ATE2253T1 - Pyrimido und imidazo-pyrido-indol-dione, ihre herstellung und therapeutische verwendung. - Google Patents
Pyrimido und imidazo-pyrido-indol-dione, ihre herstellung und therapeutische verwendung.Info
- Publication number
- ATE2253T1 ATE2253T1 AT80400050T AT80400050T ATE2253T1 AT E2253 T1 ATE2253 T1 AT E2253T1 AT 80400050 T AT80400050 T AT 80400050T AT 80400050 T AT80400050 T AT 80400050T AT E2253 T1 ATE2253 T1 AT E2253T1
- Authority
- AT
- Austria
- Prior art keywords
- alkyl
- pyrimido
- imidazo
- diones
- pyrido
- Prior art date
Links
- 230000001225 therapeutic effect Effects 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 5
- AMBZNXNKAKZDHN-UHFFFAOYSA-N 3,10,12,14-tetrazatetracyclo[7.7.0.02,6.011,15]hexadeca-1,3,5,7,9,11,13,15-octaene Chemical class C1=C2N=CN=C2N=C2C=CC3=CC=NC3=C21 AMBZNXNKAKZDHN-UHFFFAOYSA-N 0.000 abstract 1
- 206010002660 Anoxia Diseases 0.000 abstract 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 abstract 1
- 206010021143 Hypoxia Diseases 0.000 abstract 1
- -1 R2=H Chemical group 0.000 abstract 1
- 230000002378 acidificating effect Effects 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000001316 cycloalkyl alkyl group Chemical group 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 238000010438 heat treatment Methods 0.000 abstract 1
- 229910000041 hydrogen chloride Inorganic materials 0.000 abstract 1
- IXCSERBJSXMMFS-UHFFFAOYSA-N hydrogen chloride Substances Cl.Cl IXCSERBJSXMMFS-UHFFFAOYSA-N 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 239000004089 psychotropic agent Substances 0.000 abstract 1
- 238000002560 therapeutic procedure Methods 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/14—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Psychiatry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Pain & Pain Management (AREA)
- Hospice & Palliative Care (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR7910653A FR2455039A1 (fr) | 1979-04-26 | 1979-04-26 | Pyrimido et imidazo-pyrido-indole-diones et leur application en therapeutique |
| EP80400050A EP0018857B1 (fr) | 1979-04-26 | 1980-01-15 | Pyrimido et imidazo-pyrido-indole-diones, leur préparation et leur application en thérapeutique |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE2253T1 true ATE2253T1 (de) | 1983-02-15 |
Family
ID=9224796
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT80400050T ATE2253T1 (de) | 1979-04-26 | 1980-01-15 | Pyrimido und imidazo-pyrido-indol-dione, ihre herstellung und therapeutische verwendung. |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US4358451A (OSRAM) |
| EP (1) | EP0018857B1 (OSRAM) |
| JP (1) | JPS55145689A (OSRAM) |
| AT (1) | ATE2253T1 (OSRAM) |
| AU (1) | AU528634B2 (OSRAM) |
| CA (1) | CA1129854A (OSRAM) |
| DE (1) | DE3061648D1 (OSRAM) |
| DK (1) | DK16980A (OSRAM) |
| ES (1) | ES487713A1 (OSRAM) |
| FR (1) | FR2455039A1 (OSRAM) |
| GR (1) | GR74394B (OSRAM) |
| IL (1) | IL59128A (OSRAM) |
| NO (1) | NO794271L (OSRAM) |
| PT (1) | PT70698A (OSRAM) |
| ZA (1) | ZA80242B (OSRAM) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3246932A1 (de) * | 1982-12-16 | 1984-06-20 | Schering AG, 1000 Berlin und 4709 Bergkamen | Substituierte 5h-pyrimido(5,4-b)indole |
