ATE225768T1 - 1-(adamantyl)amidine und ihre verwendung bei der behandlung von zuständen, die zusammenhängen mit abweichungen bei glutamatergischen übertragungen - Google Patents
1-(adamantyl)amidine und ihre verwendung bei der behandlung von zuständen, die zusammenhängen mit abweichungen bei glutamatergischen übertragungenInfo
- Publication number
- ATE225768T1 ATE225768T1 AT98959052T AT98959052T ATE225768T1 AT E225768 T1 ATE225768 T1 AT E225768T1 AT 98959052 T AT98959052 T AT 98959052T AT 98959052 T AT98959052 T AT 98959052T AT E225768 T1 ATE225768 T1 AT E225768T1
- Authority
- AT
- Austria
- Prior art keywords
- treatment
- glutamatergic
- amidine
- adamantyl
- transmissions
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C257/00—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines
- C07C257/10—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. amidines
- C07C257/14—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. amidines having carbon atoms of amidino groups bound to acyclic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C257/00—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines
- C07C257/10—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. amidines
- C07C257/16—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. amidines having carbon atoms of amidino groups bound to carbon atoms of rings other than six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2603/00—Systems containing at least three condensed rings
- C07C2603/56—Ring systems containing bridged rings
- C07C2603/58—Ring systems containing bridged rings containing three rings
- C07C2603/70—Ring systems containing bridged rings containing three rings containing only six-membered rings
- C07C2603/74—Adamantanes
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Neurology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Biomedical Technology (AREA)
- Medicinal Chemistry (AREA)
- Neurosurgery (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Soy Sauces And Products Related Thereto (AREA)
- Peptides Or Proteins (AREA)
- Enzymes And Modification Thereof (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB9726388.3A GB9726388D0 (en) | 1997-12-12 | 1997-12-12 | Chemical compounds |
PCT/GB1998/003715 WO1999031051A1 (en) | 1997-12-12 | 1998-12-11 | 1-(adamantyl)amidines and their use in the treatment of conditions generally associated with abnormalities in glutamatergic transmission |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE225768T1 true ATE225768T1 (de) | 2002-10-15 |
Family
ID=10823580
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT98959052T ATE225768T1 (de) | 1997-12-12 | 1998-12-11 | 1-(adamantyl)amidine und ihre verwendung bei der behandlung von zuständen, die zusammenhängen mit abweichungen bei glutamatergischen übertragungen |
Country Status (9)
Country | Link |
---|---|
US (2) | US6500866B1 (de) |
EP (1) | EP1037874B1 (de) |
JP (1) | JP2002508350A (de) |
AT (1) | ATE225768T1 (de) |
AU (1) | AU1498299A (de) |
DE (1) | DE69808669T2 (de) |
ES (1) | ES2185237T3 (de) |
GB (1) | GB9726388D0 (de) |
WO (1) | WO1999031051A1 (de) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2000001376A2 (en) | 1998-07-02 | 2000-01-13 | Eisai Co., Ltd | Pharmaceutical compositions and their uses for treatment of demyelinating disorders |
GB9901691D0 (en) | 1999-01-26 | 1999-03-17 | Cerebrus Ltd | Chemical compounds |
US6444702B1 (en) | 2000-02-22 | 2002-09-03 | Neuromolecular, Inc. | Aminoadamantane derivatives as therapeutic agents |
ITTO20030668A1 (it) | 2003-09-02 | 2005-03-03 | Rotta Res Lab S P A O Ra Rottapharm | Derivati dell'adamantano dotati di attivita' neuroprotettiva, antidepressiva e anti-ischemica e procedimento per la loro preparazione. |
TW200531680A (en) * | 2004-03-03 | 2005-10-01 | Merz Pharma Gmbh & Co Kgaa | Therapy using 1-aminocyclohexane derivatives for the treatment of behavioral disorders associated with alzheimer's disease |
HUP0401523A3 (en) * | 2004-07-29 | 2007-05-02 | Richter Gedeon Vegyeszet | Indole-2-carboxamide derivatives, pharmaceutical compositions containing them and process for producing them |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE151447C (de) | ||||
BE795381A (fr) | 1972-02-15 | 1973-08-13 | Sandoz Sa | Derives de l'adamaniane |
JPS5246949B2 (de) * | 1973-10-19 | 1977-11-29 | ||
DD151447A1 (de) * | 1980-06-18 | 1981-10-21 | Heinz Paul | Verfahren zur herstellung von amidinen und deren salzen |
JPH06501002A (ja) | 1990-08-30 | 1994-01-27 | オレゴン州 | シグマ受容体に対して高い結合性を有する置換アミジン類およびその使用 |
US5677349A (en) * | 1995-04-27 | 1997-10-14 | Gilad; Gad M. | Agmatine for the treatment of neurotrauma and neurodegenerative diseases |
-
1997
- 1997-12-12 GB GBGB9726388.3A patent/GB9726388D0/en not_active Ceased
-
1998
- 1998-12-11 DE DE69808669T patent/DE69808669T2/de not_active Expired - Fee Related
- 1998-12-11 US US09/581,340 patent/US6500866B1/en not_active Expired - Fee Related
- 1998-12-11 JP JP2000538980A patent/JP2002508350A/ja not_active Withdrawn
- 1998-12-11 ES ES98959052T patent/ES2185237T3/es not_active Expired - Lifetime
- 1998-12-11 AU AU14982/99A patent/AU1498299A/en not_active Abandoned
- 1998-12-11 AT AT98959052T patent/ATE225768T1/de not_active IP Right Cessation
- 1998-12-11 WO PCT/GB1998/003715 patent/WO1999031051A1/en active IP Right Grant
- 1998-12-11 EP EP98959052A patent/EP1037874B1/de not_active Expired - Lifetime
-
2002
- 2002-11-12 US US10/291,413 patent/US20030130354A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
WO1999031051A1 (en) | 1999-06-24 |
GB9726388D0 (en) | 1998-02-11 |
EP1037874A1 (de) | 2000-09-27 |
JP2002508350A (ja) | 2002-03-19 |
ES2185237T3 (es) | 2003-04-16 |
DE69808669D1 (de) | 2002-11-14 |
EP1037874B1 (de) | 2002-10-09 |
US6500866B1 (en) | 2002-12-31 |
DE69808669T2 (de) | 2003-07-31 |
AU1498299A (en) | 1999-07-05 |
US20030130354A1 (en) | 2003-07-10 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |