ATE240109T1 - Auf die leber zielende verbindungen und reagentien zu deren herstellung - Google Patents
Auf die leber zielende verbindungen und reagentien zu deren herstellungInfo
- Publication number
- ATE240109T1 ATE240109T1 AT95943691T AT95943691T ATE240109T1 AT E240109 T1 ATE240109 T1 AT E240109T1 AT 95943691 T AT95943691 T AT 95943691T AT 95943691 T AT95943691 T AT 95943691T AT E240109 T1 ATE240109 T1 AT E240109T1
- Authority
- AT
- Austria
- Prior art keywords
- compounds
- hexose
- directed
- reagents
- hepatic
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6891—Pre-targeting systems involving an antibody for targeting specific cells
- A61K47/6893—Pre-targeting systems involving an antibody for targeting specific cells clearing therapy or enhanced clearance, i.e. using an antibody clearing agents in addition to T-A and D-M
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/041—Heterocyclic compounds
- A61K51/044—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
- A61K51/0465—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/02—Acyclic radicals, not substituted by cyclic structures
- C07H15/04—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/02—Acyclic radicals, not substituted by cyclic structures
- C07H15/14—Acyclic radicals, not substituted by cyclic structures attached to a sulfur, selenium or tellurium atom of a saccharide radical
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2121/00—Preparations for use in therapy
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Biotechnology (AREA)
- Crystallography & Structural Chemistry (AREA)
- Molecular Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Genetics & Genomics (AREA)
- Nanotechnology (AREA)
- Biochemistry (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Immunology (AREA)
- Medical Informatics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- General Engineering & Computer Science (AREA)
- Optics & Photonics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Gastroenterology & Hepatology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/351,651 US5886143A (en) | 1994-12-07 | 1994-12-07 | Hepatic-directed compounds and reagents for preparation thereof |
PCT/US1995/015875 WO1996017613A1 (en) | 1994-12-07 | 1995-12-06 | Hepatic-directed compounds and reagents for preparation thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE240109T1 true ATE240109T1 (de) | 2003-05-15 |
Family
ID=23381756
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT95943691T ATE240109T1 (de) | 1994-12-07 | 1995-12-06 | Auf die leber zielende verbindungen und reagentien zu deren herstellung |
Country Status (7)
Country | Link |
---|---|
US (2) | US5886143A (de) |
EP (1) | EP0794788B1 (de) |
JP (1) | JP2001525790A (de) |
AT (1) | ATE240109T1 (de) |
CA (1) | CA2207096A1 (de) |
DE (1) | DE69530787T2 (de) |
WO (1) | WO1996017613A1 (de) |
Families Citing this family (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP3664727B2 (ja) * | 1994-01-24 | 2005-06-29 | ネオルクス コーポレイション | 放射標識したアネキシン |
US5968477A (en) * | 1994-01-24 | 1999-10-19 | Neorx Corporation | Radiolabeled annexin conjugates with hexose and a chelator |
US6172045B1 (en) * | 1994-12-07 | 2001-01-09 | Neorx Corporation | Cluster clearing agents |
EP0906015A4 (de) * | 1996-06-06 | 2004-05-12 | Neorx Corp | Mittel zur unterdrückung von rückhalteprozessen in der leber |
DE19755367C2 (de) * | 1997-12-12 | 2001-03-22 | Afting Ernst Guenter | Pharmazeutische Zusammensetzung enthaltend D-Galaktose und ihre Verwendung |
MXPA01004239A (es) * | 1998-10-30 | 2002-06-04 | Daiichi Seiyaku Co | Compuesto dds y metodo para la medicion del mismo. |
KR20050038005A (ko) | 2002-07-18 | 2005-04-25 | 헬릭스 바이오파마 코포레이션 | 암세포 성장의 저해를 위한 우레아제의 사용 |
JP4430344B2 (ja) * | 2002-09-09 | 2010-03-10 | 独立行政法人科学技術振興機構 | 多岐用途型リンカー化合物及びリガンド、並びにそれらの製造方法 |
WO2006041613A2 (en) * | 2004-10-05 | 2006-04-20 | Nanomega Medical Corporation | Nanoparticles for targeting hepatoma cells |
CA2591496C (en) * | 2006-12-18 | 2014-09-02 | Japan Science And Technology Agency | Method of measuring interaction between biomaterial and sugar chain, method of evaluating biomaterial in sugar chain selectivity, method of screening biomaterial, method of patterning biomaterials, and kits for performing these methods |