| US20030129186A1 (en) | 2001-07-25 | 2003-07-10 | Biomarin Pharmaceutical Inc. | Compositions and methods for modulating blood-brain barrier transport |
| TWI329111B (en) | 2002-05-24 | 2010-08-21 | X Ceptor Therapeutics Inc | Azepinoindole and pyridoindole derivatives as pharmaceutical agents |
| US7595311B2 (en) | 2002-05-24 | 2009-09-29 | Exelixis, Inc. | Azepinoindole derivatives as pharmaceutical agents |
| CN101287411B (zh) | 2005-04-28 | 2013-03-06 | 普罗秋斯生物医学公司 | 药物信息系统及其用途 |
| FR2901795A1 (fr) * | 2006-05-30 | 2007-12-07 | Fourtillan Snc | Derives de pyrimidino[1',6'-1,2]pyrido[3,4-b]indoles et leur utilisation en therapeutique |
| CN101594878A (zh) | 2006-09-18 | 2009-12-02 | 雷普特药品公司 | 通过给予受体相关蛋白（rap）-缀合物对肝病症的治疗 |
| ES2728225T3 (es) | 2009-02-20 | 2019-10-23 | 2 Bbb Medicines B V | Sistema de administración de fármacos a base de glutatión |
| KR101909711B1 (ko) | 2009-05-06 | 2018-12-19 | 라보라토리 스킨 케어, 인크. | 활성제-칼슘 포스페이트 입자 복합체를 포함하는 피부 전달 조성물 및 이들을 이용하는 방법 |
| US20120077778A1 (en) | 2010-09-29 | 2012-03-29 | Andrea Bourdelais | Ladder-Frame Polyether Conjugates |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA1076114A (en) * | 1975-02-10 | 1980-04-22 | Mitsubishi Chemical Industries Limited | 1,5-alkylene-3-aryl hydantoin derivatives |
-
1979
- 1979-04-26 FR FR7910653A patent/FR2455039A1/fr active Granted
- 1979-12-27 NO NO794271A patent/NO794271L/no unknown
-
1980
- 1980-01-14 JP JP300380A patent/JPS55145689A/ja active Pending
- 1980-01-15 DK DK16980A patent/DK16980A/da not_active Application Discontinuation
- 1980-01-15 PT PT70698A patent/PT70698A/pt unknown
- 1980-01-15 ZA ZA00800242A patent/ZA80242B/xx unknown
- 1980-01-15 GR GR60963A patent/GR74394B/el unknown
- 1980-01-15 ES ES487713A patent/ES487713A1/es not_active Expired
- 1980-01-15 EP EP80400050A patent/EP0018857B1/fr not_active Expired
- 1980-01-15 US US06/112,238 patent/US4358451A/en not_active Expired - Lifetime
- 1980-01-15 AT AT80400050T patent/ATE2253T1/de not_active IP Right Cessation
- 1980-01-15 AU AU54630/80A patent/AU528634B2/en not_active Ceased
- 1980-01-15 DE DE8080400050T patent/DE3061648D1/de not_active Expired
- 1980-01-15 CA CA343,698A patent/CA1129854A/en not_active Expired
- 1980-01-15 IL IL59128A patent/IL59128A/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| FR2455039B1 (OSRAM) | 1983-05-13 |
| DK16980A (da) | 1980-10-27 |
| GR74394B (OSRAM) | 1984-06-28 |
| IL59128A0 (en) | 1980-05-30 |
| DE3061648D1 (en) | 1983-02-24 |
| NO794271L (no) | 1980-10-28 |
| ES487713A1 (es) | 1980-06-16 |
| AU528634B2 (en) | 1983-05-05 |
| AU5463080A (en) | 1980-10-30 |
| JPS55145689A (en) | 1980-11-13 |
| ZA80242B (en) | 1980-12-31 |
| CA1129854A (en) | 1982-08-17 |
| IL59128A (en) | 1982-07-30 |
| EP0018857A1 (fr) | 1980-11-12 |
| US4358451A (en) | 1982-11-09 |
| EP0018857B1 (fr) | 1983-01-19 |
| FR2455039A1 (fr) | 1980-11-21 |
| PT70698A (fr) | 1980-02-01 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification | ||
| REN | Ceased due to non-payment of the annual fee |