ATE246009T1 - Thiolierung von peptiden zur strahlendiagnostik und strahlentherapie auf radionuklidbasis - Google Patents

Thiolierung von peptiden zur strahlendiagnostik und strahlentherapie auf radionuklidbasis

Info

Publication number
ATE246009T1
ATE246009T1 AT96919062T AT96919062T ATE246009T1 AT E246009 T1 ATE246009 T1 AT E246009T1 AT 96919062 T AT96919062 T AT 96919062T AT 96919062 T AT96919062 T AT 96919062T AT E246009 T1 ATE246009 T1 AT E246009T1
Authority
AT
Austria
Prior art keywords
peptide
thiol
radiation
thiolation
radionuclide
Prior art date
Application number
AT96919062T
Other languages
English (en)
Inventor
Serengulam V Govindan
Gary L Griffiths
Hans L Hansen
Original Assignee
Immunomedics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/483,095 external-priority patent/US5746996A/en
Application filed by Immunomedics Inc filed Critical Immunomedics Inc
Application granted granted Critical
Publication of ATE246009T1 publication Critical patent/ATE246009T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/088—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins conjugates with carriers being peptides, polyamino acids or proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/083—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins the peptide being octreotide or a somatostatin-receptor-binding peptide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Physics & Mathematics (AREA)
  • Optics & Photonics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AT96919062T 1995-06-07 1996-06-07 Thiolierung von peptiden zur strahlendiagnostik und strahlentherapie auf radionuklidbasis ATE246009T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US48309895A 1995-06-07 1995-06-07
US08/483,095 US5746996A (en) 1994-06-03 1995-06-07 Thiolation of peptides for radionuclide-based radiodetection and radiotherapy
PCT/US1996/008693 WO1996040289A1 (en) 1995-06-07 1996-06-07 Thiolation of peptides for radionuclide-based radiodetection and radiotherapy

Publications (1)

Publication Number Publication Date
ATE246009T1 true ATE246009T1 (de) 2003-08-15

Family

ID=27047528

Family Applications (1)

Application Number Title Priority Date Filing Date
AT96919062T ATE246009T1 (de) 1995-06-07 1996-06-07 Thiolierung von peptiden zur strahlendiagnostik und strahlentherapie auf radionuklidbasis

Country Status (8)

Country Link
EP (1) EP0831936B1 (de)
JP (1) JPH11507623A (de)
AT (1) ATE246009T1 (de)
AU (1) AU709219B2 (de)
CA (1) CA2222966C (de)
DE (1) DE69629295T2 (de)
ES (1) ES2206579T3 (de)
WO (1) WO1996040289A1 (de)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6576746B2 (en) 1998-10-13 2003-06-10 Immunomedics, Inc. Site-specific labeling of disulfide-containing targeting vectors
JP4680387B2 (ja) * 1998-10-13 2011-05-11 イミューノメディクス、インコーポレイテッド ジスルフィド含有標的ベクターの部位特異的標識化
EP1749026B1 (de) 2004-05-24 2011-11-23 Institut de Cardiologie de Montréal Markierte adrenomedullinderivate und deren verwendung zur bilddarstellung und therapie
WO2008138141A1 (en) * 2007-05-11 2008-11-20 Institut De Cardiologie De Montréal Labelled adrenomedullin derivatives and their use for imaging and therapy.
JP2009051784A (ja) * 2007-08-28 2009-03-12 Inst Nuclear Energy Research Rocaec 癌を抑制する放射性物質及びその調整方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5180816A (en) * 1988-08-24 1993-01-19 Centocor One vial method for labeling protein/linker conjugates with technetium-99M
WO1992021383A1 (en) * 1991-06-03 1992-12-10 Mallinckrodt Medical, Inc. Radiolabelled somatostatin derivatives, their preparation and use
US5225180A (en) * 1991-09-10 1993-07-06 Diatech, Inc. Technetium-99m labeled somatostatin-derived peptides for imaging
AU683833B2 (en) * 1992-01-03 1997-11-27 Rhomed Incorporated Protein- and peptide-metal ion pharmaceutical applications
IL113610A0 (en) * 1994-06-03 1995-08-31 Immunomedics Inc A method of radiolabeling a protein, radiolabeled proteins prepared thereby and diagnostic kits containing the same

Also Published As

Publication number Publication date
CA2222966A1 (en) 1996-12-19
ES2206579T3 (es) 2004-05-16
EP0831936B1 (de) 2003-07-30
CA2222966C (en) 2007-03-13
DE69629295D1 (de) 2003-09-04
EP0831936A1 (de) 1998-04-01
AU709219B2 (en) 1999-08-26
WO1996040289A1 (en) 1996-12-19
AU6150096A (en) 1996-12-30
JPH11507623A (ja) 1999-07-06
DE69629295T2 (de) 2004-05-13
EP0831936A4 (de) 2001-05-16

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