ATE264111T1 - Neue indikationen für mannan-binding lectin (mbl) zur behandlung von immungeschwächten patienten - Google Patents

Neue indikationen für mannan-binding lectin (mbl) zur behandlung von immungeschwächten patienten

Info

Publication number
ATE264111T1
ATE264111T1 AT00925098T AT00925098T ATE264111T1 AT E264111 T1 ATE264111 T1 AT E264111T1 AT 00925098 T AT00925098 T AT 00925098T AT 00925098 T AT00925098 T AT 00925098T AT E264111 T1 ATE264111 T1 AT E264111T1
Authority
AT
Austria
Prior art keywords
treatment
mbl
mannan
binding lectin
prophylaxis
Prior art date
Application number
AT00925098T
Other languages
English (en)
Inventor
Steffen Thiel
Jens Christian Jensenius
Original Assignee
Steffen Thiel
Jens Christian Jensenius
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Steffen Thiel, Jens Christian Jensenius filed Critical Steffen Thiel
Application granted granted Critical
Publication of ATE264111T1 publication Critical patent/ATE264111T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4726—Lectins

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Immunology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Virology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Toxicology (AREA)
  • Epidemiology (AREA)
  • Marine Sciences & Fisheries (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Filtering Materials (AREA)
  • Wrappers (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
  • Chemical And Physical Treatments For Wood And The Like (AREA)
AT00925098T 1999-05-14 2000-05-10 Neue indikationen für mannan-binding lectin (mbl) zur behandlung von immungeschwächten patienten ATE264111T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DKPA199900668 1999-05-14
DKPA199901508 1999-10-20
PCT/DK2000/000247 WO2000069894A2 (en) 1999-05-14 2000-05-10 Novel indications of mannan-binding lectin (mbl) in the treatment of immunocompromised individuals

Publications (1)

Publication Number Publication Date
ATE264111T1 true ATE264111T1 (de) 2004-04-15

Family

ID=26064419

Family Applications (3)

Application Number Title Priority Date Filing Date
AT03029993T ATE336260T1 (de) 1999-05-14 2000-05-10 Neue indikationen für mannan-binding lectin (mbl) zur behandlung von immungeschwächten patienten
AT00925097T ATE352620T1 (de) 1999-05-14 2000-05-10 Rekombinantes menschliches mannan-bindendes lektin
AT00925098T ATE264111T1 (de) 1999-05-14 2000-05-10 Neue indikationen für mannan-binding lectin (mbl) zur behandlung von immungeschwächten patienten

Family Applications Before (2)

Application Number Title Priority Date Filing Date
AT03029993T ATE336260T1 (de) 1999-05-14 2000-05-10 Neue indikationen für mannan-binding lectin (mbl) zur behandlung von immungeschwächten patienten
AT00925097T ATE352620T1 (de) 1999-05-14 2000-05-10 Rekombinantes menschliches mannan-bindendes lektin

Country Status (15)

Country Link
US (5) US6846649B1 (de)
EP (3) EP1181038B1 (de)
JP (2) JP2002544286A (de)
CN (2) CN1359420A (de)
AT (3) ATE336260T1 (de)
AU (2) AU781135B2 (de)
CA (2) CA2372435A1 (de)
DE (3) DE60030173T2 (de)
DK (3) DK1181038T3 (de)
ES (3) ES2281341T3 (de)
NO (2) NO20015481L (de)
NZ (2) NZ515717A (de)
PT (3) PT1402897E (de)
RU (2) RU2292217C2 (de)
WO (2) WO2000070043A1 (de)

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US6969601B2 (en) * 1997-04-03 2005-11-29 Jensenius Jens Chr MASP-2, a complement-fixing enzyme, and uses for it
DK1181038T3 (da) * 1999-05-14 2004-08-09 Steffen Thiel Hidtil ukendte indikationer af mannanbindende lectin (MBL) til behandling af immunkompromitterede individer
EP1303288A1 (de) * 2000-07-13 2003-04-23 Natimmune A/S Mannan-bindendes lektin (mbl) zur behandlung von infektionen in tnf alphabehandelte individen
EP1186299A1 (de) 2000-09-12 2002-03-13 Universitair Medisch Centrum Utrecht Diagnose, Verbeugung und/oder Behandlung von Atherosklerose, Infectionen und Störungen des Immunsystems
CN1487839A (zh) * 2000-11-27 2004-04-07 ղ˹��C��ղ˹���˹ 用作佐剂的集合素
WO2003010188A1 (en) 2001-07-23 2003-02-06 Natimmune A/S Production of high molecular mass lectins
WO2003018617A1 (fr) * 2001-08-31 2003-03-06 Fuso Pharmaceutical Industries, Ltd. Procede de purification de lectine liant le mannose humain, compositions de lectine liant le mannose humain et utilisation medicale de la lectine liant le mannose humain
DE60207678T2 (de) * 2001-10-19 2006-08-24 Natimmune A/S Isolierung von lectinen
ATE337014T1 (de) * 2002-03-15 2006-09-15 Natimmune As Mannose-bindungsprotein enthaltende pharmazeutische zusammensetzungen
US7211396B2 (en) * 2002-04-18 2007-05-01 Antibodyshop A/S Antibody pairs and kits for immunochemical determination of mannan-binding lectin
EP1501537A4 (de) * 2002-04-24 2008-01-16 Queensland Inst Med Res Mannose bindendes lectin und seine verwendungszwecke
AU2003246119B2 (en) * 2002-06-28 2008-02-21 Fuso Pharmaceutical Industries, Ltd. Anti-HIV agent
ATE349538T1 (de) * 2002-09-10 2007-01-15 Natlmmune As Collectin-komplement aktivierende proteinchimären
GB0222014D0 (en) * 2002-09-23 2002-10-30 Leuven K U Res & Dev Mannan-binding lectin
JP2007525232A (ja) 2003-01-17 2007-09-06 イースロン メディカル インコーポレイテッド レクチンアフィニティー血液透析による血液のウイルス除去方法
PT2374819T (pt) 2003-05-12 2017-07-04 Helion Biotech Aps Anticorpos para masp-2
US7135338B2 (en) * 2003-06-11 2006-11-14 Dobeel Corporation Methods for overexpression of high molecular weight form of mannose binding lectin (MBL) and a specific formulation for active treatment for systemic infection with microorganism
DE20317914U1 (de) 2003-11-19 2004-12-30 Weh, Erwin Betätigungsvorrichtung für eine Schnellanschlusskupplung
US7335633B2 (en) 2004-01-12 2008-02-26 Cornell Research Foundation, Inc. Detecting recurrent vulvovaginal candidiasis or vulvar vestibulitis syndrome and method for treating same
JP4884367B2 (ja) * 2004-02-24 2012-02-29 アボット・ヘルスケア・プロダクツ・ベスローテン・フェンノートシャップ 神経疾患を発症する危険性を決定するための方法
EP1730176A2 (de) * 2004-03-09 2006-12-13 THE GOVERNMENT OF THE UNITED STATES OF AMERICA, represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES Mvl, ein antivirales protein aus einem cyanobakterium
US7919094B2 (en) * 2004-06-10 2011-04-05 Omeros Corporation Methods for treating conditions associated with MASP-2 dependent complement activation
EP1618887A1 (de) * 2004-07-12 2006-01-25 UMC Utrecht Holding B.V. Beseitigung von Polyolen aus dem Körper
US20090247454A1 (en) * 2004-09-29 2009-10-01 Mellitus, S.L. Method for detecting a predisposition to develop gestational diabetes mellitus and treatment for this disease
DE602005026705D1 (de) * 2004-12-23 2011-04-14 Council Scient Ind Res Pharmazeutische zusammensetzung zur behandlung von invasiver lungenaspergillose
CN101094651B (zh) * 2004-12-30 2011-03-09 多贝尔有限公司 含有胶原凝集素家族蛋白质或者其变体的喷雾干燥的组合物和其制备方法
US20080214435A1 (en) * 2005-04-11 2008-09-04 Natlmmune A/S Novel Cancer Indications of Mannan-Binding Lectin (Mbl) in the Treatment of Immunocompromised Individuals
WO2007044642A2 (en) 2005-10-06 2007-04-19 President And Fellows Of Harvard College And Children's Medical Center Corporation Device and method for combined microfluidic-micromagnetic separation of material in continuous flow
ATE516043T1 (de) 2005-12-21 2011-07-15 Pharming Intellectual Pty Bv Verwendung von c1-inhibitor zur prävention von ischämischen reperfusionsschäden
WO2007085057A1 (en) * 2006-01-25 2007-08-02 The Council Of The Queensland Institute Of Medical Research A medical protocol
US20070226567A1 (en) * 2006-03-23 2007-09-27 Gorman Kevin W High speed bist utilizing clock multiplication
CN101939531A (zh) * 2008-01-16 2011-01-05 苏佩尔帕尔汽车工业和贸易有限公司 用于重型发动机平台的电动燃料泵
WO2009126346A2 (en) * 2008-01-18 2009-10-15 The General Hospital Corporation Methods for prevention and treatment of infections with supraphysiological doses of mannan-binding lectin (mbl) and ficolin-mbl fusion proteins
WO2010123594A2 (en) 2009-01-15 2010-10-28 Children's Medical Center Corporation Device for filtration of fluids there through and accompanying method
CA2787376A1 (en) 2010-01-19 2011-07-28 President And Fellows Of Harvard College Engineered opsonin for pathogen detection and treatment
WO2011100528A2 (en) 2010-02-12 2011-08-18 Emory University Compositions and uses of lectins
DE102011003478A1 (de) * 2011-02-01 2012-08-02 Cytavis Biopharma Gmbh Antivirales Mittel enthaltend rekombinante Mistellektine
EP3081937B1 (de) 2011-07-18 2019-11-13 President and Fellows of Harvard College Manipulierte moleküle zum targeting von mikroben und verwendungen davon
CA2865744A1 (en) 2012-02-29 2013-09-06 President And Fellows Of Harvard College Rapid antibiotic susceptibility testing
WO2014014788A2 (en) 2012-07-18 2014-01-23 President And Fellows Of Harvard College Modification of surfaces for simulataneous repellency and targeted binding of desired moieties
WO2014144325A1 (en) 2013-03-15 2014-09-18 President And Fellows Of Harvard College Methods and compositions for improving detection and/or capture of a target entity
EP3010522B1 (de) 2013-05-21 2021-01-20 President and Fellows of Harvard College Manipulierte hemebindende zusammensetzungen und verwendungen davon
WO2015095604A2 (en) 2013-12-18 2015-06-25 President And Fellows Of Harvard College Methods and assays relating to circulating tumor cells
US10357780B2 (en) 2014-10-27 2019-07-23 President And Fellows Of Harvard College Magnetic capture of a target from a fluid
CN108289928A (zh) 2015-08-06 2018-07-17 哈佛大学校长及研究员协会 改进的微生物-结合分子和其用途
US11919971B2 (en) 2016-05-16 2024-03-05 President And Fellows Of Harvard College Aqueous biomolecule coupling on CO2-plasma-activated surfaces
CN107050427A (zh) * 2017-02-27 2017-08-18 新乡医学院 MBL在制备预防或治疗以Tregs为靶点的疾病药物中的应用
CN107050436B (zh) * 2017-02-27 2020-03-17 新乡医学院 Mbl在制备预防或治疗效应t细胞引发疾病药物中的应用
WO2019110706A1 (en) * 2017-12-08 2019-06-13 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods for predicting the risk of developing a sepsis or a systemic inflammatory response syndrome (sirs)
RU2739113C1 (ru) * 2019-10-04 2020-12-21 Федеральное государственное бюджетное учреждение "Национальный медицинский исследовательский центр терапии и профилактической медицины" Министерства здравоохранения Российской Федерации (ФГБУ "НМИЦ ТПМ" Минздрава России) Способ определения активности маннан-связывающих лектин-ассоциированных сериновых протеаз в тесте коагуляции фибриногена
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DE3856180T2 (de) * 1987-08-20 1998-09-03 Childrens Medical Center Nukleinsaürefragmente, die mannose bindende fragmente vom menschlichen mannosebindenden protein kodieren
US5112952A (en) 1990-09-28 1992-05-12 Pierce Chemical Company Composition and method for isolation and purification of Immunoglobulin M
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DK1084143T3 (da) * 1998-06-10 2006-12-27 Statens Seruminstitut Oprensningsproces til fremstilling af mannanbindende lectin og et medicinsk MBL-produkt
DK1181038T3 (da) * 1999-05-14 2004-08-09 Steffen Thiel Hidtil ukendte indikationer af mannanbindende lectin (MBL) til behandling af immunkompromitterede individer

Also Published As

Publication number Publication date
WO2000070043A1 (en) 2000-11-23
DE60030173D1 (de) 2006-09-28
DK1181038T3 (da) 2004-08-09
US20030191052A1 (en) 2003-10-09
US6562784B1 (en) 2003-05-13
DK1402897T3 (da) 2006-12-27
DE60030173T2 (de) 2007-08-23
CN1359420A (zh) 2002-07-17
EP1181038A2 (de) 2002-02-27
ES2219336T3 (es) 2004-12-01
AU4393500A (en) 2000-12-05
AU4393600A (en) 2000-12-05
EP1402897B1 (de) 2006-08-16
EP1181038B1 (de) 2004-04-14
EP1181363B1 (de) 2007-01-24
NO20015506D0 (no) 2001-11-09
PT1181038E (pt) 2004-08-31
US7439224B2 (en) 2008-10-21
RU2005125625A (ru) 2007-02-20
JP2002543837A (ja) 2002-12-24
PT1181363E (pt) 2007-05-31
CN1359298A (zh) 2002-07-17
DE60033147D1 (de) 2007-03-15
CA2372435A1 (en) 2000-11-23
RU2292217C2 (ru) 2007-01-27
NO20015481L (no) 2002-01-11
CA2372128A1 (en) 2000-11-23
DK1181363T3 (da) 2007-05-29
AU781135B2 (en) 2005-05-05
EP1402897A2 (de) 2004-03-31
WO2000069894A3 (en) 2001-02-08
ES2281341T3 (es) 2007-10-01
ES2271468T3 (es) 2007-04-16
US20040229212A1 (en) 2004-11-18
ATE352620T1 (de) 2007-02-15
NZ515717A (en) 2004-01-30
WO2000069894A2 (en) 2000-11-23
ATE336260T1 (de) 2006-09-15
US20070197428A1 (en) 2007-08-23
PT1402897E (pt) 2007-01-31
DE60009896D1 (de) 2004-05-19
EP1181363A1 (de) 2002-02-27
NZ515718A (en) 2004-03-26
EP1402897A3 (de) 2004-06-30
US7202207B2 (en) 2007-04-10
DE60033147T2 (de) 2007-12-13
DE60009896T2 (de) 2005-04-21
NO20015506L (no) 2002-01-09
AU779404B2 (en) 2005-01-20
NO20015481D0 (no) 2001-11-08
US6846649B1 (en) 2005-01-25
JP2002544286A (ja) 2002-12-24

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