ATE235915T1 - Behandlung von hämorrhagischem virusfieber mit protein c - Google Patents
Behandlung von hämorrhagischem virusfieber mit protein cInfo
- Publication number
- ATE235915T1 ATE235915T1 AT99965808T AT99965808T ATE235915T1 AT E235915 T1 ATE235915 T1 AT E235915T1 AT 99965808 T AT99965808 T AT 99965808T AT 99965808 T AT99965808 T AT 99965808T AT E235915 T1 ATE235915 T1 AT E235915T1
- Authority
- AT
- Austria
- Prior art keywords
- protein
- treatment
- hemorrhagic virus
- provides
- virus fever
- Prior art date
Links
- 206010037660 Pyrexia Diseases 0.000 title 1
- 241000700605 Viruses Species 0.000 title 1
- 230000002008 hemorrhagic effect Effects 0.000 title 1
- 102000004169 proteins and genes Human genes 0.000 title 1
- 108090000623 proteins and genes Proteins 0.000 title 1
- 206010062713 Haemorrhagic diathesis Diseases 0.000 abstract 1
- 101800004937 Protein C Proteins 0.000 abstract 1
- 102100036546 Salivary acidic proline-rich phosphoprotein 1/2 Human genes 0.000 abstract 1
- 101800001700 Saposin-D Proteins 0.000 abstract 1
- 208000028227 Viral hemorrhagic fever Diseases 0.000 abstract 1
- 239000003146 anticoagulant agent Substances 0.000 abstract 1
- 229940127090 anticoagulant agent Drugs 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 208000035475 disorder Diseases 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 208000031169 hemorrhagic disease Diseases 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 229960000856 protein c Drugs 0.000 abstract 1
- 238000002560 therapeutic procedure Methods 0.000 abstract 1
- 230000001988 toxicity Effects 0.000 abstract 1
- 231100000419 toxicity Toxicity 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
- A61K38/482—Serine endopeptidases (3.4.21)
- A61K38/4866—Protein C (3.4.21.69)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Virology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Epidemiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Molecular Biology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Enzymes And Modification Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10915398P | 1998-11-20 | 1998-11-20 | |
| PCT/US1999/027074 WO2000030677A1 (en) | 1998-11-20 | 1999-11-15 | Method of treating viral hemorrhagic fever |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE235915T1 true ATE235915T1 (de) | 2003-04-15 |
Family
ID=22326085
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT99965808T ATE235915T1 (de) | 1998-11-20 | 1999-11-15 | Behandlung von hämorrhagischem virusfieber mit protein c |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US6270764B1 (enExample) |
| EP (1) | EP1131091B1 (enExample) |
| JP (1) | JP2002530353A (enExample) |
| CN (1) | CN1326356A (enExample) |
| AT (1) | ATE235915T1 (enExample) |
| AU (1) | AU2149800A (enExample) |
| BR (1) | BR9915460A (enExample) |
| CA (1) | CA2351470A1 (enExample) |
| DE (1) | DE69906568T2 (enExample) |
| ES (1) | ES2195655T3 (enExample) |
| IL (1) | IL142220A0 (enExample) |
| WO (1) | WO2000030677A1 (enExample) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2000030677A1 (en) * | 1998-11-20 | 2000-06-02 | Eli Lilly And Company | Method of treating viral hemorrhagic fever |
| WO2002024215A2 (en) * | 2000-09-18 | 2002-03-28 | Eli Lilly And Company | Method for using activated protein c for the treatment of coagulation-associated disorders |
| BR0213293A (pt) | 2001-10-15 | 2004-12-21 | Chiron Corp | Uso de tfpi ou de um análogo de tfpi no tratamento de septicemia |
| US7132398B2 (en) | 2003-05-06 | 2006-11-07 | Dendreon Corporation | Method of treatment of hemorrhagic disease using a factor VIIa/tissue factor inhibitor |
| MXPA06010587A (es) * | 2004-03-17 | 2007-03-29 | Chiron Corp | Tratamiento de neumonia severa adquirida en comunidad por administracion del inhibidor de la via del factor tisular (tfpi). |
| WO2007092607A2 (en) * | 2006-02-09 | 2007-08-16 | Genetech, Inc. | Treatment of hemorrhagic viral infections using a tissue factor inhibitor |
| RU2379034C1 (ru) * | 2008-11-17 | 2010-01-20 | Государственное образовательное учреждение высшего профессионального образования "Мордовский государственный университет им. Н.П. Огарева" | Способ лечения геморрагической лихорадки с почечным синдромом |
| US20200093853A1 (en) * | 2016-12-08 | 2020-03-26 | Cellphire, Inc. | Compositions and methods for treatment of loss of fluids leading to hypotension and/or hypovolemia |
| EP3887404A4 (en) | 2018-11-30 | 2022-11-02 | Cellphire, Inc. | SLIDES LOADED WITH ANTI-CANCER AGENTS |
| US11767511B2 (en) | 2018-11-30 | 2023-09-26 | Cellphire, Inc. | Platelets as delivery agents |
| CA3138529C (en) | 2019-05-03 | 2025-10-07 | Cellphire, Inc. | MATERIALS AND PROCESSES FOR THE PRODUCTION OF BLOOD PRODUCTS |
| WO2021034719A1 (en) | 2019-08-16 | 2021-02-25 | Cellphire, Inc. | Thrombosomes as an antiplatelet agent reversal agent |
| CA3170196A1 (en) | 2020-02-04 | 2021-08-12 | Cellphire, Inc. | Anti-fibrinolytic loaded platelets |
| TW202245814A (zh) | 2021-02-17 | 2022-12-01 | 美商賽菲爾公司 | 用於治療抗血小板誘導的凝血病之凍乾血小板衍生物組成物 |
| US12702682B2 (en) | 2021-11-04 | 2026-08-11 | Cellphire, Inc. | Platelet derivative compositions, and methods of making and using such compositions |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4775624A (en) | 1985-02-08 | 1988-10-04 | Eli Lilly And Company | Vectors and compounds for expression of human protein C |
| US5516650A (en) | 1985-06-27 | 1996-05-14 | Zymogenetics, Inc. | Production of activated protein C |
| US5550036A (en) | 1986-04-09 | 1996-08-27 | Eli Lilly And Company | Method for co-amplification of human protein C genes in human cells |
| US4992373A (en) | 1987-12-04 | 1991-02-12 | Eli Lilly And Company | Vectors and compounds for direct expression of activated human protein C |
| US4981952A (en) | 1988-10-04 | 1991-01-01 | Eli Lilly And Company | Method for the purification of vitamin K-dependent proteins |
| IL97312A (en) | 1990-02-23 | 1999-01-26 | Lilly Co Eli | A method of generating a polypeptide in an eukaryotic vector AND recombinant surrogate cell containing an enhanced transcriptional control unit based on the primary late adenovirus coefficient |
| US5506134A (en) * | 1990-10-22 | 1996-04-09 | Corvas International, Inc. | Hypridoma and monoclonal antibody which inhibits blood coagulation tissue factor/factor VIIa complex |
| AT402262B (de) | 1991-06-20 | 1997-03-25 | Immuno Ag | Arzneimittel enthaltend aktiviertes protein c |
| MY110664A (en) | 1992-05-21 | 1999-01-30 | Lilly Co Eli | Protein c derivatives |
| WO1997020043A1 (en) | 1995-11-30 | 1997-06-05 | Zymogenetics, Inc. | Protein c production in transgenic animals |
| ZA983497B (en) * | 1997-04-28 | 1999-10-25 | Lilly Co Eli | Activated protein c formulations. |
| WO2000030677A1 (en) * | 1998-11-20 | 2000-06-02 | Eli Lilly And Company | Method of treating viral hemorrhagic fever |
| JP2002542832A (ja) * | 1999-04-30 | 2002-12-17 | イーライ・リリー・アンド・カンパニー | プロテインｃ誘導体 |
-
1999
- 1999-11-15 WO PCT/US1999/027074 patent/WO2000030677A1/en not_active Ceased
- 1999-11-15 CN CN99813313A patent/CN1326356A/zh active Pending
- 1999-11-15 DE DE69906568T patent/DE69906568T2/de not_active Expired - Lifetime
- 1999-11-15 AT AT99965808T patent/ATE235915T1/de not_active IP Right Cessation
- 1999-11-15 EP EP99965808A patent/EP1131091B1/en not_active Expired - Lifetime
- 1999-11-15 IL IL14222099A patent/IL142220A0/xx unknown
- 1999-11-15 ES ES99965808T patent/ES2195655T3/es not_active Expired - Lifetime
- 1999-11-15 BR BR9915460-9A patent/BR9915460A/pt not_active Application Discontinuation
- 1999-11-15 CA CA002351470A patent/CA2351470A1/en not_active Abandoned
- 1999-11-15 AU AU21498/00A patent/AU2149800A/en not_active Abandoned
- 1999-11-15 JP JP2000583560A patent/JP2002530353A/ja active Pending
- 1999-11-19 US US09/444,479 patent/US6270764B1/en not_active Expired - Fee Related
-
2001
- 2001-04-25 US US09/842,337 patent/US6767539B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| ES2195655T3 (es) | 2003-12-01 |
| DE69906568T2 (de) | 2004-02-12 |
| US6767539B2 (en) | 2004-07-27 |
| DE69906568D1 (de) | 2003-05-08 |
| US20010028880A1 (en) | 2001-10-11 |
| CN1326356A (zh) | 2001-12-12 |
| CA2351470A1 (en) | 2000-06-02 |
| US6270764B1 (en) | 2001-08-07 |
| EP1131091A1 (en) | 2001-09-12 |
| WO2000030677A1 (en) | 2000-06-02 |
| IL142220A0 (en) | 2002-03-10 |
| AU2149800A (en) | 2000-06-13 |
| JP2002530353A (ja) | 2002-09-17 |
| BR9915460A (pt) | 2001-07-17 |
| EP1131091B1 (en) | 2003-04-02 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |