ATE252545T1 - Synthese von midodrin hydrochlorid aus dem zwischenprodukt 1-(2'.5'-dimethoxyphenyl)-2- azidoethanon - Google Patents

Synthese von midodrin hydrochlorid aus dem zwischenprodukt 1-(2'.5'-dimethoxyphenyl)-2- azidoethanon

Info

Publication number
ATE252545T1
ATE252545T1 AT01931614T AT01931614T ATE252545T1 AT E252545 T1 ATE252545 T1 AT E252545T1 AT 01931614 T AT01931614 T AT 01931614T AT 01931614 T AT01931614 T AT 01931614T AT E252545 T1 ATE252545 T1 AT E252545T1
Authority
AT
Austria
Prior art keywords
dimethoxyphenyl
azidoethanone
synthesis
midodrine hydrochloride
midodrine
Prior art date
Application number
AT01931614T
Other languages
English (en)
Inventor
Anup Kumar Ray
Hiren Kumar V Patel
Mahendra R Patel
Original Assignee
Novartis Pharma Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Pharma Gmbh filed Critical Novartis Pharma Gmbh
Application granted granted Critical
Publication of ATE252545T1 publication Critical patent/ATE252545T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/14—Preparation of carboxylic acid amides by formation of carboxamide groups together with reactions not involving the carboxamide groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C237/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C237/08—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated having the nitrogen atom of at least one of the carboxamide groups bound to an acyclic carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C247/00—Compounds containing azido groups
    • C07C247/02—Compounds containing azido groups with azido groups bound to acyclic carbon atoms of a carbon skeleton
    • C07C247/08—Compounds containing azido groups with azido groups bound to acyclic carbon atoms of a carbon skeleton being unsaturated
    • C07C247/10—Compounds containing azido groups with azido groups bound to acyclic carbon atoms of a carbon skeleton being unsaturated and containing rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
AT01931614T 2000-04-17 2001-04-17 Synthese von midodrin hydrochlorid aus dem zwischenprodukt 1-(2'.5'-dimethoxyphenyl)-2- azidoethanon ATE252545T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/550,417 US6201153B1 (en) 2000-04-17 2000-04-17 Synthesis of midodrine HCI from a novel intermediate 1-(2′,5′-dimethoxyphenyl)-2-azidoethanone
PCT/EP2001/004348 WO2001079154A2 (en) 2000-04-17 2001-04-17 Synthesis of midodrine hci from a novel intermediate 1-(2',5'-dimethoxyphenyl)-2-azidoethanone

Publications (1)

Publication Number Publication Date
ATE252545T1 true ATE252545T1 (de) 2003-11-15

Family

ID=24197102

Family Applications (1)

Application Number Title Priority Date Filing Date
AT01931614T ATE252545T1 (de) 2000-04-17 2001-04-17 Synthese von midodrin hydrochlorid aus dem zwischenprodukt 1-(2'.5'-dimethoxyphenyl)-2- azidoethanon

Country Status (7)

Country Link
US (1) US6201153B1 (de)
EP (1) EP1276711B1 (de)
AT (1) ATE252545T1 (de)
AU (1) AU2001258344A1 (de)
DE (1) DE60101053T2 (de)
ES (1) ES2210160T3 (de)
WO (1) WO2001079154A2 (de)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7094928B2 (en) * 2002-08-21 2006-08-22 Sanmar Specialty Chemicals Ltd. Process for the synthesis of (±) 2-Amino-N-[2,(2,5-dimethoxy phenyl)-2-hydroxyethyl] acetamide monohydrochloride
CA2421550C (en) * 2003-03-11 2008-06-03 Brantford Chemicals Inc. Process for the preparation of midodrine, pharmaceutically-acceptable salts thereof and intermediates
CN100434415C (zh) * 2004-11-15 2008-11-19 天津药物研究院 盐酸米多君中间体2-氨基-1-（2.5-二甲氧基苯）-乙醇的制备方法
KR101356471B1 (ko) * 2011-12-09 2014-01-29 고려대학교 산학협력단 고혈압 예방 및 치료용 화합물
CN115745812A (zh) * 2022-11-11 2023-03-07 成都沣德煜晟医药科技有限公司 2-氨基-1-(2,5-二甲氧基苯基)乙醇的制备方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AT241435B (de) 1963-06-11 1965-07-26 Chemie Linz Ag Verfahren zur Herstellung von neuen Phenylalkanolaminderivaten und deren Salzen
DE2506110C2 (de) * 1975-02-13 1983-04-21 Lentia GmbH Chem. u. pharm. Erzeugnisse - Industriebedarf, 8000 München Verfahren zur Herstellung von 2- Amino-N-(β-hydroxy-2,5-dimethoxy-phenäthyl)-acetamid (Midodrin)
JPH07285921A (ja) * 1994-04-15 1995-10-31 Sanyo Kagaku Kenkyusho:Kk ２−アミノ−Ｎ−（β−ヒドロキシフェネチル）アセトアミド誘導体の製造方法

Also Published As

Publication number Publication date
EP1276711B1 (de) 2003-10-22
US6201153B1 (en) 2001-03-13
ES2210160T3 (es) 2004-07-01
AU2001258344A1 (en) 2001-10-30
DE60101053D1 (de) 2003-11-27
WO2001079154A2 (en) 2001-10-25
EP1276711A2 (de) 2003-01-22
DE60101053T2 (de) 2004-08-19
WO2001079154A3 (en) 2002-03-21

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