ATE236651T1 - Materialen und verfahren im zusammenhang mit der inhibierung der wechselwirkung der p53 und mdm2 - Google Patents

Materialen und verfahren im zusammenhang mit der inhibierung der wechselwirkung der p53 und mdm2

Info

Publication number
ATE236651T1
ATE236651T1 AT98917411T AT98917411T ATE236651T1 AT E236651 T1 ATE236651 T1 AT E236651T1 AT 98917411 T AT98917411 T AT 98917411T AT 98917411 T AT98917411 T AT 98917411T AT E236651 T1 ATE236651 T1 AT E236651T1
Authority
AT
Austria
Prior art keywords
mdm2
cells
inhibiting
interaction
materials
Prior art date
Application number
AT98917411T
Other languages
English (en)
Inventor
David Philip Lane
Original Assignee
Univ Dundee
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Dundee filed Critical Univ Dundee
Application granted granted Critical
Publication of ATE236651T1 publication Critical patent/ATE236651T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Marine Sciences & Fisheries (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Cosmetics (AREA)
  • Paper (AREA)
  • Detergent Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
  • Optical Record Carriers And Manufacture Thereof (AREA)
AT98917411T 1997-04-22 1998-04-20 Materialen und verfahren im zusammenhang mit der inhibierung der wechselwirkung der p53 und mdm2 ATE236651T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9708092.3A GB9708092D0 (en) 1997-04-22 1997-04-22 Materials and methods relating to inhibiting the interaction of p53 and mdm2
PCT/GB1998/001144 WO1998047525A1 (en) 1997-04-22 1998-04-20 MATERIALS AND METHODS RELATING TO INHIBITING THE INTERACTION OF p53 AND mdm2

Publications (1)

Publication Number Publication Date
ATE236651T1 true ATE236651T1 (de) 2003-04-15

Family

ID=10811137

Family Applications (1)

Application Number Title Priority Date Filing Date
AT98917411T ATE236651T1 (de) 1997-04-22 1998-04-20 Materialen und verfahren im zusammenhang mit der inhibierung der wechselwirkung der p53 und mdm2

Country Status (7)

Country Link
EP (1) EP0977580B1 (de)
AT (1) ATE236651T1 (de)
AU (1) AU731431B2 (de)
CA (1) CA2287344A1 (de)
DE (1) DE69813204T2 (de)
GB (1) GB9708092D0 (de)
WO (1) WO1998047525A1 (de)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2939778C (en) 2007-01-31 2019-01-29 Dana-Farber Cancer Institute, Inc. Stabilized p53 peptides and uses thereof
CN101730708B (zh) 2007-03-28 2013-09-18 哈佛大学校长及研究员协会 缝合多肽
SI2603600T1 (sl) 2010-08-13 2019-04-30 Aileron Therapeutics, Inc. Peptidomimetični makrocikli
WO2013059525A1 (en) 2011-10-18 2013-04-25 Aileron Therapeutics, Inc. Peptidomimetic macrocyles
WO2013068476A1 (en) * 2011-11-09 2013-05-16 Merz Pharma Gmbh & Co. Kgaa Neurotoxins exhibiting shortened biological activity
SG11201404648PA (en) 2012-02-15 2014-09-26 Aileron Therapeutics Inc Peptidomimetic macrocycles
CN108912211A (zh) 2012-02-15 2018-11-30 爱勒让治疗公司 三唑交联的和硫醚交联的拟肽大环化合物
EP2914256B1 (de) 2012-11-01 2019-07-31 Aileron Therapeutics, Inc. Disubstituierte aminosäuren und verfahren zur herstellung und verwendung davon
BR112017005736A2 (pt) 2014-09-24 2017-12-12 Aileron Therapeutics Inc macrociclos peptidomiméticos e formulações dos mesmos
EP3197478A4 (de) 2014-09-24 2018-05-30 Aileron Therapeutics, Inc. Peptidomimetische makrozyklen und verwendungen davon
US10253067B2 (en) 2015-03-20 2019-04-09 Aileron Therapeutics, Inc. Peptidomimetic macrocycles and uses thereof
US10023613B2 (en) 2015-09-10 2018-07-17 Aileron Therapeutics, Inc. Peptidomimetic macrocycles as modulators of MCL-1
US11091522B2 (en) 2018-07-23 2021-08-17 Aileron Therapeutics, Inc. Peptidomimetic macrocycles and uses thereof

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5411860A (en) * 1992-04-07 1995-05-02 The Johns Hopkins University Amplification of human MDM2 gene in human tumors
US5770377A (en) * 1994-07-20 1998-06-23 University Of Dundee Interruption of binding of MDM2 and P53 protein and therapeutic application thereof
AU3847997A (en) * 1996-07-05 1998-02-02 Cancer Research Campaign Technology Limited Inhibitors of the interaction between P53 and MDM2

Also Published As

Publication number Publication date
DE69813204T2 (de) 2004-02-05
EP0977580B1 (de) 2003-04-09
AU731431B2 (en) 2001-03-29
WO1998047525A1 (en) 1998-10-29
AU7064498A (en) 1998-11-13
DE69813204D1 (de) 2003-05-15
GB9708092D0 (en) 1997-06-11
EP0977580A1 (de) 2000-02-09
CA2287344A1 (en) 1998-10-29

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