ATE252545T1 - Synthese von midodrin hydrochlorid aus dem zwischenprodukt 1-(2'.5'-dimethoxyphenyl)-2- azidoethanon - Google Patents
Synthese von midodrin hydrochlorid aus dem zwischenprodukt 1-(2'.5'-dimethoxyphenyl)-2- azidoethanonInfo
- Publication number
- ATE252545T1 ATE252545T1 AT01931614T AT01931614T ATE252545T1 AT E252545 T1 ATE252545 T1 AT E252545T1 AT 01931614 T AT01931614 T AT 01931614T AT 01931614 T AT01931614 T AT 01931614T AT E252545 T1 ATE252545 T1 AT E252545T1
- Authority
- AT
- Austria
- Prior art keywords
- dimethoxyphenyl
- azidoethanone
- synthesis
- midodrine hydrochloride
- midodrine
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C231/00—Preparation of carboxylic acid amides
- C07C231/14—Preparation of carboxylic acid amides by formation of carboxamide groups together with reactions not involving the carboxamide groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
- C07C237/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
- C07C237/08—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated having the nitrogen atom of at least one of the carboxamide groups bound to an acyclic carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C247/00—Compounds containing azido groups
- C07C247/02—Compounds containing azido groups with azido groups bound to acyclic carbon atoms of a carbon skeleton
- C07C247/08—Compounds containing azido groups with azido groups bound to acyclic carbon atoms of a carbon skeleton being unsaturated
- C07C247/10—Compounds containing azido groups with azido groups bound to acyclic carbon atoms of a carbon skeleton being unsaturated and containing rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US09/550,417 US6201153B1 (en) | 2000-04-17 | 2000-04-17 | Synthesis of midodrine HCI from a novel intermediate 1-(2′,5′-dimethoxyphenyl)-2-azidoethanone |
PCT/EP2001/004348 WO2001079154A2 (en) | 2000-04-17 | 2001-04-17 | Synthesis of midodrine hci from a novel intermediate 1-(2',5'-dimethoxyphenyl)-2-azidoethanone |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE252545T1 true ATE252545T1 (de) | 2003-11-15 |
Family
ID=24197102
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT01931614T ATE252545T1 (de) | 2000-04-17 | 2001-04-17 | Synthese von midodrin hydrochlorid aus dem zwischenprodukt 1-(2'.5'-dimethoxyphenyl)-2- azidoethanon |
Country Status (7)
Country | Link |
---|---|
US (1) | US6201153B1 (de) |
EP (1) | EP1276711B1 (de) |
AT (1) | ATE252545T1 (de) |
AU (1) | AU2001258344A1 (de) |
DE (1) | DE60101053T2 (de) |
ES (1) | ES2210160T3 (de) |
WO (1) | WO2001079154A2 (de) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU2002330731A1 (en) * | 2002-08-21 | 2004-03-11 | Sanmar Speciality Chemicals Ltd | An improved process for the synthesis of (plus or minus) 2-amino-n-(2,(s,5-dimethoxyphenyl)-2-hydroxyethyl) acetamide monohydrochloride |
CA2421550C (en) * | 2003-03-11 | 2008-06-03 | Brantford Chemicals Inc. | Process for the preparation of midodrine, pharmaceutically-acceptable salts thereof and intermediates |
CN100434415C (zh) * | 2004-11-15 | 2008-11-19 | 天津药物研究院 | 盐酸米多君中间体2-氨基-1-(2.5-二甲氧基苯)-乙醇的制备方法 |
KR101356471B1 (ko) * | 2011-12-09 | 2014-01-29 | 고려대학교 산학협력단 | 고혈압 예방 및 치료용 화합물 |
CN115745812A (zh) * | 2022-11-11 | 2023-03-07 | 成都沣德煜晟医药科技有限公司 | 2-氨基-1-(2,5-二甲氧基苯基)乙醇的制备方法 |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AT241435B (de) | 1963-06-11 | 1965-07-26 | Chemie Linz Ag | Verfahren zur Herstellung von neuen Phenylalkanolaminderivaten und deren Salzen |
DE2506110C2 (de) * | 1975-02-13 | 1983-04-21 | Lentia GmbH Chem. u. pharm. Erzeugnisse - Industriebedarf, 8000 München | Verfahren zur Herstellung von 2- Amino-N-(β-hydroxy-2,5-dimethoxy-phenäthyl)-acetamid (Midodrin) |
JPH07285921A (ja) * | 1994-04-15 | 1995-10-31 | Sanyo Kagaku Kenkyusho:Kk | 2−アミノ−N−(β−ヒドロキシフェネチル)アセトアミド誘導体の製造方法 |
-
2000
- 2000-04-17 US US09/550,417 patent/US6201153B1/en not_active Expired - Lifetime
-
2001
- 2001-04-17 AT AT01931614T patent/ATE252545T1/de active
- 2001-04-17 WO PCT/EP2001/004348 patent/WO2001079154A2/en active IP Right Grant
- 2001-04-17 EP EP01931614A patent/EP1276711B1/de not_active Expired - Lifetime
- 2001-04-17 ES ES01931614T patent/ES2210160T3/es not_active Expired - Lifetime
- 2001-04-17 DE DE60101053T patent/DE60101053T2/de not_active Expired - Lifetime
- 2001-04-17 AU AU2001258344A patent/AU2001258344A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
DE60101053D1 (de) | 2003-11-27 |
AU2001258344A1 (en) | 2001-10-30 |
WO2001079154A3 (en) | 2002-03-21 |
ES2210160T3 (es) | 2004-07-01 |
US6201153B1 (en) | 2001-03-13 |
EP1276711A2 (de) | 2003-01-22 |
DE60101053T2 (de) | 2004-08-19 |
WO2001079154A2 (en) | 2001-10-25 |
EP1276711B1 (de) | 2003-10-22 |
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