US9518087B2 (en) | 2010-08-10 | 2016-12-13 | Ecole Polytechnique Federale De Lausanne (Epfl) | Erythrocyte-binding therapeutics |
US9517257B2 (en) | 2010-08-10 | 2016-12-13 | Ecole Polytechnique Federale De Lausanne (Epfl) | Erythrocyte-binding therapeutics |
US9850296B2 (en) | 2010-08-10 | 2017-12-26 | Ecole Polytechnique Federale De Lausanne (Epfl) | Erythrocyte-binding therapeutics |
RU2013133813A (ru) | 2010-12-21 | 2015-01-27 | Конинклейке Филипс Электроникс Н.В. | Средства для выведения биомолекул из кровотока |
US10046056B2 (en) | 2014-02-21 | 2018-08-14 | École Polytechnique Fédérale De Lausanne (Epfl) | Glycotargeting therapeutics |
US10953101B2 (en) | 2014-02-21 | 2021-03-23 | École Polytechnique Fédérale De Lausanne (Epfl) | Glycotargeting therapeutics |
JP6744227B2 (ja) | 2014-02-21 | 2020-08-19 | エコール・ポリテクニーク・フェデラル・ドゥ・ローザンヌ(ウペエフエル)Ecole Polytechnique Federale de Lausanne (EPFL) | 糖標的化治療剤 |
US10946079B2 (en) | 2014-02-21 | 2021-03-16 | Ecole Polytechnique Federale De Lausanne | Glycotargeting therapeutics |
WO2018232176A1 (en) | 2017-06-16 | 2018-12-20 | The University Of Chicago | Compositions and methods for inducing immune tolerance |
KR20230006800A (ko) | 2020-01-31 | 2023-01-11 | 아빌라 테라퓨틱스, 인크. | 세포외 단백질의 분해를 위한 asgpr-결합 화합물 |
Family Cites Families (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4410688A (en) * | 1981-04-29 | 1983-10-18 | Allied Corporation | Macromolecular highly branched homogeneous compound |
US4568737A (en) * | 1983-01-07 | 1986-02-04 | The Dow Chemical Company | Dense star polymers and dendrimers |
US4558120A (en) * | 1983-01-07 | 1985-12-10 | The Dow Chemical Company | Dense star polymer |
US4507466A (en) * | 1983-01-07 | 1985-03-26 | The Dow Chemical Corporation | Dense star polymers having core, core branches, terminal groups |
US4587329A (en) * | 1984-08-17 | 1986-05-06 | The Dow Chemical Company | Dense star polymers having two dimensional molecular diameter |
US4897255A (en) * | 1985-01-14 | 1990-01-30 | Neorx Corporation | Metal radionuclide labeled proteins for diagnosis and therapy |
US5045303A (en) * | 1985-05-17 | 1991-09-03 | Neorx Corporation | Radiohalogenated small molecules for protein labeling |
US5554386A (en) * | 1986-07-03 | 1996-09-10 | Advanced Magnetics, Inc. | Delivery of therapeutic agents to receptors using polysaccharides |
US5057302A (en) * | 1987-02-13 | 1991-10-15 | Abbott Laboratories | Bifunctional chelating agents |
US4965392A (en) * | 1987-03-26 | 1990-10-23 | Neorx Corporation | Chelating compounds for metal-radionuclide labeled proteins |
US5166320A (en) * | 1987-04-22 | 1992-11-24 | University Of Connecticut | Carrier system and method for the introduction of genes into mammalian cells |
GB8809616D0 (en) * | 1988-04-22 | 1988-05-25 | Cancer Res Campaign Tech | Further improvements relating to drug delivery systems |
AU642202B2 (en) * | 1989-12-27 | 1993-10-14 | Boehringer Ingelheim International Gmbh | Use of an anticoagulant as a diagnostic agent |
US5552525A (en) * | 1991-02-08 | 1996-09-03 | Diatech Inc. | Technetium-99m labeled peptides for imaging inflammation |
US5310536A (en) * | 1992-02-06 | 1994-05-10 | Mallinckrodt Medical, Inc. | Ligands for improving metal chelate formation kinetics |
US5624896A (en) * | 1992-06-09 | 1997-04-29 | Neorx Corporation | Clearing agents useful in pretargeting methods |
-
1994
- 1994-12-07 US US08/351,651 patent/US5886143A/en not_active Expired - Fee Related
-
1995
- 1995-12-06 WO PCT/US1995/015875 patent/WO1996017613A1/en active IP Right Grant
- 1995-12-06 DE DE69530787T patent/DE69530787T2/de not_active Expired - Fee Related
- 1995-12-06 JP JP51775296A patent/JP2001525790A/ja not_active Ceased
- 1995-12-06 EP EP95943691A patent/EP0794788B1/de not_active Expired - Lifetime
- 1995-12-06 AT AT95943691T patent/ATE240109T1/de not_active IP Right Cessation
- 1995-12-06 CA CA002207096A patent/CA2207096A1/en not_active Abandoned
-
1997
- 1997-03-03 US US08/808,024 patent/US5985826A/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
US5985826A (en) | 1999-11-16 |
EP0794788A1 (de) | 1997-09-17 |
EP0794788A4 (de) | 2000-05-24 |
EP0794788B1 (de) | 2003-05-14 |
WO1996017613A1 (en) | 1996-06-13 |
DE69530787D1 (de) | 2003-06-18 |
JP2001525790A (ja) | 2001-12-11 |
DE69530787T2 (de) | 2004-06-03 |
US5886143A (en) | 1999-03-23 |
CA2207096A1 (en) | 1996-06-13 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |