ATE226643T1 - Genetische diagnose und pharmazeutische produkte zur behandlung von prostatakrebs - Google Patents

Genetische diagnose und pharmazeutische produkte zur behandlung von prostatakrebs

Info

Publication number
ATE226643T1
ATE226643T1 AT95927253T AT95927253T ATE226643T1 AT E226643 T1 ATE226643 T1 AT E226643T1 AT 95927253 T AT95927253 T AT 95927253T AT 95927253 T AT95927253 T AT 95927253T AT E226643 T1 ATE226643 T1 AT E226643T1
Authority
AT
Austria
Prior art keywords
treatment
gstp1
prostate cancer
pharmaceutical products
genetic diagnosis
Prior art date
Application number
AT95927253T
Other languages
English (en)
Inventor
William G Nelson
William B Isaacs
Wen-Hsiang Lee
Original Assignee
Univ Johns Hopkins Med
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Johns Hopkins Med filed Critical Univ Johns Hopkins Med
Application granted granted Critical
Publication of ATE226643T1 publication Critical patent/ATE226643T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1085—Transferases (2.) transferring alkyl or aryl groups other than methyl groups (2.5)
    • C12N9/1088—Glutathione transferase (2.5.1.18)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/573—Immunoassay; Biospecific binding assay; Materials therefor for enzymes or isoenzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2799/00—Uses of viruses
    • C12N2799/02—Uses of viruses as vector
    • C12N2799/021—Uses of viruses as vector for the expression of a heterologous nucleic acid
    • C12N2799/027—Uses of viruses as vector for the expression of a heterologous nucleic acid where the vector is derived from a retrovirus
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/154—Methylation markers

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Analytical Chemistry (AREA)
  • Pathology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Microbiology (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • Biophysics (AREA)
  • General Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Hospice & Palliative Care (AREA)
  • Oncology (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
AT95927253T 1994-07-19 1995-07-18 Genetische diagnose und pharmazeutische produkte zur behandlung von prostatakrebs ATE226643T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/277,202 US5552277A (en) 1994-07-19 1994-07-19 Genetic diagnosis of prostate cancer
PCT/US1995/009050 WO1996002674A1 (en) 1994-07-19 1995-07-18 Genetic diagnosis of prostate cancer

Publications (1)

Publication Number Publication Date
ATE226643T1 true ATE226643T1 (de) 2002-11-15

Family

ID=23059841

Family Applications (1)

Application Number Title Priority Date Filing Date
AT95927253T ATE226643T1 (de) 1994-07-19 1995-07-18 Genetische diagnose und pharmazeutische produkte zur behandlung von prostatakrebs

Country Status (11)

Country Link
US (1) US5552277A (de)
EP (1) EP0771362B1 (de)
JP (2) JP3774473B2 (de)
AT (1) ATE226643T1 (de)
AU (1) AU695420B2 (de)
CA (1) CA2195396C (de)
DE (1) DE69528653T2 (de)
DK (1) DK0771362T3 (de)
ES (1) ES2186725T3 (de)
PT (1) PT771362E (de)
WO (1) WO1996002674A1 (de)

Families Citing this family (42)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6617434B1 (en) 1996-05-31 2003-09-09 North Shore Long Island Jewish Research Institute Identificiaton of differentially methylated and mutated nucleic acids
US5871917A (en) 1996-05-31 1999-02-16 North Shore University Hospital Research Corp. Identification of differentially methylated and mutated nucleic acids
US5925519A (en) 1996-06-03 1999-07-20 The Regents Of The University Of California Genetic alterations associated with prostate cancer
US5817497A (en) * 1996-11-26 1998-10-06 Incyte Pharmaceuticals Glutathione s-transferase
AUPP312998A0 (en) 1998-04-23 1998-05-14 Commonwealth Scientific And Industrial Research Organisation Diagnostic assay
US20080050836A1 (en) * 1998-05-01 2008-02-28 Isabelle Guyon Biomarkers for screening, predicting, and monitoring benign prostate hyperplasia
EP1100903A1 (de) * 1998-07-24 2001-05-23 THE UNITED STATES OF AMERICA, as represented by the Secretary of the Department of Health and Human Services Pb 39, ein dysreguliertes gen in prostatakrebs und deren verwendung
US7226731B1 (en) 1998-07-24 2007-06-05 The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services PB 39, a gene dysregulated in prostate cancer, and uses thereof
US6994991B1 (en) 1998-11-18 2006-02-07 North Shore - Long Island Jewish Research Institute Identification of differentially methylated multiple drug resistance loci
GB9903841D0 (en) * 1999-02-20 1999-04-14 Imp College Innovations Ltd Diagnosis and treatment of cancer
US6783933B1 (en) * 1999-09-15 2004-08-31 The Johns Hopkins University School Of Medicine CACNA1G polynucleotide, polypeptide and methods of use therefor
US6709818B1 (en) * 1999-10-13 2004-03-23 The Johns Hopkins University School Of Medicine Methods of diagnosing and treating hepatic cell proliferative disorders
US6911306B1 (en) * 1999-10-18 2005-06-28 Emory University TMS1 compositions and methods of use
WO2002006484A1 (fr) * 2000-07-19 2002-01-24 Takara Bio Inc. Procede de detection de cancer
EP1339871B1 (de) 2000-08-15 2008-10-15 The Johns Hopkins University School Of Medicine Diagnose und behandlung von tumor-suppressor assoziierten krankheiten
US7662549B1 (en) * 2000-10-27 2010-02-16 The University Of Southern California Methylation altered DNA sequences as markers associated with human cancer
US20090226915A1 (en) 2001-01-24 2009-09-10 Health Discovery Corporation Methods for Screening, Predicting and Monitoring Prostate Cancer
WO2002068694A1 (en) * 2001-02-23 2002-09-06 The Johns Hopkins University School Of Medicine Differentially methylated sequences in pancreatic cancer
SE0102627L (sv) * 2001-07-27 2002-11-19 Geneinvent Bbl Ab Vektorer motståndskraftiga mot metylering
US20030045497A1 (en) * 2001-07-27 2003-03-06 Geneinvent Bbl Ab Methylation resistant vectors
EP1485399A4 (de) * 2001-11-30 2008-01-02 Univ Johns Hopkins VERFAHREN ZUR ANALYSE METHYLIERTER CpG-INSELN UND GC-REICHER BEREICHE
US8008012B2 (en) 2002-01-24 2011-08-30 Health Discovery Corporation Biomarkers downregulated in prostate cancer
DK1342794T3 (da) * 2002-03-05 2006-04-24 Epigenomics Ag Fremgangsmåde og anordning til at bestemme vævsspecificitet af fritflydende DNA i legemsvæsker
EP1539787A4 (de) * 2002-06-27 2007-07-25 Univ Johns Hopkins Med Verfahren zur identifizierung von krebsrisiko
AU2003256995A1 (en) * 2002-07-26 2004-02-16 The Johns Hopkins University Method for identifying cancer risk
US9394332B2 (en) 2002-08-29 2016-07-19 Epigenomics Ag Method for bisulfite treatment
JP2006516391A (ja) * 2003-01-29 2006-07-06 エフ．ホフマン−ラ　ロシュ　アーゲー 重亜硫酸塩処理の改良された方法
WO2004087957A2 (en) * 2003-04-03 2004-10-14 Oncomethylome Sciences S.A. Hypermethylated genes and cervical cancer
US20060183128A1 (en) * 2003-08-12 2006-08-17 Epigenomics Ag Methods and compositions for differentiating tissues for cell types using epigenetic markers
WO2005040399A2 (en) 2003-10-21 2005-05-06 Orion Genomics Llc Methods for quantitative determination of methylation density in a dna locus
US7501240B2 (en) 2003-12-02 2009-03-10 Roche Molecular Systems, Inc. Method for bisulfite treatment
US7279281B2 (en) * 2004-06-01 2007-10-09 The Regents Of The University Of Michigan Methods and kits for diagnosing or monitoring autoimmune and chronic inflammatory diseases
US11105808B2 (en) 2004-11-12 2021-08-31 Health Discovery Corporation Methods for screening, predicting and monitoring prostate cancer
GB0501741D0 (en) * 2005-01-27 2005-03-02 Binding Site The Ltd Antibody
US7439024B2 (en) * 2005-06-01 2008-10-21 The United States Of America As Represented By The Department Of Veterans Affairs Methods and kits for diagnosing or monitoring autoimmune and chronic inflammatory diseases
EP1904649A2 (de) * 2005-07-18 2008-04-02 Epigenomics AG Zusammenstellung und verfahren zur krebsdiagnostik mit hilfe von pan-krebs-marker
US7906288B2 (en) * 2006-01-04 2011-03-15 The Johns Hopkins University Compare-MS: method rapid, sensitive and accurate detection of DNA methylation
WO2008083098A1 (en) 2006-12-27 2008-07-10 The Johns Hopkins University Agents for reversing epigenetic silencing of genes
WO2011037936A2 (en) * 2009-09-24 2011-03-31 Oregon Health & Science University Detection of dna methylation of tal1, erg and/or cd40 to diagnose prostate cancer
CN102573892B (zh) 2009-10-30 2015-07-29 维也纳医科大学 Gstp1的应用
GB0922085D0 (en) 2009-12-17 2010-02-03 Cambridge Entpr Ltd Cancer diagnosis and treatment
US20140274757A1 (en) 2013-03-14 2014-09-18 Marie K. Kirby Differential Methylation Level of CpG Loci That Are Determinative of a Biochemical Reoccurrence of Prostate Cancer

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0245520B1 (de) * 1985-11-21 1992-09-16 Teijin Limited Monoklonaler antikörper gegen glutathion s-transferase und dessen verwendung zur diagnose von krebs
US5073677A (en) * 1986-09-26 1991-12-17 Ciba-Geigy Corporation Herbicidal tolerant plants containing rat glutathione S-transferase gene
AU5435990A (en) * 1989-04-13 1990-11-05 United States of America, as represented by the Secretary, U.S. Department of Commerce, The Monoclonal antibodies to human glutathione s transferase pi
JPH0425763A (ja) * 1990-05-21 1992-01-29 Maruko Seiyaku Kk グルタチオンＳ―トランスフェラーゼπの定量方法および診断のための試薬

Also Published As

Publication number Publication date
DK0771362T3 (da) 2003-02-17
AU695420B2 (en) 1998-08-13
ES2186725T3 (es) 2003-05-16
CA2195396C (en) 2009-09-15
CA2195396A1 (en) 1996-02-01
EP0771362B1 (de) 2002-10-23
US5552277A (en) 1996-09-03
DE69528653D1 (de) 2002-11-28
DE69528653T2 (de) 2003-07-03
PT771362E (pt) 2003-03-31
EP0771362A1 (de) 1997-05-07
AU3134195A (en) 1996-02-16
WO1996002674A1 (en) 1996-02-01
JPH10504187A (ja) 1998-04-28
JP3774473B2 (ja) 2006-05-17
JP2006089500A (ja) 2006-04-06

Similar Documents

Publication Publication Date Title
ATE226643T1 (de) Genetische diagnose und pharmazeutische produkte zur behandlung von prostatakrebs
DE69737684D1 (de) Präzise wirksamkeitsbestimmungsmethode für wirkstoffe einschliesslich chemotherapeutika
DE69635848D1 (de) Verfahren zum Nachweis von Ki-ras Mutationen
GB9411671D0 (en) Tumor diagnosis and prognosis
AU2001253079A1 (en) Methods, compositions and kits for the detection and monitoring of breast cancer
ATE533056T1 (de) Verfahren zum auffinden von tumoren welche den vaskulären endothelialen wachstumsfaktor d exprimieren
AU9779498A (en) Sphingosine-1-phosphate lyase polypeptides, polynucleotides and modulating agents and methods of use therefor
ATE307536T1 (de) Vorrichtung zur erfassung des katheter- gewebekontaktes sowie von wechselwirkungen mit dem gewebe bei der katheterablation
HK1033765A1 (en) Detection of neoplasia by analysis of saliva
EP0815204A4 (de) Methode zur tumorbehandlung
TR199902828T2 (xx) Lizofosfolipidlerin de�i�mi� konsantrasyonlar� ile birle�tirilmi� kanser belirleme y�ntemi.
WO2000055629A3 (en) Methods of diagnosing and treating breast cancer
EP0567230A3 (de) Verfahren und Vorrichtung zum Nachweis von Mikroorganismen in Kulturfläschchen.
WO1997022721A3 (en) Cancer detection probes
ATE466938T1 (de) Prostata-spezifisches gen pcgem1 und methoden zu dessen verwendung zur erkennung, behandlung und prävention von prostatakrebs
ATE350083T1 (de) Apparat mit rührvorrichtung zur bestrahlung eines blutproduktes
ATE283478T1 (de) Verfahren und vorrichtung zur bestimmung des transformationspotentials von verbindungen.
DE69822149D1 (de) Erkennung von tmorspezifische genprodukte
WO2002044419A3 (en) Expression analysis of kiaa nucleic acids and polypeptides useful in the diagnosis and treatment of prostate cancer
ES2185472A1 (es) Empleo del gen slug, o de sus productos de transcripcion o expresion, en la deteccion y/o tratamiento de celulas cancerosas.
AU2934299A (en) Detection of apoptotic products
ES2187383A1 (es) Procedimiento para la deteccion precoz de cancer colorrectal mediante la valoracion en suero o plasma humano de las glicoproteinas cd26 soluble y alfa-l-fucosidasa.
IL135705A0 (en) Using polyamide nuceic acid oligomers to engender a biological response
NZ506005A (en) Recombinant proteins derived from hgf and msp
Nelson et al. Genetic diagnosis of prostate cancer

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification

Ref document number: 0771362

Country of ref document: EP