ATE252109T1 - Kupplungsarm für festträger oligonukleotid- synthese und verfahren zur herstellung davon - Google Patents
Kupplungsarm für festträger oligonukleotid- synthese und verfahren zur herstellung davonInfo
- Publication number
- ATE252109T1 ATE252109T1 AT96940965T AT96940965T ATE252109T1 AT E252109 T1 ATE252109 T1 AT E252109T1 AT 96940965 T AT96940965 T AT 96940965T AT 96940965 T AT96940965 T AT 96940965T AT E252109 T1 ATE252109 T1 AT E252109T1
- Authority
- AT
- Austria
- Prior art keywords
- group
- unsubstituted
- substituted
- hydrogen
- linker arm
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/11—Compounds covalently bound to a solid support
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US920895P | 1995-12-22 | 1995-12-22 | |
PCT/CA1996/000837 WO1997023497A1 (en) | 1995-12-22 | 1996-12-13 | Linker arm for solid support oligonucleotide synthesis and process for production thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE252109T1 true ATE252109T1 (de) | 2003-11-15 |
Family
ID=21736236
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT96940965T ATE252109T1 (de) | 1995-12-22 | 1996-12-13 | Kupplungsarm für festträger oligonukleotid- synthese und verfahren zur herstellung davon |
AT96940964T ATE219098T1 (de) | 1995-12-22 | 1996-12-13 | Wiederverwendbarer festtäger für oligonukleotid- synthese, verfahren zur herstellung davon und verfahren zur verwendung davon |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT96940964T ATE219098T1 (de) | 1995-12-22 | 1996-12-13 | Wiederverwendbarer festtäger für oligonukleotid- synthese, verfahren zur herstellung davon und verfahren zur verwendung davon |
Country Status (8)
Country | Link |
---|---|
US (1) | US6015895A (de) |
EP (2) | EP0876390B1 (de) |
JP (2) | JP2000502341A (de) |
AT (2) | ATE252109T1 (de) |
AU (2) | AU725690B2 (de) |
CA (2) | CA2241331C (de) |
DE (2) | DE69630400T2 (de) |
WO (2) | WO1997023497A1 (de) |
Families Citing this family (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6043353A (en) * | 1995-12-22 | 2000-03-28 | University Technologies International, Inc. | Reusable solid support for oligonucleotide synthesis, process for production thereof and process for use thereof |
EP1063286A4 (de) * | 1998-02-09 | 2004-03-24 | Toyo Kohan Co Ltd | Substrate zur immobilisierung und amplifikation von dns, dns-immobilisierte chips mit immobilisierter dns auf den substraten und methode zur dns amplifikation |
CA2319587C (en) * | 1998-02-11 | 2004-09-21 | University Of Houston | Method and apparatus for chemical and biochemical reactions using photo-generated reagents |
US7135564B1 (en) * | 1998-07-02 | 2006-11-14 | University Technologies International Inc. | Reusable solid support for oligonucleotide synthesis |
EP1091972A1 (de) * | 1998-07-02 | 2001-04-18 | University Technologies International Inc. | Wiederverwendbarer festträger für oligonukleotid-synthese |
US6924359B1 (en) * | 1999-07-01 | 2005-08-02 | Yale University | Neovascular-targeted immunoconjugates |
JP3786248B2 (ja) * | 1999-11-11 | 2006-06-14 | 東洋鋼鈑株式会社 | 化学修飾を施した基体およびその製造方法 |
WO2002020541A2 (en) * | 2000-09-05 | 2002-03-14 | University Technologies International Inc. | Process for producing multiple oligonucleotides on a solid support |
CA2421266A1 (en) * | 2000-09-08 | 2002-03-14 | Richard T. Pon | Linker phosphoramidites for oligonucleotide synthesis |
JP2004248503A (ja) * | 2000-10-18 | 2004-09-09 | Takara Holdings Inc | 核酸固定化用担体 |
JP2002199881A (ja) | 2000-12-28 | 2002-07-16 | Toyo Kohan Co Ltd | Dna固定化基体の再使用法 |
US7211654B2 (en) * | 2001-03-14 | 2007-05-01 | Regents Of The University Of Michigan | Linkers and co-coupling agents for optimization of oligonucleotide synthesis and purification on solid supports |
WO2003000683A1 (en) | 2001-06-25 | 2003-01-03 | Japan Science And Technology Agency | Method of the solid phase synhesis of pyrrole-imidazole polyamide |
FR2826957B1 (fr) * | 2001-07-09 | 2005-09-30 | Centre Nat Rech Scient | Procede de fonctionnalisation de supports solides, supports solides fonctionnalises et leurs utilisations |
US20030092062A1 (en) * | 2001-10-24 | 2003-05-15 | Reddy M. Parameswara | Immobilizing biological molecules |
US20030162160A1 (en) * | 2002-02-27 | 2003-08-28 | Jack Horchler | Interactive puzzle |
US7202264B2 (en) | 2003-01-31 | 2007-04-10 | Isis Pharmaceuticals, Inc. | Supports for oligomer synthesis |
DK1692139T3 (da) * | 2003-11-13 | 2013-03-11 | Isis Pharmaceuticals Inc | 5,6-dihydroxy-isoindol-derivater som linkere til fastfasesyntese af oligomerer |
GB0428020D0 (en) * | 2004-12-22 | 2005-01-26 | Amersham Health As | Stabilisation of radiopharmaceutical precursors |
EP3067359A1 (de) | 2008-09-23 | 2016-09-14 | Scott G. Petersen | Selbstfreisetzende biolabile phosphatgeschützte pro-oligos für therapeutika auf oligonukleotidbasis und vermittlung von rna-interferenz |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB9021625D0 (en) * | 1990-10-04 | 1990-11-21 | Ici Plc | Synthesis of oligonucleotides |
ATE239484T1 (de) * | 1991-10-24 | 2003-05-15 | Isis Pharmaceuticals Inc | Derivatisierte oligonukleotide mit verbessertem aufnahmevermögen |
US5476925A (en) * | 1993-02-01 | 1995-12-19 | Northwestern University | Oligodeoxyribonucleotides including 3'-aminonucleoside-phosphoramidate linkages and terminal 3'-amino groups |
DE69420307T2 (de) * | 1993-04-05 | 2000-01-27 | Perseptive Biosystems Inc | Automatisierte Allyl-Deprotektion bei der Festphasesynthese |
US5817751A (en) * | 1994-06-23 | 1998-10-06 | Affymax Technologies N.V. | Method for synthesis of diketopiperazine and diketomorpholine derivatives |
US5502068A (en) * | 1995-01-31 | 1996-03-26 | Synphar Laboratories, Inc. | Cyclopropylpyrroloindole-oligopeptide anticancer agents |
US5770687A (en) * | 1995-06-07 | 1998-06-23 | Peptor Limited | Comformationally constrained backbone cyclized somatostatin analogs |
US5798276A (en) * | 1995-06-07 | 1998-08-25 | Molecular Probes, Inc. | Reactive derivatives of sulforhodamine 101 with enhanced hydrolytic stability |
DE19532553A1 (de) * | 1995-09-04 | 1997-03-06 | Hoechst Ag | Verfahren zur Herstellung substituierter N-Ethyl-Glycinderivate |
US5736626A (en) * | 1996-01-29 | 1998-04-07 | The Perkin-Elmer Corporation | Solid support reagents for the direct synthesis of 3'-labeled polynucleotides |
-
1996
- 1996-12-13 JP JP09523166A patent/JP2000502341A/ja active Pending
- 1996-12-13 DE DE69630400T patent/DE69630400T2/de not_active Expired - Fee Related
- 1996-12-13 AT AT96940965T patent/ATE252109T1/de not_active IP Right Cessation
- 1996-12-13 DE DE69621836T patent/DE69621836T2/de not_active Expired - Fee Related
- 1996-12-13 US US09/091,513 patent/US6015895A/en not_active Expired - Fee Related
- 1996-12-13 WO PCT/CA1996/000837 patent/WO1997023497A1/en active IP Right Grant
- 1996-12-13 AU AU10278/97A patent/AU725690B2/en not_active Ceased
- 1996-12-13 AU AU10277/97A patent/AU725627B2/en not_active Ceased
- 1996-12-13 CA CA002241331A patent/CA2241331C/en not_active Expired - Fee Related
- 1996-12-13 EP EP96940964A patent/EP0876390B1/de not_active Expired - Lifetime
- 1996-12-13 CA CA002241222A patent/CA2241222C/en not_active Expired - Fee Related
- 1996-12-13 WO PCT/CA1996/000836 patent/WO1997023496A1/en active IP Right Grant
- 1996-12-13 JP JP09523167A patent/JP2000502342A/ja active Pending
- 1996-12-13 AT AT96940964T patent/ATE219098T1/de active
- 1996-12-13 EP EP96940965A patent/EP0877751B1/de not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
AU1027797A (en) | 1997-07-17 |
AU1027897A (en) | 1997-07-17 |
EP0876390B1 (de) | 2002-06-12 |
AU725690B2 (en) | 2000-10-19 |
WO1997023497A1 (en) | 1997-07-03 |
WO1997023496A1 (en) | 1997-07-03 |
DE69630400D1 (de) | 2003-11-20 |
ATE219098T1 (de) | 2002-06-15 |
EP0876390A1 (de) | 1998-11-11 |
EP0877751A1 (de) | 1998-11-18 |
DE69621836D1 (de) | 2002-07-18 |
AU725627B2 (en) | 2000-10-19 |
DE69621836T2 (de) | 2003-02-20 |
CA2241222C (en) | 2003-07-22 |
EP0877751B1 (de) | 2003-10-15 |
JP2000502341A (ja) | 2000-02-29 |
JP2000502342A (ja) | 2000-02-29 |
US6015895A (en) | 2000-01-18 |
DE69630400T2 (de) | 2005-04-14 |
CA2241222A1 (en) | 1997-07-03 |
CA2241331C (en) | 2003-06-17 |
CA2241331A1 (en) | 1997-07-03 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |