ATE238346T1 - Rho-conotoxin peptide mit selektiver antagonistischer aktivität auf den alpha-1- adrenozeptor - Google Patents
Rho-conotoxin peptide mit selektiver antagonistischer aktivität auf den alpha-1- adrenozeptorInfo
- Publication number
- ATE238346T1 ATE238346T1 AT99950405T AT99950405T ATE238346T1 AT E238346 T1 ATE238346 T1 AT E238346T1 AT 99950405 T AT99950405 T AT 99950405T AT 99950405 T AT99950405 T AT 99950405T AT E238346 T1 ATE238346 T1 AT E238346T1
- Authority
- AT
- Austria
- Prior art keywords
- adrenoceptor
- alpha
- rho
- antagonistic activity
- conotoxin peptides
- Prior art date
Links
- 108020004102 alpha-1 Adrenergic Receptor Proteins 0.000 title abstract 3
- 102000004196 processed proteins & peptides Human genes 0.000 title abstract 3
- 108090000765 processed proteins & peptides Proteins 0.000 title abstract 3
- 102000030619 alpha-1 Adrenergic Receptor Human genes 0.000 title 1
- 230000003042 antagnostic effect Effects 0.000 title 1
- 239000000556 agonist Substances 0.000 abstract 3
- SFLSHLFXELFNJZ-QMMMGPOBSA-N (-)-norepinephrine Chemical compound NC[C@H](O)C1=CC=C(O)C(O)=C1 SFLSHLFXELFNJZ-QMMMGPOBSA-N 0.000 abstract 2
- 102000015009 alpha1-adrenergic receptor activity proteins Human genes 0.000 abstract 2
- 230000002401 inhibitory effect Effects 0.000 abstract 2
- 229960002748 norepinephrine Drugs 0.000 abstract 2
- SFLSHLFXELFNJZ-UHFFFAOYSA-N norepinephrine Natural products NCC(O)C1=CC=C(O)C(O)=C1 SFLSHLFXELFNJZ-UHFFFAOYSA-N 0.000 abstract 2
- 239000005557 antagonist Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/43504—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Toxicology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Urology & Nephrology (AREA)
- Rheumatology (AREA)
- Hospice & Palliative Care (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AUPP6273A AUPP627398A0 (en) | 1998-10-02 | 1998-10-02 | Novel peptides - II |
| PCT/AU1999/000843 WO2000020443A1 (en) | 1998-10-02 | 1999-10-01 | Novel peptides |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE238346T1 true ATE238346T1 (de) | 2003-05-15 |
Family
ID=3810491
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT99950405T ATE238346T1 (de) | 1998-10-02 | 1999-10-01 | Rho-conotoxin peptide mit selektiver antagonistischer aktivität auf den alpha-1- adrenozeptor |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US6849601B1 (de) |
| EP (1) | EP1117681B1 (de) |
| JP (1) | JP4512273B2 (de) |
| AT (1) | ATE238346T1 (de) |
| AU (1) | AUPP627398A0 (de) |
| CA (1) | CA2344551A1 (de) |
| DE (1) | DE69907239T2 (de) |
| ES (1) | ES2200558T3 (de) |
| NZ (1) | NZ510812A (de) |
| WO (1) | WO2000020443A1 (de) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0612669D0 (en) * | 2006-06-27 | 2006-08-09 | Univ Leeds | Biomarkers for preeclampsia |
| EP3298086B1 (de) | 2015-05-22 | 2020-09-09 | Clemson University Research Foundation | Conotoxinpeptide zur verwendung zur biofoulingprävention |
| CN110981967B (zh) * | 2019-11-22 | 2022-10-14 | 中国海洋大学 | α-芋螺毒素Mr1.1的二聚体、合成方法及应用 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5514774A (en) * | 1993-06-29 | 1996-05-07 | University Of Utah Research Foundation | Conotoxin peptides |
| US5780433A (en) * | 1996-12-06 | 1998-07-14 | University Of Utah Research Foundation | Use of α-conotoxin MII to treat disorders resulting from nicotine stimulated dopamine release |
| WO1999021878A1 (en) | 1997-10-24 | 1999-05-06 | University Of Utah Research Foundation | Interaction of alpha-conotoxin peptides with neuronal nicotinic acetylcholine receptors |
| US6265541B1 (en) | 1997-12-31 | 2001-07-24 | University Of Utah Research Foundation | Uses of α-conotoxin peptides |
-
1998
- 1998-10-02 AU AUPP6273A patent/AUPP627398A0/en not_active Abandoned
-
1999
- 1999-10-01 DE DE69907239T patent/DE69907239T2/de not_active Expired - Lifetime
- 1999-10-01 US US09/806,376 patent/US6849601B1/en not_active Expired - Fee Related
- 1999-10-01 JP JP2000574554A patent/JP4512273B2/ja not_active Expired - Fee Related
- 1999-10-01 EP EP99950405A patent/EP1117681B1/de not_active Expired - Lifetime
- 1999-10-01 WO PCT/AU1999/000843 patent/WO2000020443A1/en not_active Ceased
- 1999-10-01 ES ES99950405T patent/ES2200558T3/es not_active Expired - Lifetime
- 1999-10-01 CA CA002344551A patent/CA2344551A1/en not_active Abandoned
- 1999-10-01 AT AT99950405T patent/ATE238346T1/de not_active IP Right Cessation
- 1999-10-01 NZ NZ510812A patent/NZ510812A/xx not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| EP1117681B1 (de) | 2003-04-23 |
| EP1117681A1 (de) | 2001-07-25 |
| US6849601B1 (en) | 2005-02-01 |
| DE69907239T2 (de) | 2004-04-01 |
| ES2200558T3 (es) | 2004-03-01 |
| JP2002526097A (ja) | 2002-08-20 |
| CA2344551A1 (en) | 2000-04-13 |
| AUPP627398A0 (en) | 1998-10-22 |
| NZ510812A (en) | 2004-02-27 |
| WO2000020443A1 (en) | 2000-04-13 |
| JP4512273B2 (ja) | 2010-07-28 |
| DE69907239D1 (de) | 2003-05-28 |
| EP1117681A4 (de) | 2002-01-02 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |