ATE229973T1 - C-terminale modifizierte (n-substituierte)-2- indolyl dipeptide als inhibitoren von der ice/ced-3 cysteinprotease familie - Google Patents

C-terminale modifizierte (n-substituierte)-2- indolyl dipeptide als inhibitoren von der ice/ced-3 cysteinprotease familie

Info

Publication number
ATE229973T1
ATE229973T1 AT97942441T AT97942441T ATE229973T1 AT E229973 T1 ATE229973 T1 AT E229973T1 AT 97942441 T AT97942441 T AT 97942441T AT 97942441 T AT97942441 T AT 97942441T AT E229973 T1 ATE229973 T1 AT E229973T1
Authority
AT
Austria
Prior art keywords
ced
ice
substituted
dipeptides
indolyl
Prior art date
Application number
AT97942441T
Other languages
English (en)
Inventor
Donald S Karanewsky
Xu Bai
Original Assignee
Idun Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/767,175 external-priority patent/US5869519A/en
Application filed by Idun Pharmaceuticals Inc filed Critical Idun Pharmaceuticals Inc
Application granted granted Critical
Publication of ATE229973T1 publication Critical patent/ATE229973T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/55—Protease inhibitors
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N1/00—Preservation of bodies of humans or animals, or parts thereof
    • A01N1/02—Preservation of living parts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic
    • C07K5/06165—Dipeptides with the first amino acid being heterocyclic and Pro-amino acid; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0821—Tripeptides with the first amino acid being heterocyclic, e.g. His, Pro, Trp
    • C07K5/0823—Tripeptides with the first amino acid being heterocyclic, e.g. His, Pro, Trp and Pro-amino acid; Derivatives thereof

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Psychiatry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Cardiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Epidemiology (AREA)
  • Dentistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Environmental Sciences (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
AT97942441T 1996-09-12 1997-09-12 C-terminale modifizierte (n-substituierte)-2- indolyl dipeptide als inhibitoren von der ice/ced-3 cysteinprotease familie ATE229973T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US2601196P 1996-09-12 1996-09-12
US08/767,175 US5869519A (en) 1996-12-16 1996-12-16 C-terminal modified (n-substituted)-2-indolyl dipeptides as inhibitors of the ICE/ced-3 family of cysteine proteases
PCT/US1997/016157 WO1998011129A1 (en) 1996-09-12 1997-09-12 C-TERMINAL MODIFIED (N-SUBSTITUTED)-2-INDOLYL DIPEPTIDES AS INHIBITORS OF THE ICE/ced-3 FAMILY OF CYSTEINE PROTEASES

Publications (1)

Publication Number Publication Date
ATE229973T1 true ATE229973T1 (de) 2003-01-15

Family

ID=26700600

Family Applications (1)

Application Number Title Priority Date Filing Date
AT97942441T ATE229973T1 (de) 1996-09-12 1997-09-12 C-terminale modifizierte (n-substituierte)-2- indolyl dipeptide als inhibitoren von der ice/ced-3 cysteinprotease familie

Country Status (11)

Country Link
EP (1) EP0920444B1 (de)
JP (1) JP3492703B2 (de)
KR (1) KR20000036056A (de)
CN (1) CN1234038A (de)
AT (1) ATE229973T1 (de)
AU (1) AU739321B2 (de)
CA (1) CA2265928A1 (de)
DE (1) DE69718012T2 (de)
IL (1) IL128940A0 (de)
NZ (1) NZ334605A (de)
WO (1) WO1998011129A1 (de)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6610683B2 (en) * 1996-09-12 2003-08-26 Idun Pharmaceuticals, Inc. Treatment of infectious disease using interleukin-1β-converting enzyme (ICE)/CED-3 family inhibitors
JP4499917B2 (ja) 1998-03-09 2010-07-14 バーテックス ファーマシューティカルズ インコーポレイテッド インターロイキン−１β変換酵素のインヒビターとしての１，２−ジアゼパン誘導体
KR100928878B1 (ko) * 1998-03-19 2009-11-30 버텍스 파마슈티칼스 인코포레이티드 카스파제의 억제제
AU3866799A (en) * 1998-05-04 1999-11-23 Zymogenetics Inc. Cytoplasmic antiproteinase-3 coding sequence in gene therapy
ATE384695T1 (de) 2000-03-29 2008-02-15 Vertex Pharma Carbamat caspase inhibitoren und deren verwendung
PE20011350A1 (es) * 2000-05-19 2002-01-15 Vertex Pharma PROFARMACO DE UN INHIBIDOR DE ENZIMA CONVERTIDORA DE INTERLEUCINA-1ß (ICE)
ES2283456T3 (es) * 2000-11-21 2007-11-01 Vertex Pharmaceuticals Incorporated Inhibidores de caspasa de imidazol y bencimidazol y sus usos.
US20030039661A1 (en) * 2001-03-02 2003-02-27 Teresa Aja Methods, compositions and kits for preserving antigenicity
EP1381602A1 (de) * 2001-04-19 2004-01-21 Vertex Pharmaceuticals Incorporated Heterocyclylbiscarbonsäureamide als caspasehemmer
US7297714B2 (en) * 2003-10-21 2007-11-20 Irm Llc Inhibitors of cathepsin S
NZ549665A (en) * 2004-02-27 2010-09-30 Vertex Pharma Caspase inhibitors and uses thereof
EP1725548B1 (de) 2004-03-12 2015-01-14 Vertex Pharmaceuticals Incorporated Verfahren und zwischenprodukte für die herstellung von asparaginsäureacetalen als caspase-inhibitoren
GB0411056D0 (en) 2004-05-18 2004-06-23 Novartis Ag Organic compounds
KR20080038369A (ko) 2005-07-28 2008-05-06 버텍스 파마슈티칼스 인코포레이티드 카스파제 억제제 프로드럭
JP5183907B2 (ja) * 2006-11-07 2013-04-17 株式会社パーマケム・アジア ペリンドプリルの前駆体の製造方法、及び、ペリンドプリルエルブミンの製造方法と精製方法
US9956260B1 (en) 2011-07-22 2018-05-01 The J. David Gladstone Institutes Treatment of HIV-1 infection and AIDS

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5514694A (en) * 1992-09-21 1996-05-07 Georgia Tech Research Corp Peptidyl ketoamides
US5486623A (en) * 1993-12-08 1996-01-23 Prototek, Inc. Cysteine protease inhibitors containing heterocyclic leaving groups
US5498616A (en) * 1994-11-04 1996-03-12 Cephalon, Inc. Cysteine protease and serine protease inhibitors
US5843904A (en) * 1995-12-20 1998-12-01 Vertex Pharmaceuticals, Inc. Inhibitors of interleukin-1βconverting enzyme

Also Published As

Publication number Publication date
IL128940A0 (en) 2000-02-17
AU4413897A (en) 1998-04-02
DE69718012T2 (de) 2003-09-25
CN1234038A (zh) 1999-11-03
AU739321B2 (en) 2001-10-11
EP0920444A1 (de) 1999-06-09
CA2265928A1 (en) 1998-03-19
NZ334605A (en) 2000-08-25
DE69718012D1 (de) 2003-01-30
JP2001501923A (ja) 2001-02-13
EP0920444B1 (de) 2002-12-18
WO1998011129A1 (en) 1998-03-19
JP3492703B2 (ja) 2004-02-03
KR20000036056A (ko) 2000-06-26

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