-03 2009-03-19 Zheng-Rong Lu MRI-Guided Photodynamic Therapy For Cancer
WO2006073314A1 (en) 2005-01-06 2006-07-13 Ge Healthcare As Optical imaging
US20060198783A1 (en) * 2005-02-25 2006-09-07 Health Research, Inc., Roswell Park Cancer Institute Division Porphyrin-based compounds for tumor imaging and photodynamic therapy
US8198432B2 (en) * 2005-02-25 2012-06-12 Health Research, Inc. Porphyrin-based compounds for tumor imaging and photodynamic therapy
US20090169480A1 (en) * 2007-12-31 2009-07-02 Industrial Technology Research Institute Dendritic polymers and magnetic resonance imaging contrast agent employing the same
US20110092961A1 (en) * 2008-08-13 2011-04-21 Searete Llc Artificial cells
US9095624B2 (en) * 2011-05-23 2015-08-04 Contango Partners Group, Inc. Modular transport platform for targeted delivery of therapeutic agents
CN104193753A (zh) * 2014-08-26 2014-12-10 江苏红豆杉药业有限公司 一种由红豆杉枝叶提取物制备光敏剂hpph的方法
CN114887055B (zh) * 2022-04-18 2023-06-16 浙江大学 一种糖靶向具有mr/nir显像和光动力治疗功能的诊疗一体化制剂及其制备方法和应用

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Also Published As

Publication number Publication date
DK1110963T3 (da) 2004-07-05
EP1110963A3 (en) 2001-12-19
AU7238400A (en) 2001-06-28
DE60010028T2 (de) 2005-04-28
DE60010028D1 (de) 2004-05-27
AU779361B2 (en) 2005-01-20
EP1110963B1 (en) 2004-04-21
JP4885354B2 (ja) 2012-02-29
US6534040B2 (en) 2003-03-18
CA2329320C (en) 2010-08-24
EP1110963A2 (en) 2001-06-27
US20010046983A1 (en) 2001-11-29
CA2329320A1 (en) 2001-06-23
JP2001335578A (ja) 2001-12-04

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